Clinical trials: Bacteraemia
Diet, Healthy, Endotoxemia
Different Dietary Patterns
The aim of the present study is to determine the effects of different standardized dietary patterns on general health markers, intestinal function, immune response and affective processes/ cognitive skills in healthy subjects.
- Trial name
- NCT06147440
- Testing
- Dietary intervention
- Where
- Austria
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Vienna
Bacteremia Due to Staphylococcus Aureus, Left Sided Infective Endocarditis (Disorder)
ERAdicate S. Aureus in Patients With Bacteremia and Endocarditis
This study evaluates safety and tolerability of endolysin-derived LSVT-1701 (tonabacase) as an add-on to standard of care (SOC) antibiotic therapy for the treatment of patients with complicated Staphylococcus aureus bacteremia…
- Conditions
- Bacteremia Due to Staphylococcus Aureus, Left Sided Infective Endocarditis (Disorder), Right Sided Infective Endocarditis (Disorder), Endocarditis Infective
- Trial name
- ERASE (NCT05329168)
- Testing
- Tonabacase (LSVT-1701)
- Where
- United States
- Sponsor
- Lysovant
Endotoxemia
A Possible Therapeutic Role for Adenosine During Inflammation
The adenosine receptor is known for its anti-inflammatory actions and could therefore be a potential target in the treatment of sepsis and septic shock.
- Trial name
- NCT00513110
- Testing
- AMPD1 polymorphism, Caffeine infusion
- Where
- Netherlands
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
SIRS, Sepsis
The Value of sTREM-1, PCT, and CRP as Markers for the Detection of Sepsis and Bacteremia Among Patients With a FUO
The investigators enrolled 144 subjects admitted to ICUs: 60 patients with systemic inflammatory response syndrome (SIRS) and 84 patients with sepsis.
- Conditions
- SIRS, Sepsis, Bacteremia
- Trial name
- NCT01410578
- Where
- China
- Volunteers
- 144 people
- Sponsor
- Chinese PLA General Hospital
Infective Endocarditis (IE)
From Commensalism to Pathogenicity: Exploring the Pathophysiology of Bacteremia to Better Understand Enterococcus Faecalis Infective Endocarditis
Enterococci are pathobionts of the human intestinal microbiota: they colonize the gastrointestinal tract as well as the skin, urine, wounds, bile, the oral cavity and endodontic canal, and medical devices (urinary catheters…
- Trial name
- BAC-ENDO (NCT07313865)
- Testing
- Microbiological sampling (swab collection)
- Where
- France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Clermont-Ferrand
Staphylococcus Aureus Septicemia, Staphylococcus Aureus Bacteremia
Daptomycin vs. Vancomycin for the Treatment of Methicillin Resistant S. Aureus Bacteremia
This is an open label randomized controlled trial for patients with methicillin resistant S. aureus (MRSA) bloodstream infection which will directly compare the two most commonly used therapies, vancomycin and daptomycin.
- Conditions
- Staphylococcus Aureus Septicemia, Staphylococcus Aureus Bacteremia, S. Aureus Bacteremia, S. Aureus Bloodstream Infection
- Trial name
- DAPTO-SNAP (NCT06637332)
- Testing
- Daptomycin for Injection, Vancomycin (IV)
- Where
- 20 sites in Australia, Canada and 1 more
- Volunteers
- 300 people
- Sponsor
- Todd C. Lee MD MPH FIDSA
Infection, Neutropenia
Daptomycin or Vancomycin in Treating Bacteria in the Blood in Patients With Neutropenia Caused By Chemotherapy
RATIONALE: Antibiotics, such as daptomycin and vancomycin, may be effective in treating bacteria in the blood. It is not yet known whether daptomycin is more effective than vancomycin in treating bacteria in the blood in patients…
- Conditions
- Infection, Neutropenia, Unspecified Adult Solid Tumor, Protocol Specific, Unspecified Childhood Solid Tumor, Protocol Specific
- Trial name
- NCT00296049
- Testing
- daptomycin, vancomycin
- Where
- United States
- Sponsor
- Wake Forest University Health Sciences
Liver Fibrosis, Liver Cirrhosis
Influence of Probiotics Administration Before Liver Resection in Liver Disease
Surgical resection is one of the curative treatment modalities for HCC. Limits are postoperative septic and liver functional complications related to an increase in bacterial translocation and systemic endotoxemia.
- Conditions
- Liver Fibrosis, Liver Cirrhosis, Permeability; Increased, Hepatocellular Carcinoma
- Trial name
- LIPROCES (NCT02021253)
- Testing
- Probiotic
- Where
- France
- Volunteers
- 64 people
- Sponsor
- University Hospital, Rouen
Septic Shock, Endotoxemia
Safety and Efficacy of Polymyxin B Hemoperfusion (PMX) for Endotoxemic Septic Shock in a Randomized, Open-Label Study
Prospective, multicenter, randomized, open-label study of standard of care plus the PMX cartridge versus standard of care alone in patients with endotoxemic septic shock
- Trial name
- TIGRIS (NCT03901807)
- Testing
- Toraymyxin PMX 20R Extracorporeal Hemoperfusion Cartridge
- Where
- 20 sites in United States
- Volunteers
- 157 people
- Sponsor
- Spectral Diagnostics (US) Inc.
Enterocolitis, Necrotizing, Bacteremia
Antibiotic "Dysbiosis" in Preterm Infants
Prolonged antibiotic use in preterm neonates has significant consequences on the developing intestinal microbiome, metabolome and host response, predisposing the neonate to various major morbidities, including necrotizing…
- Conditions
- Enterocolitis, Necrotizing, Bacteremia, Bronchopulmonary Dysplasia, Intraventricular Hemorrhage
- Trial name
- NCT02784821
- Testing
- Antibiotic, Gastric fluid, Breast milk
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- University of Florida
Bloodstream Infections, Bacteremia and Sepsis
Clinical Efectiveness of a Multiplex PCR-Based Rapid Diagnostic Method in Bloodstream Infections
Bloodstream infections (BSIs) are associated with high morbidity and mortality, and delays in initiating appropriate antimicrobial therapy significantly worsen clinical outcomes.
- Conditions
- Bloodstream Infections, Bacteremia and Sepsis, Fungemia
- Trial name
- CEMP-RDI (NCT07408544)
- Testing
- Multiplex PCR-Based Rapid Diagnostic Test, Standard Microbiological Diagnostic Methods
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people
- Sponsor
- Istanbul Medipol University Hospital
Pneumonia, Hematologic Malignancy
Ceftolozane-Tazobactam for Directed Treatment of Pseudomonas Aeruginosa Bacteremia and Pneumonia in Patients With Hematological Malignancies and Hematopoietic Stem Cell Transplantation
The goal of this clinical trial is to learn whether the antibiotic ceftolozane-tazobactam works to treat serious Pseudomonas aeruginosa infections in people with blood cancers or who received a stem cell transplant.
- Conditions
- Pneumonia, Hematologic Malignancy, Pseudomonas Aeruginosa Infection, Bacteremia
- Trial name
- NCT04673175
- Testing
- Ceftolozane / Tazobactam Injection
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Weill Medical College of Cornell University
Staphylococcus Aureus Bacteremia
Staphylococcus Aureus Bacteraemia (SAB)-Support-Study
The main objective of this study is to investigate whether checklist-based close telephone consultation and process surveillance for S.
- Trial name
- SABOT (NCT06249451)
- Testing
- Checklist-based phone calls
- Where
- Germany
- Volunteers
- 124 people
- Sponsor
- University Medicine Greifswald
Cancer
Dental Study in Cancer Patients With Central Venous Catheters
Patients who are preparing to receive chemotherapy are asked to have their teeth cleaned before starting treatment as standard of care.
- Trial name
- NCT00798330
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Rajesh Lalla
Autoimmune Diseases
Concentration/Meditation Limits Inflammation
Auto-immune diseases are characterized by an inappropriate inflammatory response against tissues in the body and represent a major health care burden.
- Trial name
- NCT01835457
- Testing
- Lipopolysaccharide, Concentration/meditation
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Enterococcus Faecalis Bacteremia
Treatment of Enterococcus Faecalis Bacterem
Enterococcus faecalis is a germ frequently responsible for bacteremia which can be severe with 15-25% risk of mortality and 26% risk of infectious endocarditis.
- Trial name
- E-faecalis (NCT07299539)
- Where
- France
- Volunteers
- 700 people
- Sponsor
- University Hospital, Strasbourg, France
Bacteremia, Streptococcus Infection
Beta-lactam Plus Levofloxacin to Enhance Therapy in Streptococcal Septicemia
A double-blind randomized controlled trial comparing beta-lactam plus levofloxacin versus beta-lactam monotherapy for the treatment of Streptococcal bacteremia
- Trial name
- BLESS (NCT07240077)
- Testing
- Beta-lactam monotherapy, Beta-lactam plus levofloxacin combination therapy
- Where
- 4 sites in Thailand
- Volunteers
- 165 people
- Sponsor
- Mahidol University
Healthy Volunteers, Endotoxemia
Defibrotide in the Human Endotoxemia Model --- an Exploratory Trial Investigating the Effects and the Mechanisms of Defibrotide
Defibrotide is an anti-inflammatory and anti-coagulatory agent approved for treatment of veno-occlusive disease. Although it has been in clinical use for almost 30 years, the exact mechanism of action has never been fully…
- Trial name
- LPS_DF (NCT02876601)
- Testing
- Defibrotide, Lipopolysaccharide
- Where
- Austria
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Bernd Jilma
Periodontitis
Evaluation of the Systemic Burden of Non-surgical Periodontal Therapy: A Randomized Clinical Trial on Five Different Treatment Protocols
Periodontitis is a chronic inflammatory disease of the periodontal tissues leading to the destruction of the tooth supporting structures.
- Trial name
- NCT07077122
- Testing
- Scaling and Root Planing, antibiotic prophylaxis, 810nm Diode Laser
- Where
- Greece
- Volunteers
- 75 people
- Sponsor
- National and Kapodistrian University of Athens
Bacteraemia Caused by Gram-Negative Bacteria
Antibiotic Durations for Gram-negative Bacteremia
Gram-negative bacteremia (GNB) is a frequent hospital \& community-acquired infection, yet there is as yet no evidence from randomized studies on the optimal duration of antibiotic therapy.
- Trial name
- PIRATE (NCT03101072)
- Testing
- "Fixed long" antibiotic course of 14 days, "Fixed short" antibiotic course of 7 days, "Individualized duration" of antibiotic therapy
- Where
- 3 sites in Switzerland
- Volunteers
- 504 people
- Sponsor
- University of Geneva, Switzerland