Clinical trials: BRONCHIAL ASTHMA
Asthma
Environmental Exposures, Genetics, and Exhaled Nitric Oxide in Pediatric Asthma
Asthma is one of the most common childhood diseases. It is chronic and often severely disabling. The amount of nitric oxide that is exhaled while breathing increases with airway inflammation, a symptom of asthma.
- Trial name
- NCT00395096
- Where
- United States
- Volunteers
- 225 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Childhood Asthma, Passive Smoke Exposure
The Invisible Trigger: A Quasi-Experimental Study on the Effect of Passive Smoke Exposure and Counselling Intervention in Childhood Asthma
This study evaluates the effect of passive smoke exposure on childhood asthma and the role of structured counseling in reducing SHS exposure and improving asthma control.
- Trial name
- Asthma (NCT07069192)
- Testing
- Counselling
- Where
- Pakistan
- Volunteers
- 126 people
- Sponsor
- Foundation University Islamabad
Asthma
Study to Evaluate the Effect of Benralizumab on Allergen-Induced Inflammation in Mild, Atopic Asthmatics
This is a randomized, double-blind, parallel group, placebo-controlled study designed to evaluate the effect of a fixed 30 mg dose of benralizumab administered subcutaneously every 4 weeks on allergen-induced inflammation in…
- Trial name
- ARIA (NCT02821416)
- Testing
- Benralizumab
- Where
- 6 sites in Canada
- Volunteers
- 46 people
- Sponsor
- AstraZeneca
Asthma
Diesel Exhaust and Mechanism of Asthma
This experiment is designed to test the hypothesis that oxidative stress is responsible for changes in airway responsiveness in humans exposed to diesel exhaust.
- Trial name
- NCT01699204
- Testing
- N-acetylcysteine, Diesel exhaust, Filtered air
- Where
- Canada
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Asthma
A Study to Compare Safety of 4 Weeks Exposure to Propellants Hydrofluoroalkane 1,1-difluoroethane (HFA-152a) and HFA-1,1,1,2-tetrafluoroethane (134a)
This study aims to generate additional safety data on the propellant component of the reformulated product by comparing metered dose inhaler (MDIs) containing HFA-152a (test) with HFA-134a (reference).
- Trial name
- NCT07645248
- Testing
- HFA-152a, HFA-134a
- Where
- 18 sites in United States, Argentina and 2 more
- Volunteers
- 110 people
- Sponsor
- GlaxoSmithKline
Asthma
Repeated High-dose Inhaled Corticosteroids for Asthma
The purpose of this study is to to compare the effects of high-dose Inhaled Corticosteroids (ICS) vs. placebo in adults with chronic stable asthma.
- Trial name
- ReHICS (NCT00695604)
- Testing
- Fluticasone
- Where
- United States
- Sponsor
- University of Chicago
Asthma
Effectiveness of Ciclesonide Versus Budesonide in Patients With Asthma (18 to 75 y) (BY9010/M1-136)
This trial will compare the effectiveness of one dose of ciclesonide against one dose of budesonide in patients with asthma. The aim of the present trial is to compare the efficacy of ciclesonide versus budesonide on pulmonary…
- Trial name
- NCT00163384
- Testing
- Ciclesonide
- Where
- 19 sites in South Korea
- Volunteers
- 240 people
- Sponsor
- AstraZeneca
Asthma, Acute Asthma
Single Dose Oral Dexamethasone Versus Multi-dose Prednisolone in the Treatment of Acute Exacerbations of Asthma in Children
A trial to investigate if a single dose of the oral corticosteroid, Dexamethasone is as effective in treating exacerbations of asthma in children as 3 days of treatment with another oral corticosteroid, Prednisolone
- Trial name
- NCT03698630
- Testing
- Prednisolone Sodium Phosphate, Dexamethasone
- Where
- Ireland
- Volunteers
- 250 people
- Sponsor
- University College Dublin
Asthma, Moderate Asthma
Study of Safety, Tolerability, and Pharmacokinetics of Multiple Ascending Doses of REGN3500 in Adults With Moderate Asthma
Purpose of this study is to assess the safety and tolerability of multiple ascending subcutaneous doses of REGN3500 to moderate asthmatics.
- Trial name
- NCT02999711
- Testing
- REGN3500
- Where
- 3 sites in United Kingdom
- Volunteers
- 23 people
- Sponsor
- Regeneron Pharmaceuticals
Asthma
A Comparative Study to Investigate the Difference in Blood Levels of Two Different Formulations of GSK5784283
The purpose of this study is to compare how two different formulations of the study medicine (GSK5784283) move through the body over time (pharmacokinetic [PK] study) in healthy adults.
- Trial name
- NCT07712393
- Testing
- GSK5784283
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Asthma, HIV
Determine the Prevalence and Severity of Asthma in HIV (Human Immunodeficiency Virus) Infected Patients
The purpose of this study is to determine the prevalence and severity of asthma in patients with HIV. To determine the immunological phenotype of HIV-infected patients with asthma.
- Trial name
- NCT02405026
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- Duke University
Asthma in Children
Rhode Island Asthma Integrated Response Program
The study's purpose is to evaluate the RI-Asthma Integrated Response (RI-AIR) Asthma Care Implementation Program (ACIP). RI-AIR ACIP uses an electronic information system to screen children with asthma and identify what specific…
- Trial name
- RI-AIR (NCT03583814)
- Testing
- CASE Program, HARP Program
- Where
- United States
- Volunteers
- 432 people
- Sponsor
- Rhode Island Hospital
Asthma
A Study Comparative of Formoterol/Fluticasone Foraseq® and Fluticasone in Asthma Patients
The primary objective will be to compare the impact of the study formulations on pulmonary function in persistent asthma carriers.
- Trial name
- NCT01202084
- Testing
- Formoterol/Fluticasone, Foraseq®, Fluticasone
- Where
- Brazil
- Volunteers
- 222 people
- Sponsor
- Eurofarma Laboratorios S.A.
Atherosclerosis
A Study To Determine The Effect Of SB-480848 On Asthma
The purpose of this study is to compare the effects of SB-480848 with placebo in subjects with asthma.
- Trial name
- NCT00368576
- Testing
- SB 480848, tablets
- Where
- 7 sites in United States, Germany
- Volunteers
- 67 people
- Sponsor
- GlaxoSmithKline
Severe Asthma
Defining the Severe Paediatric Asthma Endotype
The primary objective of this project is to extensively characterize the endotypes of pre-schoolers (0 to 6 years) and school-age children (6 to 12 years) with SA using an integrated approach, combining a description of their…
- Trial name
- SevAsthma (NCT04680117)
- Testing
- Blood collection, Saliva sample, Nasal
- Where
- France
- Volunteers
- 54 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Asthma
Assessment Of Disease Pathology And Key Therapeutic Targets In Severe Asthma
To evaluate and compare the expression and change in expression of key severe asthma targets at baseline in mile to moderate asthmatics vs. severe asthmatic subjects.
- Trial name
- NCT00327197
- Testing
- Prednisolone, Bronchoscopy
- Where
- United Kingdom
- Volunteers
- 47 people
- Sponsor
- GlaxoSmithKline
Asthma
Phenotypic and Functional Characterization of Neutrophils and Eosinophils in Severe Asthma Treated With Biotherapy
Neutrophils and eosinophils can have different functions. Depending on their environment, they can be more or less active, with more or less inflammatory activity.
- Trial name
- CaPHe (NCT05972213)
- Where
- France
- Volunteers
- 105 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Asthma
Periostin-guided Withdrawal of Inhaled Corticosteroids in Patients With Non-eosinophilic Asthma
Background: Asthma is a common chronic condition characterized by respiratory symptoms and hyperresponsive airways. According to treatment guidelines, patients with persistent asthma require daily treatment with inhaled…
- Trial name
- NCT03141424
- Testing
- Tapering of inhaled corticosteroid (ICS) treatment
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Hvidovre University Hospital
Asthma
A Study of Lebrikizumab in Participants With Uncontrolled Asthma Who Are on Inhaled Corticosteroids and a Second Controller Medication
This randomized, multicenter, double-blind, placebo-controlled, parallel-group study will evaluate the efficacy and safety of lebrikizumab in participants with asthma whose disease remains uncontrolled despite daily treatment…
- Trial name
- NCT01867125
- Testing
- Lebrikizumab
- Where
- 181 sites in United States, Argentina and 24 more
- Volunteers
- 1,081 people
- Sponsor
- Hoffmann-La Roche
COPD, Asthma
Writing About Disease: Effect on Rehabilitation?
Therapeutic writing about one's emotions has been described previously (J Pennebaker: Emotions, disclosure and health. Am Psychol. Assoc 1995).
- Trial name
- NCT00251420
- Testing
- writing about disease
- Where
- Norway
- Volunteers
- 180 people
- Sponsor
- LHL Helse
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