Clinical trials: BRONCHIAL ASTHMA
Asthma (Diagnosis), COPD (Chronic Obstructive Pulmonary Disease)
A Study to Understand the Accuracy of a New Breathing Device Compared to Standard Testing for Asthma and COPD
The diagnosis of either asthma or chronic obstructive pulmonary disease (COPD) is currently based on a combination of symptoms, different lung tests and sometimes a 'trial by treatment'.
- Trial name
- STARDUST (NCT07253883)
- Testing
- Partial pressure of CO2 during tidal breathing, FENO, Spirometry
- Where
- United Kingdom
- Volunteers
- 1,200 people
- Sponsor
- Liverpool Heart and Chest Hospital NHS Foundation Trust
Asthma
A Study to Evaluate the Effect of a Single-Dose Intravenous Administration of MEDI-528
To evaluate the effect of MEDI-528 in adults with atopic asthma.
- Trial name
- NCT00483041
- Testing
- MEDI528 9 mg/kg
- Where
- 4 sites in United States
- Volunteers
- 11 people
- Sponsor
- MedImmune LLC
Asthma
Study of Multiple Doses of PRS-060 Administered by Oral Inhalation in Subjects With Mild Asthma
Study of Multiple Doses of PRS-060 Administered by Oral Inhalation in Subjects with Mild Asthma
- Trial name
- NCT03574805
- Testing
- PRS-060
- Where
- 4 sites in Australia
- Volunteers
- 76 people
- Sponsor
- Pieris Australia Pty Ltd
Qualitative Research
IMT in Asthma: Activity, Coping, Self-Management
The aim of this study is to investigate asthma patients' experiences with an 8 week IMT and the perceived effects of this intervention on physical activity, coping strategies, and asthma self-management.
- Trial name
- IMT in Asthma (NCT07320066)
- Testing
- other
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people
- Sponsor
- Istanbul Esenyurt University
Asthma
GSK2190915 Moderate to Severe Asthma Study
A randomised, double-blind, placebo-controlled, parallel group study to evaluate the effect of treatment with GSK2190915, a FLAP inhibitor, as add-on to current inhaled corticosteroid therapy in patients with moderate to severe…
- Trial name
- NCT00850642
- Testing
- GSK2190195 100mg
- Where
- 8 sites in Canada, United Kingdom
- Volunteers
- 7 people
- Sponsor
- GlaxoSmithKline
Asthma, Rhinitis
Asthma Phenotypes in the Inner City
This is an epidemiologic, multi-center, cross-sectional study to define the phenotypic characteristics of Difficult-to-Treat asthma, among children between the ages of 6 to 17 years, receiving one year of guidelines-based therapy…
- Trial name
- APIC (NCT01383941)
- Testing
- Guidelines-based asthma and rhinitis/rhinosinusitis therapy
- Where
- 9 sites in United States
- Volunteers
- 717 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Asthma
The Effect of Manual Therapy Techniques on the Mobility of the Diaphragm in People With Asthma
The mechanical alterations related to the overload of respiratory muscles observed in people with persistent asthma can lead to the development of musculoskeletal dysfunctions.
- Trial name
- NCT05709054
- Testing
- Experimental: Diaphragmatic Manual Therapy Group A
- Where
- Greece
- Volunteers
- 6 people
- Sponsor
- University of West Attica
Organ Transplant, Cancer
ORCHARD- Optimising Home Assessment of Rural Patients
This project assesses feasibility of providing medically vulnerable rural patients with Medical-Self-Assessment-Boxes containing equipment to use at home during telephone and video consultations (telemedicine) with GPs and other…
- Conditions
- Organ Transplant, Cancer, Inborn Errors of Metabolism, Immunosuppression
- Trial name
- ORCHARD (NCT05732922)
- Testing
- A sphygmanometer, a digital thermometer, a pulse oximeter and a peak flow meter will be given to participants to use during their telemedicine consultations with health care providers.
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- University of Aberdeen
Asthma
Use of Buventol Easyhaler and Bufomix Easyhaler in Methacoline Challenge Testing
The study compares Buventol® Easyhaler® and Bufomix® Easyhaler® to the current standard treatment during methacholine challenge test. The trial will also provide inspiratory flow profile data for Easyhaler inhaler.
- Trial name
- EASYRELIEF (NCT05084222)
- Testing
- Buventol® Easyhaler® 200 µg/inhalation dmDPI, Bufomix® Easyhaler® 160/4.5 µg/inhalation dmDPI, Ventoline® Evohaler® 100 µg/inhalation pMDI
- Where
- 2 sites in Finland
- Volunteers
- 180 people
- Sponsor
- Orion Corporation, Orion Pharma
Sickle Cell Disease, Asthma
Inhaled Corticosteroid Use to Prevent Acute Chest Syndrome Recurrence in Children Between 1 and 4 With Sickle Cell Disease: a Feasibility Trial
Acute and chronic pulmonary complications with concomitant inflammatory response are a leading cause of morbidity and mortality in children with sickle cell disease (SCD).
- Conditions
- Sickle Cell Disease, Asthma, Acute Chest Syndrome
- Trial name
- NCT02187445
- Testing
- Budesonide inhalation suspension
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Vanderbilt University
Asthma
Uncontrolled and Possible Severe Asthma in Denmark
Asthma is a common, chronic disease with a high prevalence in children, adolescents and populations normally fit-to-work. Most asthma patients have a well-controlled disease and thereof a low usage of primary and secondary health…
- Trial name
- REASSESS (NCT04193150)
- Testing
- Full pulmonary specialist assessment
- Volunteers
- 550 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Asthma
Bicentric Prospective Study, Evaluating Bronchial THERMOPLASTY in a Patient Presenting Severe Uncontrolled Asthma
To determine, from patients presenting severe asthma and an increase in bronchial smooth muscle mass, those who would be the best candidates for bronchial THERMOPLASTY.
- Trial name
- ASMATHERM (NCT01777360)
- Testing
- ALAIR, radiofrequency catheter for bronchial THERMOPLASTY
- Where
- France
- Volunteers
- 46 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Asthma Attack
Impact of Asthma Exacerbations
The purpose of the study is to gain a deeper understanding of the impact of asthma attacks on the lives of patients who experience them.
- Trial name
- IMPAX (NCT04410120)
- Testing
- Interview
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Nottingham
Healthy Subjects, Chronic Obstructive Pulmonary Disease
Multicenter Study of Impulse Oscillometry in Chinese
The purpose of this study is to establish the reference values of impulse oscillometry (IOS) in healthy Chinese, and compare the indices of IOS in patients with lung disease, such as chronic obstructive pulmonary disease (COPD)…
- Conditions
- Healthy Subjects, Chronic Obstructive Pulmonary Disease, Asthma, Interstitial Lung Disease
- Trial name
- NCT03467880
- Testing
- Clinical Observation
- Where
- 2 sites in China
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Guangzhou Institute of Respiratory Disease
Asthma
Evaluation of Efficacy and Safety for Single Dose of E004 in Children With Asthma
This is a multi-center, randomized, double-blinded, placebo-controlled, crossover, single dose study in 24 pediatric patients (4-11 years old) with asthma.
- Trial name
- NCT01737905
- Testing
- Epinephrine HFA-MDI (E004)
- Where
- 6 sites in United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Amphastar Pharmaceuticals, Inc.
Asthma, Chronic Obstructive Pulmonary Disease (COPD)
Open-Label Assessment of the Albuterol Spiromax® Dry Powder Inhaler (DPI)
This is a prospective, open-label, multicenter Phase 3 study evaluating the performance of the Albuterol Spiromax dose counter in patients with a diagnosis of asthma and/or COPD.
- Trial name
- NCT01857323
- Testing
- Albuterol Spiromax®
- Where
- 30 sites in United States
- Volunteers
- 317 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Asthma
Sample Collections From the Airways of Asthmatic Patients
Fiberoptic bronchoscopy is a procedure which involves passing a pencil-thin tube into the lung in order to collect fluid and cells from the airways.
- Trial name
- NCT00001888
- Where
- United States
- Volunteers
- 574 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Asthma, Allergic, Cardiovascular Diseases
Plant Stanol Esters and Preventing Asthma Symptoms
Plant stanols are known to lower low-density lipoprotein cholesterol. However, studies have suggested that these compounds also influence the immune system.
- Trial name
- PLANTASTIC (NCT03983603)
- Testing
- Soft chews containing 0.5g plant stanols (delivered as plant stanol esters)
- Where
- Netherlands
- Volunteers
- 160 people
- Sponsor
- Maastricht University Medical Center
Asthma, Chronic Obstructive Pulmonary Disease
Study to Assess the Safety and Efficacy of SelK2 on Airway Responses Following Allergen Challenge in Subjects With Asthma (Part 1) and in Subjects With Chronic Obstructive Pulmonary Disease (Part 2)
This study has two parts. The main purpose of Part 1 of this study will be to examine how safe and effective two doses of SelK2 is on participants with mild asthma.
- Trial name
- NCT04540042
- Testing
- SelK2 (Part 1), SelK2 (Part 2)
- Where
- 2 sites in United Kingdom
- Volunteers
- 61 people
- Sponsor
- Tetherex Pharmaceuticals Corporation
Asthma
Qvar vs FP in Pediatrics
The primary aim of this study was to compare the absolute and relative effectiveness of asthma management in paediatric patients in the UK on inhaled corticosteroid (ICS) maintenance therapy as extra-fine HFA-BDP (Qvar®)…
- Trial name
- NCT01877954
- Testing
- Extra-fine hydrofluoroalkane beclometasone dipropionate, Fluticasone propionate
- Volunteers
- 2,654 people
- Sponsor
- Research in Real-Life Ltd
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