Clinical trials: Barrett Adenocarcinoma
Barrett Esophagus, Dysplasia
Swallowable Sponge Cell Sampling Device and Next Generation Sequencing in Detecting Esophageal Cancer in Patients With Low or High Grade Dysplasia, Barrett Esophagus, or Gastroesophageal Reflux Disease
This pilot clinical trial studies how well a swallowable sponge cell sampling device and next generation sequencing work in detecting esophageal cancer in patients with low or high grade dysplasia, Barrett esophagus, or…
- Conditions
- Barrett Esophagus, Dysplasia, Esophageal Adenocarcinoma, Esophageal Squamous Cell Carcinoma
- Trial name
- NCT02890979
- Testing
- Cytology Specimen Collection Procedure, Laboratory Biomarker Analysis, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- OHSU Knight Cancer Institute
Barrett Esophagus, Barrett Esophagus Adenocarcinoma
A Study of Barrett's Esophagus Patients: Optimization of a Risk Model to Better Predict the Development of Cancer Recurrence and the Effect of Risk Profile Disclosure on Patient Quality of Life and Fear of Cancer
The goal of the study is: The collection of various tissue samples (blood, biopsies and "esophageal brushes") and their analysis.
- Conditions
- Barrett Esophagus, Barrett Esophagus Adenocarcinoma, Adenocarcinoma - GEJ, Gastroenterology
- Trial name
- Endeavor-2 (NCT07455422)
- Testing
- Risk profile disclosure
- Where
- 10 sites in Belgium, Denmark and 5 more
- Volunteers
- 266 people
- Sponsor
- University Hospital, Antwerp
Barretts Esophagus With Dysplasia, Barrett Esophagus
Surveillance vs. Endoscopic Therapy for Barrett's Esophagus With Low-grade Dysplasia
The purpose of this study is to learn the best approach to treating patients with known or suspected Barrett's esophagus by comparing endoscopic surveillance to endoscopic eradication therapy.
- Conditions
- Barretts Esophagus With Dysplasia, Barrett Esophagus, Esophageal Adenocarcinoma
- Trial name
- SURVENT (NCT05753748)
- Testing
- Endoscopic Eradication Therapy
- Where
- 30 sites in United States
- Volunteers
- 680 people
- Sponsor
- University of Colorado, Denver
High Grade Intraepithelial Neoplasia, Barrett Adenocarcinoma
ESD Versus EMR for Treatment of Early Barrett's Adenocarcinoma
Conventional techniques of endoscopic mucosal resection (EMR) by snare resection do usually not achieve resection of gastrointestinal mucosal neoplastic lesions larger than 1 cm in diameter in a single piece.
- Trial name
- NCT01871636
- Testing
- Endoscopic mucosal resection, Waterjet-assisted ESD, HybridKnife
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Evangelisches Krankenhaus Düsseldorf
Esophageal Cancer, Precancerous Condition
Endoscopy Every 2 Years or Only as Needed in Monitoring Patients With Barrett Esophagus
RATIONALE: Screening tests may help doctors find cancer cells early and plan better treatment. It is not yet known whether endoscopy every 2 years is more effective than endoscopy only as needed in finding esophageal cancer in…
- Trial name
- NCT00987857
- Testing
- 2 yearly endoscopy, comparison of screening methods, diagnostic endoscopic procedure
- Where
- United Kingdom
- Volunteers
- 3,400 people
- Sponsor
- Gloucestershire Hospitals NHS Foundation Trust
Barrett Esophagus, Esophageal Neoplasm
ESD for the Treatment of Early Barrett's Neoplasia
This study assesses the quality of the resection of early neoplasia arinsing in Barrett's esophagus using endoscopic submucosal dissection.
- Trial name
- ESTEBAN (NCT02583087)
- Testing
- endoscopic submucosal dissection
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Hôpital Cochin
Barrett Esophagus, Esophageal Adenocarcinoma
Esophageal Protocol for Detection of Neoplasia in the Digestive Tract
You are invited to participate in a research study to develop new ways to look for abnormal areas/tissues of the esophagus. The current endoscopes used to look at the esophagus are very good, but if the area doesn't look…
- Trial name
- NCT01391208
- Testing
- GI heptapeptide
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Michigan
Barretts Esophagus
Long Term Barrett's Endoscopic Mucosal Resection Study
Analysis of long term outcomes of patients undergoing endoscopic mucosal resection for Barrett's oesophagus with high grade dysplasia and/or early intramucosal carcinoma (IMC).
- Trial name
- CBE (NCT02200250)
- Where
- Australia
- Sponsor
- Professor Michael Bourke
Barrett Esophagus, Esophageal Adenocarcinoma
Aspirin in Preventing Disease Recurrence in Patients With Barrett Esophagus After Successful Elimination by Radiofrequency Ablation
This randomized phase II trial studies the safety of and how well aspirin works in preventing Barrett's esophagus from returning after it has been successfully eliminated by radiofrequency ablation.
- Trial name
- NCT02521285
- Testing
- Aspirin, Laboratory Biomarker Analysis, Questionnaire Administration
- Where
- 10 sites in United States, Canada
- Volunteers
- 21 people
- Sponsor
- National Cancer Institute (NCI)
Barrett's Metaplasia
Effect of Zinc on Barrett's Metaplasia
Using orally administered zinc to patients already diagnosed with the pre-cancerous condition, Barrett's Esophagus, this study is asking two questions: 1.
- Trial name
- NCT01984580
- Testing
- zinc gluconate
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Main Line Health
Barrett Esophagus, Esophageal Adenocarcinoma
Minimally Invasive Molecular Approaches for the Diagnosis of Barrett's Esophagus and Esophageal Adenocarcinoma
This study will evaluate if the sponge capsule device can accurately detect the presence of Barrett's Esophagus and prevalent dysplasia/adenocarcinoma detection, in a screening population, with and without chronic…
- Trial name
- NCT03961945
- Testing
- Sponge Capsule
- Where
- 8 sites in United States
- Volunteers
- 1,526 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Barrett's Esophagus, Gastroesophageal Reflux
Evaluation of MicroRNA Expression in Blood and Cytology for Detecting Barrett's Esophagus and Associated Neoplasia
The primary purpose of this study is to test new methods to diagnose BE in time before it turns into advanced cancer. Once BE is diagnosed, the current standard of care is to monitor the disease so that complication such as…
- Conditions
- Barrett's Esophagus, Gastroesophageal Reflux, Esophageal Adenocarcinoma
- Trial name
- NCT02464930
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Midwest Biomedical Research
Barrett Esophagus, Esophageal Adenocarcinoma
Efficacy of EsoGuard Assay on Esophageal Surface Cells Collected With EsoCheck vs EGD for the Diagnosis of BE or EAC
The study will assess the performance of the combined system, i.e., the use of the EsoGuard assay (lab developed test) on cells collected using the EsoCheck (501k cleared device) to detect Barrett's Esophagus (BE), with or…
- Conditions
- Barrett Esophagus, Esophageal Adenocarcinoma, Barretts Esophagus With Dysplasia, Barrett's Esophagus Without Dysplasia
- Trial name
- ESOGUARDBE2 (NCT04295811)
- Testing
- EsoGuard (lab assay), Esophagogastroduodenoscopy
- Where
- 35 sites in United States, Netherlands
- Volunteers
- 784 people, healthy volunteers welcome
- Sponsor
- Lucid Diagnostics, Inc.
Barrett's Esophagus
Accuracy, Yield and Clinical Impact of a Low-Cost HRME in the Early Diagnosis of Esophageal Adenocarcinoma
The overall goal of the study is to determine whether imaging with the low-cost High Resolution Microendoscope(HRME) will increase the efficiency and yield of the current standard of endoscopic surveillance of Barrett's…
- Trial name
- NCT02018367
- Testing
- Proflavine, high resolution imaging
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Anandasabapathy, Sharmila, M.D.
Barretts Esophagus, High Grade Dysplasia
Endoscopic Tri-Modal Imaging in Patients With Barrett's Esophagus
This study is being done to determine if a new endoscope will help doctors identify pre-cancer or early cancer lesions in patients who have Barrett's esophagus.
- Conditions
- Barretts Esophagus, High Grade Dysplasia, Early Esophageal Adenocarcinoma
- Trial name
- ETMI (NCT00586989)
- Testing
- Upper endoscopy with biopsy
- Where
- 2 sites in United States, Netherlands
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Esophageal Adenocarcinoma, Barrett's Esophagus
Trial to Assess the Effects of an Antimicrobial Mouthwash on the Esophageal Microbiome
This is a randomized, open-label pilot study to assess whether treatment with chlorhexidine mouthwash can alter the esophageal and gastric cardia microbiome
- Conditions
- Esophageal Adenocarcinoma, Barrett's Esophagus, Reflux Esophagitis
- Trial name
- Mouthwash (NCT02513784)
- Testing
- Chlorhexidine gluconate
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Columbia University
Barrett's Esophagus, Esophageal Adenocarcinoma
Micro-RNA (miR) Expression in Upper Gastrointestinal Mucosal Tissue
This is a laboratory-based, exploratory study using tissue obtained from our clinical practice. The purpose of this study is to confirm our ability to characterize miR expression in various tissues (proximal and distal esophagus…
- Trial name
- NCT00909350
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Barrett Esophagus, Barrett Adenocarcinoma
Real-time Computer Aided Detection of Barrett's Neoplasia
In the real-time pilot study, the performance of a recently developed Computer Aided Detection (CADe) system will be investigated in 30 patients during real-time live endoscopic examination.
- Trial name
- NCT05628441
- Testing
- Computer Aided Detection system for Barrett's neoplasia
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Barrett Esophagus
High Resolution Virtual Chromoendoscopy Versus Seattle Protocol for the Surveillance of Barrett's Esophagus
The investigators hypothesize that careful examination of Barrett's esophagus by high-resolution endoscopy combined with virtual chromoendoscopy could replace the Seattle protocol for Barrett's esophagus monitoring and detection…
- Trial name
- CONVERSE (NCT05229783)
- Testing
- Electronic chromoendoscopy, White light endoscopy with Seattle protocol
- Where
- 15 sites in France
- Volunteers
- 110 people
- Sponsor
- Nantes University Hospital
Gastroesophageal Reflux, GERD
Influence of Central Obesity on the Esophageal Epithelial Barrier
This study is being done to help understand why some people with an increased amount of central obesity, without gastroesophageal reflux, develop changes to the lining of their esophagus that can potentially lead to esophageal…
- Trial name
- NCT02776982
- Testing
- Confocal endomicroscopy, Mucosal impedance, Research biopsies
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic