Clinical trials: Bacteria
Black Stains
Investigating the Bactericidal Effect of Probiotics on Chromogenic Bacteria in Children An In Vivo and In Vitro Study
To investigate the bactericidal effect of probiotics (Streptococcus salivarius M18 and Lactobacillus reuteri) on two types of bacteria (Aggregatibacter actinomycetemcomitans and Actinomyces naeslundii) causing black stains of…
- Trial name
- NCT06834815
- Testing
- Probiotic with Prebiotic
- Where
- Egypt
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Pneumonia
M-ROSE Combined With mNGS in Severe Hospital-acquired Pneumonia
The purpose of this study is to determine the value of M-ROSE（microbiological rapid on-site evaluation）in severe hospital-acquired pneumonia.
- Trial name
- NCT05300776
- Testing
- M-ROSE analysis
- Where
- China
- Volunteers
- 166 people
- Sponsor
- Chinese PLA General Hospital
Respiratory Syncytial Viral Infections
Phase I Study for SynGEM, an Intranasal Respiratory Syncytial Virus (RSV) Prefusion F Subunit Candidate Vaccine
The study is a double-blind (within dose level), placebo-controlled Phase I study to assess the safety, reactogenicity and tolerability of two intranasal dose levels of SynGEM®: a low dose level (140 μg F-protein/2mg BLPs) and a…
- Trial name
- SynGEM (NCT02958540)
- Testing
- SynGEM
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Mucosis BV
Diet, Healthy, Microbial Colonization
Networks of Bacterium-Metabolite Interactions in the Small Intestine
Probands with an Ileo- or Colostomy are assigned to consume a test meal which is either high in fat or high in carbohydrates. After the test meal samples from the stoma, urine, blood and skin are retrieved.
- Trial name
- NCT04978077
- Testing
- Test meal (high fat = Nutricia Calogen®, or high carbohydrate = Nutricia preOp®)
- Where
- Switzerland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Infections, Streptococcal
Study to Identify and Characterize Bacteria Causing Acute Otitis Media in Young Children in Turkey
The purpose of this study is to identify and characterize the bacteria causing complicated Acute Otitis Media episode in children >= 3 months to < 5 years in Turkey.
- Trial name
- NCT01031329
- Testing
- Tympanocenthesis and urine collection
- Where
- 8 sites in Turkey (Türkiye)
- Sponsor
- GlaxoSmithKline
Overactive Bladder
Bacterial Genomic Sequencing in Overactive Bladder
No one really knows what causes overactive bladder syndrome (OAB). Urinary tract infection (UTI)causes similar symptoms to OAB with the difference being the presence of bacteria, as evidenced by routine microbiology cultures.
- Trial name
- NCT01642277
- Testing
- Solifenacin
- Where
- United States
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Loyola University
Pathogenic Bacteria in the Oropharynx, Ventilator-associated Pneumonia
Chlorhexidine vs Lactobacillus Plantarum for Oral Care in Intubated ICU Patients
Critically ill patients often need ventilatory support through a plastic tube connected to a ventilator. Those patients have a altered microbiological flora in the mouth, oropharynx as well as throughout the intestine.
- Trial name
- NCT01105819
- Testing
- Lactobacillus plantarum 299 for oral care, Chlorhexidine for standard oral care
- Where
- 3 sites in Sweden
- Volunteers
- 100 people
- Sponsor
- Region Skane
Diabetes, Chronic Foot Wounds
The Effect of Aquacel® Ag+ Extra Dressing on Wound Biofilms
The purpose of the research is to assess the effects of Aquacel Ag+ Extra dressing on chronic wound bacterial biofilms
- Trial name
- NCT02228122
- Testing
- Aquacel® Ag+ Extra
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Dr Angela Oates
Periodontal Pocket
Quantitation of Bacteria Associated With Severe Periodontitis by Real -Time PCR Following Application of Diode Laser
1. Primary objective To measure the gingival crevicular levels of A.actinomycetemcomitans and P.gingivalis after intra-pocket application of diode laser in severe periodontitis (stage 3 grade C) patients. 2.
- Trial name
- NCT05222737
- Testing
- medency diode laser, spirazole forte
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Bronchitis
Therapy of Ventilator-associated Tracheobronchitis Caused by Gram Negative Bacteria With Nebulized Colistin
The purpose of this study is to determine whether inhaled colistin is effective in the treatment of ventilator associated tracheobronchitis due to gram negative organism susceptible to colistin.
- Trial name
- NCT02619786
- Testing
- Inhaled colistin
- Volunteers
- 62 people
- Sponsor
- Mahidol University
Pulp Necrosis, Apical Periodontitis
Antibacterial Efficacy and Outcomes of Root Canal Irrigation Methods
This randomized clinical trial aims to evaluate the antibacterial efficacy and treatment outcomes of three different final irrigation protocols during root canal therapy: 2.5% sodium hypochlorite alone, sodium hypochlorite with…
- Conditions
- Pulp Necrosis, Apical Periodontitis, Endodontic Treatment
- Trial name
- ENDOABG (NCT06959602)
- Testing
- Final Irrigation with 2.5% Sodium Hypochlorite, Passive Ultrasonic Irrigation (PUI) with Sodium Hypochlorite, XP-Endo Finisher Activation with Sodium Hypochlorite
- Where
- Greece
- Volunteers
- 66 people
- Sponsor
- National and Kapodistrian University of Athens
Bacterial Infections, Fungal Infection
Study to Optimize the Use of New Antibiotics
Quasi-experimental intervention multicenter trial of patients treated with new antibiotics (before-after study). The study will be carried out in 14 hospitals of the Andalusian Public Health System with representation from all…
- Trial name
- NEW_SAFE (NCT03941951)
- Testing
- Non-impositive Program for Optimizing the Use of Antimicrobials
- Where
- 14 sites in Spain
- Volunteers
- 900 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Multidrug-resistant Bacteria Screening
Carbapenemase-Producing Organism and Vancomycin-Resistant Enterococcus Management
Emergence of vancomycin-resistant enterococci (VRE) and carbapenemase-producing enterobacteria (CPE) is nowadays a major public health concern worldwide.
- Trial name
- CPO-VRE (NCT05200546)
- Testing
- molecular assays to screen for eXDR
- Where
- France
- Volunteers
- 3,921 people
- Sponsor
- University Hospital, Grenoble
Gram Negative Bacterial Infections
Efficacy and Mortality of a Loading Dose of Colistin in Critical Ill Patients
The study hypothesis is that the loading dose of intravenous colistin (6 million of international units) is associated with greater clinical and microbiological efficacy, and reduced mortality of critically ill patients infected…
- Trial name
- NCT02117986
- Testing
- colistin
- Where
- 2 sites in Chile
- Volunteers
- 200 people
- Sponsor
- Hospital Barros Luco Trudeau
Non-Small Cell Lung Cancer
EXL01 in Combination With Nivolumab for Advanced NSCLC Refractory to Immunotherapy.
As treatment options are limited following progression on anti PD-(L)1 and platinum-based chemotherapy, we propose this trial for patients who have failed to respond or have shown intolerance to standard therapies or for whom no…
- Trial name
- EXLIBRIS (NCT06448572)
- Testing
- EXL01
- Where
- France
- Volunteers
- 21 people
- Sponsor
- University Hospital, Lille
Bacteria Infection, Respiratory Tract Infections
Early Versus Expectant Treatment of Ureaplasma Infection in Very Low Birth Weight Neonates
Our hypothesis is that treatment of known Ureaplasma spp. infection of the airways in very low birth weight (VLBW) infants with azithromycin will eradicate the organisms and lessen the proinflammatory state caused by infection…
- Trial name
- NCT00599053
- Testing
- Azithromycin
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Alabama at Birmingham
Atopic Dermatitis, Food Hypersensitivity
Use of Probiotic Bacteria in Prevention of Allergic Disease in Children 1999-2008
The aim of the study is to find out if allergic diseases can be prevented buy giving probiotic bacteria to pregnant mothers and their newborn infants
- Conditions
- Atopic Dermatitis, Food Hypersensitivity, Allergic Rhinitis, Seasonal, Allergic Conjunctivitis
- Trial name
- NCT00298337
- Testing
- Mixture of probiotic bacteria and prebiotic oligosaccharide
- Where
- Finland
- Sponsor
- University of Helsinki
Bacterial Sensitivity Tests, Antimicrobial Drug Resistance
AMR-DetecTool for the Diagnostic of MDR Bacterial Infections
The fight against bacteria is one of the greatest challenges faced by societies, especially with the spread of multi drug resistant (MDR) bacteria.
- Trial name
- AMR DetecTool (NCT05378217)
- Testing
- AMR LFIA Assay
- Where
- 3 sites in France, Hungary and 1 more
- Volunteers
- 167 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Bloodstream Infection, Septic Shock
Bloodstream Infection Due to Multidrug-Resistant Organisms - Multicenter Study on Determinants of Clinical Outcomes
Continual surveillance of both community-acquired and nosocomial bloodstream infections for specific target organisms. Analysis of comorbidities, complications, bacterial resistance patterns, bacterial genomics (e. g.
- Trial name
- BLOOMY-COM (NCT03578835)
- Where
- 6 sites in Germany
- Volunteers
- 6,000 people
- Sponsor
- University Hospital Tuebingen
Carbapenem Resistant Bacteria Infection
European Prospective Cohort Study on Enterobacteriaceae Showing Resistance to Carbapenems
Among antibiotic-resistant organisms, the Gram-negative bacteria are now the most important challenge because of the rapid worldwide spread of mechanisms conferring resistance to multiple drugs.
- Trial name
- EURECA (NCT02709408)
- Where
- 50 sites in Albania, Bulgaria and 9 more
- Volunteers
- 2,515 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla