Clinical trials: Azoospermia
Azoospermia, Nonobstructive
Interest of Clomiphene Citrate in Patients With Non-obstructive Azoospermia on the Quantity of Sperm Cells
In the absence of sperm in the semen (azoospermia), there is no chance of natural paternity. It is found in about 1% of men and is either due to an obstruction of the seminal tracks (obstructive azoospermia (OA)) in 1/3 of the…
- Trial name
- CLOMINOA (NCT03615547)
- Testing
- Clomifene Citrate
- Where
- France
- Sponsor
- Hospices Civils de Lyon
Azoospermia
Intra Testicular Artery Injection of Bone Marrow Stem Cell in Management of Azoospermia
Azoospermia due to low sperm production (non-obstructive azoospermia) affects approximately 1% of the male population and 10% of men who seek fertility evaluation.
- Trial name
- NCT02008799
- Testing
- Bone marrow stem cell injection
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Man Clinic for Andrology, Male Infertility and Sexual Dysfunction
Azoospermia
GnRHa Combined With hCG and hMG for Treatment of Patients With Non-obstructive Azoospermia
Preliminary reports showed that hormonal treatment may improve the chance of retrieving viable testicular sperm from men with NOA.
- Trial name
- NCT02544191
- Testing
- GnRHa/ hCG/ hMG
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Jinling Hospital, China
Infertility Due to Azoospermia
PKB171 Against Placebo in Couples With Mild Male Factor Infertility
The test medication Gel PKB171 is a vaginal gel that has not yet been licensed by the regulatory authorities. However, the active substance pentoxifylline has been available as tablets for decades and is used to increase…
- Trial name
- NCT07669584
- Testing
- Intravaginal gel, Vaginal Gel with Applicator
- Where
- 12 sites in Spain
- Volunteers
- 732 people
- Sponsor
- Prokrea BCN, S.L.
Azoospermia, Nonobstructive, Varicocele
Seminal TEX101 as a Predictor of Recovery of Spermatogenesis in Azoospermic Men With Palpable Varicocele
The aim of the study is to assess if seminal TEX 101 can predict the restoration of spermatogenesis and appearance of sperms in the ejaculate after micro-surgical varicocelectomy among azoospermic patients.
- Trial name
- NCT04397887
- Testing
- micro-surgical varicocelectomy
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Oligospermia, Azoospermia, Nonobstructive
Isotretinoin vs hCG for Male Infertility Due to Low or Absent Sperm
This study compares two medical treatments to see how well they improve sperm production in men with infertility due to low sperm counts (oligospermia) or no sperm in the semen due to non-obstructive causes (nonobstructive…
- Conditions
- Oligospermia, Azoospermia, Nonobstructive, Infertility
- Trial name
- NCT07481370
- Testing
- isotretinoin, Human chorionic gonadotrophin (hCG)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Nebraska
Azoospermia
Comparison of Medical Results of Testicular Sperm Extraction by Conventional Surgery and Microsurgical Track
To compare mobile sperm extraction rate between microTESE and conventional TESE in 18-50 years-old men with non obstructive azoospermia.
- Trial name
- Microsperm (NCT02773498)
- Testing
- conventional TESE, Micro TESE
- Where
- 5 sites in France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Toulouse
Healthy Related
Azoospermia Patients
The Prospective Cohort Study for Azoospermia Patients was set up to investigate the short- and long-term health consequences in Reproductive Medical Center, First Affiliated Hospital of Zhengzhou University, China.
- Trial name
- NCT03991663
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- The First Affiliated Hospital of Zhengzhou University
Fertility
Secretory Azoospermia and FDG (Fluoro Deoxyglucose) PET-CT
Compare FDG PET-CT parameters between azoospermia patients having an extraction of sperm cells by positive testicular extraction and those with a negative extraction.
- Trial name
- AzoPredHisto (NCT02043444)
- Testing
- FDG PET-CT
- Where
- 5 sites in France
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Infertility, Male
Modern Analyses of the Semen in Evaluating Male Fertility and Treatment Options of Male Infertility
Men are recruited to collect seminal plasma samples and serum samples from men with azoospermia, men receiving medical treatment of infertility and men attending semen analysis.
- Trial name
- SemiFluid (NCT02932865)
- Where
- Finland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Infertility
Metformin for the Treatment of Unexplained Oligozspermia
Insulin resistance (IR) in men may be the underlying pathogenesis for metabolic abnormalities and chronic hypospermatogenesis similar to women with polycystic ovarian disease (PCOD).
- Trial name
- NCT01529177
- Testing
- Metformin / clomid / hCG, Clomiphene citrate / hCG
- Where
- Egypt
- Volunteers
- 600 people
- Sponsor
- The Egyptian IVF-ET Center
Azoospermia, Nonobstructive, Non-obstructive Azoospermia
Inhibin B/FSH Ratio as a Predictor of Testicular Pathology in NOA
This retrospective observational study evaluated the diagnostic and predictive value of serum Inhibin B (INHB), follicle-stimulating hormone (FSH), and the INHB/FSH ratio in differentiating histopathological subtypes of…
- Trial name
- NCT07415928
- Where
- Turkey (Türkiye)
- Volunteers
- 73 people
- Sponsor
- Elazıg Fethi Sekin Sehir Hastanesi
ICSI AZOOSPERMIA VARICOCELE
Outcome of ICSI Using Cryopreserved Testicular Sperm From Infertile Men With Varicocele-associated Azoospermia
This study will include cryopreserved sperm from infertile azoospermic men, with proven diagnosis of varicocele (clinical \& sonographic), which will be used for ICSI in an ART program in Sohag.
- Trial name
- NCT02306499
- Testing
- ICSI
- Where
- Egypt
- Volunteers
- 16 people
- Sponsor
- Sohag University
Azoospermia, Nonobstructive
Hormonal Stimulation of Spermatogenesis
Urologists and reproductive specialists are often challenged when facing patients with severe male infertility scenarios. In particular, the treatment of men with NOA demands a deeper insight. In such cases, .
- Trial name
- NCT05483621
- Testing
- Beta-hCG
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Egymedicalpedia
Infertility Due to Azoospermia
Role of Transrectal-ultrasound in Evaluation of Azoospermia
Azoospermia is a word meaning to ejaculates with no spermatozoa without a definite underlying cause .1% of men has azoospermia, representing nearly 10 to 15% of all infertile men.
- Trial name
- NCT05026190
- Testing
- transrectal ultrasound
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Azoospermia
Testicular Injection of Autologous Stem Cells for Treatment of Patients With Azoospermia
Azoospermia is defined as the complete lack of sperm in the ejaculate. In humans, Azoospermia affects about 1% of the male population and may be seen in up to 20% of male infertility situations.
- Trial name
- NCT02041910
- Testing
- Stem Cells
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Hesham Saeed Elshaer
Azoospermia, Infertility
Microdissection Testicular Sperm Extraction (MicroTESE) and IVF-ICSI Outcome in Non-Obstructive Azoospermia (NOA)
We evaluated the application of surgical testicular exploration with the aid of a microscope (MictoTESE) to increase the chances of obtaining sperm in men with impaired sperm production, a condition known as non-obstructive…
- Trial name
- NCT00484081
- Testing
- Microdissection Testicular Sperm Extraction, ICSI
- Where
- Brazil
- Volunteers
- 53 people
- Sponsor
- Clinic and Research Center in Human Reproduction Roger Abdelmassih
Azoospermia or Severe Oligozoospermia
Detection of Microdeletions in the Azoospermia Factor (AZF) Regions in Infertile Male Patients
In this prospective study, we used Multiplex ligation-dependent probe amplification and next-generation sequencing technology to detect AZF microdeletion types accurately in selected genetic locus, and made correlation analysis…
- Trial name
- NCT03497728
- Where
- China
- Volunteers
- 5,000 people
- Sponsor
- Reproductive & Genetic Hospital of CITIC-Xiangya
Non-obstructive Azoospermia
Anti-mullerian Hormone,Testesterone,Esrtadiol,Testesterone/Esrtadiol Ratio as Predictive Values for TESA and TESE Outcome in Non Obstructive Azoospermia
*Evaluate the predictive value of AMH, Testosterone,Estradiol,Testosterone Estradiol ratio for TESA and TESE outcome in non obstructive azoospermic patients.
- Trial name
- NCT04308486
- Volunteers
- 50 people
- Sponsor
- Assiut University
Gonadal Dysfunction, Gonadal Failure
Fertility Enhancement Through Regenerative Treatment in Ovaries and Testes
This study investigates the safety and efficacy of stem cell or stem cell-derived exosome therapy for gonadal failure, including testicular failure, hypogonadism, ovarian insufficiency, and premature ovarian failure (POF).
- Conditions
- Gonadal Dysfunction, Gonadal Failure, Azoospermia, Testosterone Deficiency
- Trial name
- FERTILE (NCT06841328)
- Testing
- Stem cells
- Where
- United Arab Emirates
- Volunteers
- 60 people
- Sponsor
- Jumeirah American Clinic