Clinical trials: Bacteraemia
Enterobacteriaceae Infections
Study on Reduced Antibiotic Treatment vs Broad Spectrum Betalactam in Patients With Bacteremia by Enterobacteriaceae
The continuous increase in the bacterial resistance rate and the slow arrival of new therapeutic options have turned into an antibiotic crisis.
- Trial name
- SIMPLIFY (NCT02795949)
- Testing
- Antipseudomonal beta-lactam antibiotic, De-escalation(short-spectrum antibiotic)
- Where
- 21 sites in Spain
- Volunteers
- 344 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Urinary Tract Infections
Comparative Study of the Genomic Characteristics of Uropathogenic Escherichia Coli According to the Severity of Community-Acquired Urinary Tract Infections in Guadeloupe (COLIGENURI)
The aim is to identify genomic determinants (genes or gene clusters) associated with the severity of community-acquired E. coli urinary tract infections in Guadeloupe through a comparative approach integrating clinical…
- Trial name
- COLIGENURI (NCT07905638)
- Testing
- Whole-genome sequencing (WGS) of E. coli isolates (applies to all 3 groups)
- Volunteers
- 210 people
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe
Sepsis Affecting Skin, Central Venous Catheter Related Bacteremia
Comparison Trial for Chloraprep Versus Aqueous Chlorhexidine (2%) for the Prevention of Catheter-related Bacteremia
A multicentre, open-label clinical trial of two groups comparing cutaneous asepsis with chlorhexidine gluconate at 2% + isopropyl alcohol 70% in relation to the placement of central venous catheters (Study group) with standard…
- Trial name
- NCT03489512
- Testing
- A (Chloraprep), B (Clorhexidine 2%)
- Sponsor
- Instituto de Investigacion Sanitaria La Fe
Bacteremia
Daptomycin Pharmacokinetics in Continuous Veno-venous Hemodiafiltration
The purpose is to investigate daptomycin pharmacokinetics in critically ill patients with suspected or verified bacteremia with Gram-positive cocci undergoing combined continuous hemodiafiltration at a filtration rate of…
- Trial name
- NCT01171547
- Testing
- Daptomycin
- Where
- Switzerland
- Volunteers
- 15 people
- Sponsor
- University of Zurich
Staphylococcus Aureus Bacteremia, Staphylococcus Aureus Septicemia
18-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in S. Aureus Bacteraemia
Having bacteria in the blood can be very dangerous. This is called bacteraemia (or bacteremia) or bloodstream infection. It can lead to problems across the whole body, which is what happens in sepsis.
- Conditions
- Staphylococcus Aureus Bacteremia, Staphylococcus Aureus Septicemia, Sepsis Bacterial, Bloodstream Infection
- Trial name
- PET-SAB (NCT05361135)
- Testing
- PET/CT
- Volunteers
- 820 people
- Sponsor
- University College, London
Bacteremia and Sepsis, Toll-Like-Receptors (TLRs)
Bacteremia in Intensive Care Unit (ICU)
The presence of bacteremia and sepsis in percent of critically ill patients and none at all, associated with different expression and faction of Toll-Like-Receptors (TLRs.
- Trial name
- NCT00932243
- Where
- Greece
- Volunteers
- 300 people
- Sponsor
- University of Thessaly
Catheter Bacteremia, Staphylococcus Aureus Infection
Dalbavancin Versus Standard Antibiotic Therapy for Catheter-related Bloodstream Infections Due to Staphylococcus Aureus
The primary objective of the study is to demonstrate, among patients with non-complicated CR-BSIs due to S. aureus, that a single-dose of intravenous (IV) dalbavancin 1500 mg is non-inferior to standard documented antibiotic…
- Trial name
- DALICATH (NCT05117398)
- Testing
- Dalbavancin administration, Standard antibiotic therapy
- Where
- 2 sites in France
- Volunteers
- 406 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Bacteremia, Infective Endocarditis
Impact of the Blood Culture Technique on the Diagnosis of Infective Endocarditis
To evaluate the performance of a single high volume blood culture sampling strategy versus the actually used multiple sampling strategy for the diagnosis and categorization of infective endocarditis according to the Duke-Li…
- Trial name
- UniEndo (NCT03153384)
- Testing
- Blood Culture
- Where
- 8 sites in France
- Volunteers
- 269 people
- Sponsor
- Central Hospital, Nancy, France
Endothelial Dysfunction
The Association Between Food Timing and Composition on Gastrointestinal Injury, Stress Hormone and Gastrointestinal Complains.
The study aimed to check the influence of timing and composition of diet on markers of gut injury, endotoxemia and stress.
- Trial name
- NCT06403241
- Testing
- 2000 meter ergometer test
- Where
- Poland
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education
Bacteremia
Establish Quantitative PCR to Measure Bacteria Load of the VRE Bacteremia
The investigators hypothesized that quantitative PCR can be used in VRE bacteremia outcome monitoring. Vancomycin-resistant enterococci (VRE) was first found in 1988 and has become an important healthcare-associated pathogen due…
- Trial name
- NCT01265095
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
Bacteremia Sepsis
Machine Learning Assisted Electrochemical Profiling to Provide Early Identification of Bloodstream Infections Pathogens
In the context of a bacteremia, although significant progress has been made in speeding up pathogen identification once a blood culture bottle turns positive, few cost-effective solutions have been proposed to improve the earlier…
- Trial name
- E-MOC (NCT06853301)
- Testing
- Blood culture sampling
- Where
- 2 sites in France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Grenoble
Bacterial Infections, Bacteremia
Procalcitonin Level and Kinetics in Children With Bacterial Infections
The purposes of this study are: 1. To determine whether procalcitonin level at admission of pediatric patients with bacterial infections can be used as a marker for prediction of defervescence and hospitalization length 2.
- Conditions
- Bacterial Infections, Bacteremia, Meningitis, Urinary Tract Infection
- Trial name
- NCT00714402
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Shaare Zedek Medical Center
Pneumonia, Bacteremia
Steady State Serum and Epithelial Lining Fluid (ELF) Antibiotics Concentrations Under Continous Infusion
The purpose of our study is to determine the penetration of continuously infused antibiotics at steady state, mainly Meropenem, Vancomycin, Linezolid, Piperacillin/tazobactam and additionally cefepim and ceftazidim, into…
- Trial name
- NCT00435305
- Testing
- Meropenem, Vancomycin, Linezolid
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- University Hospital Tuebingen
Health Care Associated Pneumonia, Osteomyelitis/Septic Arthritis
Safety and Efficacy of Strategy to Prevent Drug-Induced Nephrotoxicity in High-Risk Patients
For more than fifty years, vancomycin has been cited as a nephrotoxic agent. Reports of vancomycin induced kidney injury (a.k.a vancomycin induced nephrotoxicity or VIN), have waxed and waned throughout the years for various…
- Conditions
- Health Care Associated Pneumonia, Osteomyelitis/Septic Arthritis, Endocarditis, Bacteremia
- Trial name
- STOP-NT (NCT01734694)
- Testing
- Vancomycin, Ceftaroline, Daptomycin
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Henry Ford Health System
Bacteremia
Multicenter Blood Culture Quality Improvement
False positive blood culture results due to specimen contamination with bacteria inhabiting patients' skin is a common problem in emergency departments (EDs) in the United States.
- Trial name
- NCT01413555
- Testing
- Blood Culture QI Program
- Where
- 2 sites in United States
- Volunteers
- 14,889 people
- Sponsor
- Vanderbilt University
Staphylococcus Aureus Bacteremia
Adjunctive Fosfomycin for Treatment of Staphylococcus Aureus Bacteraemia
Staphylococcus aureus bacteraemia is a frequent and life-threatening infection, despite current standard antibiotic monotherapy.
- Trial name
- BACSAFO (NCT06695832)
- Where
- 6 sites in Australia, Canada and 1 more
- Volunteers
- 369 people
- Sponsor
- Hospital Universitari de Bellvitge
Bacteremia
Efficacy of 2% Chlorhexidine Gluconate in 70% Alcohol Compare 10% Povidone Iodine in Blood Culture in Children
To evaluate the efficacy of 2% chlorhexidine gluconate in 70% alcohol compared with 10% povidone iodine in reducing blood culture contamination in pediatric patients.
- Trial name
- NCT01919593
- Testing
- 2% chlorhexidine gluconate in 70% alcohol, 10%povidone iodine
- Where
- Thailand
- Volunteers
- 1,269 people
- Sponsor
- Thammasat University
Esophageal Achalasia
Bacteremia and Procalcitonin Levels in Peroral Endoscopic Myotomy for Achalasia
Peroral Endoscopic Myotomy (POEM) is a novel, promising endoscopic technique for achalasia because it is safer and more effective than traditional Heller's myotomy.
- Trial name
- NCT01750385
- Testing
- no antibiotic prophylaxis, second-generation cephalosporin
- Volunteers
- 60 people
- Sponsor
- Shanghai Zhongshan Hospital
Bacterial Infections, Gram-Positive Bacterial Infections
Antibiotic Treatment for Infections of Short Term In-dwelling Vascular Catheters Due to Gram Positive Bacteria
This study will treat patients who have a short term central catheter that is thought to be infected with a specific bacteria (gram positive bacteria)
- Conditions
- Bacterial Infections, Gram-Positive Bacterial Infections, Bacteremia
- Trial name
- NCT00037050
- Testing
- Linezolid, Vancomycin, Oxacillin
- Volunteers
- 739 people
- Sponsor
- Pfizer
Sepsis, Severe Sepsis
Clarithromycin as Immunomodulator for the Management of Sepsis
The herein protocol is based on the results of one former clinical trial conducted by our study group showing the considerable efficacy of intravenously administered clarithromycin as an adjuvant to antimicrobial chemotherapy for…
- Conditions
- Sepsis, Severe Sepsis, Septic Shock
- Trial name
- NCT01223690
- Testing
- Clarithromycin, Dextrose 5%
- Where
- 6 sites in Greece
- Volunteers
- 600 people
- Sponsor
- University of Athens