Clinical trials: BIS
Dilated Cardiomyopathy (DCM)
A Phase 1 AAV Gene Therapy Trial Evaluating Safety and Preliminary Efficacy of RP-A701 in Subjects With BAG3 Dilated Cardiomyopathy
This is a Phase 1, open-label, dose-escalation trial to characterize the safety, tolerability, and preliminary efficacy of RP-A701 following a single IV administration in high-risk adult patients with BAG3-DCM.
- Trial name
- NCT07137338
- Testing
- RP-A701 is a recombinant viral vector composed of an AAV serotype rh.74 (AAVrh.74) capsid encapsulating the transgene, BCL2-associated Athanogene 3 (BAG3)
- Where
- 3 sites in United States
- Volunteers
- 8 people
- Sponsor
- Rocket Pharmaceuticals Inc.
Renal Failure Acute Chronic
Bispectral-Electroencephalography (EEG) in First Time Hemodialysis
The severity of minimal dialysis disequilibrium syndrome (DDS) is currently detected and graded clinically using clinical criteria.
- Trial name
- BIS7 (NCT03276273)
- Testing
- recording of Bispectral Index
- Where
- 2 sites in China, Egypt
- Volunteers
- 20 people
- Sponsor
- Suez Canal University
Anesthesia, General, Gynecologic Surgical Procedures
DSA vs. BIS for Anesthesia and Analgesia Management
The purpose of this study is to compare two different methods of monitoring brain activity (anesthesia depth) during gynecological surgeries.
- Conditions
- Anesthesia, General, Gynecologic Surgical Procedures, Intraoperative Monitoring, Anesthesia Depth Monitoring
- Trial name
- DSA-PRECISION (NCT07502261)
- Testing
- Density Spectral Array (DSA) Monitoring, Bispectral Index (BIS) Monitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Breast Cancer
Effects of a Single Chemotherapy Administration on Skeletal Muscle of Breast Cancer Patients: Comparison of Paclitaxel vs Paclitaxel + Trastuzumab vs Paclitaxel + Carboplatine: the PROTECT-06 Bis Study
This study aims to investigate the acute effects (i.e. 4 days) of paclitaxel or paclitaxel vs trastuzumab or paclitaxel and carboplatine on skeletal muscle of breast cancer patients.
- Trial name
- PROTECT-06-bis (NCT06536556)
- Testing
- First Assessment, Second Assessment
- Where
- France
- Volunteers
- 5 people
- Sponsor
- Institut de cancérologie Strasbourg Europe
NYHA Class III Heart Failure
Correlation of SOZO BIS Measures With CardioMEMS PA Pressure
This study aims to establish the degree to which change in the ratio of ECF to TBW measured using the SOZO BIS device correlates with change in end-expiratory end-diastolic PAP measured using the CardioMEMS HF System (St.
- Trial name
- NCT02939053
- Testing
- SOZO
- Where
- 2 sites in United States
- Volunteers
- 3 people
- Sponsor
- ImpediMed Limited
Unspecified Adult Solid Tumor, Protocol Specific
MG98 in Treating Patients With Advanced Solid Tumors
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase I trial to study the effectiveness of MG98 in treating patients who have advanced solid tumors.
- Trial name
- NCT00003890
- Testing
- MG 98
- Where
- 2 sites in United States, Canada
- Volunteers
- 19 people
- Sponsor
- NCIC Clinical Trials Group
Stress
Comparison Between IV Propofol and Propofol/ Fentanyl Anesthesia on Patients Stress Response
It is hypothesized that propofol, when used in general anesthesia (GA) influence patient's stress status and consequently affect stress response parameters.
- Trial name
- NCT03143933
- Testing
- Propofol, Fentanyl
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Emergence Delirium, Anesthesia
The Effect of EEG and BIS-guided Anaesthesia on the Incidence of Emergent Delirium in Children
The aim of the study is to compare two modalities of measuring the depth of general anaesthesia on the incidence of emergent delirium in children.
- Trial name
- NCT07534215
- Testing
- EEG monitoring, BIS monitoring
- Where
- Czechia
- Volunteers
- 540 people
- Sponsor
- University Hospital Ostrava
Papillomavirus Infections
Efficacy of 851B Gel for Treating High-Risk Cervical Human Papillomavirus Infection in Women.
The purpose of this study was to evaluate efficacy of 851B gel over a range of concentrations and dosing regimens on high-risk cervical human papillomavirus infection in women.
- Trial name
- NCT00117884
- Testing
- 851B
- Where
- 23 sites in United States, Canada
- Volunteers
- 240 people
- Sponsor
- Takeda
Anesthesia, Intraocular Pressure
Establishment of an Anaesthetic Protocol for Examinations for Children With Glaucoma or Suspected Glaucoma
Correct measurement of the intraocular pressure of children with glaucoma or suspected glaucoma is essential for diagnosis and therapy.
- Conditions
- Anesthesia, Intraocular Pressure, Glaucoma, Suspect, Pediatric Glaucoma
- Trial name
- eyeBIS (NCT03972852)
- Where
- Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Johannes Gutenberg University Mainz
End Stage Renal Failure on Dialysis
A Pilot Trial of Twice-weekly Versus Thrice-weekly Hemodialysis in Patients With Incident End-stage Kidney Disease
The optimal frequency of hemodialysis treatments in patients with incident end-stage kidney disease in not known. This pilot trial will randomize patients with incident end-stage kidney disease due to chronic kidney disease…
- Trial name
- TWOPLUS-HD (NCT03740048)
- Testing
- Hemodialysis, Patiromer Oral Product
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Ankylosing Spondylitis
Study Comparing Etanercept 50 mg Once Weekly to 25 mg Twice Weekly in Patients With Ankylosing Spondylitis
The purpose of this study is to compare efficacy, pharmacokinetics, and safety of investigational formulations of etanercept administered as 50 mg once weekly with 25 mg twice weekly and placebo in patients with ankylosing…
- Trial name
- NCT00418548
- Testing
- Etanercept
- Volunteers
- 350 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Esophageal Squamous Cell Carcinoma
Study of Concurrent Chemoradiotherapy for Locally Advanced Esophageal Squamous Cell Carcinoma
The phase I study is to determine the maximum tolerated dose and dose limiting toxicity of docetaxel and nedaplatin prescribed twice weekly in combination with concurrent chest radiotherapy in patients with locally advanced…
- Trial name
- NCT02964455
- Testing
- Docetaxel, Nedaplatin, chest radiation
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Sun Yat-sen University
Untreated Adult Acute Myeloid Leukemia
6,8-Bis(Benzylthio)Octanoic Acid, Cytarabine, and Daunorubicin Hydrochloride in Treating Older Patients With Newly Diagnosed Acute Myeloid Leukemia
This phase I/II trial studies the side effects and the best dose of 6,8-bis(benzylthio)octanoic acid (CPI-613) when given together with cytarabine and daunorubicin hydrochloride and to see how well it works in treating older…
- Trial name
- NCT02472626
- Testing
- 6,8-Bis(benzylthio)octanoic Acid, Cytarabine, Daunorubicin Hydrochloride
- Where
- United States
- Sponsor
- Wake Forest University Health Sciences
Chronic Renal Failure
Initiative for Patient Outcomes in Dialysis - Peritoneal Dialysis (PD) (IPOD-PD Study)
The aim of the study is to asses the hydration status of incident peritoneal dialysis (PD) patients and its evolution over a period of four years, independent of the PD treatment modality (APD or CAPD) and the PD solution type.
- Trial name
- IPOD-PD (NCT01285726)
- Testing
- Non-interventional study
- Where
- 134 sites in Austria, Belgium and 26 more
- Volunteers
- 1,092 people
- Sponsor
- Fresenius Medical Care Deutschland GmbH
Sovra and Intra Tentorial Lesions
Reliability of BIS Monitoring in Neurosurgical Patients
The aim of the study is to assess the reliability of Bispectral Index (BIS Vista , Covidien) in neurosurgical patients . BIS values at Loss of Consciousness (LOC), Post Intubation (PI) and Return of Consciousness (ROC) in…
- Trial name
- NCT01483547
- Testing
- Bispectral Index (BIS Vista, Covidien)
- Where
- Italy
- Volunteers
- 405 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Morbid Obesity
Sevoflurane Versus Intravenous Anaesthetic Agents in Morbid Obese Patients
The objective of this prospective randomized clinical study was to compare anesthesia, in morbidly obese patents (BMI >50) who underwent BPD-RYGBP with either sevoflurane or propofol with remifentanyl.
- Trial name
- NCT01279499
- Testing
- Sevoflurane, Propofol- Remifentanyl, Propofol, Remifentanyl
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- University of Patras
Internal Carotid Artery Stenosis
EEG, Cerebral Oximetry, and Arterial to Jugular Venous Lactate to Assess Cerebral Ischemia During Carotid Endarterectomy
A highly desired result during carotid endarterectomy (CEA) is the ability to predict and warn the surgeon if the brain is at risk of damage during the period of time that the carotid artery is cross-clamped for surgical repair…
- Trial name
- NCT00737334
- Testing
- EEGo, BIS, FORE-SIGHT cerebral oximeter
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Manitoba
Delirium, Cognitive Impairment
The SOMNUS Study: Sedative Optimization Via Monitoring Neurological Status
A combined strategy of Richmond Agitation and Sedation Scale (RASS) clinical targeting plus bispectral index (BIS) guided sedation in mechanically ventilated, critically ill patients will decrease time on mechanical ventilation…
- Conditions
- Delirium, Cognitive Impairment, Critically Ill
- Trial name
- SOMNUS (NCT00469482)
- Testing
- Sedation,RASS Targeted plus BIS Monitoring, Sedation, RASS Targeted
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Vanderbilt University Medical Center
Laryngoscopy
The Effect of Rocuronium on the Response of Composite Variability Index (CVI) to Laryngoscopy
Eighty subjects will be recruited from those scheduled for surgery requiring general anesthesia at St Vincent's Hospital. Subjects must have American Society of Anesthesiologists (ASA) status of 1 or 2 (be fairly healthy), a BMI…
- Trial name
- NCT00926718
- Testing
- remifentanil infusion, rocuronium dose + remifentanil infusion
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- St. Vincent's Medical Center