Clinical trials: Bacteremia
Hypoxia, Endotoxemia
Cerebral Blood Flow and Metabolism During Hypoxia and Endotoxemia
The objective of the present protocol is to study whether a low level of oxygen in the blood will affect the immune response to as well as cerebral blood flow and metabolism during an infection and, conversely, whether the acute…
- Conditions
- Hypoxia, Endotoxemia, Healthy
- Trial name
- NCT00332267
- Testing
- Endotoxin infusion, Normobaric hypoxia
- Where
- Denmark
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Healthy Volunteers, Endotoxemia
Defibrotide in the Human Endotoxemia Model --- an Exploratory Trial Investigating the Effects and the Mechanisms of Defibrotide
Defibrotide is an anti-inflammatory and anti-coagulatory agent approved for treatment of veno-occlusive disease. Although it has been in clinical use for almost 30 years, the exact mechanism of action has never been fully…
- Trial name
- LPS_DF (NCT02876601)
- Testing
- Defibrotide, Lipopolysaccharide
- Where
- Austria
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Bernd Jilma
Endotoxemia
Effects of Vasopressors on Immune Response
Noradrenaline is a catecholamine and the cornerstone treatment for the improvement of hemodynamic parameters in septic shock. Catecholamines exert profound immunomodulatory effects.
- Trial name
- NCT02675868
- Testing
- Norepinephrine, Phenylephrine, Vasopressins
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Endotoxemia
Ticagrelor in Human Endotoxemia Response to Human Endotoxemia
Rationale: In patients suffering a myocardial infarction the P2Y12 receptor antagonists prasugrel and ticagrelor improve outcome and prognosis compared to clopidogrel.
- Trial name
- NCT02612480
- Testing
- ticagrelor, Clopidogrel, Acetylsalicylic acid lysinate
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Endotoxemia, Inflammation
Short-Chain Fatty Acids in Lypopolysaccharide-Induced Inflammation and Executive Function
Short-chain fatty acids (SCFAs) are substances produced by gut bacteria when they ferment dietary fiber. They can act as signals between the gut and the brain and may help regulate the body's immune and stress responses.
- Conditions
- Endotoxemia, Inflammation, Executive Function (Cognition)
- Trial name
- NCT07713641
- Testing
- Short-Chain Fatty Acid Colon-Delivery Capsules, Lipopolysaccharide (LPS)
- Where
- Belgium
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Endotoxemia, Inflammation
The Effects of Immunostimulation With GM-CSF or IFN-y on Immunoparalysis Following Human Endotoxemia
The human body knows a biphasic immunological reaction to sepsis. First, the pro-inflammatory reaction takes place, marked by the release of pro-inflammatory cytokines like TNF-α, as a reaction to the bacterial toxins.
- Conditions
- Endotoxemia, Inflammation, Multi Organ Dysfunction Syndrome, Sepsis
- Trial name
- NCT01374711
- Testing
- GM-CSF, IFN-Y, E.coli endotoxin
- Where
- Netherlands
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Dietary Habits, Endotoxemia
Effect of Monosaccharides on Intestinal Barrier Function
The aim of the present study is to determine the effect of monosaccharides on intestinal barrier function in healthy subjects.
- Trial name
- ENDO-META (NCT03482284)
- Testing
- Dietary Intervention
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Prof. Dr. Ina Bergheim
Endotoxemia, Inflammation
The Effects of Atazanavir-induced Hyperbilirubinemia During Human Endotoxemia
Excessive inflammation, production of free radicals and vascular injury are considered the main contributors to the development of organ dysfunction in patients with severe infections and sepsis.
- Conditions
- Endotoxemia, Inflammation, Multi Organ Dysfunction Syndrome, Sepsis
- Trial name
- NCT00916448
- Testing
- Atazanavir, E. coli endotoxin
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Bacteremia, Periodontal Diseases
Bacteremia From Periodontal Treatment to Elucidate the Underpinnings of Sepsis
Approximately 40,000 Swedes suffer from sepsiseach year, about 20% die. Biomarkers that are sensitive to current or previous bacteremia are needed in the treatment of sepsis.
- Conditions
- Bacteremia, Periodontal Diseases, Sepsis, Heart Diseases
- Trial name
- NCT04565691
- Testing
- Non-surgical periodontal treatment
- Where
- Sweden
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Malmö University
Enteritis, Bleeding
Balloon-assisted Enteroscopy and Bacteria
1. Balloon-assisted enteroscopy (BAE) is a new tool to investigate small intestinal diseases. 2. Deep enteroscopy made possible by balloon expansion and manipulation of small intestines. 3.
- Trial name
- NCT01065324
- Where
- 2 sites in Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital