Clinical trials: Autotransplantation
Multiple Myeloma
MGTA-145 + Plerixafor in the Mobilization of Hematopoietic Stem Cells for Autologous Transplantation in Multiple Myeloma
This study evaluates a new drug MGTA-145 in combination with plerixafor (Mozobil) to mobilize stem cells into the peripheral blood for collection by apheresis.
- Trial name
- NCT04552743
- Testing
- MGTA-145, Plerixafor
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Surbhi Sidana, MD
Degenerative Disc Disease
A Pilot Study to Evaluate an Osteogenic Protein 1 (OP-1) Putty Spinal System and an Autograft Spinal System
This study will explore the use of recombinant OP-1 in conjunction with surgical treatment of single-level TLIF of the lumbar spine.
- Trial name
- NCT00678171
- Testing
- TLIF with a PEEK Spacer System and XIA Spinal System
- Where
- 10 sites in United States
- Volunteers
- 30 people
- Sponsor
- Olympus Biotech Corporation
Stem Cell Transplantation, Cirrhosis
Autologous Bone Marrow Stem Cells in Cirrhosis Patients
Liver cirrhosis (LC) is the end stage of chronic liver disease. The liver transplantation is one of the only effective therapies available to such patients.
- Trial name
- NCT00713934
- Testing
- CD133, BM-MNC
- Where
- 2 sites in Iran
- Volunteers
- 7 people
- Sponsor
- Royan Institute
Glioma, Glioma, Malignant
Laparoscopically Harvested Omental Free Tissue Autograft to Bypass the Blood Brain Barrier (BBB) in Human Recurrent Glioblastoma Multiforme (rGBM)
This single center, single arm, open-label, phase I study will assess the safety of a laparoscopically harvested omental free flap into the resection cavity of recurrent glioblastoma multiforme (GBM) patients.
- Conditions
- Glioma, Glioma, Malignant, Glioblastoma, Glioblastoma Multiforme
- Trial name
- NCT04222309
- Testing
- Laparoscopically harvested omental free flap
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Northwell Health
Malignant Lymphoma, Multiple Myeloma
A Randomized, Comparative, Double-blind Trial of Pentaisomaltose and Dimethyl Sulphoxide for Cryoprotection of Hematopoietic Stem Cells in Subjects With Multiple Myeloma or Malignant Lymphoma With a Need for Autologous Transplantation
A randomized, comparative, double-blind trial of pentaisomaltose and dimethyl sulphoxide for cryoprotection of hematopoietic stem cells in subjects with multiple myeloma or malignant lymphoma with a need for autologous…
- Trial name
- NCT05545202
- Testing
- Pentaisomaltose
- Volunteers
- 150 people
- Sponsor
- Pharmacosmos A/S
Pterygium of Conjunctiva and Cornea
Cauterization Versus fibrin Glue for Conjunctival Autografting in Primary Pterygium Surgery
Pterygium is a noncancerous growth of the conjunctival tissue over the cornea. It is a progressive disease that may lead to visual impairment in advanced stages, as well as restriction of ocular motility, chronic inflammation and…
- Trial name
- NCT03321201
- Testing
- Cauterization, Fibrin glue
- Where
- Croatia
- Volunteers
- 164 people
- Sponsor
- University of Split, School of Medicine
Thyroid
Thyroid Autotransplantation in Quadriceps Femoris Muscle
providing an almost natural ectopic thyroid in patients undergoing total thyroidectomy, remains a challenging subject that can benefits patients with a non-pharmacological substitute for their normal gland.
- Trial name
- NCT04684953
- Testing
- Throid autotransplantation, Hormone
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Assiut University
Retinal Perforations
Evaluation of a New Surgical Technique for Macular Hole Which Was Not Closed After a Previous Surgery
Macular hole is an infrequent retinal pathology (2 to 4/1000) which most often affects people aged over 60, and twice common in women than men. The vast majority of cases are idiopathic.
- Trial name
- ILMT (NCT02946372)
- Testing
- internal limiting membrane transplantation (ILMT)
- Where
- France
- Volunteers
- 16 people
- Sponsor
- Groupe Hospitalier de la Region de Mulhouse et Sud Alsace
Recurrent Pterygium, Micro-Conjunctival Autografting Combined With Amniotic Membrane Transplantation
Micro-Conjunctival Autografting Combined With Amniotic Membrane Transplantation Treating Recurrent Pterygium Trial
To observe the effect of micro-conjunctival autografting combined with amniotic membrane transplantation on the postoperative recurrence, complications and ocular surface symptoms among patients with recurrent pterygium.
- Trial name
- NCT05362253
- Testing
- Micro-Conjunctival Autograft Combined with Amniotic Membrane Transplantation, Conventional Autologous Conjunctival Transplantation
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Yifeng Yu
PCL TEAR
Posterior Cruciate Ligament Reconstruction Using Knot/Press-fit Technique
This study presents an arthroscopic-assisted PCL reconstruction using femoral knot/press-fit technique with a periosteum-enveloping graft in tibial tunnel.
- Trial name
- NCT01200095
- Volunteers
- 30 people
- Sponsor
- Taipei Medical University WanFang Hospital
Anterior Cruciate Ligament Tear, Anterior Cruciate Ligament Injuries
Anterior Cruciate Ligament Reconstruction With Quadriceps Tendon Bone Autograft
Anterior cruciate ligament injuries are one of the most common sports knee injuries. Their effect on the knee joint can be detrimental with patients experiencing instability and progressive damage of the intraarticular…
- Conditions
- Anterior Cruciate Ligament Tear, Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture
- Trial name
- NCT05673356
- Testing
- Arthroscopic anterior cruciate ligament reconstruction with quadriceps tendon bone autograft (QTB)
- Where
- Poland
- Volunteers
- 25 people
- Sponsor
- Artromedical Konrad Malinowski Clinic
Anterior Cruciate Ligament Injuries
Anterior Cruciate Ligament Reconstruction Made With Hamstring Tendon And Quadriceps Tendon Autografts
Anterior cruciate ligament reconstruction (ACLR) is one of the most common procedure all around the world, however optimal graft source for ACLR still remains controversial.
- Trial name
- NCT04940169
- Testing
- anterior cruciate ligament recontruction
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people
- Sponsor
- SB Istanbul Education and Research Hospital
Cancer, Myeloma
Imageguided Theranostics in Multiple Myeloma
Theranostics is the use of a diagnostic test to decide which patients will benefit from a certain treatment. The current standard treatment for patients with myeloma is induction chemotherapy followed by peripheral stem cell…
- Trial name
- iTIMM (NCT02403102)
- Where
- United Kingdom
- Volunteers
- 61 people
- Sponsor
- Institute of Cancer Research, United Kingdom
Secondary Hyperparathyroidism
Comparison of Total Parathyroidectomy With and Without Autotransplantation
The purpose of this study is to compare short-term and long-term efficacy of total parathyroidectomy with autotransplantation and total parathyroidectomy without autotransplantation for Secondary hyperparathyroidism.
- Trial name
- NCT02536287
- Testing
- total PTX without autotransplantation, total PTX with autotransplantation
- Where
- China
- Volunteers
- 96 people
- Sponsor
- The Second Hospital of Anhui Medical University
Vitiligo
Hair Transplantation for Treatment of Vitiligo
There are several surgical methods to treat vitiligo patches, and follicular unit extraction (FUE) is one among them. FUE, performed using punch biopsy extraction and hair follicle transplantation, has proven safe and effective…
- Trial name
- NCT04858152
- Testing
- Follicular Unit Extraction via punch biopsy
- Where
- United States
- Sponsor
- Mehdi Rashighi
Blood Diseases
Efficacy of Biosimilar Filgrastim on the Mobilization of Hematopoietic Stem Cell CD34+ (Cluster of Differentiation 34) and on the Kinetic Engraftment
The endogenous growth factor granulocyte (G-CSF) stimulates the proliferation and differentiation of hematopoietic progenitors commissioned to mature as neutrophils and activated granulocytes mature neutrophils.
- Trial name
- NCT02806791
- Testing
- FILGRASTIM
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Azienda Ospedaliera San Giovanni Battista
Anterior Cruciate Ligament Tear, Ankle Sprains
Effect of ACL Reconstruction in Biomechanical Properties of Ankle Joint Complex
BACKGROUND: Anterior cruciate ligament (ACL) is an important ligamentous structure in the knee joint which contributes in maintaining stability.
- Trial name
- NCT06631690
- Testing
- Isokinetic and functional balance tests
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Significant Bone Defect in the Orbit
Efficiency of 3D-printed Implant Versus Autograft for Orbital Reconstruction (TOR-3D)
Two scenarios may result in significant bone defect in the orbit: surgical oncology (meningioma, cancers of the upper aerodigestive tract) or severe trauma.
- Trial name
- TOR-3D (NCT03608280)
- Testing
- Bone autograft, Orbital reconstruction by 3D-printed porous titanium implant
- Where
- France
- Volunteers
- 92 people
- Sponsor
- Hospices Civils de Lyon
Tibial Fractures
rhBMP-2 Versus Autograft in Critical Size Tibial Defects
The purpose of our study is to evaluate the use of recombinant human bone morphogenetic protein 2 (RhBMP-2) as compared to standard ICBG in the treatment of severe open tibia fractures with a critical size bone defect (at least…
- Trial name
- NCT00853489
- Testing
- recombinant bone morphogenetic protein 2, Autogenous iliac crest bone graft
- Where
- 13 sites in United States
- Volunteers
- 33 people
- Sponsor
- St. Louis University
Multiple Myeloma
Stem Cell Transplant With Lenalidomide Maintenance in Patients With Multiple Myeloma (BMT CTN 0702)
The study is designed as a Phase III, multicenter trial of tandem autologous transplants plus maintenance therapy versus the strategy of single autologous transplant plus consolidation therapy with lenalidomide, bortezomib and…
- Trial name
- NCT01109004
- Testing
- Lenalidomide, lenalidomide, bortezomib and dexamethasone
- Where
- 54 sites in United States
- Volunteers
- 758 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)