Clinical trials: Azoospermia
Infertility, Male, Azoospermia, Nonobstructive
Machine Learning Based-Personalized Prediction of Sperm Retrieval Success Rate
Non-obstructive azoospermia (NOA) stands as the most severe form of male infertility. However, due to the diverse nature of testis focal spermatogenesis in NOA patients, accurately assessing the sperm retrieval rate (SRR) becomes…
- Trial name
- NCT06358794
- Testing
- Machine learning-based predictive model
- Where
- China
- Volunteers
- 2,612 people
- Sponsor
- Peking University Third Hospital
Klinefelter Syndrome, Azoospermia
Sperm Production in Kleinfelter Syndrome Patients After Mesenchymal Stem Cell Injection
Klinefelter syndrome KS is caused by an additional X chromosome in males (47,XXY). Clinical findings are nonspecific during childhood; thus, the diagnosis commonly is made during adolescence or adulthood in males who have small…
- Trial name
- NCT02414295
- Testing
- Mesenchymal stem cell injection
- Where
- Egypt
- Volunteers
- 1 people
- Sponsor
- Man Clinic for Andrology, Male Infertility and Sexual Dysfunction
Infertility, Male
NT-NOA - Novel Treatment of Some Men With Non-Obstructive Azoospermia
This clinical interventional study aims to assess whether treatment with denosumab in combination with letrozole can improve sperm production in infertile men with non-obstructive azoospermia selected by serum anti-mullerian…
- Trial name
- NT-NOA (NCT06706414)
- Testing
- Denosumab (Prolia), Letrozole (Aromatase Inhibitors)
- Where
- Denmark
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Martin Blomberg Jensen
Erectile Dysfunction, Azoospermia
Trial to Evaluate Erectile Function, Fertility and Sperm Count in Male Cyclists Compared to Age Matched Controls
Bicycle riding is associated with related diverse urogenital symptoms ranging from genital numbness to erectile dysfunction (ED).
- Trial name
- NCT00282477
- Where
- Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Infertility Due to Azoospermia, Infertility, Male
A Novel Aromatase Inhibitor, Leflutrozole, for Treatment of Non-Obstructive Azoospermia
This clinical interventional study aims to assess whether treatment with with leflutrozole can improve sperm production in infertile men with non-obstructive azoospermia selected by serum anti-mullerian hormone (AMH) or Inhibin B…
- Trial name
- NOVA-NOA (NCT07571928)
- Testing
- Leflutrozole, Dose 2
- Where
- Denmark
- Volunteers
- 15 people
- Sponsor
- Martin Blomberg Jensen
Microdissection Testicular Sperm Extraction
Timing of Oocyte Retrieval and Micro Testicular Sperm Extraction
This is a retrospective study to assess outcomes of micro-TESE performed 24 or 48 hours before oocyte retrieval and ICSI.
- Trial name
- NCT07268235
- Where
- Canada
- Volunteers
- 129 people
- Sponsor
- Clinique Ovo
Azoospermia or Severe Oligozoospermia, Infertility
Fertility Restoration With Autografting of Cryopreserved Immature Testicular Tissue
This is a pilot clinical trial to evaluate the feasibility and outcome of autologous transplantation of immature testicular tissue cryopreserved during childhood as a method of fertility preservation for prepubertal boys in case…
- Conditions
- Azoospermia or Severe Oligozoospermia, Infertility, Autologous Transplantation
- Trial name
- TESTIGRAFT (NCT07542626)
- Testing
- autologous transplantation of cryopreserved testicular tissue
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Non-obstructive Azoospermia
Effect of Age on Sperm Recovery of Microdissection Testicular Sperm Extraction in Nonobstructive Azoospermia Patients
Males with non-obstructive azoospermia (NOA) have an opportunity to obtain sperm by treatment with microdissection testicular sperm extraction (mTESE), gold-standard surgical technique for them.
- Trial name
- NCT05958576
- Where
- China
- Volunteers
- 3,104 people
- Sponsor
- Peking University Third Hospital
Non-obstructive Azoospermia
Gabapentin for Post-Operative Pain Control and Narcotic Reduction in Scrotal Surgery
The use of non-narcotic multi-modal analgesia to be used in the pre-operative, peri-operative and post-operative period to reduce or potentially eliminate narcotic usage following scrotal surgery.
- Trial name
- NCT04230980
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Weill Medical College of Cornell University
Azoospermia, Nonobstructive
2015-Metabolomics&Microbiome-infertility
The study aims to carry out a translational analysis of the microbiome and metabolomics in patients suffering from non-obstructive azoospermia, with the aim of investigating prognostic factors predictive of the possible finding…
- Trial name
- NCT06181851
- Testing
- Analysis of microbiome and metabolomics
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- IRCCS San Raffaele
Azoospermia
Obtaining Undifferentiated Cells From Testis Biopsy
The purpose of this study is to isolate and culture stem cell from adult human testicular biopsies for future transplantation in fertility preservation.
- Trial name
- NCT01375062
- Testing
- analyse and proliferate the cells
- Where
- Spain
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Igenomix
Non-obstructive Azoospermia, Hormone Deficiency
Sperm Retrieval Rates in Non-obstructive Azoospermic Men Subjected to Gonadotropin Therapy
Azoospermia is defined as the complete absence of spermatozoa in the ejaculate. Two-thirds of azoospermic patients have non-obstructive azoospermia (NOA); the latter comprises up to 10% of infertile men overall.
- Conditions
- Non-obstructive Azoospermia, Hormone Deficiency, Hypogonadism, Male, Male Infertility
- Trial name
- NCT05110391
- Testing
- Hormonal Therapy Agent
- Where
- Brazil
- Volunteers
- 616 people
- Sponsor
- ANDROFERT - Clinica de Andrologia e Reproducao Humana
Oligospermia
A Preliminary Study on Effect of Omega-3 on Human Sperm
The phospholipids of mammalian spermatozoa possess a distinctive fatty acid composition with high proportion of long chain polyunsaturated fatty acids.
- Trial name
- NCT00479960
- Testing
- commercially available omega-3 fatty acids supplementation
- Where
- Israel
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Azoospermia, Nonobstructive
The Effects of Intratesticular PRP Injection in Men With Azoospermia or Cryptozoospermia
The study will be conducted in men with a diagnosis of non-obstructive azoospermia or cryptozoospermia after obtaining written informed consent.
- Trial name
- NCT04237779
- Testing
- PRP injection into at least one testis
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Acibadem University
Male Infertility Due to Azoospermia
Seminal Levels of PGK2 and ACRV1 as Predictors of Micro-TESE Results in NOA
Measurement of PGK2 and ACRV1 levels in the semen of infertile males undergoing testicular sperm extraction (TESE). Correlate seminal levels of PGK2 and ACRV1 with sperm retrieval results and histopathology analysis of testicular…
- Trial name
- NCT06307639
- Testing
- Measurement of PGK2 and ACRV1 levels in the semen of infertile males undergoing testicular sperm extraction (TESE).
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Assiut University
Non-obstructive Azoospermia
Testicular Sperm Retrieval Rate After Varicocele Ligation in Men With Non Obstructive Azoospermia
A varicocele is an abnormal dilatation and tortuosity of the veins of the spermatic cord. Although varicoceles are common in the general population and are frequently found on routine physical examinations, they represent the…
- Trial name
- NCT07008495
- Testing
- varicocelectomy
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- South Valley University
Non-obstructive Azoospermia
Surgical Sperm Retrieval in Non-obstructive Azoospermic Men: mTESE vs. TESA
Infertility is a significant social- and health problem in the Western World and at the moment in Denmark one in ten babies are born with the help of assisted reproduction.
- Trial name
- NCT03550716
- Testing
- mTESE, TESA
- Where
- 4 sites in Denmark, Sweden
- Volunteers
- 110 people
- Sponsor
- Herlev and Gentofte Hospital
Genetic Disease
Genetic Study of Obstructive Azoospermia
In 1% of men with infertility, obstructive azoospermia (OA) may occur in congenital absence of the vas (CAVD) or idiopathic obstructive azoospermia .
- Trial name
- NCT05631509
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
APHRODITE Group
Gonadotropin Therapy in Idiopathic Hypogonadal Non-Obstructive
The goal of this clinical trial is to determine whether short-term gonadotropin therapy (hCG + FSH) can increase sperm availability for ICSI in men with idiopathic non-obstructive azoospermia (NOA) and hypogonadism.
- Trial name
- GTIHNO (NCT07540611)
- Testing
- No intervention, hCG + FSH therapy
- Where
- 8 sites in India
- Volunteers
- 860 people, healthy volunteers welcome
- Sponsor
- Indira IVF Hospital Pvt Ltd
Infertility
Quantitative MRI for Functional Imaging of the Testis: A New Methodology for Evaluation of the Infertile Male
Infertility-the inability to conceive despite one year of properly timed unprotected intercourse-is a common problem. Of all types of male factor infertility, non-obstructive azoospermia may be the most difficult for couples.
- Trial name
- NCT02756325
- Testing
- MRI
- Sponsor
- NYU Langone Health