Clinical trials: Autoregulation
Homeostasis, Metabolism and Nutrition Disorder
Energy Metabolism Profiles Over Weight-loss and Eating Responses
This is an exploratory controlled before-after study, which involves 112 participants, of whom 28 are with normal weight and 84 are overweight or obese.
- Conditions
- Homeostasis, Metabolism and Nutrition Disorder, Healthy, Obesity
- Trial name
- NCT05785221
- Testing
- General lifestyle and nutritional education, Personalized nutritional and lifestyle weight reduction intervention
- Where
- China
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Sciences
Pregnancy Anemia, Newborn; Anemia
Erythroferrone and Its Impact on Maternal and Neonatal Iron Homeostasis
Erythroferrone (ERFE) is a recently identified iron-regulatory hormone that couples iron homeostasis to erythropoiesis but at this time there are no human data on this hormone in pregnant women and their neonates.
- Trial name
- NCT04517734
- Where
- 2 sites in United States
- Volunteers
- 338 people, healthy volunteers welcome
- Sponsor
- Cornell University
Glucose Homeostasis, Protein Metabolism
The Role of Glucocorticoid Receptor SNPs in Receptor Function and Metabolic Disease
Background: Glucocorticoids are primary stress response hormones released from the adrenal gland when an individual is under stress.
- Conditions
- Glucose Homeostasis, Protein Metabolism, Lipid Metabolism, Respiratory Function
- Trial name
- NCT01143493
- Where
- United States
- Volunteers
- 278 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Diabetes, Prediabetic
Sleep Effectiveness and Insulin and Glucose Homeostasis
The purpose of this study is to examine the influence of sleep effectiveness on glucose and insulin metabolism in health and disease (prediabetes and type two diabetes).
- Conditions
- Diabetes, Prediabetic, Prediabetes, Glucose Intolerance
- Trial name
- NCT01887691
- Testing
- eszopiclone
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Diabetes Mellitus, Type 1, Hypoglycemia
The Role of Glucose-Dependent Insulinotropic Polypeptide in the Pathological Glucose Homeostasis Of Type 1 Diabetes
In the present project the investigators will evaluate whether glucagonotropic properties of the gut-derived incretin hormone glucose-dependent insulinotropic polypeptide (GIP) may be utilized as a safeguard against hypoglycemia…
- Trial name
- NCT03734718
- Testing
- GIP
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Steno Diabetes Center Copenhagen
Dental Caries, Probiotics
Effect of Probiotics on Oral Homeostasis During Sugar Stress
The present study is a double-blinded randomized clinical trial with a duration of 28 days.
- Conditions
- Dental Caries, Probiotics, Gingivitis
- Trial name
- NCT05073393
- Testing
- Sugar stress
- Where
- Denmark
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Vitamin D and Calcium Homeostasis
CYP3A4 Activity and Mineral Homeostasis
The purpose of this study is to determine whether changes in the activity of the enzyme CYP3A4 can change the Vitamin D and bone mineral homeostasis.
- Trial name
- NCT02019875
- Testing
- Rifampin, Clarithromycin, Grapefruit Juice
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- University of Washington
Healthy, Aging
Homeostatic Sleep Regulation in Older Persons
The purpose of this study is to test the hypothesis that sleep homeostasis, also known as sleep pressure or sleep drive, is different in healthy older and younger individuals.
- Trial name
- NCT00601445
- Testing
- Amount of sleep and wake
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Acute Ischemic Stroke
Effect of Serial Remote Ischemic Conditioning on Dynamic Cerebral Autoregulation in Patients With Intravenous Thrombolysis (SRICDCA-IVT)
The purpose of this study is to determine the effect of serial remote ischemic conditioning on dynamic cerebral autoregulation in patients with intravenous thrombolysis with alteplase.
- Trial name
- SRICDCA-IVT (NCT05550103)
- Testing
- Remote ischemic conditioning, Standard medical treatment
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Yi Yang
Oxidative-reduction Homeostasis, Post-stroke Cognitive Impairment
Oxidation-reduction Homeostasis in Cognitive Impairment Patients After Stroke
Cognitive impairment after ischemic stroke can affect not only the social adaptation ability, but also affect the comprehensive rehabilitation of patients.
- Trial name
- NCT03519828
- Testing
- No intervention has been conducted
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Hui-Sheng Chen
Acute Brain Injuries, TBI (Traumatic Brain Injury)
Dynamic and Static Autoregulation After Brain Injury
The aim of the study assesses static and dynamic cerebrovascular autoregulation daily over one week in patients with traumatic brain injury or intracranial hemorrhage to quantify the temporal profile of the autoregulatory status.
- Conditions
- Acute Brain Injuries, TBI (Traumatic Brain Injury), Intracranial Hemorrhages
- Trial name
- NCT01069250
- Testing
- There are no interventions in this study
- Where
- Germany
- Volunteers
- 16 people
- Sponsor
- Johannes Gutenberg University Mainz
Healthy
Human Beta-2 Adrenergic Stimulation and Muscle Glucose Uptake
The purpose of this study is to investigate the effect of two weeks clenbuterol/placebo supplementation on skeletal muscle glucose disposal in healthy male volunteers.
- Trial name
- NCT03800290
- Testing
- Clenbuterol Hydrochloride
- Where
- Netherlands
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Maastricht University
Healthy
Storage Lesion in Banked Blood Due to Disruption of Nitric Oxide (NO) Homeostasis
The purpose of this study is to explore the impact of aged blood on endothelial function by measuring forearm blood flow during intra-arterial acetylcholine infusion in normal healthy human volunteers after infusion of autologous…
- Trial name
- NCT01137656
- Testing
- Acetylcholine and Blood
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Mark Gladwin
Insulin Sensitivity, Oxidative Stress
Racial Differences in Vagal Control of Glucose Homeostasis, Chronic Study
Investigators will test the hypothesis that chronic restoration of vagal nerve activity with a central acetylcholinesterase inhibitor improves insulin sensitivity and reduces adipose tissue oxidation in obese African American…
- Trial name
- RDVCGH (NCT03014323)
- Testing
- Galantamine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Transradial Catheterization
Differences in Radial Artery Occlusion From Two Different Compressive Methods Used in Patients in Order to Achieve Homeostasis After Transradial Catheterization and Their Repercussion in Artery Functionality and Hand Mobility
The aim of the study is to determine differences on radial artery occlusion from two compressive methods used after transradial catheterization and its functional impact on hand mobility.
- Trial name
- NCT02697526
- Testing
- Terumo, Tensoplast
- Where
- Spain
- Volunteers
- 274 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Cerebral Small Vessel Diseases
Effects of Remote Ischemic Conditioning on Dynamic Cerebral Autoregulation, Blood Pressure and Heart Rate Variability in Patients With Cerebral Small Vessel Disease
The purpose of this study is to determine effects of remote ischemic conditioning on dynamic cerebral autoregulation, blood pressure and heart rate variability in patients with cerebral small vessel disease.
- Trial name
- ESCAPE-SVD (NCT05225948)
- Testing
- Remote ischemic conditioning
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Yi Yang
Type 2 Diabetes Mellitus (T2DM), Chronic Renal Insufficiency
Study on Improving Blood Glucose Homeostasis With Dorzagliatin Tablets in the Treatment of Type 2 Diabetes Mellitus Patients With Moderate to Severe Chronic Renal Insufficiency
This study aims to evaluate whether dorzagliatin can improve glycemic homeostasis in patients with type 2 diabetes mellitus (T2DM) complicated by chronic renal insufficiency, and to compare the efficacy of dorzagliatin with…
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Chronic Renal Insufficiency, Chronic Kidney Disease (Stages 3b-5), Glucose Homeostasis
- Trial name
- NCT07786571
- Testing
- Dorzagliatin, Linagliptin
- Where
- China
- Sponsor
- Sun Yat-sen University
Cardiac Arrest (CA)
Integrated Near-Infrared Spectroscopy and Hemodynamic Monitoring for Cerebral Autoregulation in Post-Cardiac Arrest Care Neuroprognostication
Neurological outcome is the primary outcome for post-cardiac arrest patients. Hypoxic-ischemic brain injury is a key element in post-cardiac arrest syndrome, and remains the leading cause of mortality and morbidity in…
- Trial name
- NCT07875348
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Hormonal Contraception
Stress Reactivity and Hormonal Contraception
For almost 60 years, millions of women globally have relied on oral contraceptive (OC) pills for pregnancy prevention and addressing menstrual irregularities.
- Trial name
- NCT06223126
- Testing
- Combined oral contraception, Discontinuation of a combined oral contraception
- Where
- Germany
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Acute Myocardial Infarction, Persisting Ischemia
Intra-aortic Balloon Pump in Extensive Myocardial Infarction With Persistent Ischemia
Patients presenting with large myocardial infarction and signs of persistent ischemia after successful percutaneous coronary intervention, have a poor prognosis with respect to outcome and development of heart failure in the…
- Conditions
- Acute Myocardial Infarction, Persisting Ischemia, No Reflow
- Trial name
- SEMPER FI (NCT02125526)
- Testing
- Intra-aortic balloon pump
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Lokien van Nunen