Clinical trials: Axillary Dissection
Early Stage Breast Cancer
Registry Trial to Evaluate the Clinical Utilization of Targeted Axillary Dissection (TAD)
A downstaging of axillary tumor-spread can be achieved in about 40% of the patients receiving neoadjuvant chemotherapy (NACT). The impact of NACT on loco-regional tumor control has not yet been sufficiently investigated.
- Trial name
- NCT03102307
- Testing
- Not suitable for TAD, Suitable for TAD
- Where
- 3 sites in Germany
- Volunteers
- 548 people
- Sponsor
- Kliniken Essen-Mitte
Anesthesia, Local
Anesthetic Efficacy of PECS II Block and Parasternal Block
The study evaluate the anesthetic efficacy of Pecs II block II and parasternal block during quadrantectomy with or without axillary dissection, in breast cancer surgery
- Trial name
- NCT03016117
- Testing
- Pecs II block and parasternal block
- Where
- Italy
- Volunteers
- 65 people
- Sponsor
- San Salvatore Hospital of L'Aquila
Breast Carcinoma, Breast Cancer
Omission of Axillary Lymph Node Dissection in Case of Tumor Spread to Lymph Nodes in the Armpit in Breast Cancer
SENOMAC-ULTRA enrols patients who are planned for upfront surgery for a breast cancer that has spread to lymph nodes in the armpit, and that have been detected already prior to surgery by imaging, e.g. ultrasonography.
- Conditions
- Breast Carcinoma, Breast Cancer, Breast Surgery
- Trial name
- SENOMAC-ULTRA (NCT06869629)
- Testing
- Targeted axillary dissection, Axillary lymph node dissection
- Where
- 4 sites in Finland, South Korea and 1 more
- Volunteers
- 1,380 people
- Sponsor
- Karolinska Institutet
Axillary Drainage Volume After Lymph Node Dissection.
Effect of Gentamicin Lavage of the Axillary Surgical Bed After Lymph Node Dissection on Drainage Discharge Volume
The effect of axillary lavage with a gentamicin solution before wound closure will reduce the drainage volume and subsequently day of drainage removal.
- Trial name
- NCT01700504
- Testing
- Axillary lavage with gentamicin solution
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Hospital General Universitario Elche
Breast Cancer, Surgery
Intraoperative Neuromonitoring (IONM) and Bipolar Electrocautery (BE) During Axillary Lymph Node Dissection (ALND)
The purpose of this study is to determine whether the implementation of existing neurosurgical techniques of intraoperative neuromonitoring (IONM) and the replacement of monopolar electrocautery with bipolar electrocautery (BE)…
- Trial name
- NCT07528638
- Testing
- IONM procedure
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Cincinnati
Breast Cancer, Lymphedema Arm
Impact of the ARM Technique on the Prevention of Lymphedema After Axillary Lymphadenectomy: A Multicenter Randomized Clinical Trial
To evaluate the reduction of secondary lymphedema following axillary lymphadenectomy by incorporating the ARM technique during the procedure, without negatively impacting patient prognosis.
- Trial name
- ARM-LIFE (NCT07515300)
- Testing
- Axillary Reverse Mapping
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Hospital Universitari de Bellvitge
Seroma
Evaluation of a Hemostatic and Sealing Agent to Prevent Surgical Complications After Axillary Lymphadenectomy
This study was intended to assess the value of a hemostatic and sealing agent, a collagen sponge coated with human coagulation factors (fibrinogen and thrombin) (TachoSil®), for decreasing occurrence of seroma after axillary…
- Trial name
- NCT00852826
- Testing
- Standard axillary lymphadenectomy, Collagen sponge coated with human coagulation factors
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Hospital Universitario Virgen de la Arrixaca
Breast Carcinoma
Axillary Dissection Based on the Histological Result of the Sentinel Node, in Patients With Breast Carcinoma
The purpose of this study is to evaluate the disease free and overall survival of patients with breast carcinomas of small size, i.e., not greater than 2.0 cm and with clinically non palpable axillary lymph nodes, undergoing…
- Trial name
- NCT00970983
- Testing
- quadrantectomy and axillary dissection, quadrantectomy + sentinel node biopsy
- Where
- Italy
- Volunteers
- 532 people
- Sponsor
- European Institute of Oncology
Breast Cancer
Comparison of Complete Axillary Lymph Node Dissection With Axillary Radiation Therapy in Treating Women With Invasive Breast Cancer
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells and may be a less invasive treatment and cause fewer side effects than complete axillary lymph node dissection.
- Trial name
- AMAROS (NCT00014612)
- Testing
- axillary lymph node dissection, lymphoscintigraphy, therapeutic conventional surgery
- Where
- 29 sites in France, Italy and 6 more
- Volunteers
- 4,813 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Breast Cancer
Axillary Reverse Mapping
It has been hypothesized that the proximity of the anatomic locations of the arm lymphatic drainage system to the breast lymphatic system in the axilla put the arm lymphatics at risk for disruption during a sentinel lymph node…
- Trial name
- NCT01381315
- Testing
- Injection of isotope, Axillary lymph node dissection
- Where
- United States
- Volunteers
- 210 people
- Sponsor
- University of Kansas Medical Center
Breast Cancer, Axillary Lymph Nodes Dissection
Audit of Targeted Sentinel Node Biopsy (TSNB) in Patients With Limited Nodal Disease Undergoing Primary Surgery
Axillary ultrasound scan (AUS) is routinely employed in the UK for preoperative axillary staging and can diagnose approximately 50 - 80% of node positive patients when combined with percutaneous needle biopsy techniques (either…
- Conditions
- Breast Cancer, Axillary Lymph Nodes Dissection, Axillary Metastases, Sentinel Lymph Node Biopsy (SLNB)
- Trial name
- NodeSMART (NCT07085442)
- Testing
- Targeted Sentinel Node Biopsy (TSNB)
- Where
- 14 sites in United Kingdom
- Volunteers
- 400 people
- Sponsor
- University Hospitals of Derby and Burton NHS Foundation Trust
Breast Cancer, Muscle Strength
Effectiveness of PNF Training for Improving for Muscle Strength, Function, and Pain After Axillary Lymph Node Dissection
Breast cancer is the most common type of cancer affecting women of all ages worldwide. Advanced and comprehensive treatment options have increased survival rate and life expectancy, necessitating a focus on the complications of…
- Trial name
- NCT05288036
- Testing
- Proprioceptive Neuromuscular Rehabilitation group, Progressive Resistance Exercise Group, Control Group
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Breast Cancer, Breast Neoplasms
Pectoral Nerve Block Type-II and Rhomboid Intercostal Block for Pain Management Following Mastectomy Surgery
Postoperative pain is an important issue in patients underwent mastectomy and axillary dissection surgery. Postoperative effective pain treatment provides early mobilization and shorter hospital stay.
- Conditions
- Breast Cancer, Breast Neoplasms, Breast Diseases, Breast Fibroadenoma
- Trial name
- NCT04297007
- Testing
- PECS block, Rhomboid intercostal block
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Medipol University
Lymphedema, Lymphedema Arm
A Study of a Comprehensive Prevention Program to Reduce Lymphedema After Axillary Lymph Node Dissection in People With Breast Cancer
The purpose of this study to test whether a comprehensive program may help the lymph fluid to drain out of the arm and prevent lymphedema in participants with breast cancer.
- Conditions
- Lymphedema, Lymphedema Arm, Lymphedema of Upper Arm, Breast Cancer
- Trial name
- NCT06144164
- Testing
- Immediate Lymphatic Reconstruction, Volumetric arm measurements, Lymphatic massage
- Where
- 7 sites in United States
- Volunteers
- 285 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Breast Cancer, Lymphedema
Lymphedema Surveillance Study
This study is being done to find out how many women develop lymphedema after an axillary lymph node dissection. The investigators also want to look for reasons why some women get lymphedema and others don't.
- Trial name
- NCT02743858
- Testing
- Bilateral arm measurements, Body mass index (BMI), Quality of Life Questionnaire
- Where
- 7 sites in United States
- Volunteers
- 1,250 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Breast Carcinoma Metastatic in Lymph Node, HER2 Positive Breast Carcinoma
Validation of TAD in HER-2 with More Than 2 Lymph Nodes
The main objective of the study is to validate the DAT technique in patients with Her2-positive breast cancer who have more than two positive axillary lymph nodes at diagnosis.
- Trial name
- DAD-HER2 (NCT06821490)
- Testing
- Targeted axillary dissection and subsequently a lymphadenectomy
- Where
- Spain
- Volunteers
- 21 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Breast Cancer
Effectivenes of Cyanoacrylate (Glubran 2®) in Reducing Seroma Formation in Breast Cancer Patients Post-Axillary Dissection
Glubran 2 as a surgical glue maybe effective in reducing seroma formation post axillary dissection in breast cancer patients.
- Trial name
- NCT02141373
- Testing
- Glubran 2
- Where
- Jordan
- Volunteers
- 136 people
- Sponsor
- King Hussein Cancer Center
Breast Cancer, Chronic Pain
Can Chronic Post-surgical Pain be Reduced by Preserving Intercostobrachial Nerve During Axillary Lymph Node Dissection? : A Randomized Controlled Trial
Intercostobrachial nerve (ICBN) is a cutaneous nerve that provides sensation to the lateral chest, upper medial arm and axilla. It arises from the second intercostal nerve and leave intercostal space at the level of midaxillary…
- Conditions
- Breast Cancer, Chronic Pain, Intercostobrachial Nerve Injury
- Trial name
- PAINE (NCT05198622)
- Testing
- Intercostobrachial Nerve Preserving Axillary Lymph Node Dissection, Intercostobrachial Nerve Sacrificing Axillary Lymph Node Dissection
- Where
- Pakistan
- Volunteers
- 182 people
- Sponsor
- Shaukat Khanum Memorial Cancer Hospital & Research Centre
Breast Cancer
Sentinel Node Biopsy in Breast Cancer: Omission of Axillary Clearance After Macrometastases. A Randomized Trial.
Since the introduction of sentinel node biopsy in breast cancer, it has become clear that its use is reliable and reproducible. Today, it is clinical routine to not remove further lymph nodes from the axilla (arm pit) in case the…
- Trial name
- NCT02240472
- Testing
- Omission of axillary clearance
- Where
- 33 sites in Denmark, Greece and 1 more
- Volunteers
- 2,766 people
- Sponsor
- Karolinska Institutet
Breast Cancer
Feasibility of Carbon-Dye Marking of Axillary Lymph Nodes Before Neoadjuvant Chemotherapy in Patients With Breast Cancer
Although treatment is started with surgery in early stage tumors depending on the molecular subtype, neoadjuvant chemotherapy is the initial treatment in locally advanced tumors or if axillary lymph node involvement is present.
- Trial name
- NCT05735795
- Testing
- Carbon Black Tattoo
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Gaziosmanpasa Research and Education Hospital