Clinical trials: Autosomal Recessive Congenital Ichthyosis
Autosomal Recessive Congenital Ichthyosis, Skin Barrier Dysfunction
Cholesterol Cream vs Urea Cream for Skin Barrier and Quality of Life in Ichthyosis
This study looks at whether a cream containing 10% cholesterol works better than a cream containing 10% urea for people with autosomal recessive congenital ichthyosis (ARCI), a rare inherited skin condition that causes dry…
- Conditions
- Autosomal Recessive Congenital Ichthyosis, Skin Barrier Dysfunction, Ichthyosis Inherited
- Trial name
- CURE-ARCI (NCT07689435)
- Testing
- 10% Cholesterol Cream, 10% Urea cream
- Where
- Thailand
- Volunteers
- 24 people
- Sponsor
- Institute of Dermatology, Thailand
Autosomal Recessive Congenital Ichthyosis, Epidermolytic Ichthyosis
Study of in Vivo and in Vitro Transcriptomic and Proteomic Signatures in Unhereditary Ichtyosis
The goal of this study is to identify important biological pathways involved in a variety of ichtyosis, using transcriptomic and proteomic techniques, with the aim of guiding the development of new therapeutis.
- Trial name
- OMICHTYOSE (NCT05312073)
- Testing
- Biological samples, Skin biopsy
- Where
- France
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
TGM-1 Related Autosomal Recessive Congenital Ichthyosis
Topical KB105 Gene Therapy for the Treatment of TGM1-deficient Autosomal Recessive Congenital Ichthyosis (ARCI)
This study is an intra-patient comparison of KB105 and placebo-administered Target Areas. The primary objectives of this study are to evaluate safety and Investigator Global Assessment (IGA) scale improvement of topically…
- Trial name
- NCT04047732
- Testing
- KB105
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- Krystal Biotech, Inc.
Ichthyosis, Autosomal Recessive Congenital Ichthyosis
The Efficacy and Safety of Secukinumab in Patients With Ichthyoses
The ichthyoses are a group of lifelong genetic disorders which share characteristics of generalized skin thickening, scaling and underlying cutaneous inflammation.
- Conditions
- Ichthyosis, Autosomal Recessive Congenital Ichthyosis, Lamellar Ichthyosis, Congenital Ichthyosiform Erythroderma
- Trial name
- NCT03041038
- Testing
- Secukinumab
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Northwestern University