Clinical trials: Bacteria
Urinary Tract Infection
The Clinical Impact of Isolation of Two Different Bacteria in Urinary Cultures
The purpose of this study is to determine whether identification of two different bacteria in urine culture of patients with indwelling catheter has a clinical impact - change in antibiotic, duration of antibiotic, days to…
- Trial name
- NCT01060956
- Testing
- reporting of two different bacteria in urine culture, reporting "mixed growth" on urine culture
- Volunteers
- 81 people
- Sponsor
- Shaare Zedek Medical Center
Caries
Technique for Localization of Caries Associated Bacteria on Tooth Surfaces.
There is a simple laboratory technique for localization of caries associated bacteria on tooth surfaces by taking an impression of the teeth with a material containing sucrose.
- Trial name
- NCT00421577
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Venous Leg Ulcer
Differential Effects of Bacteria Colonising Venous Leg Ulcers on Pain and Healing Rates
This Study aims to identify whether venous leg ulcers which are colonised by Pseudomonas Aeruginosa cause more pain than those which are not and if this bacteria affects healing time.
- Trial name
- NCT04249661
- Where
- Ireland
- Volunteers
- 100 people
- Sponsor
- University Hospital of Limerick
Coronary Stenosis, Periodontal Diseases
Periodontal Disease, Inflammation and Acute Coronary Syndromes
Recent studies have shown that the systemic inflammation caused by periodontal disease (PD) can determine important changes in the coronary arteries, favoring atherosclerosis progression and development of acute coronary…
- Conditions
- Coronary Stenosis, Periodontal Diseases, Acute Coronary Syndrome, Non-ST Elevation Myocardial Infarction
- Trial name
- ATHERODENT (NCT03395041)
- Testing
- cardiac imaging tests
- Where
- Romania
- Volunteers
- 149 people
- Sponsor
- Cardio Med Medical Center
Fatty Liver, Hepatic Steatosis
The Effect of Good Bacteria on Nonalcoholic Fatty Liver Disease in Diabetics
The purpose of this study is to determine whether probiotics, bacteria that may improve liver health, can effectively treat a chronic condition in diabetics that increases fat in the liver.
- Conditions
- Fatty Liver, Hepatic Steatosis, Diabetes Mellitus, Liver Diseases
- Trial name
- NCT00068094
- Testing
- Probiotic-containing powder
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Non-invasive and Sensitive Faecal Bacterial Markers for Early Screening and Diagnosis of Gastric Cancer
Study of Faecal Bacteria Detection in Early Screening and Diagnosis of GC
In this clinical trial, we aim to explore the synergistic alteration of specific bacteria both in gastric mucosas and feces of gastric cancer patients for the method of non-invasive and cost-effective faecal marker detection.
- Trial name
- NCT04638959
- Testing
- collect gastric tissue and stool samples
- Where
- 10 sites in China
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Bacteremia Caused by Gram-Negative Bacteria
Ceftolozane-tazobactam Versus Meropenem for ESBL and AmpC-producing Enterobacterales Bloodstream Infection
The purpose of this study is to determine whether ceftolozane-tazobactam is as effective as meropenem with respect to 30 day mortality in the treatment of bloodstream infection due to third-generation cephalosporin…
- Trial name
- MERINO III (NCT04238390)
- Testing
- Ceftolozane-Tazobactam, Meropenem
- Where
- 29 sites in Australia, Italy and 3 more
- Sponsor
- The University of Queensland
Healthy Volunteer
An Open Study to Assess the Safety and Pharmacokinetics of Fluorothyazinone as a Single-Dose Administration or a Treatment Course in Healthy Volunteers
The current Phase I clinical trial has been developed to assess the safety and tolerability of the Fluorothyazinone drug used as a single-dose administration and a treatment course in healthy volunteers.
- Trial name
- NCT03205462
- Testing
- Fluorothyazinone 300 mg, Fluorothyazinone 600 mg, Fluorothyazinone 3900 mg
- Where
- Russia
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Gamaleya Research Institute of Epidemiology and Microbiology, Health Ministry of the Russian Federation
Community-acquired Pneumonia
Monotherapy Versus Bitherapy in Non-severe Hospitalized Community-acquired Pneumonia
The purpose of this study is to determine whether a monotherapy with a Beta-Lactam is not inferior to an association of a Beta-Lactam and a macrolide in treating adult patients with community-acquired pneumonia.
- Trial name
- BICAP (NCT00818610)
- Testing
- Beta lactam (amoxicillin / clav. acid OR cefuroxime), Beta-lactam (amoxicillin / clav. acid OR cefuroxime) AND macrolide (clarithromycin)
- Where
- 6 sites in Switzerland
- Volunteers
- 601 people
- Sponsor
- Swiss National Fund for Scientific Research
Major Depressive Disorder
Gut Feeling: Understanding the Mechanisms Underlying the Antidepressant Properties of Probiotics
Previous research has suggested that probiotics can improve depressive symptoms in patients with Major Depressive Disorder (MDD), particularly when used in addition to antidepressants.
- Trial name
- PROMEX (NCT03893162)
- Testing
- Multi-strain probiotic
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- King's College London
Caries, Dental, Cariostatic Agents
Reducing Bacteria That Cause Tooth Decay
The purpose of the study is to determine the effect of a two-step mouth rinsing procedure on reducing the germs (mutans Streptococci) that cause tooth decay.
- Trial name
- NCT03062605
- Testing
- Iodine (Betadine), NaOCL
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Gram-Positive Bacterial Infections
A Retrospective Observational Study to Evaluate the Utilization, Outcomes, and Adverse Events in Participants Treated With Orbactiv® (Oritavancin) for Infections Caused by Gram Positive Bacteria in a Real World Setting
This study is a retrospective, observational study to evaluate oritavancin use in participants under real world conditions.
- Trial name
- NCT03159403
- Testing
- Oritavancin
- Where
- 21 sites in United States
- Volunteers
- 325 people
- Sponsor
- Melinta Therapeutics, Inc.
Necrotic Pulp
Effect of Irrigation With Antibiotic-containing Solutions on Postoperative Pain and Intra-canal Bacteria
The aim of this study is to compare the degree of postoperative pain and the antimicrobial effect in terms of bacterial count reduction after using co-amoxiclav-clindamycin solution versus MTAD and sodium hypochlorite irrigating…
- Trial name
- NCT04035070
- Testing
- co-amoxiclav-clindamycin solution, MTAD, 2.5% sodium hypochlorite
- Where
- Egypt
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Cairo University
Small Intestine Bacteria
Small Bowel Microbiota Characterization in Healthy Individuals Before and After Consumption of a Western Diet
Does the small bowel microbiota in healthy individuals change after consumption of a Western diet?
- Trial name
- Microbiota (NCT03266536)
- Testing
- Western diet
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Parkinson's Disease, Multiple System Atrophy
Increased Gut Permeability to Lipopolysaccharides (LPS) in Parkinson's Disease
The gut may be a portal of entry for agents that cause or contribute to the causes of Parkinson's disease (PD). The investigators are studying changes in the normal population of gut flora and in intestinal permeability and their…
- Trial name
- NCT01155492
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Irritable Bowel Syndrome
Manipulation of Visceral Sensitivity and Immune System in IBS
Irritable bowel syndrome (IBS) is a common condition. At least 20% of the population suffer from IBS. The symptoms of abdominal pain, diarrhoea, constipation, bloating and difficulty with bowel motions are often disabling.
- Trial name
- NCT00418340
- Testing
- probiotic (bacterial/dietary supplement)
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- London North West Healthcare NHS Trust
Gingivitis, Dental Plaque Accumulation
Study of an Essential Oil and a Delmopinol Mouthrinse Effect on Dental Plaque Accumulation Index, Gingivitis Index and on Streptococcus Mutans, Lactobacillus, Aerobic and Anaerobic Oral Bacteria Colony Counts.
The use of mouthrinses may be of relevance as a complement to daily dental hygiene procedures, especially for patients who do not comply with a proper mechanical removal of dental plaque.
- Trial name
- NCT01236950
- Testing
- Essential oils mouthrinse, Delmopinol mouthrinse
- Where
- Portugal
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Lisbon
Bacterial Infections, Gram-Positive Bacterial Infections
Antibiotic Treatment for Infections of Short Term In-dwelling Vascular Catheters Due to Gram Positive Bacteria
This study will treat patients who have a short term central catheter that is thought to be infected with a specific bacteria (gram positive bacteria)
- Conditions
- Bacterial Infections, Gram-Positive Bacterial Infections, Bacteremia
- Trial name
- NCT00037050
- Testing
- Linezolid, Vancomycin, Oxacillin
- Volunteers
- 739 people
- Sponsor
- Pfizer
Central Retinal Vein Occlusion, Choroidal Neovascularization
A Research Study to Evaluate the Effects of Repeated Intravitreal Injections on Bacteria Around the Eye
This is a research study to evaluate the effects of repeated intravitreal injections on bacteria around the eye.
- Conditions
- Central Retinal Vein Occlusion, Choroidal Neovascularization, Age-related Macular Degeneration, Branch Retinal Vein Occlusion
- Trial name
- NCT01531842
- Testing
- Conj flora Antibiotic resistance
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Mid Atlantic Retina
Advanced ENT Surgery, Microbiological Flora in the Oropharynx and Lower Airways
Probiotics Against Pathogenic Bacteria in Advanced ENT-Surgery
Surgery in the mouth and oropharynx is performed in an area colonised by bacteria non-pathogenic and pathogenic. Antibiotics are used regularly resulting in disturbances in the intestinal microbiological flora and consequently…
- Trial name
- NCT01730066
- Testing
- L. plantarum 299 and L. plantarum 299v (+maltodextrin)
- Where
- Sweden
- Volunteers
- 45 people
- Sponsor
- Region Skane