Clinical trials: BRONCHIAL ASTHMA
Bronchial Asthma (Only the Patients With Severe or Intractable Bronchial Asthma Which Could Not be Controlled With the Existing Therapy)
TEZSPIRE (Tezepelumab) Asthma Japan Post-Marketing Study (PMS)
The purpose of the investigation is to confirm the followings under the post-marketing actual long-term use of Tezspire. 1. Development of related AEs 2.
- Trial name
- NCT05729711
- Where
- 33 sites in Japan
- Volunteers
- 416 people
- Sponsor
- AstraZeneca
Education, Asthma
Evaluating the Collaborative Management in Pediatrics (CMP) Training Program Among Pediatric Resident Doctors and Their Patients With Asthma or Obesity
Self-care behaviors are decisions and actions that people can take to improve their health or cope with a health problem. It is important for people with long-term illnesses to develop and maintain effective self-care behaviors.
- Conditions
- Education, Asthma, Obesity
- Trial name
- CMP (NCT00510341)
- Testing
- Collaborative Management in Pediatrics (CMP) Program
- Where
- 3 sites in United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Washington
Asthma
Pharmacokinetic Study to Compare Absorption of Budesonide/Formoterol Easyhaler and Symbicort Turbuhaler
The purpose of this study is to compare Budesonide/formoterol Easyhaler test products with the marketed product Symbicort Turbuhaler in terms of the drug absorbed into the bloodstream.
- Trial name
- NCT03073057
- Testing
- Budesonide/formoterol, Charcoal, Symbicort Turbuhaler
- Where
- Finland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Orion Corporation, Orion Pharma
Asthma, Case Management
Impact of a PERsonalized CAse MAnagement Program for the Follow-up of Moderate and Severe aSTHma Patients on Exacerbations, Health Resource Use and Asthma Control: PERCASTHMA STUDY
The goal of this randomized clinical trial is to learn about the impact of the implementation of an intervention-based case management follow-up program during periods of clinical worsening or poor adherence in patients with…
- Conditions
- Asthma, Case Management, Telemedicine
- Trial name
- PERCASTHMA (NCT05642728)
- Testing
- Case management follow-up program
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- MurciaSalud
Asthma
Impact of Reduction of Dust Mite Allergenic Load on Step Down of Inhaled Corticosteroids in Stable Asthma
Eviction methods for dust mite allergy have been evaluated in asthma control in a recent Cochrane meta-analysis. None have shown efficacy on asthma control and there are not recommended.
- Trial name
- NCT02773628
- Testing
- Acar'up system
- Where
- Belgium
- Volunteers
- 3 people
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Asthma
Towards Participatory Paediatric Asthma Action Plans
Asthma is the most common chronic disease in children. The management of asthma attacks at home is based on asthma action plans that are very heterogeneous and reflect the diversity of recommendations on this subject.
- Trial name
- PACAP (NCT04810169)
- Testing
- Smart inhaler
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Asthma
TNF-alpha Directed Therapy in Asthma
This trial is a randomised, single-center, placebo-controlled, double blind, parallel group study in patients with asthma symptomatic on inhaled steroids.
- Trial name
- NCT00278083
- Testing
- Study drug administration, Tuberculin intradermal skin test, Lung function test for FEV1
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Imperial College London
Health, Health Adult Subjects
DBM-1152A Inhalation Solution in Chinese Healthy Subjects
This is a Phase Ia, single-center, randomized, double-blind, placebo-controlled, single ascending dose (SAD) study. The primary purpose of this study is to evaluate the safety, tolerability, and pharmacokinetics (PK) of DBM-1152A…
- Trial name
- NCT07447141
- Testing
- DBM-1152A Inhalation Solution
- Where
- China
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Joincare Pharmaceutical Group Industry Co., Ltd
Asthma
Study of T-Regulatory Cells in Asthma
To study whether the immune response as directed by regulatory T cells is different between obese asthmatics, normal weight asthmatics and healthy controls.
- Trial name
- NCT02574351
- Testing
- blood draw, breathing test
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Acute Respiratory Infection, Asthma Exacerbations
Reusable Face Masks to Reduce Risk of Viral Respiratory Infections and Asthma Exacerbations
REMASK trial is a Trial within Cohort study (TwiCs), nested within the COVIDENCE UK longitudinal study. It has been designed to determine whether the offer of a free reusable, elastomeric face mask to adults with asthma and other…
- Trial name
- REMASK (NCT06885229)
- Testing
- FloMask - reuseable face mask
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Asthma
AIM2ACT: A Mobile Health Tool to Help Adolescents Self-Manage Asthma
The aim is to test the efficacy of AIM2ACT and long-term maintenance of treatment effects in a fully-powered randomized controlled trial with 160 early adolescents with poorly controlled persistent asthma, ages 12-15 years, and a…
- Trial name
- AIM2ACT (NCT04448002)
- Testing
- AIM2ACT, mHealth Attention Control Condition
- Where
- 2 sites in United States
- Volunteers
- 320 people
- Sponsor
- University of Florida
Asthma
p38 Mitogen-Activated Protein Kinase (MAPK) and Steroid Insensitivity in Asthma
This research aims to find out how the inflammation in patients suffering from severe asthma is different from that in non-severe asthma, and how it may prevent corticosteroids from working efficiently in severe asthma.
- Trial name
- NCT00676572
- Testing
- Fiberoptic bronchoscopy; blood test
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- Imperial College London
Pediatric Asthma, Uncontrolled Asthma
Systems Pharmacology Approach to Uncontrolled Pediatric Asthma
Background: Asthma is a heterogeneous respiratory disease and the most common chronic disease in children. A small subset of children has continuous poor asthma control despite appropriate adherence to asthma medication.
- Trial name
- NCT04865575
- Where
- 6 sites in Germany, Netherlands and 3 more
- Volunteers
- 145 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Asthma, Severe Persistent Asthma
Implications and Stability of Clinical and Molecular Phenotypes of Severe Asthma
The Severe Asthma Research Program III is an NIH cooperative agreement involving 7 clinical centers that encompass a multidisciplinary partnerships between asthma clinician-scientists and scientists with expertise in immunology…
- Trial name
- SARPIII (NCT01748175)
- Testing
- Triamcinolone Acetonide
- Where
- United States
- Volunteers
- 715 people, healthy volunteers welcome
- Sponsor
- Sally E. Wenzel MD
Asthma
Telemedicine Education for Rural Children With Asthma
The investigators will implement an interactive school-based telemedicine education program for rural low-income, minority children with asthma, their caregivers, and school nurses in the Delta region of Arkansas.
- Trial name
- NCT00964301
- Testing
- Telemedicine Education, Usual care
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Arkansas Children's Hospital Research Institute
Rhinoconjunctivitis
ToleroMune House Dust Mite (HDM) Tolerability Study
House Dust Mites (HDMs) are arachnids that infest bedding, carpet, upholstered furniture and fabric. Like many other allergens, exposure to HDMA in sensitised patients is associated with poorer lung function, greater medication…
- Trial name
- NCT01949441
- Testing
- ToleroMune HDM
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Circassia Limited
Allergic Asthma, Allergic Rhinitis
The Effect of Allergen Immunotherapy on Exhaled Nitric Oxide in Adult Patients With Asthma and Allergic Rhinitis
This study will evaluate whether exhaled nitric oxide levels are affected by allergen immunotherapy ("allergy shots"). The investigators' hypothesis is that successful allergen immunotherapy may be accompanied by decreased…
- Trial name
- NCT01318954
- Testing
- Allergen immunotherapy
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Rohr and Columbo Asthma, Allergy and Immunology Specialists, P.C.
Chronic Rhinosinusitis With Nasal Polyps, Asthma; Eosinophilic
A Real-world, Head-to-head Comparison of Dupilumab Versus Mepolizumab in Danish Patients With Chronic Rhinosinusitis With Nasal Polyps
The goal of this randomized clinical trial is to compare the effects of two newly available biological drugs for the treatment of severe chronic rhinosinusitis with nasal polyps in Danish patients.
- Conditions
- Chronic Rhinosinusitis With Nasal Polyps, Asthma; Eosinophilic, Eosinophilia
- Trial name
- TORNADO (NCT05942222)
- Testing
- dupilumab, mepolizumab
- Where
- 9 sites in Denmark
- Volunteers
- 220 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Asthma
A Study to Evaluate the Efficacy and Safety of Meptin® Swinghaler® and Ventolin® MDI in Stable Asthma Patients
This is an open-label, randomized, cross-over, active-controlled study to evaluate the efficacy and safety effects using Meptin® Swinghaler and Ventolin® MDI in stable asthma patients.
- Trial name
- NCT01076322
- Testing
- Meptin® Swinghaler, Ventolin® MDI
- Where
- Taiwan
- Volunteers
- 17 people
- Sponsor
- Taiwan Otsuka Pharm. Co., Ltd
Asthma
A Dose-ranging Study of Fluticasone Furoate (FF)
This is a Phase IIb, multi-centre, stratified, randomised, double-blind, double-dummy, parallel-group, placebo and active controlled study in children aged 5-11 years with persistent uncontrolled asthma.
- Trial name
- NCT01563029
- Testing
- Fluticasone Furoate, Fluticasone Propionate
- Where
- 139 sites in United States, Bulgaria and 13 more
- Volunteers
- 597 people
- Sponsor
- GlaxoSmithKline
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