Clinical trials: Barrett Esophagus
Barrett Esophagus, Esophagus
TECR & ECM Placement for Esophageal High Grade Dysplasia
This study will test the safety and effectiveness of esophageal transoral endoscopic circumferential resection (TECR) using an extracellular matrix (ECM) placement to treat Barrett's esophagus in patients with high-grade…
- Conditions
- Barrett Esophagus, Esophagus, High Grade Dysplasia
- Trial name
- NCT02396745
- Testing
- Subjects undergoing TECR with ECM placement (ACell MatriStem, Boston Scientific WallFlex))
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Barretts Esophagus With High Grade Dysplasia
Calcium Electroporation in Patients With Cell Changes in the Esophagus
The aim of this first-in-man study is to evaluate the safety of calcium electroporation used in patients with Barrett's esophagus high-grade dysplasia through an endoscopic system.
- Trial name
- NCT04605419
- Testing
- Calcium electroporation
- Where
- Denmark
- Volunteers
- 6 people
- Sponsor
- Michael Patrick Achiam
Barrett's Esophagus
APE-Study: Ablation of Barrett's Mucosa vs. Surveillance Without Ablation in Patients Cured From Barrett's Cancer Combined With Randomization of Esomeprazole vs. Placebo for Symptomatic Reflux Control After Successful Barrett's Ablation
This is a prospective, randomized, controlled, double-blinded, multi-center trial in a parallel-group design. Aim of the study is the evaluation of tumor-free survival after ablation (by APC, argon plasma coagulation) of…
- Trial name
- APE (NCT00546065)
- Testing
- esomeprazole treatment
- Where
- Germany
- Volunteers
- 68 people
- Sponsor
- HSK Wiesbaden
Gastroesophageal Reflux Disease, Barrett Esophagus
The Johns Hopkins Heartburn Center Registry
A multi-center, multi-year registry of patients with gastroesophageal reflux disease (GERD) undergoing diagnostic evaluation and/or treatment of GERD and associated diseases and complications.
- Conditions
- Gastroesophageal Reflux Disease, Barrett Esophagus, Laryngopharyngeal Reflux, Esophagitis
- Trial name
- NCT03853772
- Where
- 9 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- Johns Hopkins University
Barrett's Esophagus
The Captivator EMR Registry
To confirm performance of the Captivator™ EMR device for resection of early neoplasia in Barrett's Esophagus.
- Trial name
- NCT02482701
- Testing
- Captivator™ EMR
- Where
- 13 sites in United States, Belgium and 4 more
- Volunteers
- 291 people
- Sponsor
- Boston Scientific Corporation
Oesophageal Cancer, Barrett Esophagus
Non-invasive Testing for Early oEesophageal Cancer and Dysplasia
This study aims to determine whether a breath test could be used for early detection of oesophageal cancer and Barrett's high grade dysplasia.
- Conditions
- Oesophageal Cancer, Barrett Esophagus, Barretts Esophagus With Dysplasia
- Trial name
- NEED (NCT04001478)
- Testing
- Breath test
- Where
- 12 sites in United Kingdom
- Volunteers
- 1,000 people
- Sponsor
- Imperial College London
Barrett's Esophagus, Radiofrequency Ablation
Radiofrequency Ablation in Patients With Barrett's Esophagus
The aim of this study is to establish a nationwide registry to collect data regarding the treatment of Barrett's Esophagus (BE) with radiofrequency ablation.
- Conditions
- Barrett's Esophagus, Radiofrequency Ablation, Gastroesophageal Reflux Disease
- Trial name
- RABE (NCT02793479)
- Where
- Austria
- Volunteers
- 500 people
- Sponsor
- Matthias Paireder
Barrett Esophagus
Healing of the Esophageal Mucosa After RFA of Barrett's Esophagus
Radiofrequency ablation (RFA) is a mainstay of treatment for patients who have Barrett's esophagus (BE) with dysplasia. For unclear reasons, Barrett's esophagus recurs after successful RFA treatment in approximately 1/3 of…
- Trial name
- NCT02688114
- Testing
- Baseline surveillance endoscopy, Radiofrequency ablation, Follow up endoscopy 1
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- Dallas VA Medical Center
Gastro Esophageal Reflux, Barrett Esophagus
Confocal Endomicroscopy for Permeability of Esophageal Wall in Refractory Gastroesophageal Reflux Disease (GERD)
Confocal Endomicroscopy for Permeability of Esophageal Wall in Refractory Gastroesophageal Reflux Disease (GERD)
- Conditions
- Gastro Esophageal Reflux, Barrett Esophagus, Erosive Esophagitis
- Trial name
- NCT03228407
- Testing
- Confocal endomicroscopy, Endoscopic biopsies, Mucosal impedance (MI)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- McGuire Research Institute
Barrett's Esophagus
Efficacy of CryoBalloon Focal Ablation System on Human Esophageal Barrett's Epithelium
The purpose of this study is to assess the efficacy and performance of the C2 Focal Cryoablation System in patients with BE.
- Trial name
- NCT02249975
- Testing
- C2 CryoBalloon Focal Ablation System
- Where
- 2 sites in Netherlands
- Volunteers
- 50 people
- Sponsor
- Pentax Medical
Barrett Esophagus
C2 CryoBalloon™ 180 Ablation System Dose De-escalation Study.
The primary objective is to determine the safety and efficacy of the C2 CryoBalloon 180 Ablation System ("CryoBalloon 180") used at decreasing doses in ablation naïve patients with low- or high-grade dysplastic Barrett's…
- Trial name
- NCT03311451
- Testing
- C2 CryoBalloon 180° Ablation System
- Where
- 6 sites in Netherlands
- Volunteers
- 62 people
- Sponsor
- Merit Medical Systems, Inc.
Esophageal Reflux, Barrett Esophagus
Histology Post-Endoscopic Eradication Therapy (EET)
This study is looking at a cohort of patients who have undergone treatment for Barrett's Esophagus (BE) and who have experienced complete eradication of the disease.
- Trial name
- NCT03375060
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Northwestern University
Barrett's Esophagus
Evaluation of a Miniaturized Microscope Device for the Detection of Barrett's Neoplasia: A Pilot Study
The overall objective of this study is to obtain data to evaluate whether high-resolution imaging of barrett's esophagus in vivo can assist clinicians in detecting dysplastic (precancerous) areas.
- Trial name
- NCT01384227
- Testing
- Proflavine Hemisulfate
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Anandasabapathy, Sharmila, M.D.
Barrett Esophagus, Esophageal Cancer
Microbiome Involvement With Barrett's Esophagus and Progression to Esophageal Adenocarcinoma
This study will examine the hypothesis that altered esophageal microbiome leads to the development of esophageal adenocarcinoma (EAC).
- Trial name
- NCT03216135
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Ochsner Health System
Gastroesophageal Reflux Disease, Hiatal Hernia
Nissen and Gastroplasty in Gastroesophageal Reflux Disease (GERD)
Laparoscopic Nissen Fundoplication has established itself as the procedure of choice in the surgical management of the majority of patients suffering from gastroesophageal reflux disease (GERD).
- Conditions
- Gastroesophageal Reflux Disease, Hiatal Hernia, Barrett's Esophagus, Esophagitis
- Trial name
- NCT00872755
- Testing
- Nissen, Gastropexy
- Where
- Greece
- Volunteers
- 90 people
- Sponsor
- G. Hatzikosta General Hospital
Barrett's Esophagus, Esophageal Cancer
TREAT-BE Study (Treatment With Resection and Endoscopic Ablation Techniques for Barrett's Esophagus)
A prospective outcomes study in patients with and esophageal cancer (EAC) and Barrett's esophagus (BE) associated neoplasia being evaluated for endoscopic eradication therapy (EET).
- Trial name
- NCT02634645
- Testing
- Endoscopic eradication therapies (EET), Esophagectomy, Chemotherapy
- Where
- 4 sites in United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Barrett Esophagus, Esophageal Adenocarcinoma
Barrett's Esophagus Patient Registry
The ultimate goal of the Barrett's Esophagus Patient Registry is to help develop more effective targeted screening strategies and treatment options for Barrett's esophagus and esophageal adenocarcinoma (EAC).
- Conditions
- Barrett Esophagus, Esophageal Adenocarcinoma, Gastroesophageal Reflux
- Trial name
- BPR (NCT01776346)
- Where
- United States
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Barrett's Esophagus
"Acetic Acid Chromoendoscopy in Barrett's Esophagus Surveillance
Neoplasia in Barrett's esophagus could be missed during routine random biopsies. We propose a study using chromoendoscopy with Acetic Acid to increase the yield of biopsies in detecting neoplasia.
- Trial name
- NCT02614703
- Testing
- Chromoendoscopy using Acetic Acid 2.5%, Standard random esophageal biopsies
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- DHR Health Institute for Research and Development
Esophageal Cancer, Precancerous Condition
Erlotinib in Treating Patients With Barrett Esophagus
RATIONALE: Chemoprevention is the use of certain drugs to keep cancer from forming. Erlotinib may keep esophageal cancer from forming in patients with Barrett esophagus by blocking some of the enzymes needed for cell growth.
- Trial name
- NCT00566800
- Testing
- erlotinib hydrochloride, laboratory biomarker analysis, biopsy
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Kansas City Veteran Affairs Medical Center
Barrett Esophagus, Esophageal Adenocarcinoma
Efficacy of EsoGuard on Samples Collected Using EsoCheck Versus EGD for the Diagnosis of BE
The study will assess the performance of the combined system, i.e., the use of the EsoGuard assay on cells collected using the EsoCheck 510(k) cleared device, to detect Barrett's Esophagus, with and without dysplasia, and/or…
- Conditions
- Barrett Esophagus, Esophageal Adenocarcinoma, Barretts Esophagus With Dysplasia, Barrett's Esophagus Without Dysplasia
- Trial name
- ESOGUARDBE1 (NCT04293458)
- Testing
- EsoGuard
- Where
- 27 sites in United States, Spain
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- Lucid Diagnostics, Inc.