Clinical trials: Barrett's Esophagus (BE)
Barrett's Esophagus
Enhancing Screening Practices for BE
Previous studies have shown that screening for Barrett's esophagus (BE), the main risk factor for esophageal adenocarcinoma, is under-utilized in the primary care setting.
- Trial name
- NCT07335445
- Testing
- Screening Reminder
- Where
- United States
- Volunteers
- 3,000 people
- Sponsor
- Rutgers, The State University of New Jersey
GERD, Gastroesophageal Reflux
Effect of Antireflux Therapy on the Expression of Genes in Patients With GERD
Although the symptomatic and epithelial (histologic and endoscopic) response to antireflux therapy are well known and extensively studied, little is known of the genetic events occurring in response to proton pump inhibitor…
- Trial name
- NCT00624546
- Testing
- Prevacid Solutabs, Antireflux surgery
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Rochester
Barrett's Esophagus, Intestinal Metaplasia
The Prevalence, Risk Factors and Optimal Biopsy Protocol of BE
Detections of goblet cells and dysplasia are crucial for diagnosis and determining the surveillance program of Barrett's esophagus (BE).
- Trial name
- NCT05818072
- Testing
- One biopsy, Three biopsy, Seattle protocol
- Where
- Taiwan
- Volunteers
- 165 people
- Sponsor
- E-DA Hospital
Barrett's Esophagus, Gastroesophageal Reflux Disease (GERD)
Racial Disparity in Barrett's Esophagus
The goal of the proposed research is to investigate the molecular mechanisms of racial disparity in Barrett's esophagus (BE), the premalignant lesion of esophageal adenocarcinoma.
- Conditions
- Barrett's Esophagus, Gastroesophageal Reflux Disease (GERD), Intestinal Metaplasia
- Trial name
- NCT01374074
- Where
- United States
- Volunteers
- 255 people
- Sponsor
- University of North Carolina, Chapel Hill
Barrett Esophagus, Barretts Esophagus With Dysplasia
CLUE: CLinical Utility Study of EsoGuard
Utilize real-world data from the commercial use of EsoGuard testing on samples collected with EsoCheck (EC/EG) to evaluate the impact of EsoGuard results on health care provider's decision for endoscopy referral.
- Conditions
- Barrett Esophagus, Barretts Esophagus With Dysplasia, Esophagus Adenocarcinoma
- Trial name
- PR-0410 (NCT06030180)
- Testing
- EsoGuard
- Where
- 8 sites in United States
- Volunteers
- 566 people
- Sponsor
- Lucid Diagnostics, Inc.
Gastroesophageal Reflux Disease, Barrett's Esophagus
Survey Study on Barrett's Esophagus Screening
The goal of this study is to optimize Barrett's Esophagus (BE) screening to reduce the incidence, morbidity, and mortality of Esophageal Adenocarcinoma (EAC).
- Conditions
- Gastroesophageal Reflux Disease, Barrett's Esophagus, Esophagus Adenocarcinoma
- Trial name
- SCREEN-BE (NCT04408105)
- Testing
- Primary Care Provider Survey, Gastroenterologist Survey, Patient Survey
- Where
- 7 sites in United States
- Volunteers
- 725 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Barrett Esophagus, Intestinal Metaplasia
Nitrous Oxide For Endoscopic Ablation of Refractory Barrett's Esophagus (NO FEAR-BE)
A multicenter, prospective, single arm, non randomized clinical trial to evaluate the safety and efficacy of the C2 CryoBalloon Focal Ablation System (CbFAS) for the treatment of persistent dysplasia or intestinal metaplasia (IM)…
- Conditions
- Barrett Esophagus, Intestinal Metaplasia, Esophageal Dysplasia
- Trial name
- NO FEAR-BE (NCT03554356)
- Testing
- CryoBalloon Focal Ablation System
- Where
- 11 sites in United States
- Volunteers
- 70 people
- Sponsor
- University of North Carolina, Chapel Hill
Barrett Esophagus
Efficacy of Potassium-Competitive Acid Blockers in Barrett's Esophagus (PCAB BE Study)
This is a research study to look at how a new medication compares to standard treatment for reducing acid reflux in patients with Barrett's Esophagus. The study drug is Vonoprazan.
- Trial name
- NCT07788742
- Testing
- Potassium-Competitive Acid Blockers (PCABs)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of North Carolina, Chapel Hill
Barrett's Esophagus, Barrett's Esophagus With Dysplasia
Lucid BE Biomarkers Study
The goal of this study is to learn more about genetic factors that may predict if patients with Barrett's Esophagus (BE) will respond to endoscopic treatment.
- Conditions
- Barrett's Esophagus, Barrett's Esophagus With Dysplasia, Esophageal Adenocarcinoma (EAC)
- Trial name
- NCT07887568
- Testing
- Tissue
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Barrett Esophagus, Barretts Esophagus With Dysplasia
Seattle Biopsy Protocol Versus Wide-Area Transepithelial Sampling in Patients With Barrett's Esophagus Undergoing Surveillance
The purpose of this research study is to learn about the best approach to sample patients with known or suspected Barrett's esophagus (BE) by comparing the standard Seattle biopsy protocol to sampling using wide area…
- Conditions
- Barrett Esophagus, Barretts Esophagus With Dysplasia, Esophageal Adenocarcinoma
- Trial name
- SWAT-BE (NCT05530343)
- Testing
- Seattle protocol, WATS3D brushings
- Where
- 14 sites in United States
- Volunteers
- 2,298 people
- Sponsor
- University of Colorado, Denver
Barrett Esophagus
Longitudinal Oral Microbiome Sampling for BE
This is a longitudinal cohort study to assess the impact of repeated sampling of an oral microbiome signature for Barrett's esophagus (BE).
- Trial name
- NCT05133102
- Testing
- Sample collection
- Where
- 2 sites in United States
- Volunteers
- 275 people, healthy volunteers welcome
- Sponsor
- Columbia University
Barrett Esophagus, Esophageal Adenocarcinoma
Efficacy of EsoGuard on Samples Collected Using EsoCheck Versus EGD for the Diagnosis of BE
The study will assess the performance of the combined system, i.e., the use of the EsoGuard assay on cells collected using the EsoCheck 510(k) cleared device, to detect Barrett's Esophagus, with and without dysplasia, and/or…
- Conditions
- Barrett Esophagus, Esophageal Adenocarcinoma, Barretts Esophagus With Dysplasia, Barrett's Esophagus Without Dysplasia
- Trial name
- ESOGUARDBE1 (NCT04293458)
- Testing
- EsoGuard
- Where
- 27 sites in United States, Spain
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- Lucid Diagnostics, Inc.
Barrett Esophagus, Esophageal Adenocarcinoma
The Microbiome, Bile Acids, and Notch in Barrett's Esophagus (BE)
The purpose of this study is to prospectively collect and analyze clinical data and biospecimens from a cohort of 100 patients without BE (20), with non-dysplastic BE (40), or with BE and high grade dysplasia (HGD) or EAC (40).
- Trial name
- NCT05524844
- Testing
- Sample Collection, Endoscopy results, Dietary questionnaire
- Where
- 2 sites in United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Columbia University
Gastro Esophageal Reflux Disease, Barrett Esophagus
Patient Preferences for Barrett's Esophagus and Esophageal Cancer Screening Tests
This study plans to learn more about what patients think about screening for esophageal cancer (EAC) and Barrett's esophagus (BE); a pre-cancerous condition associated with esophageal cancer.
- Trial name
- NCT06693622
- Testing
- Patient survey
- Where
- United States
- Volunteers
- 556 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Barrett Esophagus, Esophageal Adenocarcinoma
Efficacy of EsoGuard Assay on Esophageal Surface Cells Collected With EsoCheck vs EGD for the Diagnosis of BE or EAC
The study will assess the performance of the combined system, i.e., the use of the EsoGuard assay (lab developed test) on cells collected using the EsoCheck (501k cleared device) to detect Barrett's Esophagus (BE), with or…
- Conditions
- Barrett Esophagus, Esophageal Adenocarcinoma, Barretts Esophagus With Dysplasia, Barrett's Esophagus Without Dysplasia
- Trial name
- ESOGUARDBE2 (NCT04295811)
- Testing
- EsoGuard (lab assay), Esophagogastroduodenoscopy
- Where
- 35 sites in United States, Netherlands
- Volunteers
- 784 people, healthy volunteers welcome
- Sponsor
- Lucid Diagnostics, Inc.
Barrett's Esophagus, Gastroesophageal Reflux Disease
Narrow Band Imaging Project on Barrett's Esophagus
Narrow Band Imaging(NBI) improves image contrast by allowing the blue light centered at 415 nanometers which is heavily absorbed by oxyhemoglobin to highlight the tissue's microvasculature and enhances detail on the surface of…
- Trial name
- NCT01580631
- Where
- 4 sites in United States, Germany and 1 more
- Volunteers
- 50 people
- Sponsor
- Midwest Biomedical Research
Barrett Esophagus
Safety of Photodynamic Therapy (PDT) in the Ablation of High-grade Dysplasia (HGD) in Barrett's Esophagus (BE)
Photodynamic therapy (PDT) uses a combination of a drug, porfimer sodium, and a light from a non heated laser. The activation of the drug is done by lighting of abnormal areas using a fiber optic device.
- Trial name
- Oedisse (NCT01209013)
- Testing
- Medlight PDT Balloon, Endoscopy, Endoscopy with biopsy
- Sponsor
- Pinnacle Biologics Inc.
Barrett's Esophagus, Esophageal Adenocarcinoma
Micro-RNA (miR) Expression in Upper Gastrointestinal Mucosal Tissue
This is a laboratory-based, exploratory study using tissue obtained from our clinical practice. The purpose of this study is to confirm our ability to characterize miR expression in various tissues (proximal and distal esophagus…
- Trial name
- NCT00909350
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Barrett Esophagus, Esophageal Cancer
Molecular Fluorescence Endoscopy of (Pre)Malignant Esophageal Lesions
To improve detection of esophageal (pre)malignant lesions during surveillance endoscopy of patients at risk of developing malignancies, for example in Barrett's Esophagus (BE), there is a need for better endoscopic visualization…
- Conditions
- Barrett Esophagus, Esophageal Cancer, Dysplasia in Barrett Esophagus
- Trial name
- EAGLE (NCT03205501)
- Testing
- IV-administation of EMI-137, Molecular Fluorescence Endoscopy platform
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- University Medical Center Groningen
Precancerous Condition
Risk Factors for Barrett's Esophagus in Patients With BE, Gastroesophageal Reflux, or Gastrointestinal Bleeding
RATIONALE: A study that evaluates DNA changes and other disease-related health information in patients with Barrett's esophagus, gastroesophageal reflux, or gastrointestinal bleeding may help doctors learn more about the risk…
- Trial name
- NCT00445653
- Where
- 2 sites in United States
- Volunteers
- 170 people
- Sponsor
- Massachusetts General Hospital