Clinical trials: Autonomic Nervous System Modulation
Coronary Arterial Disease (CAD)
Effects of Heart Rate Variability-guided Training vs Standard Aerobic Prescription on Cardiovagal Modulation and Cardiorespiratory Fitness in Coronary Artery Disease
Coronary artery disease (CAD) is associated with autonomic dysfunction and is characterized by reduced heart rate variability (HRV) and impaired heart rate recovery.
- Trial name
- ParaDox (NCT06919237)
- Testing
- HIIT Intervention, MICT Intervention, HRV-Guided Intervention
- Where
- Portugal
- Volunteers
- 48 people
- Sponsor
- Faculdade de Motricidade Humana
POTS - Postural Orthostatic Tachycardia Syndrome
Does a Periaqueductal Gray-vagus Nerve Interface Malfunction Explain the Nat hx With Its Numerous Co-morbidities?
Postural tachycardia syndrome (POTS) is a common and disabling disorder among adolescents. No epidemiologic data exist to support the often cited 0.5 to 2% prevalence.
- Trial name
- NCT06616363
- Testing
- Questionnaires to be competed, Provide list of medication and lifetime events, Use phone App to record new life events
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Sepsis, Lymphocyte Disorder T
Esmolol in Sepsis Management:Evaluating Immunomodulatory Effects and Impact on Patient Outcomes
Evaluate the effectiveness of esmolol, a selective β1-adrenergic receptor blocker, in modulating immune responses and improving patient outcomes in sepsis.
- Conditions
- Sepsis, Lymphocyte Disorder T, Immunologic Paralysis, Catecholamine; Overproduction
- Trial name
- NCT06390748
- Testing
- esmolol
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Lin Chen
Mood Modulation, Modulation of Cognition
Investigation of the Acute Cognitive, Mood and Autonomic Effects of Hops in Healthy Participants
Hops have been used for many years for their supposed sedative and anxiety reducing properties and can be found in many natural remedies for stress, anxiety and sleeping that are already available to buy.
- Trial name
- NCT01376869
- Testing
- Hops Extract
- Where
- United Kingdom
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Arthritis, Rheumatoid, Pain
Pain Modulation in Rheumatoid Arthritis (RA) - Influence of Adalimumab
The purpose of this study is to obtain increased knowledge concerning central pain and fatigue processing in rheumatoid arthritis, and how these conditions are influenced by treatment with Tumor Necrosis Factor (TNF) blockade…
- Conditions
- Arthritis, Rheumatoid, Pain, Fatigue
- Trial name
- PARADE (NCT01197144)
- Testing
- adalimumab
- Where
- 2 sites in Sweden
- Volunteers
- 70 people
- Sponsor
- Karolinska Institutet
Temporary Cardio-neural Pacing, Pacemaker Implantation
Cardioneural Temporary Pacing to Achieve Autonomic Modulation
Atrial fibrillation (AF) is the most common arrhythmia, with a lifetime risk of 1 in 3-5. In cases of rapid ventricular rate, patients often experience low blood pressure, making standard rate and rhythm control medications…
- Trial name
- NCT07247422
- Testing
- Temporary cardio-neural pacing
- Where
- Hong Kong
- Volunteers
- 33 people
- Sponsor
- Chinese University of Hong Kong
Pain Perception, Autonomic Nervous System Functioning
Music-based Intervention for the Reduction of Pain
This study aims to compare the impact of listening to frequency-modulated music vs. non-modulated music (both researcher-selected), and to test whether there are differential effects on pain and stress perception.
- Trial name
- MINTREP (NCT02991014)
- Testing
- researcher-selected frequency-modulated music, researcher-selected non-modulated music, participant-selected non-modulated music
- Where
- 2 sites in Austria, Germany
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Vienna
Diabetes Complications, Inspiratory Muscle Weakness
Effects of Inspiratory Muscle Training on Type 2 Diabetes Mellitus Patients With Inspiratory Muscle Weakness
The purpose of the study is to determine if inspiratory muscle training improves inspiratory muscle strength of type 2 diabetes mellitus patients with inspiratory muscle weakness.
- Trial name
- NCT00815178
- Testing
- Inspiratory muscle training
- Where
- Brazil
- Volunteers
- 25 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Premature Ventricular Contraction
LLTS to Treat Premature Ventricular Contractions
This randomized control trial is designed to explore the effect of low-level tragus stimulation in patients with frequent premature ventricular contractions.
- Trial name
- TREAT-PVC (NCT04909528)
- Testing
- Low-level tragus stimulation
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Paroxysmal Atrial Fibrillation
The Impact of Expandable Cryoballoon on Autonomic Control of the Heart
Approximately 40% of patients following cryoballoon ablation show signs of parasympathetic denervation. The presence of such effect is related to better outcomes in terms of clinical efficacy (freedom from atrial fibrillation).
- Trial name
- NCT06053606
- Testing
- cryoablation of atrial fibrillation using only 28 mm size balloon, cryoablation of atrial fibrillation using expandable balloon (28 / 31 mm)
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Wroclaw Medical University
Postmenopausal Disorder, Autonomic Imbalance
Inspiratory Muscle Training X CardioBreath App Effects On Vagal Modulation And Pulse Wave Velocity
Existing data points to relevant beneficial effects of respiratory exercises on cardiovascular health, with special regards to decreases on arterial pressure and improves on autonomic and vascular profiles, though mechanistics of…
- Conditions
- Postmenopausal Disorder, Autonomic Imbalance, Vascular Stiffness
- Trial name
- CardioBreath (NCT03672760)
- Testing
- CardioBreathApp, IMT PowerBreath
- Where
- Brazil
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Instituto de Cardiologia do Rio Grande do Sul
Stroke
Evaluation of Autonomic Modulation in Stroke After Transcranial Direct Current Stimulation and Treadmill Training
Introduction: Patients post-stroke may have autonomic dysfunction, with increased blood pressure, heart rate (HR) and increased risk of sudden death.
- Trial name
- NCT02956096
- Testing
- Transcranial direct current stimulation (tDCS), training on the running belt
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- University of Nove de Julho
Plaque Psoriasis
Efficacy and Safety Study of Autonomic Nerve Modulation (ANM) in Subjects With Moderate Plaque Psoriasis
This is a 16-week, prospective, multicenter, double-blind, controlled, randomized study assessing change in psoriasis severity and level of stress in patients with moderate psoriasis treated with ANM.
- Trial name
- NCT03817164
- Testing
- Autonomic Nerve Modulation - Active, Autonomic Nerve Modulation - Control
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Thync Global, Inc.
Subarachnoid Hemorrhage, Aneurysmal, Delayed Cerebral Ischemia
Noninvasive CA Monitoring Validation and Autonomic Modulation in Aneurysmal Subarachnoid Hemorrhage
This is a two-component prospective study of adult aneurysmal subarachnoid hemorrhage (aSAH) patients admitted to the Neurosciences Intensive Care Unit (NSICU) at UT Southwestern Medical Center.
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Delayed Cerebral Ischemia, Cerebral Vasospasm, Autonomic Nervous System Diseases
- Trial name
- NCT07577739
- Testing
- Right-Sided Cervical Sympathetic Block at C6, Transcutaneous Auricular Vagal Nerve Stimulation (taVNS)
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Texas Southwestern Medical Center
Metabolic Syndrome, Metabolic Syndrome X
Periodized Aerobic Interval Training in Metabolic Syndrome
Autonomic disfunction present in metabolic syndrome subjects is related by a greater vulnerability of the heart and risk of cardiovascular events.
- Trial name
- NCT03119493
- Testing
- Periodized aerobic interval training
- Where
- Brazil
- Volunteers
- 52 people
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Healhty
Acute Effects of Reformer, Cadillac, and Chair Pilates Appa-ratuses on Cardiac Autonomic Modulation and Flexibility
This study looked at how different types of Pilates equipment affect heart function and flexibility right after exercise in sedentary middle-aged women.
- Trial name
- NCT07308626
- Testing
- Reformer-based Pilates, Cadillac-based Pilates, Chair Pilates Session
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Princess Nourah Bint Abdulrahman University
Cardiovascular Diseases, Cardiovascular Risk Factor
Stratification Protocols and Clinical, Physical and Biochemical Parameters to Forecast Cardiovascular Intercurrences.
Introduction: Despite the various beneficial effects, cardiovascular rehabilitation programs (CVRP) have been associated with the appearance of signs and symptoms.
- Trial name
- NCT03446742
- Testing
- Cardiovascular rehabilitation
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Autonomic Nervous System, Heart Rate Variability
Non-invasive Modulation of Autonomic Cardiac Nervous System
To demonstrate the effect of non invasive vagus nerve (VNS) stimulation on heart rate variability and MSNA signal.
- Conditions
- Autonomic Nervous System, Heart Rate Variability, Muscle Sympathetic Nerve Activity
- Trial name
- MSNA (NCT04057508)
- Testing
- Modulation of muscle sympathetic nerve activity
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Université Catholique de Louvain
Healthy Volunteers
Effects of Massage in Different Moments of Application on Autonomic Cardiac Modulation and Cardiorespiratory Parameters
Performing physical exercise alters the body's homeostasis, and recuperative techniques seek to anticipate and potentiate the body's recovery.
- Trial name
- NCT03094676
- Testing
- Massage, Exercise
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Cardiac Autonomic Function, Hemodynamic Changes
Effects of Post-Match Foam Rolling, Static Stretching, and Passive Rest on Acute Cardiac-Autonomic, Hemodynamic, and Neuromuscular Recovery in National Wrestlers
This study looks at three common ways athletes recover after a wrestling match: foam rolling, static stretching, and resting. We want to learn which method helps the body recover better in the short time that athletes often have…
- Conditions
- Cardiac Autonomic Function, Hemodynamic Changes, Neuromuscular Adaptations, Exercise and Recovery
- Trial name
- NCT07305506
- Testing
- Foam Rolling, Static Stretching
- Where
- Turkey (Türkiye)
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Ali Kamil GÜNGÖR