Clinical trials: Barotrauma
Pain, Chronic Pain
Chronic Pain After Combat-Related Traumatic Brain Injury (cTBI-Pain Study) A Prospective Cohort Study of Pain Chronification After Combat-Related Traumatic Brain Injury
Combat-related traumatic brain injury (cTBI), particularly blast-related injury, is frequently associated with the development of persistent and disabling chronic pain.
- Conditions
- Pain, Chronic Pain, Chronic Pain Due to Injury
- Trial name
- TBI-Pain (NCT07424248)
- Where
- Ukraine
- Volunteers
- 100 people
- Sponsor
- Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans)
Barotrauma
Barotrauma in Hyperbaric Oxygen Therapy
The purpose of this research is to study whether the use of pseudoephedrine can help prevent middle ear trauma during HBOT. Pseudoephedrine is an approved drug that is used for temporary relief of nasal or sinus pain and pressure.
- Trial name
- HBOT (NCT05697328)
- Testing
- Pseudoephedrine Pill
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- John Muir Health
COVID-19, Barotrauma
Barotrauma in Adults With Critical COVID-19
During the pandemic of COVID-19, studies reporting a high incidence of barotrauma, both pneumothorax but also pneumomediastinum, in patients with critical COVID-19.
- Trial name
- NCT05877443
- Testing
- Open system, Non-invasive mechanical ventilation, Invasive mechanical ventilation
- Where
- Sweden
- Volunteers
- 669 people
- Sponsor
- Karolinska Institutet
Mechanical Ventilation
Continuous Monitoring of the Lungs Ventilation Dynamics During Mechanical Ventilation
Background: Patients that suffer from respiratory failure and need mechanical ventilation are at risk of further deterioration due to complications induced by progression of lung disease or the mechanical ventilation.
- Trial name
- NCT00702169
- Where
- Israel
- Volunteers
- 15 people
- Sponsor
- Carmel Medical Center
Injury of Trachea, Friction and Pressure Injuries
The Ornge Comparison of Tracheal Occlusion Pressures to Ensure Safety Trial
Patients who are intubated (breathing tube in windpipe) are often transported by air ambulance. Changes in atmospheric pressure during flight may cause pressure increases in the air-filled cuff holding the tube in the windpipe.
- Conditions
- Injury of Trachea, Friction and Pressure Injuries, Barotrauma, Transfer/Transport Injury
- Trial name
- OCTOPUS (NCT01384500)
- Testing
- Saline in tube cuff
- Where
- Canada
- Sponsor
- Ornge Transport Medicine
Pediatric ARDS
The Specific Elastance in ARDS Patients: a Pediatric Study
Aim of this study is to assess lung specific elastance in a population of pediatric patients with Acute Respiratory Distress Syndrome (ARDS) treated with mechanical ventilation, and in a pediatric population of ICU patients with…
- Trial name
- NCT02036801
- Testing
- Lung specific elastance
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Policlinico Hospital
Perilymphatic Fistulas
Imaging Perilymphatic Fistulas After Barotrauma
Our objective is to validate the CT / MRI combination of non-injected rock for the rapid positive diagnosis of perilymphatic fistulas.
- Trial name
- NCT03543293
- Where
- France
- Volunteers
- 101 people
- Sponsor
- University Hospital, Strasbourg, France
Blast Overpressure Exposure, Blast Injuries
Biomarkers of Brain Health in Blast Overpressure Exposure
The purpose of this study is to learn whether headsets that measure brainwaves can find early signs of changes in brain health in tactical operators who train near explosive blasts.
- Conditions
- Blast Overpressure Exposure, Blast Injuries, Brain Health, Occupational Exposure
- Trial name
- NCT07783048
- Testing
- Blast overpressure exposure during explosive breaching training
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Neurable, Inc
Decompression Sickness, Acute Mountain Sickness
Decompression Tables for Diving at Altitude
The aims of this proposal are to test current USN procedures for adjusting decompression procedures during air diving at 8,000 and 10,000 ft altitude and to provide a decompression algorithm for no-stop dives to 100 feet of sea…
- Trial name
- NCT03390335
- Testing
- Pressure, Breathing Gas
- Where
- United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Duke University
Decompression Sickness
Markers of Central Nervous System Injury in Decompression Sickness
Research hypothesis There is a correlation between the quantity of fluid markers of CNS injury in blood and DCS. There is a correlation between quantity and kind of fluid markers of CNS injury in blood and both diving profile and…
- Trial name
- DCS NEURO (NCT03192956)
- Testing
- No active intervention
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Sahlgrenska University Hospital
Nerve Injury
A Single Dose Pharmaco-Diagnostic for Peripheral Nerve Continuity After Trauma
The purpose of this study is to evaluate the role of 4-aminopyridine (4-AP) on the course of recovery after peripheral nerve traction and/or crush injury.
- Trial name
- NCT04026568
- Testing
- 4-Aminopyridine
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Milton S. Hershey Medical Center
Hyperbaric, Diving Medicine
Reduction of Venous Emboli Load After Breathing Normobaric Oxygen Compared to Air
Primary objective: Assessment of venous gas emboli load post diving when breathing normobaric oxygen compared to air. Secondary objective: Assessment of fluid markers of central nervous system injury in blood post diving…
- Conditions
- Hyperbaric, Diving Medicine, Decompression Sickness, Central Nervous Injury
- Trial name
- NCT02468752
- Testing
- Oxygen, Air
- Where
- 2 sites in Sweden
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Göteborg University
Ventilator Associated Pneumonia (VAP)
Pulmonary Infections and Barotrauma Associated With MV IN PICU
This study aims to determine the incidence, risk factors and outcome of ventilation associated common complication in the PICUs at Assiut University Children Hospital in Egypt.
- Trial name
- NCT05792501
- Testing
- Mechanical ventilation
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Assiut University
Brain Concussion, Blast Injuries
Metacognitive Training to Enhance Strategy Use in Blast-Related TBI
Enhanced Goal Management Training (GMT) is a 10-week group or individual therapy that teaches strategies to improve an individual's ability to complete everyday tasks.
- Trial name
- NCT00857207
- Testing
- Goal Management Training
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- VA Office of Research and Development
Ventilator-Induced Lung Injury, Lung Ventilator
Respiratory Mechanics During One-lung Ventilation
Intraoperative lung protective ventilatory strategy has been widely recognized to reduce postoperative pulmonary complications in laparotomy and laparoscopic surgeries.
- Conditions
- Ventilator-Induced Lung Injury, Lung Ventilator, One-lung Ventilation
- Trial name
- NCT04519606
- Testing
- Optimal lung compliance during OLV
- Where
- Taiwan
- Volunteers
- 10 people
- Sponsor
- E-DA Hospital
Decompression Sickness
Prediction & Mechanisms of Recovery Following IEDS
Inner Ear Decompression sickness (IEDS) accounts for 20% of all types of decompression sickness (the bends) in divers. The condition commonly affects the peripheral vestibular system (inner ear).
- Trial name
- NCT06370897
- Volunteers
- 41 people
- Sponsor
- University of Plymouth
Hyperbaric Oxygen Therapy, Middle Ear Barotrauma
Effect of Self-acupressure on Middle Ear Barotrauma Associated With Hyperbaric Oxygen Therapy
Middle ear barotrauma (MEB) is the most common complication during hyperbaric oxygen therapy (HBOT). Though Valsalva and Toynbee maneuvers have been proposed to prevent MEB, still some patients discontinue HBOT due to severe…
- Trial name
- NCT04311437
- Testing
- Self-acupressure therapy, Combined Valsalva and Toynbee maneuvers
- Where
- Taiwan
- Volunteers
- 152 people
- Sponsor
- Chang Gung Memorial Hospital
Decompression Sickness
Decreases in Diffusing Lung Capacity for Carbon Monoxide (DLCO) in Occupational Divers and Their Impact on Decompression Sickness Risks
Diving disorders and particularly Decompression sickness (DCS) represent a major concern in recreational and occupational pressure-related activities.
- Trial name
- DACODEC (NCT02736006)
- Testing
- 20 meters air dive
- Where
- France
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Diving Medicine, Inflammation
Inflammatory and Cerebrospinal Biochemical Markers in Blood After Trimix Diving
Research hypothesis Diving to depths up to 90msw with an oxygen partial pressure of 130kPa in the breathing gas will affect the central nervous system.
- Conditions
- Diving Medicine, Inflammation, Central Nervous System Injury
- Trial name
- TriMix17-18 (NCT03190252)
- Testing
- Exposure to oxygen partial pressure of 130 kPa, Exposure to ambient pressure of maximum 11 ATA
- Where
- Sweden
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Sahlgrenska University Hospital
Acute Respiratory Distress Syndrome, Barotrauma
Imaging Biomarkers to Stratify the Risk of Barotrauma in ARDS
The high incidence of barotrauma in patients with COVID-19-related acute respiratory distress syndrome (ARDS) (16.1%, with a mortality rate >60%) provides rationale for considering COVID-19 ARDS a paradigm for lung frailty.
- Trial name
- FRAIL ARDS (NCT05816954)
- Testing
- Chest Computed Tomography Scan per normal clinical practice
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Università Vita-Salute San Raffaele