Clinical trials: Axial Spondyloarthritis
Axial Spondyloarthritis
Optimizing Anti-IL17 Antibody Therapy by Associating Fiber Supplementation to Correct Treatment-aggravated Gut Dysbiosis in Axial Spondyloarthritis - RESPOND-IL17
Fiber is the main source of energy for colonic bacteria and its consumption favorably modifies the composition of the microbiota in only a few days. Their fermentation in the colon releases short-chain fatty acids (SCFAs).
- Trial name
- RESPOND-IL17 (NCT05812157)
- Testing
- Daily dietary supplementation with Fibruline, Anti-IL-17 therapy
- Where
- 3 sites in France
- Volunteers
- 76 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Spondylitis, Ankylosing
16-week Efficacy and 2-year Safety, Tolerability and Efficacy of Secukinumab in Participants With Active Ankylosing Spondylitis
The purpose of this study is to provide 16-week efficacy, safety and tolerability data versus placebo to support the use of secukinumab 150 mg by subcutaneous (s.c.) self-administration with or without a loading regimen and…
- Trial name
- MEASURE4 (NCT02159053)
- Testing
- Secukinumab
- Where
- 90 sites in United States, Australia and 17 more
- Volunteers
- 350 people
- Sponsor
- Novartis Pharmaceuticals
Ankylosing Spondylitis (AS), Irisin
The Effect of Exercise on Serum Irisin Levels and Clinical Parameters in Patients With Axial Spondyloarthritis.
This study aimed to investigate the effects of high-intensity intermittent exercise and moderate-intensity continuous exercise on serum irisin levels, disease activity, functional status, and quality of life in patients with…
- Trial name
- NCT07327073
- Testing
- High-Intensity Interval Training, Moderate-Intensity Continuous Exercise, control group
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Kirsehir Ahi Evran Universitesi
Axial Spondyloarthritis
Continuing Versus Withdrawing Adalimumab in Maintaining Remission in Non-Radiographic Axial Spondyloarthritis
The objective of this multicenter, randomized, double-blind study was to evaluate the efficacy and safety of continuing versus withdrawing therapy with adalimumab 40 mg given every other week SC in maintaining remission in…
- Trial name
- NCT01808118
- Testing
- adalimumab
- Volunteers
- 673 people
- Sponsor
- AbbVie
Carotid Artery Plaque, Ankylosing Spondylitis
Effects of Rosuvastatin on Carotid Artery Plaques in Patients With Inflammatory Joint Disease
Patients with rheumatoid Arthritis (RA) and Ankylosing Spondylitis (AS) are at greater risk of developing cardiovascular disease.
- Conditions
- Carotid Artery Plaque, Ankylosing Spondylitis, Rheumatoid Arthritis
- Trial name
- RORAAS (NCT01389388)
- Testing
- Rosuvastatin
- Where
- Norway
- Volunteers
- 114 people
- Sponsor
- Diakonhjemmet Hospital
Ankylosing Spondylitis, Arthritis, Psoriatic
Study Evaluating the Safety of Etanercept in Rheumatoid Arthritis, Ankylosing Spondylitis and Psoriatic Arthritis
This is a Phase 4 open label, non-interventional, multi-center study to evaluate the safety of Enbrel (etanercept) treatment in patients receiving etanercept 25mg sc twice weekly or 50mg of etanercept once weekly.
- Conditions
- Ankylosing Spondylitis, Arthritis, Psoriatic, Arthritis, Rheumatoid, Spondylitis, Ankylosing
- Trial name
- NCT00273858
- Testing
- There is no Intervention. The study is observational.
- Where
- 9 sites in Greece
- Volunteers
- 880 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Ankylosing Spondylitis, Osteoporosis
Bone Mineral Density, Disease Duration, and Activity in Ankylosing Spondylitis
Our clinical study aimed to evaluate the prevalence of osteoporosis (OP) in patients with ankylosing spondylitis (AS) and to investigate the relationship between clinical, disease activity, physical function and disease duration…
- Conditions
- Ankylosing Spondylitis, Osteoporosis, BMD
- Trial name
- NCT03866135
- Where
- Turkey (Türkiye)
- Volunteers
- 111 people
- Sponsor
- Bezmialem Vakif University
Ankylosing Spondylitis
Etanercept (Enbrel) in Ankylosing Spondylitis
The study has the aim to investigate the efficacy and safety of etanercept in patients with active ankylosing spondylitis (AS) over 520 weeks.
- Trial name
- Enbrel_AS-2 (NCT01289743)
- Testing
- Etanercept
- Where
- 2 sites in Germany
- Volunteers
- 24 people
- Sponsor
- Charite University, Berlin, Germany
Ankylosing Spondylitis, Axial Spondyloarthritis
Does Immunogenicity Have an Influence on the Efficacy of Anti-TNF Therapy in Patients With AS: An Inception Cohort Study
The purpose of this prospective cohort study is to evaluate the influence of serum drug levels and development of anti-drug antibodies on clinical response to anti-TNF agents in ankylosing spondylitis(AS) treatment.
- Trial name
- NCT02687620
- Where
- 13 sites in Turkey (Türkiye)
- Volunteers
- 180 people
- Sponsor
- Izmir Katip Celebi University
Rheumatoid Arthritis, Ankylosing Spondylitis
Artificial Intelligence Literacy and E-Health Literacy in Rheumatic Diseases
This study aims to evaluate digital health competencies in individuals with rheumatic and degenerative joint diseases. Specifically, it assesses e-health literacy and artificial intelligence literacy, which refer to individuals'…
- Conditions
- Rheumatoid Arthritis, Ankylosing Spondylitis, Psoriatic Arthritis, Knee Osteoarthritis
- Trial name
- NCT07054749
- Where
- Turkey (Türkiye)
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- Gulseren Demir Karakilic
Ankylosing Spondylitis
Safety and Tolerability of AIN457 in Adults (18-65 Years) With Moderate to Severe Ankylosing Spondylitis
This study is designed as an extension study to the proof-of-concept trial CAIN457A2209 in patients with moderate to severe ankylosing spondylitis and aims to provide continuous treatment with AIN457 for patients in the core…
- Trial name
- NCT01109940
- Testing
- AIN457A
- Where
- 15 sites in United States, Germany and 2 more
- Volunteers
- 39 people
- Sponsor
- Novartis Pharmaceuticals
Axial Spondyloarthritis
RENEW Intervention for Axial Spondyloarthritis
The researchers are testing a web-based peer-led program to help manage energy and symptoms in people who have axial spondyloarthritis (axSpA).
- Trial name
- NCT07836374
- Testing
- RENEW
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Michigan
Spondyloarthritis, Crohn's Disease
Effectiveness and Safety of Spondylitis Related to Inflammatory Bowel Disease
Adalimumab is an antibody treatment that targets and neutralizes a molecule produced in the body that is associated with inflammation, tumor necrosis factor (TNF).
- Trial name
- NCT00972218
- Testing
- Adalimumab
- Where
- Canada
- Sponsor
- University of Alberta
Ankylosing Spondylitis
A Clinical Study of JS005 in Patients With Ankylosing Spondylitis
This is a multicentre, randomized, double-blind, parallel, placebo-controlled Phase II clinical study of 261 adults with active ankylosing spondylitis to evaluate the efficacy and safety of JS005 in the treatment of active…
- Trial name
- NCT06250062
- Testing
- Recombinant humanized IL-17A Monoclonal Antibody（JS005）
- Where
- 38 sites in China
- Volunteers
- 265 people
- Sponsor
- Shanghai Junshi Bioscience Co., Ltd.
Spondyloarthritis
A Study of Ixekizumab (LY2439821) in Chinese Participants With Radiographic Axial Spondyloarthritis
The main purpose of this study is to evaluate the efficacy and safety of ixekizumab in Chinese participants with radiographic axial spondyloarthritis (r-axSpA).
- Trial name
- NCT04285229
- Testing
- Ixekizumab
- Where
- 19 sites in China
- Volunteers
- 147 people
- Sponsor
- Eli Lilly and Company
Rheumatoid Arthritis, Psoriatic Arthritis
Endothelial Function, Inflammatory Disease Activity, and Bone and Cartilage Markers in Rheumatic Patients: The Influence of Antirheumatic Treatment
The aim of this study is to examine the associations between inflammatory disease activity and endothelial function in rheumatoid arthritis (RA) and spondyloarthritis patients treated with methotrexate and Tumor Necrosis Factor…
- Conditions
- Rheumatoid Arthritis, Psoriatic Arthritis, Ankylosing Spondylitis, Endothelial Dysfunction
- Trial name
- PSARA (NCT00902005)
- Where
- Norway
- Volunteers
- 145 people
- Sponsor
- Revmatismesykehuset AS
Axial Spondyloarthritis
Serum Creatinine Change / Renal Adverse Effect With Use of Non-steroidal Painkillers in Axial Spondyloarthritis Patients
2 Non-steroidal anti-inflammatory drugs (NSAIDs), indomethacin and etoricoxib were prescribed sequentially in Axial Spondyloarthritis patients according to the internationally accepted guidelines to determine serum creatinine…
- Trial name
- NCT03582332
- Testing
- Indomethacin SR, 75 Mg Oral Capsule, Extended Release, Indomethacin 25 Mg Oral Capsule, Etoricoxib 90 mg
- Volunteers
- 64 people
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Fever of Unknown Origin, IgG4 Related Disease
The Investigators Will Evaluate the Diagnostic Performance of [18F]-AlF-FAPI-74 PET/CT in Inflammatory Disorders and Compare it With the Current Gold Standard for Inflammation, FDG PET/CT, in Three Patient Cohort: Patients Presenting With Fever of Unknown Origin, IgG4-RD and AxSpA.
The aim of the study to evaluate the performance of new [18F]-AlF-FAPI-74 PET/CT in three inflammatory disorders (fever of unknown origin, IgG4-related disease and axial spondyloarthritis) and compare with the current…
- Conditions
- Fever of Unknown Origin, IgG4 Related Disease, Axial Spondylarthritis (axSpA), Inflammation of Unknown Origin
- Trial name
- NCT07535554
- Testing
- [18F]AlF-FAPI-74 PET/CT
- Where
- Belgium
- Volunteers
- 140 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Back Pain, Spondylitis, Ankylosing
Biopsychosocial Exploration of Pain Profiles in Inflammatory and Chronic Non-specific Axial Low Back Pain
The biopsychosocial model is well established in chronic low back pain (CLBP) research. Nevertheless, researchers to date have overlooked the biopsychosocial aspects of Inflammatory Low Back pain (ILBP).
- Conditions
- Back Pain, Spondylitis, Ankylosing, Low Back Pain
- Trial name
- NCT02704845
- Where
- 3 sites in Ireland
- Volunteers
- 58 people
- Sponsor
- University of Dublin, Trinity College
Ankylosing Spondylitis, Aerobic Exercise
The Effects of Aerobic Exercise in Patients With Ankylosing Spondylitis
The aim of our study is to investigate the effects of aerobic exercise and stretching exercises applied in high-intensity interval training protocol on disease activity, quality of life, spinal mobility and calprotectin…
- Conditions
- Ankylosing Spondylitis, Aerobic Exercise, Disease Activity
- Trial name
- NCT05968469
- Testing
- Aerobic exercises with cycling ergometry, Stretching exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people
- Sponsor
- Afyonkarahisar Health Sciences University