Clinical trials: Autotransplantation
Pterygium
Bevacizumab for Primary Pterygium Treatment
The aim of this study was to investigate the efficacy and safety of subconjunctival bevacizumab application as an adjuvant therapy for primary pterygium.
- Trial name
- NCT01686529
- Testing
- Autoconjunctival grafting, Subconjuntival bevacizumab injection
- Where
- Mexico
- Volunteers
- 49 people
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana
Knee Injury
Evaluation of the CR Plug for Repair of Defects Created at the Harvest Site From an Autograft in the Knee.
The main objective of this study is to test the ability of an allograft plug to provide a successful repair of an osteochondral defect left at the harvest site during OATS procedure.
- Trial name
- CRB (NCT00821873)
- Testing
- CR Plug
- Where
- 4 sites in United States
- Volunteers
- 9 people
- Sponsor
- RTI Surgical
Degenerative Disc Disease, Spinal Stenosis
Comparison of nanOss Bioactive With Autograft and Bone Marrow Aspirate to Autograft in the Posterolateral Spine
nanOss Bioactive is approved for use in the U.S. The purpose of this study is to compare fusion results in the posterolateral spine using nanOss Bioactive mixed with autograft bone and bone marrow aspirate (BMA) on one side and…
- Conditions
- Degenerative Disc Disease, Spinal Stenosis, Spondylolisthesis
- Trial name
- NCT01968993
- Testing
- nanOss Bioactive - posterolateral gutter
- Where
- 3 sites in United States
- Volunteers
- 24 people
- Sponsor
- Pioneer Surgical Technology, Inc.
Breast Cancer, Lymphoma
Biological Therapies Following Peripheral Stem Cell Transplantation in Treating Patients With Non-Hodgkin's Lymphoma, Hodgkin's Disease, or Advanced Breast Cancer
RATIONALE: Interleukin-2 may stimulate a person's white blood cells to kill cancer cells. Filgrastim and stem cell factor may increase the number of immune cells found in bone marrow or peripheral blood and may help a person's…
- Trial name
- NCT00005993
- Testing
- aldesleukin, filgrastim, recombinant human stem cell factor
- Sponsor
- Masonic Cancer Center, University of Minnesota
Leg Ulcer, Diabetic Foot
Autologous Transplantation of BM-ECs With Platelet-Rich Plasma Extract for the Treatment of Critical Limb Ischemia
The intent of this clinical study is to evaluate the safety of the injection composed of autologous bone marrow derived endothelial cells (BM-ECs) and platelet-rich plasma extract (PRPE) for the treatment of critical limb…
- Conditions
- Leg Ulcer, Diabetic Foot, Gangrene, Peripheral Vascular Disease
- Trial name
- NCT02993809
- Testing
- BM-ECs and PRPE, BM-ECs
- Volunteers
- 40 people
- Sponsor
- South China Research Center for Stem Cell and Regenerative Medicine
Lymphoma, Myeloma
Pedometer Activity Monitoring After ASCT
The trial assess the proportion of patients who resumed their professional activity within 100 days after ASCT (autologous stem cell Transplantation).
- Conditions
- Lymphoma, Myeloma, High-dose Chemotherapy, Autologous Stem Cell Transplantation
- Trial name
- PAMAL (NCT03238599)
- Testing
- Pedometer-based activity monitoring after ASCT
- Where
- Switzerland
- Volunteers
- 62 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Glioma, Malignant, Glioblastoma
Surgical Tissue Flap to Bypass the Blood Brain Barrier in Glioblastoma
This single center, single arm, open-label, phase 2 study will assess the safety and efficacy of a pedicled temporoparietal fascial (TPF) or pericranial flap into the resection cavity of newly diagnosed glioblastoma multifome…
- Conditions
- Glioma, Malignant, Glioblastoma, Glioblastoma Multiforme, Glioblastoma Multiforme, Adult
- Trial name
- NCT05954858
- Testing
- Tissue autograft of pedicled temporoparietal fascial (TPF) or pericranial flap to bypass the blood brain barrier (BBB)
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Northwell Health
Partial Pancreatectomy Due to Benign Pancreatic Neoplasm
Effect of Islet Autotransplantation Compared to Oral Antidiabetic Drug.
Effects of autologous islet transplantation were compared to those of oral anti-diabetic drugs after distal pancreatectomy. The primary interest is a insulin-secretory function after the surgery in two intervention groups.
- Trial name
- NCT01922492
- Testing
- Autologous islet transplantation, Oral anti-diabetic drugs
- Where
- South Korea
- Volunteers
- 28 people
- Sponsor
- Seoul National University Hospital
Waldenstrom Macroglobulinemia
DT PACE, Tandem Autologous Transplant, Maintenance Therapy for Waldenstrom's Macroglobulinemia Patients
The purpose of this study is to find out what the response is and the side effects are with chemotherapy using a combination of drugs called D.T.
- Trial name
- NCT00107614
- Testing
- DT PACE + Rituxan
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Arkansas
Anterior Cruciate Ligament Injuries
Comparative Study of Functional Outcomes Between Peroneus Longus and Hamstring Tendon Autografts in Arthroscopic ACL Reconstruction
This is a prospective, single-blinded, randomized controlled trial. Sixty patients (≥18 years) with an isolated ACL injury will be randomly assigned to receive an ACL reconstruction using either a Peroneus Longus Tendon (PLT)…
- Trial name
- NCT07346326
- Testing
- Hamstring Tendon Autograft Harvest and ACL Reconstruction, Peroneus Longus Tendon Autograft Harvest and ACL Reconstruction
- Where
- Pakistan
- Volunteers
- 64 people
- Sponsor
- Khyber Medical University Peshawar
Cancer, Myeloma
Imageguided Theranostics in Multiple Myeloma
Theranostics is the use of a diagnostic test to decide which patients will benefit from a certain treatment. The current standard treatment for patients with myeloma is induction chemotherapy followed by peripheral stem cell…
- Trial name
- iTIMM (NCT02403102)
- Where
- United Kingdom
- Volunteers
- 61 people
- Sponsor
- Institute of Cancer Research, United Kingdom
COPD
Autologous Transplantation of Bronchial Basal Cells for Treatment of COPD
Chronic Obstructive Pulmonary Disease (COPD) is a disease characterized by long-term poor airflow, resulting in chronic pulmonary heart disease, chronic respiratory failure or even death.
- Trial name
- NCT03655795
- Testing
- Bronchial basal cells
- Volunteers
- 20 people
- Sponsor
- Ruijin Hospital
Ovarian Function Insufficiency
Constitution of a Cohort for Monitoring Patients Candidating for Ovarian Tissue Autograft
Ovarian cryopreservation is one of the available option for preserving fertility prior to potentially sterilizing treatments. In the absence of other techniques such as in vitro folliculogenesis or injection of isolated ovarian…
- Trial name
- PERIDATOR (NCT02855827)
- Where
- France
- Volunteers
- 240 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Xerostomia, Head and Neck Cancer
Salivary Gland Autotransplantation for Treatment of XRT Induced Xerostomia
Xerostomia, or dry mouth, is a common side effect of head neck radiation. Current treatment options for radiation-induced xerostomia are generally supportive in nature.
- Trial name
- NCT04007081
- Testing
- Bone Marrow Aspiration, Ultrasound Imaging of Salivary Glands, Salivary Assay
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Wisconsin, Madison
Partial-thickness Burn Wounds
Evaluating Whether Intact Fish Skin Graft Can Decrease the Need for Autograft in the Treatment of Deep Partial-Thickness Burns
The goal of this randomized controlled clinical trial is to determine whether use of Kericis Intact Fish Skin Graft (IFSG) can decrease the amount of autograft tissue needed for treatment of deep partial-thickness burns in…
- Trial name
- LOGI (NCT07326657)
- Testing
- Intact fish skin graft, autograft
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Kerecis Ltd.
Non-Hodgkin's Lymphoma, Diffuse Large Cell Lymphoma
Rituximab After Autologous Stem Cell Transplant for Relapsed B-cell Non-Hodgkin's Lymphoma
Conventional therapy is effective for diffuse aggressive lymphomas and low grade lymphomas, but is limited by relapse occurs in 40 to 50% of subjects.
- Conditions
- Non-Hodgkin's Lymphoma, Diffuse Large Cell Lymphoma, Mantle Cell Lymphoma, Transformed Lymphoma
- Trial name
- NCT00225212
- Testing
- Rituximab 375 mg/m2
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Stanford University
Anterior Cruciate Ligament Tear, Anterior Cruciate Ligament Injuries
Anterior Cruciate Ligament Reconstruction With Quadriceps Tendon Bone Autograft
Anterior cruciate ligament injuries are one of the most common sports knee injuries. Their effect on the knee joint can be detrimental with patients experiencing instability and progressive damage of the intraarticular…
- Conditions
- Anterior Cruciate Ligament Tear, Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture
- Trial name
- NCT05673356
- Testing
- Arthroscopic anterior cruciate ligament reconstruction with quadriceps tendon bone autograft (QTB)
- Where
- Poland
- Volunteers
- 25 people
- Sponsor
- Artromedical Konrad Malinowski Clinic
Nonunion Fracture
Allograft vs. Autograft Nonunion
The purpose of this research study is to find out if patients treated for nonunion fracture with autograft or allograft return to activity faster.
- Trial name
- NCT07310082
- Testing
- Autograft, Allograft
- Where
- United States
- Volunteers
- 156 people
- Sponsor
- Wake Forest University Health Sciences
Systemic Lupus Erythematosus
Lupus Immunosuppressive/Immunomodulatory Therapy or Stem Cell Transplant (LIST)
Systemic lupus erythematosus, also known as lupus or SLE, is a chronic, multisystem, autoimmune disease in which the body's internal system of defense attacks its own normal tissues.
- Trial name
- NCT00230035
- Testing
- Leukapheresis, Non-myeloablative high dose immunosuppressive therapy conditioning (HDIT), Autologous CD34+HPC transplantation (HSCT)
- Where
- 5 sites in United States
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
ACL Deficient Knee
ACLR: Isolated Autograft vs Allograft With Lateral Extra-articular Tenodesis
This study seeks to evaluate the utility of non-irradiated allograft tissue with lateral extra-articular tenodesis (LET) in the setting of anterior cruciate ligament reconstruction (ACLR).
- Trial name
- NCT06668155
- Testing
- Autograft Group, Allograft with LET Group
- Volunteers
- 60 people
- Sponsor
- University of Alabama at Birmingham