Clinical trials: Bacteria
Pre-diabetic
Investigation of the Ability of a Supplement to Increase Good Bacteria in the Human Intestine and Blood Sugar Levels
This study aims to determine whether the use of a supplement called xylooligosaccharide (XOS) increases the number of good bacteria that live in human intestines and can maintain healthy blood sugar levels, and whether XOS has…
- Trial name
- XOS2 (NCT01944904)
- Testing
- Sugar Pill, XOS 2.8
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Fibromyalgia, Diet, Gluten-Free
The Effects of Dietary Changes on Gut-bacteria and Fibromyalgia Symptoms
The purpose of this study is to evaluate the efficacy of two diets - gluten-free and low-FODMAP diet- in relieving symptoms of fibromyalgia, and study whether these changes could be associated with changes in the gut microbiome…
- Trial name
- NCT05329571
- Testing
- Low-FODMAP diet, Gluten-free Diet, Control group
- Where
- Canada
- Volunteers
- 59 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Multi-antibiotic Resistance
Use of New Antibiotics in Sweden
Antibiotic resistance is a growing global health problem of great concern, especially multidrug-resistant Gram-negative bacteria. In recent years some new antibiotics targeting these bacteria have been developed.
- Trial name
- NCT05048693
- Where
- 7 sites in Sweden
- Volunteers
- 41 people
- Sponsor
- Uppsala University
Soft Tissue Infections
Phase 2 Safety and Efficacy Study of Daptomycin in Complicated Skin and Skin Structure Infections
multicenter, randomized (1:1), semi-single blind study comparing the safety and efficacy of HDSD daptomycin (10 mg/kg q24h for 4 days) with that of comparator (vancomycin +/- SSP for 7-14 days) in patients with cSSSI due to…
- Trial name
- NCT00426933
- Testing
- Daptomycin, Vancomycin
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Decay, Dental
Effect of Natural Antibacterial Mouthwash on Taste, Salivary pH and Bacteria in High Caries Risk pt
Evaluate the effect of propolis extract mouthwash and pomegranate extract mouthwash on taste alteration, salivary pH and antibacterial activity against streptococcus mutans in high caries risk patients.
- Trial name
- NCT03623048
- Testing
- chlorhexidine, saline, Propolis extract
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Cairo University
Group B Streptococcal Infection, Infection Due to ESBL Bacteria
Simplified GBS Screening and Prevalence of ESBL in Pregnant Women
1. At the University Hospital Basel, Switzerland, a simplified screening for group B streptococci (GBS) of vagina and perineum has been performed since several years.
- Trial name
- NCT02142933
- Testing
- vagino-perineal swab
- Where
- Switzerland
- Volunteers
- 250 people
- Sponsor
- University Hospital, Basel, Switzerland
Maxillary Sinusitis
Trial to Evaluate Time to Symptom Relief and Elimination of Infecting Bacteria in Treating Sinusitis With Avelox
This study evaluated the time to bacteriological eradication of common pathogens during moxifloxacin therapy for acute bacterial maxillary sinusitis.
- Trial name
- SPEED (NCT00668304)
- Testing
- Avelox (Moxifloxacin, BAY12-8039)
- Where
- 35 sites in United States, Argentina
- Volunteers
- 192 people
- Sponsor
- Bayer
Bacterial Keratitis, Fungal Keratitis
The Antibiogram and Outcomes of Antimicrobial Regimens in Microbial Keratitis: A Prospective Cohort Study
This study is an observational prospective cohort study which aims to generate an antibiogram and to assess the clinical responses and outcomes of microbial keratitis patients, treated with empiric topical antimicrobial…
- Conditions
- Bacterial Keratitis, Fungal Keratitis, Mixed Bacterial and Fungal Keratitis, Microbial Keratitis
- Trial name
- NCT05655689
- Testing
- Moxifloxacin Ophthalmic 0.5% Ophthalmic Solution, Ceftazidime 5% + vancomycin 5%, Gentamicin 1.4% + vancomycin 5%
- Where
- Egypt
- Volunteers
- 123 people
- Sponsor
- Alexandria University
Severe Aplastic Anemia (SAA)
A Description of Bacteria in the Mouths of Patients With Severe Aplastic Anemia
Background: This research is being done to describe the types of bacteria found in the mouths of patients who have severe aplastic anemia (SAA) and are treated with drugs that suppress the immune system or with stem cell…
- Trial name
- NCT01900119
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Complement Deficiency, Antibody Deficiency
Systematic Search for Primary Immunodeficiency in Adults With Infections
Antibody deficiencies and complement deficiencies are the most frequent Primary immunodeficiencies (PIDs) in adults, and are associated with greatly increased susceptibility to recurrent and/or severe bacterial infections …
- Conditions
- Complement Deficiency, Antibody Deficiency, Chronic Sinus Infection, Meningitis, Bacterial
- Trial name
- SPIDAC (NCT02972281)
- Testing
- Immunological diagnosis tests
- Where
- 19 sites in France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Lille
Rotavirus Infections, Intestinal Bacteria Flora Disturbance
The Role of the Intestinal Microbiome in Enteric and Systemic Vaccine Immune Responses
The purpose of this study is to evaluate if the intestinal microbiota influences rotavirus vaccine immune responses in healthy adult volunteers.
- Conditions
- Rotavirus Infections, Intestinal Bacteria Flora Disturbance, Reaction - Vaccine Nos, Tetanus
- Trial name
- Rota-biome (NCT02538211)
- Testing
- Rotavirus vaccine, Tetanus vaccine and Pneumococcal vaccine
- Where
- Netherlands
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Risk Factor
Digestive Colonisation by Highly Resistant Bacteria (CODBAHRE)
The aim of this study is to identify in hospitalized patients, the risk factors associated with the digestive colonisation by emergent extensively drug-resistant bacteria (eXDR), to optimize their detection and the medical care…
- Trial name
- CODBAHRE (NCT04085380)
- Where
- France
- Volunteers
- 2,396 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Overweight and Obesity
The Alberta FYBER (Feed Your Gut Bacteria morE fibeR) Study
Too much body-fat has been linked to a low-grade inflammation throughout the body. This inflammation is thought to then cause different diseases, like heart disease and diabetes.
- Trial name
- NCT02322112
- Testing
- Microcrystalline Cellulose Supplementation, Acacia Gum Supplementation, Resistant Starch Type 4 Supplementation
- Where
- Canada
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- University of Alberta
A03 - Digestive System, B03 - Bacteria
Fermented Dairy Product and Bifidobacterium Diversity
Bifidobacterium strains with potential health benefits can contribute to the gastrointestinal wellbeing. However, the ability of these strains to survive gastro-intestinal tract stress and their impact on gut microbiome remains…
- Trial name
- NCT07700381
- Testing
- 28-days consumption of Product A in 45 to 60-year-old healthy subjects, 28-days consumption of Control product in 45 to 60-year-old healthy subjects
- Where
- France
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Danone Global Research & Innovation Center
Intracranial Infections
Intraventricular Administration of Intracranial Infections Caused by （Carbapenem-resistant Gram-negative Bacilli）CRGNB
This clinical trial aims to compare two methods of administering polymyxin B for treating severe brain infections caused by carbapenem-resistant Gram-negative bacteria (CRGNB).
- Trial name
- NCT06595979
- Testing
- Polymyxin B
- Where
- 3 sites in China
- Volunteers
- 222 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Healthy
Collection of Dental Plaque and Saliva for Studies of Bacterial Colonization of Teeth
This study will explore how bacteria colonize human teeth and how this process changes over the lifetime of individuals. It will include an investigation of transmission of bacteria that initiate colonization between adults and…
- Trial name
- NCT00098267
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Colistin Resistance in Bacteria
Detection of Colistin-resistant Isolates From Patients of Intensive Care Units and Oncohaematology Wards.
The increasing use of colistin in multidrug resistant strains, as Enterobacteriaceae producing extended-spectrum β-lactamases or carbapenemases, is associated with the emergence of colistin resistant isolates.
- Trial name
- RESCO (NCT03971877)
- Testing
- Rapid Polymyxin NP test
- Where
- 4 sites in France
- Volunteers
- 1,934 people
- Sponsor
- University Hospital, Bordeaux
Dental Caries
Evaluation of the Antibacterial Effect of Laser Diode and Zinc Oxide Nano Particles in Cavity Disinfection
this is a randomized controlled clinical trial, evaluating the antibacterial effect of laser diode and zinc oxide nano-particles when used as cavity disinfectants.Two groups, including 15 patients each, will be randomly allocated…
- Trial name
- NCT03478150
- Testing
- zinc oxide nano-particles, laser diode
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Acinetobacter Baumannii Infection
Evaluation of the Safety, Tolerability and Pharmacokinetics of Intravenous ETX2514 Administered in Healthy Subjects
This research project is being conducted to look at the safety, tolerability, and pharmacokinetics (PK; how the human body processes a substance) of ETX2514 when given to healthy volunteers intravenously as a single dose, and…
- Trial name
- NCT02971423
- Testing
- ETX2514, Sulbactam, Imipenem/Cilastatin
- Where
- Australia
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Entasis Therapeutics
Healthcare Associated Pneumonia
Clinical Characteristics and Microbiology of Healthcare Associated Pneumonia
Background The prediction of multi-drug resistant (MDR) pathogens is a key issue in the management of health-care associated pneumonia (HCAP).
- Trial name
- NCT01966796
- Where
- Taiwan
- Volunteers
- 530 people
- Sponsor
- Far Eastern Memorial Hospital