Clinical trials: Baroreflex
Increased Intracranial Pressure Disorders
Assessment of Autonomic Neuronal Changes During Moderate Rise of Intracranial Pressure in Human
The purpose of this project is to determine during moderate rise of intracranial pressure (ICP) in awake patient, the change in autonomic function and its influence on cerebral and systemic haemodynamics.
- Trial name
- CESNA (NCT01776801)
- Testing
- Infusion
- Where
- 3 sites in France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Toulouse
Obstructive Sleep Apnea Syndrome
Improvement in Baroreflex Sensitivity in OSAS
Individuals with obstructive sleep apnea syndrome (OSAS) are at high risk for cardiovascular morbidity and mortality. The effect of long-term nocturnal therapy with continuous positive airway pressure (CPAP) on daytime baroreflex…
- Trial name
- NCT00284037
- Testing
- continuous positive airway pressure therapy
- Where
- Japan
- Sponsor
- Nagoya University
Hypertension
Behavioral Neurocardiac Training and Hypertension
This randomized controlled trial will examine whether behavioral neurocardiac training with heart rate variability biofeedback (BNT) augments reduction in ambulatory daytime and 24-hour SBP, DBP and PP, in comparison to an active…
- Trial name
- NCT00811811
- Testing
- Behavioral neurocardiac training, Autogenic relaxation training
- Where
- Canada
- Volunteers
- 65 people
- Sponsor
- University Health Network, Toronto
Heart Failure
Baroreflex Activation Therapy in Heart Failure
The purpose of this clinical investigation is to evaluate the efficacy and safety of the CVRx Barostim Neo System in the treatment of patients with heart failure.
- Trial name
- NCT01484288
- Testing
- Barostim Neo System
- Where
- Italy
- Volunteers
- 12 people
- Sponsor
- CVRx, Inc.
Healthy Volunteers
Interaction of Otolith Stimulation and Carotid Baroreflex in Humans
It is well documented that a few days stay in space induces a change in the vestibular-ocular reflex reflecting a reinterpretation of sensory inputs following the disappearance of gravity.
- Trial name
- OTOBAR (NCT02565095)
- Testing
- Stimulation of the carotid baroreceptors with a pressure system
- Where
- France
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Baroreflex Failure Syndrome, Hypertension, Resistant to Conventional Therapy
UK Registry for Baroreflex Activation Therapy
This study is a post-marketing open label single arm, single centre clinical trial of electrical carotid sinus stimulation with the Barostim Neo device to target sub-optimally controlled arterial hypertension or highly variable…
- Trial name
- UK-BAT (NCT03730519)
- Testing
- Baroreflex Activation Therapy with Barostim Neo
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- Queen Mary University of London
Hypertension
Device Based Therapy in Hypertension Trial
The purpose of this study is to demonstrate the safety and efficacy of the Rheos Baroreflex Hypertension Therapy System in patients with refractory hypertension.
- Trial name
- DEBuT-HT (NCT00710190)
- Testing
- Rheos Baroreflex Hypertension Therapy System
- Where
- 9 sites in Czechia, Germany and 4 more
- Volunteers
- 46 people
- Sponsor
- CVRx, Inc.
Physical Fitness, Patient Adherence
Home-based Exercise Training in Cardiac Patients
The investigators hypothesize that exercise training program guided by virtual augmented reality glasses or by video from computer screen used at home will improve motivation into exercise training and results in superior…
- Conditions
- Physical Fitness, Patient Adherence, Quality of Life, Autonomic Nervous System Imbalance
- Trial name
- VAPA-Oulu (NCT03704025)
- Testing
- Current guidelines rehabilitation, Mobile device guided rehabilitation
- Where
- Finland
- Volunteers
- 50 people
- Sponsor
- University of Oulu
Sex
Baroreflex Sensitivity Response to Exercise
Males and females show distinct differences in cardiovascular function, especially during exercise. Evidence suggests that females generally have lower blood pressure due to hormonal influences that reduce blood vessel…
- Trial name
- PACE MAKERS (NCT06709560)
- Testing
- Moderate Intensity Continuous Exercise, Vigorous Intensity Continuous Exercise, Moderate Intensity Continuous Exercise Matched for Blood Pressure
- Where
- Portugal
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Egas Moniz - Cooperativa de Ensino Superior, CRL
Autonomic Nervous System Disease
Resonance Breathing and Postural Resonance: Acute Modulation of Autonomic and Hemodynamic Responses Via Arterial Baroreflex Mechanisms
This study aimed to compare the acute autonomic and hemodynamic effects of two arterial baroreflex resonance interventions-Resonance Breathing (RB) and Postural Resonance (PR)-in healthy young adults.
- Trial name
- Autonomic (NCT07536997)
- Testing
- Resonance Breathing, Postural Resonance
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Beijing Sport University
Transgender Men, Blood Pressure
Mechanisms of Blood Pressure Dysfunction in Transmen Receiving Testosterone
The purpose of this research is to explore the effects of chronic androgen exposure on sympathetic nervous system activity (SNSA) and baroreflex control of blood pressure responses in transgender men (trans men) taking gender…
- Conditions
- Transgender Men, Blood Pressure, Hyperandrogenism
- Trial name
- NCT04524325
- Testing
- Trans men
- Volunteers
- healthy volunteers welcome
- Sponsor
- Yale University
Autonomic Nervous System Diseases, Baroreflex Failure
Effects of Water and Glucose Drinks on Cardiovascular Function in Subjects With and Without Postprandial Hypotension
To determine whether the changes in blood pressure (BP) which occur following meals in normal people and patients who have substantial falls in BP after a meal postprandial hypotension (PPH)) are associated with changes in…
- Conditions
- Autonomic Nervous System Diseases, Baroreflex Failure, Blood Pressure, Hypotension
- Trial name
- NCT02713412
- Testing
- Glucose, Water
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Royal Adelaide Hospital
Paroxysmal Atrial Fibrillation
Baroreflex Sensitivity in Patients Undergoing Ablation of Atrial Fibrillation
Atrial fibrillation is the most common arrhythmia. The posterior surface of the left atrium is covered by an extensive network belonging to the autonomic nervous system that can be damaged during the ablation.
- Trial name
- BARO-AF (NCT04503122)
- Testing
- pulmonary vein isolation
- Where
- France
- Volunteers
- 116 people
- Sponsor
- Poitiers University Hospital
Women Under Hormonal Contraception (Pill) or Without Hormonal Contraception
Cardiovascular Impact of the Menstrual Cycle and Contraception - Longitudinal Evaluation
The present study aims to understand the impact of the hormonal cycle and contraceptive pill on cardiac and vascular function, as well as aerobic capacity among women.
- Trial name
- CICCLE (NCT07779447)
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- Université Libre de Bruxelles
Atrial Fibrillation
Change of Heart Rate Variability and Baroreflex Sensitivity After Ventral Cardiac Denervation
Atrial fibrillation (Af) is the most common morbid event after open heart surgery. Its incidence ranges from 19% to 27%, as reported by the Society of Thoracic Surgeons database.
- Trial name
- NCT00190112
- Testing
- ventral cardiac denervation
- Volunteers
- 30 people
- Sponsor
- Far Eastern Memorial Hospital
Heart Failure, Congestive
Effects of CPAP on Ventricular Function Modifications
To assess modifications of ventricular function induced by CPAP (Continuous Positive Airway Pressure).
- Trial name
- NCT00455611
- Testing
- CPAP (Continuous Positive Airway Pressure)
- Where
- Italy
- Sponsor
- Ospedale S. Giovanni Bosco
Postural Orthostatic Tachycardia Syndrome (POTS), POTS
Cardiovagal Baroreflex Deficits Impair Neurovascular Coupling and Cognition in POTS
Postural tachycardia syndrome (POTS), is the chronic form of orthostatic intolerance associated with excessive upright tachycardia, and occurs predominantly in young females (>85%).
- Conditions
- Postural Orthostatic Tachycardia Syndrome (POTS), POTS, Orthostatic Intolerance
- Trial name
- NCT03261570
- Testing
- Pyridostigmine, Digoxin
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- New York Medical College
Orthostatic Intolerance
Blood Pressure and Brain Blood Flow Regulation After Midodrine Administration in Those With Spinal Cord Injury
This project aims to evaluate the physiological effects of Midodrine administration during orthostatic challenge in those with high level spinal cord injury.
- Trial name
- NCT01498809
- Testing
- Midodrine
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- University of British Columbia
Heart Failure
Baroreflex Activation Therapy for Heart Failure
The purpose of this clinical trial (NCT02627196) is to develop valid scientific evidence for safety and effectiveness of Baroreflex Activation Therapy with the BAROSTIM NEO System in subjects with heart failure, defined as New…
- Trial name
- BeAT-HF (NCT02627196)
- Testing
- BAROSTIM NEO® System, Medical Management
- Where
- 92 sites in United States, United Kingdom
- Volunteers
- 1,090 people
- Sponsor
- CVRx, Inc.
Binge Drinking
Afferent Neurocardiac Signals, Cue Reactivity, and Cognitive Control
Conscious attempts to regulate alcohol use are often undermined by automatic attention and arousal processes activated by alcohol cues, as well as by diminished ability to inhibit in-the-moment behaviors.
- Trial name
- NCT05369169
- Testing
- Resonance breathing, Low demand cognitive task
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey