Clinical trials: Barrett's Esophagus
Barrett's Esophagus
Optical Frequency Domain Imaging (OFDI) Surveillance and Image Guided Biopsy of the Esophagus
The specific aim of this study is to determine the feasibility of marking target pathologic locations identified on Optical Frequency Domain Imaging (OFDI) datasets using superficial cautery marks of the esophagus that are…
- Trial name
- NCT01439633
- Testing
- MGH OFDI marking
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Massachusetts General Hospital
Barrett's Esophagus
The Role of the Fujinon Intelligent Chromo Endoscopy (FICE™) in Barrett's Esophagus
The purpose of this study to assess post ablation, if there are areas of Barrett's mucosa post ablation and to assess the ability of the Fujinon FICE system to detect this, as compared to white light endoscopy.
- Trial name
- NCT01084629
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mayo Clinic
Barrett Esophagus, Esophageal Adenocarcinoma
Minimally Invasive Molecular Approaches for the Diagnosis of Barrett's Esophagus and Esophageal Adenocarcinoma
This study will evaluate if the sponge capsule device can accurately detect the presence of Barrett's Esophagus and prevalent dysplasia/adenocarcinoma detection, in a screening population, with and without chronic…
- Trial name
- NCT03961945
- Testing
- Sponge Capsule
- Where
- 8 sites in United States
- Volunteers
- 1,526 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Barrett's Oesophagus, Oesophageal Varices
The Accuracy and Acceptability of Magnet Assisted Capsule Endoscopy in the Diagnosis of Esophageal Pathology: a Pilot Study
A pilot study to assess the accuracy and acceptability of a magnet assisted capsule endoscopy in detecting esophageal pathology compared to standard endoscopy.
- Trial name
- MACE (NCT02852161)
- Testing
- Magnet assissted capsule endoscopy
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- University of Nottingham
Barrett's Esophagus, GERD
Study of Endoscopic Barrett's Esophagus Diagnosis
Barrett's esophagus (BE) is a condition that often occurs in patients who have had GERD for a long time. The researchers are interested in BE because it can sometimes become a cancer in the esophagus.
- Trial name
- NCT00591461
- Where
- 2 sites in United States
- Volunteers
- 13 people
- Sponsor
- Oregon Health and Science University
High-grade Dysplasia in Barrett Esophagus, Non Small Cell Lung Cancer
Efficacy and Safety of a Sunscreen Against Porfimer Sodium-induced Phototoxicity to Visible Light
Photodynamic therapy (PDT) uses a combination of a drug, porfimer sodium, and a light from a non heated laser. The activation of the drug is done by illuminating abnormal areas using a fiber optic device.
- Conditions
- High-grade Dysplasia in Barrett Esophagus, Non Small Cell Lung Cancer, Esophageal Cancer
- Trial name
- NCT01256203
- Testing
- Solar Protection Formula SPF® 60, Photobiological testing
- Sponsor
- Pinnacle Biologics Inc.
Barrett's Esophagus
"Acetic Acid Chromoendoscopy in Barrett's Esophagus Surveillance
Neoplasia in Barrett's esophagus could be missed during routine random biopsies. We propose a study using chromoendoscopy with Acetic Acid to increase the yield of biopsies in detecting neoplasia.
- Trial name
- NCT02614703
- Testing
- Chromoendoscopy using Acetic Acid 2.5%, Standard random esophageal biopsies
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- DHR Health Institute for Research and Development
Barrett Esophagus, Barrett Adenocarcinoma
Neoplastic Barrett Esophagus: Endoscopic Piecemeal vs. En Bloc Resection
The study will compare EMR versus ESD technique (both combined with subsequent ablative therapy) of mucosal resection in Barrett's esophagus with regard to efficacy and risk in a long term setting.
- Conditions
- Barrett Esophagus, Barrett Adenocarcinoma, Esophagus Neoplasm
- Trial name
- BEEPER (NCT03427346)
- Testing
- Endoscopic mucosal resection, Endoscopic submucosal dissection
- Where
- 2 sites in United States, Germany
- Volunteers
- 407 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Gastro Esophageal Reflux, Barrett Esophagus
Confocal Endomicroscopy for Permeability of Esophageal Wall in Refractory Gastroesophageal Reflux Disease (GERD)
Confocal Endomicroscopy for Permeability of Esophageal Wall in Refractory Gastroesophageal Reflux Disease (GERD)
- Conditions
- Gastro Esophageal Reflux, Barrett Esophagus, Erosive Esophagitis
- Trial name
- NCT03228407
- Testing
- Confocal endomicroscopy, Endoscopic biopsies, Mucosal impedance (MI)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- McGuire Research Institute
Barrett's Esophagus
Ramanspectroscopy in Barrett's Esophagus
This study is being done to see if a new device, called near-infrared Raman spectroscopy, can provide similar information as that obtained from taking biopsies of the lining of your Barrett's esophagus
- Trial name
- NCT00588575
- Where
- United States
- Volunteers
- 119 people
- Sponsor
- Mayo Clinic
Superficial Esophageal Cancer, Oesophageal Adenocarcinoma
Multicenter Prospective Cohort on Esophageal Endoscopic Submucosal Dissection
In France in 2018, there were an estimated 2,074 new cases of esophageal adenocarcinoma and 3,224 cases of squamous cell carcinoma.
- Conditions
- Superficial Esophageal Cancer, Oesophageal Adenocarcinoma, Oesophageal Squamous Cell Carcinoma, Barretts Esophagus With Dysplasia
- Trial name
- FEO (NCT07343869)
- Where
- France
- Volunteers
- 750 people
- Sponsor
- Société Française d'Endoscopie Digestive
Barrett's Esophagus
Accuracy, Yield and Clinical Impact of a Low-Cost HRME in the Early Diagnosis of Esophageal Adenocarcinoma
The overall goal of the study is to determine whether imaging with the low-cost High Resolution Microendoscope(HRME) will increase the efficiency and yield of the current standard of endoscopic surveillance of Barrett's…
- Trial name
- NCT02018367
- Testing
- Proflavine, high resolution imaging
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Anandasabapathy, Sharmila, M.D.
Esophageal Cancer
Eflornithine to Prevent Cancer in Patients With Barrett's Esophagus
RATIONALE: Chemoprevention therapy is the use of drugs to try and prevent the development or recurrence of cancer. It is not known whether eflornithine is effective in preventing cancer in patients with Barrett's esophagus.
- Trial name
- NCT00003076
- Testing
- eflornithine
- Where
- 5 sites in United States
- Volunteers
- 152 people
- Sponsor
- University of Michigan Rogel Cancer Center
Barretts Esophagus, High Grade Dysplasia
Endoscopic Tri-Modal Imaging in Patients With Barrett's Esophagus
This study is being done to determine if a new endoscope will help doctors identify pre-cancer or early cancer lesions in patients who have Barrett's esophagus.
- Conditions
- Barretts Esophagus, High Grade Dysplasia, Early Esophageal Adenocarcinoma
- Trial name
- ETMI (NCT00586989)
- Testing
- Upper endoscopy with biopsy
- Where
- 2 sites in United States, Netherlands
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Barrett Esophagus, Barretts Esophagus With Dysplasia
CLUE: CLinical Utility Study of EsoGuard
Utilize real-world data from the commercial use of EsoGuard testing on samples collected with EsoCheck (EC/EG) to evaluate the impact of EsoGuard results on health care provider's decision for endoscopy referral.
- Conditions
- Barrett Esophagus, Barretts Esophagus With Dysplasia, Esophagus Adenocarcinoma
- Trial name
- PR-0410 (NCT06030180)
- Testing
- EsoGuard
- Where
- 8 sites in United States
- Volunteers
- 566 people
- Sponsor
- Lucid Diagnostics, Inc.
Barrett Esophagus, Adenocarcinoma Esophagus
Outcomes of Endoscopically Resected High-risk Mucosal and Low- and High-risk Submucosal Adenocarcinoma Arising in Barrett's Esophagus
The purpose of this study is to assess lymph node metastasis rate, distant metastasis rate, disease-specific mortality, and overall mortality in patients with Barrett's related T1b and high risk T1a esophageal adenocarcinoma…
- Conditions
- Barrett Esophagus, Adenocarcinoma Esophagus, Submucosal Esophageal Adenocarcinoma, High-risk Mucosal Esophageal Adenocarcinoma
- Trial name
- NCT04818476
- Testing
- diagnostic endoscopic resection
- Where
- 16 sites in Australia, Belgium and 5 more
- Volunteers
- 1,000 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Barrett Esophagus
Barrett's Esophagus in Patients with GERD
To assess the prevalence and characteristics of BE in patients suffering of chronic GERD symptoms
- Trial name
- NCT06897540
- Testing
- Upper endoscopy
- Volunteers
- 70 people
- Sponsor
- Assiut University
Barrett Esophagus, Esophageal Adenocarcinoma
Nitrates and IL-8 in Barrett's Esophagus
The purpose of this study is to determine if nitrates and IL-8 (which are found in food and throughout the body regulating stomach acidity) play a role in Barrett's Esophagus and/or Esophageal Adenocarcinoma severity and if…
- Trial name
- NCT04642690
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Barrett's Esophagus, High-grade Dysplasia in Barrett Esophagus
Eradicating Barrett's Esophagus Using Radiofrequency Ablation or a Novel Hybrid Argon Plasma Coagulation Technique
Lay summary: Barrett's Esophagus (BE) involves a change of the esophagus lining (BE epithelium) which in a small proportion of patients could be the starting point for the development of cancer (esophageal adenocarcinoma).
- Conditions
- Barrett's Esophagus, High-grade Dysplasia in Barrett Esophagus, Low Grade Dysplasia in Barrett Esophagus
- Trial name
- BURN (NCT03621319)
- Testing
- Hybrid argon plasma ablation (HAPC), Radiofrequency ablation (RFA)
- Where
- 13 sites in United States
- Volunteers
- 41 people
- Sponsor
- Erbe Elektromedizin GmbH
Barrett Esophagus, Proton Pump Inhibitor
On-demand PPI Therapy is Effective on Controlling Symptoms in Patients With Barrett's Esophagus.
On-demand PPI therapy is feasible for the long-term treatment of patients with Barrett's esophagus.
- Conditions
- Barrett Esophagus, Proton Pump Inhibitor, Symptom, Reflux
- Trial name
- NCT04329000
- Testing
- Esomeprazole 40mg, Esomeprazole
- Volunteers
- 218 people
- Sponsor
- Kaohsiung Veterans General Hospital.