Clinical trials: Autophagy
Biological Aging
Healthy Aging Through Time- Restricted Eating in Adults With Overweight/Obesity and Incipient Liver Disease: ENSATI
The goal of this clinical trial is to evaluate the effect of a time-restricted eating (TRE) regimen on hallmarks of aging, in comparison with traditional caloric restriction and an unrestricted diet in adults with…
- Trial name
- ENSATI (NCT05880095)
- Testing
- Unrestricted Mediterranean diet, Energy-reduced Mediterranean diet, Mediterranean diet with time-restricted eating
- Where
- Spain
- Volunteers
- 176 people
- Sponsor
- IMDEA Food
Non-alcoholic Fatty Liver Disease, Obesity
The Influence of Autophagy on Fatty Liver
Non-alcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease worldwide. It is not known why only some obese subjects develop NAFLD.
- Trial name
- NCT01988441
- Where
- Taiwan
- Volunteers
- 800 people
- Sponsor
- Far Eastern Memorial Hospital
Endometrial Polyp, Autophagy
Autophagy Markers in Endometrial Polyps
The aim of this research is to evaluate autophagy markers in patients with endometrial polyps
- Trial name
- NCT04706000
- Testing
- Beclin 1 gene
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Muğla Sıtkı Koçman University
Uterine Cervical Neoplasms
MR Metabolic Biomarkers for Cervical Cancer
The purposes of this study are: (1) to develop magnetic resonance (MR) imaging and spectroscopy as surrogate biomarkers for altered cancer metabolism in cervical cancer; (2) to understand the function of human papillomavirus…
- Trial name
- NCT01874548
- Where
- Taiwan
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Pregnancy Complications, Pre-Eclampsia
Autophagy/Apoptosis Balance in Placental Vascular Pathologies
Pregnancy increases the risk of thrombosis. Placenta-mediated diseases are a risk factor for cardiovascular pathologies and can lead to maternal-fetal morbidity and mortality.
- Conditions
- Pregnancy Complications, Pre-Eclampsia, Growth Retardation, Intrauterine
- Trial name
- GROSSAUTOP-2 (NCT06779916)
- Testing
- Blood test, Urine test
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Depression - Major Depressive Disorder, Overweight (BMI > 25)
Fasting, Exercise, and Diet to Activate Autophagy in Depression
Depression is a common mental health condition that affects millions of people worldwide and is a leading cause of disability. Although current treatments can be effective, many patients do not fully recover or experience…
- Trial name
- AutoFast (NCT07664540)
- Testing
- Performance test
- Where
- Switzerland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Advanced BRAF Mutant Melanoma
Dabrafenib, Trametinib and Hydroxychloroquine in Patients With Advanced BRAF Mutant Melanoma
The primary purpose of this study is to determine the maximum tolerated dose (MTD) and preliminary safety of hydroxychloroquine (HCQ) when administered in conjunction with oral dabrafenib and trametinib (D+T) in patients with…
- Trial name
- BAMM (NCT02257424)
- Testing
- Trametinib 2 mg daily, hydroxychloroquine (HCQ), dabrafenib 150 mg orally twice a day
- Where
- 4 sites in United States
- Volunteers
- 50 people
- Sponsor
- Abramson Cancer Center at Penn Medicine