Clinical trials: Back Pain Lower Back
Chronic Low Back Pain
MEPS-Pain: Personalized Pain Self-management Planning by and for Veterans Pilot Study
Chronic low back pain is the #1 cause of disability and low quality of life in Veterans. Pain is a huge burden- stealing enjoyment, fulfillment, and time. Sometimes surgery, injections, or medications can help but sometimes not.
- Trial name
- MEPS-Pain (NCT04075487)
- Testing
- Web-module for patient education and planning
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- VA Office of Research and Development
Low Back Pain
Predicting Patients' Response to Spinal Manipulation
The purpose of this study is to compare the clinical effectiveness of two types of chiropractic spinal manipulation to conservative medical care for patients at least 55 years old with sub-acute or chronic LBP.
- Trial name
- NCT00285649
- Testing
- HVLA-SM, LVVA-SM, Usual Medical Care
- Where
- United States
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- Palmer College of Chiropractic
Low Back Pain, Sciatica
Integrated Supported Biopsychosocial Self-Management for Back Related Leg Pain
Guidelines advocate several complementary modalities as alternatives to drugs and other invasive treatments for chronic low back pain (LBP) conditions.
- Conditions
- Low Back Pain, Sciatica, Back Related Leg Pain, Pain, Chronic
- Trial name
- SUPPORT (NCT05022121)
- Testing
- Supported Biopsychosocial Self-Management (SBSM), Medical Care
- Where
- 2 sites in United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Low Back Pain, Musculoskeletal Pain
Soft Active Back Exosuit to Reduce Workplace Back Pain
The goal of this clinical trial is to determine if a wearable back exosuit can make it safer and easier for workers who bend, lift, and lower objects in an industrial setting.
- Conditions
- Low Back Pain, Musculoskeletal Pain, Low Back Injury
- Trial name
- NCT05802914
- Testing
- Back Exosuit
- Where
- United States
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Wyss Institute at Harvard University
Chronic Low Back Pain, Mechanical Low Back Pain
Use of Biofeedback Training to Correct Abnormal Neuromechanical Pattern in Chronic Low Back Pain Patients
The purpose of the present study is to evaluate the benefit of biofeedback training on the capacity of chronic low back pain patients to decrease their lumbar paraspinal muscles activity during trunk full flexion and its…
- Trial name
- NCT02239289
- Testing
- Biofeedback
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- Université du Québec à Trois-Rivières
Low Back Pain
Efficacy Study to Evaluate Buprenorphine HCl Buccal Film in Opioid-Naive Subjects
The purpose of this study is to determine if buprenorphine hydrochloride (HCl) buccal film is effective in treating opioid-naive subjects, with moderate to severe chronic low back pain (CLBP), who require continuous…
- Trial name
- NCT01633944
- Testing
- Buprenorphine
- Where
- 60 sites in United States
- Volunteers
- 752 people
- Sponsor
- BioDelivery Sciences International
Chronic Low Back Pain
A Study for Patient With Chronic Low Back Pain
The purpose of this study is to determine if duloxetine reduces the severity of chronic low back pain.
- Trial name
- NCT00767806
- Testing
- Duloxetine
- Where
- 26 sites in United States, Brazil and 5 more
- Volunteers
- 401 people
- Sponsor
- Eli Lilly and Company
Back Pain, Low Back Pain
Electrical Stimulation for the Treatment of Back Pain Using Peripheral Nerve Stimulation (PNS)
The purpose of this study is to evaluate the effectiveness of electrical stimulation (low levels of electricity) on low back pain. This study involves the SPRINT Peripheral Nerve Stimulation (PNS) system.
- Trial name
- NCT03179202
- Testing
- SPRINT Peripheral Nerve Stimulation (PNS) System
- Where
- 8 sites in United States
- Volunteers
- 166 people
- Sponsor
- SPR Therapeutics, Inc.
Chronic Low Back Pain
tDCS for Chronic Low Back Pain
The goal of this study is to investigate the role of central neural pathways in mediating chronic pain. The aim of the study is to test the effect of stimulating brain regions that are part of a network underlying central pain…
- Trial name
- NCT02771990
- Testing
- transcranial direct current stimulation
- Volunteers
- 30 people
- Sponsor
- Providence VA Medical Center
Low Back Pain
Effectiveness of Percutaneous Lumbar Epidural Adhesiolysis and Neurolysis on Low Back Pain
Clinically significant improvements in the percutaneous adhesiolysis patients with hypertonic neurolysis compared to those patients randomized to the control group who did not receive adhesiolysis and hypertonic saline…
- Trial name
- NCT00370994
- Testing
- Caudal epidural injection, Percutaneous adhesiolysis
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Pain Management Center of Paducah
Pain
An Efficacy and Safety Study of Acetaminophen Plus Tramadol Hydrochloride (JNS013) in Participants With Chronic Pain
The purpose of this study is to evaluate the efficacy and safety of tramadol hydrochloride plus acetaminophen (JNS013) in participants with chronic pain accompanied by osteoarthritis (a progressive and degenerative joint disease…
- Trial name
- NCT00736853
- Testing
- Tramadol Hydrochloride Plus Acetaminophen (Open-Label), Tramadol Hydrochloride Plus Acetaminophen (Double-Blind)
- Where
- 20 sites in Japan
- Volunteers
- 321 people
- Sponsor
- Janssen Pharmaceutical K.K.
Chronic Pain, Back Pain
Group-based Mindfulness for Chronic Pain in the Primary Care Setting
The purpose of this pragmatic clinical trial (PCT) research is to determine whether a group-visit approach modeled on Mindfulness-Based Stress Reduction can improve function for persons with chronic low back pain.
- Trial name
- OPTIMUM (NCT04129450)
- Testing
- Group medical visits with mindfulness-based stress reduction, Usual PCP care
- Where
- United States
- Volunteers
- 451 people
- Sponsor
- Boston Medical Center
Chronic Low Back Pain
CLBP Single-Arm Long-Term Follow-up Study
This is a prospective, noninterventional, observational post market data collection of long-term effectiveness and satisfaction outcomes for "A Prospective, Open-Label, Single-Arm Study of Intraosseous Basivertebral Nerve…
- Trial name
- NCT05207813
- Testing
- Intracept Procedure
- Where
- 2 sites in United States
- Volunteers
- 42 people
- Sponsor
- Boston Scientific Corporation
Low Back Pain
The Back Exercises to Neutralize Disability Study
A pilot randomized control trial (RCT) to generate effect sizes on the effects of blood flow restricted exercise on trunk extensor cross-sectional area (primary outcome), strength and endurance, whole body and regional lean mass…
- Trial name
- BEND (NCT02308189)
- Testing
- Exercise with blood flow restriction, Exercise
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Ohio University
Anxiety Disorders, Anxiety Disorders and Symptoms
Anxiety Level Among Patients With Chronic Low Back Pain
The goal of this observational cross-sectional study is to learn about the intensity of anxiety symptoms among Polish people suffering from chronic lower back pain.
- Conditions
- Anxiety Disorders, Anxiety Disorders and Symptoms, Lower Back Pain, Chronic Pain
- Trial name
- NCT06404788
- Where
- Poland
- Volunteers
- 202 people
- Sponsor
- Medical University of Silesia
Chronic Low Back Pain, Chronic Leg Pain
Comparison of the Effects of Two Spinal Cord Stimulation (SCS) Therapies on Subject Reported Pain (BENEFIT-02)
A BIOTRONIK wearable stimulator will be utilized in order to investigate the effects of two study spinal cord stimulation (SCS) therapies on subject reported pain and paresthesia perception observed over 12 days of study…
- Trial name
- NCT03594266
- Testing
- Therapy A spinal cord stimulation parameter set using BIO-RNA system and associated components, Therapy B spinal cord stimulation parameter set using BIO-RNA system and associated components
- Where
- 18 sites in United States
- Volunteers
- 136 people
- Sponsor
- Biotronik, Inc.
Osteoarthritis, Back Pain
A Study to Compare Oxycodone/Naloxone Prolonged Release Against Codeine/Paracetamol in the Treatment of Moderate to Severe Chronic Low Back Pain or Pain Due to Osteoarthritis
The purpose of this study is to compare oxycodone/naloxone combination tablet and codeine/paracetamol tablets in the treatment of moderate to severe chronic low back pain or pain due to osteoarthritis.
- Trial name
- NCT00784810
- Testing
- Oxycodone/Naloxone, Codeine/Paracetamol
- Where
- United Kingdom
- Volunteers
- 247 people
- Sponsor
- Napp Pharmaceuticals Limited
Back Pain
Safety and Efficacy of the TransDiscal System Versus Medical Management in Treating Chronic Discogenic Low Back Pain
The primary objective of this randomized controlled trial is to evaluate the safety and efficacy of the TransDiscal System (TDS) in treating discogenic pain of the lumbar spine using a modified disc biacuplasty procedure.
- Trial name
- COLD (NCT01263054)
- Testing
- TransDiscal System, Medical Management
- Where
- 9 sites in United States
- Volunteers
- 67 people
- Sponsor
- Halyard Health
Chronic Low Back Pain
Virtual Reality Therapy for Chronic Low Back Pain
This study will test the efficacy of an evidence-based virtual reality (VR) therapy program as a non-pharmacological supplement for the management of chronic lower back pain.
- Trial name
- NCT04409353
- Testing
- Distraction-Based VR, Skills-Based VR, Activity Tracker
- Where
- United States
- Volunteers
- 413 people
- Sponsor
- Cedars-Sinai Medical Center
Chronic Low-back Pain
Chronic Pain Master Protocol (CPMP): A Study of LY3556050 in Participants With Chronic Low Back Pain
This study is being done to test the safety and efficacy of the study drug LY3556050 for the treatment of chronic low back pain.
- Trial name
- NCT04874636
- Testing
- LY3556050
- Where
- 35 sites in United States, Puerto Rico
- Volunteers
- 153 people
- Sponsor
- Eli Lilly and Company