Clinical trials: BK Virus Nephropathy After Kidney Transplantation
BK Virus Nephropathy After Kidney Transplantation
Multicenter Randomized Two-arms Study Evaluating the BK Viral Clearance in Kidney Transplant Recipients With BK Viremia.
BK virus nephropathy (BKVN), a consequence of the strong immunosuppressive therapy given after kidney transplantation, represents a growing problem in the kidney transplant (KT) setting.
- Trial name
- BK EVER (NCT03216967)
- Testing
- everolimus
- Where
- 15 sites in France
- Volunteers
- 130 people
- Sponsor
- University Hospital, Strasbourg, France
BK Virus, Salivary Replication
Salivary Replication of BK Virus in Post-kidney Transplant
BK virus infection in kidney transplantation can compromise graft function. Current data suggest that BK virus nephropathy results not only from transmission of virus from the donor but also from reactivation of latent virus in…
- Conditions
- BK Virus, Salivary Replication, Kidney Transplantation, Nephropathy
- Trial name
- BKSAL (NCT07256470)
- Testing
- Salivary self-collection
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Disorder Related to Renal Transplantation, Immunosuppression Related Infectious Disease
Studying the Effect of Changing Immunosuppression in Case of Polyoma BK Virus Infection of the Renal Transplant
Polyomavirus BK nephropathy is a serious complication after renal transplantation leading to graft loss in 40% of cases. Since no virustatic drug exists, the investigators want to study the best way to manage viral invasion by…
- Conditions
- Disorder Related to Renal Transplantation, Immunosuppression Related Infectious Disease, Virus Diseases
- Trial name
- BKVIRUS (NCT01289301)
- Testing
- mTOR inhibitor (everolimus), cyclosporine or tacrolimus
- Where
- 4 sites in Germany
- Volunteers
- 124 people
- Sponsor
- Hannover Medical School
BK Virus Nephropathy, Risk Factor
Evaluation of Renal Pretransplant Serology for BK Virus on the Risk of Post-transplant Viral Reactivation
Due to the increasing importance of BKV infection on the survival of kidney transplants, a better knowledge, in the pretransplant phase, of the risk factors leading to viral reactivation could allow the follow-up physician to be…
- Conditions
- BK Virus Nephropathy, Risk Factor, Kidney Transplantation
- Trial name
- BKSEREIN (NCT04506060)
- Testing
- serum withdrawal
- Where
- France
- Volunteers
- 378 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
BK Virus Infection, BK Virus Nephropathy
BK Virus Post-Kidney Transplant: New Practice Versus Traditional Approach
The investigator's aim in this study is to evaluate the impact of a new standard of care protocol for the treatment of BK viremia and nephropathy (BKVAN), which includes switching from Tacrolimus to equivalent dose of…
- Trial name
- NCT02758288
- Testing
- New Protocol - BK viremia or BK virus nephropathy, Standard Protocol - BK viremia or BK virus nephropathy
- Where
- United States
- Sponsor
- Loma Linda University
Kidney Diseases, Kidney Injury
ID-ENTITY Trial- Evaluating Serial T-ID Monitoring
To evaluate the association between time-updated CMV and BK viral loads measured monthly by T-ID and the risk of CMV disease and/or biopsy-proven BK virus-associated nephropathy (BKVAN) during the first 12 months following kidney…
- Conditions
- Kidney Diseases, Kidney Injury, BK Virus Infection, CMV
- Trial name
- ID-ENTITY (NCT07393594)
- Testing
- Blood tests, TRAC( cell free DNA) and T-ID
- Where
- 14 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Transplant Genomics, Inc.
BK Virus Infection, Nephropathy
Study to Confirm of the Safety and Tolerability of Brincidofovir in Subjects With BK Virus Infection (Viremia) After Kidney Transplantation
This is a Phase II, multicenter, open-label, randomized, standard of care (SOC) controlled, multiple ascending dose study to assess the safety and tolerability of IV Brincidofovir (BCV) in subjects with BKV infection after kidney…
- Conditions
- BK Virus Infection, Nephropathy, Kidney Transplantation
- Trial name
- NCT05511779
- Testing
- Brincidofovir
- Where
- Japan
- Volunteers
- 1 people
- Sponsor
- SymBio Pharmaceuticals