Clinical trials: Axial Spondylarthritis (axSpA)
Axial Spondylarthritis (axSpA)
Changes in Serum Calprotectin and Their Clinical Correlates in Axial Spondyloarthritis Patients Undergoing Pulmonary Rehabilitation
Our study aims to investigate changes in serum calprotectin levels in patients with axial spondyloarthritis enrolled in a pulmonary rehabilitation programme and to examine the relationship between serum calprotectin levels and…
- Trial name
- NCT07821541
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Giresun University
Axial Spondylarthritis (axSpA)
Presenting Patient-generated Data in axSpA Care
Chronic health conditions are often managed in secondary care services that are facing long waiting lists, limited appointment times, and financial pressures.
- Trial name
- NCT07782541
- Where
- United Kingdom
- Volunteers
- 17 people
- Sponsor
- Royal United Hospitals Bath NHS Foundation Trust
Axial Spondyloarthritis (AxSpA), Spondyloarthritis (SpA)
Multicenter Validation of the 2025 Classification Criteria for Axial Spondyloarthritis
This study aims to validate the 2025 ASAS-SPARTAN revised classification criteria for axial spondyloarthritis (axSpA) in the Chinese population through a multicenter, prospective, cross-sectional observational study.
- Conditions
- Axial Spondyloarthritis (AxSpA), Spondyloarthritis (SpA), Chronic Back Pain
- Trial name
- MVAS2025 (NCT07724847)
- Testing
- Diagnostic Assessment
- Where
- China
- Volunteers
- 247 people
- Sponsor
- Chinese PLA General Hospital
Axial Spondyloarthritis (AxSpA), Axial Spondyloarthritis, Non-Radiographic
The REFLECT Study- Flares in axSpA
Axial spondyloarthritis (axSpA) is a long-term inflammatory condition that affects the spine and sacroiliac joints. People living with axSpA often experience periods when their symptoms suddenly worsen, known as disease "flares."…
- Conditions
- Axial Spondyloarthritis (AxSpA), Axial Spondyloarthritis, Non-Radiographic, Axial Spondyloarthritis, Radiographic, Axial Spondylarthritis (r-axSpA)
- Trial name
- REFLECT (NCT07688174)
- Where
- 2 sites in United Kingdom
- Volunteers
- 40 people
- Sponsor
- Royal United Hospitals Bath NHS Foundation Trust
Axial Spondylarthritis (r-axSpA)
A Study to Assess Disease Activity in Adult Participants With Axial Spondyloarthritis Who Receive Upadacitinib in a Real-world Setting
Axial spondyloarthritis (axSpA) is an immune-mediated inflammatory disease primarily affecting the axial skeleton. The most frequent axSpA symptom is chronic, often inflammatory back pain that might be difficult to distinguish…
- Trial name
- UpSPINE (NCT05094128)
- Testing
- Upadacitinib
- Where
- 72 sites in Germany
- Volunteers
- 338 people
- Sponsor
- AbbVie
Fever of Unknown Origin, IgG4 Related Disease
The Investigators Will Evaluate the Diagnostic Performance of [18F]-AlF-FAPI-74 PET/CT in Inflammatory Disorders and Compare it With the Current Gold Standard for Inflammation, FDG PET/CT, in Three Patient Cohort: Patients Presenting With Fever of Unknown Origin, IgG4-RD and AxSpA.
The aim of the study to evaluate the performance of new [18F]-AlF-FAPI-74 PET/CT in three inflammatory disorders (fever of unknown origin, IgG4-related disease and axial spondyloarthritis) and compare with the current…
- Conditions
- Fever of Unknown Origin, IgG4 Related Disease, Axial Spondylarthritis (axSpA), Inflammation of Unknown Origin
- Trial name
- NCT07535554
- Testing
- [18F]AlF-FAPI-74 PET/CT
- Where
- Belgium
- Volunteers
- 140 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Axial Spondylarthritis (axSpA)
A Study of the Change in Early and Sustained Pain Control in Axial Spondylarthritis in Adult Participants Receiving Upadacitinib
Axial spondyloarthritis (axSpA) is an immune-mediated inflammatory disease primarily affecting the axial skeleton. The most frequent axSpA symptom is chronic, often inflammatory back pain (IBP) that might be difficult to…
- Trial name
- UPSTAND (NCT04846244)
- Where
- 160 sites in Argentina, Australia and 14 more
- Volunteers
- 708 people
- Sponsor
- AbbVie
Axial Spondylarthritis (axSpA)
Impact Of Upadacitinib On The Frequency Of Acute Recurrent Anterior Uveitis In Patients With Axial Spondyloarthritis
This is a Phase IV, open-label, multicenter study evaluating the impact of upadacitinib on the frequency of acute anterior uveitis (AAU) in adults with axial spondyloarthritis (axSpA) and a documented history of AAU in the prior…
- Trial name
- UP-FOR-U (NCT07018206)
- Testing
- Upadacitinib 15 MG [Rinvoq]
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- CARE ARTHRITIS LTD.
Axial Spondylarthritis (axSpA), Psoriatic Arthritis (PsA)
Treatment Effectiveness in People With axSpA or PsA Starting Treatment With Bimekizumab, Risankizumab, Guselkumab, Upadacitinib, or a TNF Inhibitor
This observational study will target patients with axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA) who have started treatment with bimekizumab, upadacitinib, risankizumab, guselkumab, or a tumour necrosis…
- Trial name
- NCT07166315
- Testing
- observational study
- Where
- United Kingdom
- Volunteers
- 700 people
- Sponsor
- Adelphi Real World
Rheumatic Diseases, Rheumatoid Arthritis (RA)
Clinical Assessment for Rheumatologic Disease - Research and Advancement in Safety and Efficacy
The CARe RAiSE project represents a pioneering translational initiative aimed at advancing precision medicine in the treatment of autoimmune rheumatic diseases.
- Conditions
- Rheumatic Diseases, Rheumatoid Arthritis (RA), Giant Cell Arteritis (GCA), Psoriatic Arthritis (PsA)
- Trial name
- CARe RAiSE (NCT07150000)
- Testing
- Ex Vivo Assay
- Where
- Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Bonn
Axial Spondylarthritis (axSpA)
Initial Standardized Global Review in Axial Spondyloarthritis
This study will be a pragmatic, cluster-randomized, controlled study with two parallel arms ( 'intervention' and 'usual care' (UC) arms) of one year duration.
- Trial name
- REVINSPA (NCT07141017)
- Testing
- Initial standardized global review
- Where
- 21 sites in France
- Volunteers
- 154 people
- Sponsor
- Association de Recherche Clinique en Rhumatologie
Axial Spondylarthritis (axSpA), Secukinumab
Efficacy and Influencing Factors of Secukinumab in Patients With Axial Spondyloarthritis
This study aimed to explore the efficacy and influencing factors of secukinumab in axSpA patients by conducting a real-world retrospective analysis.
- Trial name
- NCT07130331
- Testing
- Secikinumab
- Where
- China
- Volunteers
- 200 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Axial Spondylarthritis (axSpA), Myofascial Trigger Point Pain (MTrP)
Ultrasonographic Assessment of Thoracolumbar Fascia in AxSpA and Controls With Trigger Point Evaluation
The goal of this observational study is to evaluate whether changes in the thoracolumbar fascia (TLF)-a connective tissue in the lower back-are related to pain and disease severity in patients with axial spondyloarthropathy…
- Conditions
- Axial Spondylarthritis (axSpA), Myofascial Trigger Point Pain (MTrP), Ultrasound Exams
- Trial name
- NCT06978374
- Testing
- Sonographic examination of thoracolumbar fascia, manual examination of MTrP
- Where
- Turkey (Türkiye)
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Ankara University
Axial Spondyloarthritis, Axial Spondyloarthritis (AxSpA)
A LONGITUDINAL OBSERVATIONAL STUDY to EVALUATE the EFFICACY of MOVEMENT and IMPLEMENT CONCRETE MOVEMENT RECOMMENDATIONS with the HELP of MOBILITY TRACKING with SMARTWATCHES in SUBJECTS with AXIAL SPONDYLOARTHRITIS
Axial spondyloarthritis (axSpa) is a chronic inflammatoric autoimmune disease of the back with a prevalence around 1,4% (1) . In patients decreased function and decreased quality of life as well as chronic pain are strong burdens…
- Conditions
- Axial Spondyloarthritis, Axial Spondyloarthritis (AxSpA), Axial Spondylarthritis (r-axSpA), Axial Spondyloarthopathy
- Trial name
- SPARTAKUS (NCT06807853)
- Testing
- Smartwatch
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- University of Bonn
Axial Spondyloarthritis, Ankylosing Spondylitis
axSEND: Exploring Immune and Microbiota Effects of a Partial Enteral Nutrition Diet in Axial Spondyloarthritis
People with axial spondyloarthritis (axSpA) often have intestinal inflammation and intestinal microbiome dysbiosis, with some similarities to Crohn's-like inflammatory bowel disease (IBD) gut inflammation.
- Conditions
- Axial Spondyloarthritis, Ankylosing Spondylitis, Inflammation, Dysbiosis
- Trial name
- axSEND (NCT06460805)
- Testing
- Partial enteral nutrition
- Where
- 2 sites in United Kingdom
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- NHS Greater Glasgow and Clyde