Clinical trials: Bacterial Load Reduction
Necrotic Pulp, Apical Periodontitis
Effect of Diclofenac Sodium Versus Calcium Hydroxide as Intracanal Medication on the Intensity of Postoperative Pain, Bacterial Load Reduction and MMP-9 Levels in Patients With Necrotic Pulp.
the aim of this study is to compare the effect of using Diclofenac Sodium Versus Calcium Hydroxide as Intracanal medication on intensity of postoperative pain, bacterial load reduction after root canal preparation and periapical…
- Trial name
- NCT05582421
- Testing
- Diclofenac Sodium
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Skin Diseases, Surgical Site Infection
Effectiveness of Preoperative Surgical Scrubbing Using Clorhexidine Digluconate and Parachlorometaxylenol (ECP)
Despite the wide variety of products and antiseptic agents, no agent is ideal for every situation. The investigators would like to evaluate the difference in reducing bacterial load, using 4% chlorhexidine digluconate and 3%…
- Trial name
- ECP (NCT02500758)
- Testing
- Preparatory handwash, Preoperative surgical scrubbing using 3% PCMX, Preoperative surgical scrubbing using 4% CHG
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ricardo Becerro de Bengoa Vallejo
Pulp Necrosis, Postoperative Pain
Evaluation of Post-operative Pain and Bacterial Load Reduction After Application of Three Intra-canal Medications (Cocoa Husk Versus Calcium Hydroxide With and Without Cocoa) in Necrotic Mandibular First Molar.
The study will aim to evaluate the postoperative pain and bacterial load after application of two intracanal medications in mandibular first molar teeth with necrotic pulp.
- Trial name
- NCT07790796
- Testing
- Root canal treatment with intracanal medication by calcium hydroxide for one week., Root canal treatment with intracanal medication by cocoa husk for one week, Root canal treatment with intracanal medication by calcium hydroxide with cocoa husk for one week.
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
Intensity of Postoperative Pain, Bacterial Load Reduction and Periapical MMP-9 Levels in Patients With Necrotic Pulp
Effect of 1% Melatonin Gel Versus Calcium Hydroxide as an Intracanal Medicament on the Intensity of Postoperative Pain, Bacterial Load Reduction and Periapical MMP-9 Levels in Patients With Necrotic Pulp.
To compare the effect of 1% melatonin gel versus calcium hydroxide as intra canal medication in necrotic mandibular premolars on: Intensity of postoperative pain. Bacterial load reduction. Periapical (MMP-9) level.
- Trial name
- RCT (NCT07495605)
- Testing
- 1% melatonin gel, Calcium Hydroxide (Ca(OH)2)
- Volunteers
- 50 people
- Sponsor
- Cairo University
Antisepsis
Pre-surgical Antisepsis Using an Alcoholic Solution of Chlorhexidine Digluconate and Potassium Sorbate ( Sorbectol )
The present study evaluates the effects of bactericidal load reduction after surgical hand antisepsis using the reference antiseptic product propanol- 1 60% as control versus a surgical hand antisepsis with addition of a solution…
- Trial name
- NCT04683146
- Testing
- Hand antisepsis with Propanolol- 1 60%., Hand antisepsis with a solution of alcohol, chlorhexidine digluconate and potassium sorbate.
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Centro Ortopedico y Quirurgico del Pie
Cataracts
Comparison of the Effectiveness of Povidone-iodine in Reducing Conjunctival Bacterial Load Prior to Cataract Surgery in Patients Treated With a Lidocaine Gel Dilating Formulation Versus Eye Drops: A Randomized Controlled Trial
The eye contains a lens that focuses light. A clouding of the lens is known as a cataract. Cataracts decrease vision. The treatment for cataracts is cataract surgery.
- Trial name
- NCT01898728
- Testing
- topical povidone-iodine after premedication with topical liquid eye drops, topical povidone-iodine after premedication with topical gel
- Where
- Canada
- Volunteers
- 101 people
- Sponsor
- McMaster University
Helicobacter
Efficacy of Probiotics in the Gut Microbiota and H Pylori Density
We aimed to assess the efficacy of Lactobacillus acidophilus and Lactobacillus rhamnosus in the reduction of bacterial load of H.
- Trial name
- NCT02725138
- Testing
- Probiotic
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Statistical Center, NTUHCTC
Necrotic Pulp
Effect of Commiphora Myrrh Solution as a Root Canal Irrigant on Post Operative Pain and Bacterial Load Reduction in Necrotic Tooth
Clinically compare the post-operative pain , incidences post-operative swelling , post-operative number of analgesic tablets taken by patient and amount of bacterial load reduction after using 50% Commiphora Myrrh Chemomechanical…
- Trial name
- NCT06310044
- Testing
- Root canal irrigant Commiphora Myrrh 50%
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Cairo University
Hand Hygiene
Randomised Controlled Trial (RCT) of 6 Versus 3 Steps for Hand Hygiene
The aim is to compare the effectiveness of the 6 step hand rub technique versus 3 step hand rub technique in hand coverage and in reducing bacterial contamination on the hands of healthcare workers in practice.
- Trial name
- SHoRT (NCT02396836)
- Testing
- 6 step technique, 3 step technique
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- Glasgow Caledonian University
Necrotic Pulp
Evaluation of Pain Relief and Bacterial Reduction After Using Calcium Hydroxide With Mesoporous Silica Nanoparticles as an Intracanal Medicament in Necrotic Mandibular Molars: A Randomized Controlled Clinical Trial
This study compares how well different root canal medications reduce pain and bacteria after treatment of lower molar teeth with necrotic pulp.
- Trial name
- NCT07327996
- Testing
- Calcium Hydroxide Intracanal medication, mesoporous silica nanoparticles paste, Calcium Hydroxide + mesoporous silica nanoparticles
- Where
- Egypt
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
Post Operative Pain
Evaluation of Postoperative Pain and Bacterial Load Reduction With ProTaper Ultimate Versus ProTaper Gold Rotary Systems
This study aims to research the effect of different instrument designs by comparing protaper ultimate versus protaper gold systems on root canal preparation by evaluating post-operative pain and bacterial count reduction…
- Trial name
- NCT05305742
- Testing
- Instrument Design
- Where
- Egypt
- Volunteers
- 56 people
- Sponsor
- Cairo University
Periapical Periodontitis, Polymerase Chain Reaction
Quantitative Assessment of the Efficacy of Two Irrigation Activation Systems
Aim of the present study was to determine the intraradicular microbiota of previously root canal-treated teeth with apical periodontitis using droplet digital polymerase chain reaction (ddPCR) and to investigate the antibacterial…
- Conditions
- Periapical Periodontitis, Polymerase Chain Reaction, Enterococcus Faecalis Infection, Irrigation Activation
- Trial name
- NCT05690763
- Testing
- XP-endo Finisher to use irrigation activation, EndoActivator to use irrigation activation
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Seyda Ersahan, DDS, PhD
Necrotic Pulp, Post Operative Pain
Effect of Vachellia Nilotica Versus Sodium Hypochlorite as Root Canal Irrigant on Postoperative Pain and Bacterial Load Reduction in Mandibular Premolar Teeth With Necrotic Pulp
The aim of this study is to assess the effect of V. nilotica extract solution versus 2.5% NaOCl on the intensity of postoperative pain and the amount of bacterial load reduction.
- Trial name
- NCT06116214
- Testing
- Vachellia Nelotica, sodium hypochlorite
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Cairo University
Intracanal Medication, Bromelain
Effect of Bromelain Versus Calcium Hydroxide as an Intracanal Medication on the Intensity of Postoperative Pain and Bacterial Load Reduction in Necrotic Single Rooted Lower Premolars
the aim of the study is to compare the effect of bromelain vs calcium hydroxide as intracanal medication on intensity of pain and bacterial load in necrotic single lower premolars
- Conditions
- Intracanal Medication, Bromelain, Calcium Hydroxide, Bacterial Load Reduction
- Trial name
- NCT05687760
- Testing
- bromelain, Calcium hydroxide
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Antisepsis
Pre-surgical Antisepsis Using an Alcoholic Solution of Chlorhexidine Digluconate and Potassium Sorbate
The present study evaluates the effects of bactericidal load reduction after surgical hand scrub antisepsis using the reference antiseptic product propan-ol-1 60% as control versus a surgical hand scrub antisepsis with addition…
- Trial name
- sorbectol (NCT04454619)
- Testing
- Hand antisepsis with Clorhexidine and solution
- Where
- Spain
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Centro Ortopedico y Quirurgico del Pie
Cataract
The Usefulness of Visuprime in Cataract Surgery
This is a multicentre, post-market, open label, randomized, placebo-controlled prospective study exploring the performance of Visuprime in improving ocular surface homeostasis and reducing conjunctival bacterial load in patients…
- Trial name
- NCT06533995
- Testing
- Visuprime
- Where
- 2 sites in Italy
- Volunteers
- 75 people
- Sponsor
- VISUfarma SpA
Evaluation of Postoperative Pain and Antimicrobial Efficacy
Evaluation of Postoperative Pain and the Antimicrobial Effect of Super Oxidized Water (Microcyn) and Chlorhexidine When Compared With Sodium Hypochlorite in Teeth With Asymptomatic Necrotic Pulps. A Randomized Clinical Trial
The objective of this study is to evaluate the postoperative pain and antimicrobial efficacy when using super-oxidized water (Microcyn) and 2% Chlorhexidine as irrigating solutions in comparison to 2.5% Sodium hypochlorite in…
- Trial name
- NRS (NCT07852260)
- Testing
- super-oxidized water (Microcyn) irrigating solution, 2% chlorhexidine irrigating solution, 2.5% sodium hypochlorite
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Cairo University
Bacterial Load Reduction, Postoperative Pain
Evaluation of Postoperative Pain and Bacterial Load After Hyalone or Calcium Hydroxide Medication in Mandibular First Molars
This randomized controlled clinical trial aims to evaluate the effect of Hyalone hydrogel compared with calcium hydroxide as an intracanal medicament on postoperative pain and bacterial load reduction in mandibular first molars…
- Trial name
- HYACAL-ENDO (NCT07775456)
- Testing
- Hyalone, Calcium Hydroxide (Ca(OH)2) Intracanal Medication
- Where
- Egypt
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
Intervention
Effect of NanoChitosan Impregnated Calcium Hydroxide as an Intracanal Medication on Postoperative Pain Intensity and Bacterial Load Reduction
This research will study the effect of NanoChitosan impregnated Calcium Hydroxide versus Calcium Hydroxide as an intracanal medication on postoperative pain intensity measured using numerical rating scale (NRS) and bacterial load…
- Trial name
- NCT06253247
- Testing
- NanoChitosan impregnated Calcium Hydroxide
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Cairo University
Bacterial Load Reduction
Bacterial Reduction for a Manual Toothbrush With a 360-Degree Mouth Cleaner Design Versus a Standard Toothbrush
The objective of this study is to determine and compare the effectiveness of a manual toothbrush with a 360-degree mouth cleaner design versus a standard flat-trim manual toothbrush in achieving whole mouth bacterial load…
- Trial name
- NCT07471477
- Testing
- Colgate 360 SupraClean Manual Toothbrush brush with 0.76% Na MFP, (1000 ppm F), Colgate Adult Extra Clean soft-bristle toothbrush brush with 0.76% Na MFP, (1000 ppm F)
- Where
- Costa Rica
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive