Clinical trials: Barotrauma, open to volunteers
Residual Limb Pain, Stump Pain
Post-Amputation Stump Infection as a Predictor of Persistent Residual Limb Pain: A Prospective Cohort Study
Persistent residual limb pain is common after traumatic amputation and significantly impairs rehabilitation and prosthetic use. Postoperative stump infection may contribute to peripheral nerve sensitization, scar fibrosis, and…
- Conditions
- Residual Limb Pain, Stump Pain, Post-Amputation Pain, Surgical Site Infection
- Trial name
- INF-STUMP-PAIN (NCT07438795)
- Volunteers
- 150 people
- Sponsor
- Ukrainian Society of Regional Anesthesia and Pain Therapy
Burn Scar Pain, Neuropathic Pain
Ultrasound Predictors of Persistent Burn Scar Pain After Blast and Drone-Related Injuries: A Prospective Cohort Study
Persistent burn scar pain is common after blast and drone-related injuries and may be driven by scar fibrosis, vascular activity, and peripheral nerve involvement within scar tissue.
- Conditions
- Burn Scar Pain, Neuropathic Pain, Combat-Related Burn Injury, Scar-Related Pain
- Trial name
- US-SCAR-PAIN (NCT07438769)
- Where
- Ukraine
- Volunteers
- 150 people
- Sponsor
- Ukrainian Society of Regional Anesthesia and Pain Therapy
Auditory Diseases, Central
Comparing Hearing Aid Fitting Methods in Blast-exposed Veterans
Since 2000, at least 250,000 U.S. Service members have experienced a blast-related mild traumatic brain injury. A retrospective analysis of over 100,000 post-9/11 Veterans shows that blast injury more than doubles the risk of a…
- Trial name
- SBA (NCT06309264)
- Testing
- Phonak Lumina P90
- Where
- 3 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Decompression Sickness
Impact of Hyperoxia and Involvement of the Immune System in Diving Accident
The impact of oxygen therapy in many pathologies has been subject of recent work, arguing both favourable and harmful effects. Consequently, one can wonder about the influence of hyperoxic gas mixture during diving on the genesis…
- Trial name
- OXYDIVE (NCT04791488)
- Testing
- Hyperbaric oxygen therapy, Diving simulation
- Where
- France
- Volunteers
- 265 people, healthy volunteers welcome
- Sponsor
- Direction Centrale du Service de Santé des Armées
Blast Injury
Precision Biomarkers to Detect Brain Injury in Active-Duty United States Special Operations Forces With Repeated Blast Exposure
This is a 4-year, longitudinal study of 100 active-duty Navy SEALs. The goal of the study is to determine whether repeated blast exposure affects SEAL brain health and to develop an initial diagnostic testing protocol that…
- Trial name
- NCT07131475
- Testing
- PBR28 TSPO PET
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Acute Respiratory Distress Syndrome, Barotrauma
Imaging Biomarkers to Stratify the Risk of Barotrauma in ARDS
The high incidence of barotrauma in patients with COVID-19-related acute respiratory distress syndrome (ARDS) (16.1%, with a mortality rate >60%) provides rationale for considering COVID-19 ARDS a paradigm for lung frailty.
- Trial name
- FRAIL ARDS (NCT05816954)
- Testing
- Chest Computed Tomography Scan per normal clinical practice
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Università Vita-Salute San Raffaele
Pain, Chronic Pain
Chronic Pain After Combat-Related Traumatic Brain Injury (cTBI-Pain Study) A Prospective Cohort Study of Pain Chronification After Combat-Related Traumatic Brain Injury
Combat-related traumatic brain injury (cTBI), particularly blast-related injury, is frequently associated with the development of persistent and disabling chronic pain.
- Conditions
- Pain, Chronic Pain, Chronic Pain Due to Injury
- Trial name
- TBI-Pain (NCT07424248)
- Where
- Ukraine
- Volunteers
- 100 people
- Sponsor
- Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans)
Acute Respiratory Distress Syndrome, Barotrauma
Laboratory Biomarkers and Pulmonary Interstitial Emphysema in ARDS (PIE-ARDS)
Barotrauma (pneumothorax, pneumomediastinum) is a well-described complication of Acute Respiratory Distress Syndrome (ARDS), especially in patients with coronavirus disease 2019 (COVID-19) (16.1% in COVID-19, and about 6% in…
- Trial name
- PIE-ARDS (NCT06001645)
- Testing
- Blood and bronchoalveolar fluid collection and analysis, Chest CT scan
- Where
- 4 sites in Italy
- Volunteers
- 110 people
- Sponsor
- Università Vita-Salute San Raffaele
Compartment Syndrome, Compartment Syndrome Nontraumatic Lower Extremity
From Blast Injury to Multicompartment Dysfunction:
Blast injuries can cause swelling and pressure problems in more than one part of the body. This study will review existing medical records of people treated for blast-related injuries to learn how often these problems affect…
- Conditions
- Compartment Syndrome, Compartment Syndrome Nontraumatic Lower Extremity, Compartment Syndrome Traumatic Upper Extremity, Compartment Syndromes
- Trial name
- BLAST-PCS (NCT07911085)
- Where
- Ukraine
- Volunteers
- 100 people
- Sponsor
- Ukrainian Society of Regional Anesthesia and Pain Therapy
Nerve Block, Nerve Blocks
Blast-related Regional Anaesthesia and Peripheral nerVe Injury Evaluation
This randomized study will examine whether ultrasound-guided regional anaesthesia (a nerve block) contributes to new or worsening peripheral nerve problems after blast-related limb trauma.
- Conditions
- Nerve Block, Nerve Blocks, Nerve Injury, Blast Injury
- Trial name
- BRAVE (NCT07879508)
- Testing
- Standardized Multimodal Analgesia, Ultrasound-Guided Regional Anaesthesia
- Volunteers
- 150 people
- Sponsor
- Ukrainian Society of Regional Anesthesia and Pain Therapy
Decompression Sickness
Prediction & Mechanisms of Recovery Following IEDS
Inner Ear Decompression sickness (IEDS) accounts for 20% of all types of decompression sickness (the bends) in divers. The condition commonly affects the peripheral vestibular system (inner ear).
- Trial name
- NCT06370897
- Volunteers
- 41 people
- Sponsor
- University of Plymouth
Barotrauma
Barotrauma in Hyperbaric Oxygen Therapy
The purpose of this research is to study whether the use of pseudoephedrine can help prevent middle ear trauma during HBOT. Pseudoephedrine is an approved drug that is used for temporary relief of nasal or sinus pain and pressure.
- Trial name
- HBOT (NCT05697328)
- Testing
- Pseudoephedrine Pill
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- John Muir Health
Barotrauma;Ear, Tympanum; Perforation
Effectiveness of Sequential Eustachian Tube Maneuvers in Hyperbaric Oxygen Conditions
Middle ear barotrauma represents the predominant complication associated with hyperbaric oxygen therapy, manifesting symptoms ranging from otalgia to tympanic membrane perforation.
- Trial name
- NCT06408363
- Testing
- Maneuver group
- Where
- Brazil
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hospital Felicio Rocho
Decompression Sickness
NASA Exercise Prebreathe Study
This study evaluates oxygen prebreathe protocols and exercise conditions to reduce risk of decompression sickness during simulated extravehicular activity.
- Trial name
- NCT07702539
- Testing
- Oxygen Prebreathe and Hypobaric Exposure
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Duke University
Decompression Sickness, Barotrauma
Health, Fitness, and Safety Knowledge as Determinants of Adverse Events in Recreational Divers in Poland
This cross-sectional online survey study assesses health status, physical fitness, and safety knowledge as potential determinants of diving-related adverse events among recreational divers in Poland.
- Conditions
- Decompression Sickness, Barotrauma, Recreational Diving
- Trial name
- DIVE-PL (NCT07855861)
- Testing
- Anonymous online questionnaire
- Where
- 2 sites in Poland
- Volunteers
- 384 people, healthy volunteers welcome
- Sponsor
- Medical University of Bialystok
Otic Barotrauma, Pressure Injury
Diagnostic Precision and Accuracy Using the Teed Scoring System Versus the O'Neill Grading System
This validation study investigates the diagnostic precision and accuracy when grading otic barotrauma using two alternative gradings systems including the TEED and the OGS grading systems.
- Conditions
- Otic Barotrauma, Pressure Injury, Ear Injury, Barotitis
- Trial name
- OGS (NCT04726306)
- Testing
- Otic Barotrauma Grading System
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Northwell Health