Clinical trials: BRONCHIAL ASTHMA
Asthma
Sputum Matrix Metalloproteinases (MMP) mRNA and Montelukast
Matrix metalloproteinases (MMPs) are a group of 24 zinc containing enzymes in man. These enzymes were originally described as cleaving extracellular matrix (ECM) substrates with a predominant role in ECM homeostasis, but it is…
- Trial name
- NCT00947453
- Testing
- montelukast
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- University of East Anglia
Asthma
Effects of Aerobic Training With and Without Sniff Maneuver
This study was planned to assess effects of Aerobic training with and without Sniff maneuver on Dyspnea, Functional capacity and Quality of life among Asthma Patients.
- Trial name
- NCT07064057
- Testing
- Aerobic exercise combined with the sniff maneuver technique, Aerobic exercise
- Where
- Pakistan
- Volunteers
- 28 people
- Sponsor
- Riphah International University
Asthma
Dose Response of Fractional Exhaled Nitric Oxide (FeNO) to Inhaled Steroids in Mild-to-moderate Asthma
Asthma is a chronic disease, which means that it cannot be cured, but the investigators can use inhalers and tablets to control the symptoms.
- Trial name
- NCT00995657
- Testing
- Fluticasone Propionate
- Where
- United Kingdom
- Volunteers
- 21 people
- Sponsor
- University of Dundee
Asthma
NHFT Effects on Symptatheic Drive of Asthma Patients
The project will be pursued in our respiratory, autonomic nervous system physiology laboratory (Respiratory, autonomic nervous system physiology laboratory, Department of Pneumology and Intensive Care Medicine, RWTH Aachen…
- Trial name
- MSNA in Asthma (NCT05704101)
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- RWTH Aachen University
Asthma, Healthy
Air Pollution, Asthma and Circadian Clocks
Societies become increasingly urban - more than half the world's population now lives in cities. Urbanization elevates anthropogenic (man-made) exposure to air pollutants.
- Trial name
- APACC (NCT03406351)
- Testing
- Observational
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Asthma
Efficacy, Safety and Pharmacokinetics of QAV680 Versus Placebo in Patients With Asthma
This study will assess the safety and efficacy of QAV680 in patients with mild to moderate asthma
- Trial name
- NCT01103037
- Testing
- QAV680
- Where
- 7 sites in United States, Germany and 1 more
- Volunteers
- 8 people
- Sponsor
- Novartis Pharmaceuticals
Asthma
A Phase II Study to Investigate Lung Function With 2 Different Doses of Inhaled Glycopyrronium Taken With BFF Compared to BFF in Participants of 4 to Less Than 12 Years of Age With Asthma
The purpose of this study is to evaluate the effect of 2 different GP metered dose inhaler (MDI) doses relative to placebo MDI as add-on treatment to BFF MDI on lung function in participants 4 to less than 12 years of age with…
- Trial name
- FAROS (NCT07525375)
- Testing
- GP MDI, BFF MDI
- Where
- 44 sites in United States, Argentina and 5 more
- Volunteers
- 69 people
- Sponsor
- AstraZeneca
Severe Eosinophilic Asthma, Nasal Polyps
RANS. Study in Patients With Severe Eosinophilic Asthma and Nasal Polyps.
The purpose of this observational study is to describe the population of patients with SEA + NP who have been prescribed FASENRA and assess available clinical outcomes for both NP and asthma.
- Trial name
- RANS (NCT05180357)
- Testing
- FASENRA(benralizumab)
- Where
- 45 sites in United States, France and 4 more
- Volunteers
- 273 people
- Sponsor
- AstraZeneca
Asthma COPD
Clinical and Medico-economic Validation of the HEPHAI Solution.
In a context where the use of inhalation devices for respiratory medications is associated with a high frequency of critical errors, our primary hypothesis is that the use of the HEPHAÏ solution reduces this frequency compared to…
- Trial name
- VAL-HEPHAI (NCT06099145)
- Testing
- Hephaï
- Where
- 5 sites in France
- Volunteers
- 238 people
- Sponsor
- Hephai
Asthma
AIR Extension Study - Long-Term Safety of Alair Treated Subjects
The primary purpose of this study is to gather additional safety data for subjects who previously completed the one-year study entitled: "Multicenter Randomized Clinical Trial of the Alair System for the Bronchial Thermoplasty…
- Trial name
- AIRx (NCT00448812)
- Testing
- Bronchial Thermoplasty with the Alair System
- Where
- 5 sites in Brazil, Canada and 1 more
- Volunteers
- 69 people
- Sponsor
- Boston Scientific Corporation
Asthma
Managing Asthma Patients With AMAZE™: A Novel Disease Management Platform
The primary study objective is to generate evidence as to the feasibility, usability, perceived value, and potential benefits of implementing the AMAZE™ platform into clinical practice.
- Trial name
- NCT04868500
- Testing
- AMAZE™ Application, AMAZE™ Dashboard
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- AstraZeneca
Asthma
Dose-Response of Salmeterol in Children
To examine whether a breathing test (methacholine challenge using impulse oscillometry) can be used to tell the difference between two different doses of an inhaled drug, salmeterol, delivered by Advair in children with asthma
- Trial name
- NCT01907334
- Testing
- Advair Diskus100/50 µg, Flovent Diskus 100 µg, Methacholine Chloride
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Florida
Asthma
A Safety and Efficacy Study of Beclomethasone Dipropionate Delivered Via Breath-Actuated Inhaler (BAI) or Metered-Dose Inhaler (MDI) in Participants Ages 4-11 Years Old With Persistent Asthma
This randomized, double-blind, double-dummy, placebo-controlled, parallel-group, 12-week study will evaluate the efficacy and safety of beclomethasone dipropionate (80 or 160 mcg/day) administered via breath-actuated inhaler…
- Trial name
- NCT02040766
- Testing
- Beclomethasone dipropionate BAI, albuterol/salbutamol 90 mcg, Beclomethasone dipropionate MDI
- Where
- 102 sites in United States, Croatia and 3 more
- Volunteers
- 628 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Asthma Bronchiale
Evaluation of Alterations in the Gut Microbiota in Pediatric Bronchial Asthma
Asthma constitutes a major chronic noncommunicable disease, globally it affects about 300 million people and the incidence has been steadily increasing in recent decades; it affects about 10% of children and is the leading…
- Trial name
- MicroAsm (NCT06842836)
- Testing
- Study intervention
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria
Croup, Bronchiolitis
A Study Evaluating the Use of ResAppDx v2.0 as an Aid to Diagnose Respiratory Disease in Paediatric Patients in an Emergency Department
Aim of study is to demonstrate that the ResAppDx v2.0 algorithms provide an accurate diagnosis of paediatric respiratory disease in the study's clinical setting compared to a Clinical Adjudication Committee's (CAC) diagnosis; and…
- Conditions
- Croup, Bronchiolitis, Asthma in Children, Reactive Airway Disease
- Trial name
- NCT06156436
- Testing
- ResAppDx v.20
- Where
- 5 sites in United Kingdom
- Volunteers
- 75 people
- Sponsor
- ResApp Health Limited
Asthma
Study to Compare QVM149 and Free Triple Combination of Salmeterol/Fluticasone + Tiotropium
The purpose of this trial was to demonstrate that the efficacy of two treatment arms of the fixed-dose combination product QVM149 was non-inferior to the efficacy of the free combination arm of salmeterol/ fluticasone+ tiotropium…
- Trial name
- ARGON (NCT03158311)
- Testing
- QVM149, Salmeterol/fluticasone plus tiotropium
- Where
- 163 sites in Argentina, Chile and 18 more
- Volunteers
- 1,426 people
- Sponsor
- Novartis Pharmaceuticals
Asthma, Obesity
Role of Cysteinyl Leukotrienes in the Pathogenesis of Asthma in Obesity
The purpose of this study is to examine whether there are higher levels of cysteinyl leukotrienes in obese subjects than in non-obese subjects.
- Trial name
- NCT01158573
- Where
- United States
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Asthma
Asthma Severity in Children and Environmental Agents
This study measures residential exposures (indoor allergens, mold, nitrogen dioxide, nicotine) and relates exposure levels to daily symptoms (wheeze, persistent cough, chest tightness, shortness of breath) and medication use, in…
- Trial name
- NCT00042705
- Where
- United States
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Asthma, COPD
Protein Biomarker Discovery and Validation in Chronic Obstructive Pulmonary Disease (COPD) And Asthma
The purpose of the study is to better understand proteomics of asthma and COPD, and response to therapy. There are two Phases to this study broken into two arms.
- Trial name
- Proteomics (NCT02487394)
- Testing
- Exhaled Breath Condensate (EBC)
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Asthma
Safety and Efficacy of Mometasone Furoate Delivered Via Concept1 Device or Twisthaler® Device in Adult and Adolescent Patients With Persistent Asthma
The purpose of this study is to compare the efficacy, safety and pharmacokinetics of Mometasone furoate delivered via Concept1 device or Twisthaler® device in adult and adolescent patients with persistent asthma.
- Trial name
- NCT01555151
- Testing
- Mometasone furoate, Concept 1, Twisthaler
- Where
- 165 sites in Belgium, Canada and 15 more
- Volunteers
- 739 people
- Sponsor
- Novartis Pharmaceuticals
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