Clinical trials: Baseline
Hiv, HIV-1-infection
Efficacy of Dolutegravir Plus Lamivudine in HIV-1-infected Treatment-naïve Adults Without a Baseline Genotyping Test
The purpose of this study is to evaluate the efficacy of DTG + 3TC versus DTG + TDF/FTC over 48 weeks in HIV-1 naive patients in a real life setting with no baseline HIV genotypic resistance testing available.
- Trial name
- D2ARLING (NCT04549467)
- Testing
- Lamivudine 300 MG, Emtricitabine / Tenofovir Disoproxil Pill
- Where
- Argentina
- Volunteers
- 244 people
- Sponsor
- Fundacion IDEAA
Relapsed/Refractory Diffuse Large B-Cell Lymphoma (DLBCL), Lymphoma
Hypofractionation Radiotherapy in Combination With Glofitamab in Relapsed/Refractory Diffuse B-cell Lymphoma With Baseline High Tumor Burden
Glofitamab has shown efficacy and safety in the treatment of patients with relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL) and has been approved for marketing in China.
- Trial name
- GLOHRT-01 (NCT06867536)
- Testing
- Glofitamab + Obinutuzumab
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Liling Zhang
Intellectual Disabilities
Reading Intervention for Children With Intellectual Disabilities Who Require Augmentative and Alternative Communication
The goal of this multiple single case study with multiple randomized baseline (with four starting points and 18 measurements across time) is to conduct a reading intervention for 40 children with intellectual disabilities who…
- Trial name
- NCT05709405
- Testing
- Reading intervention
- Where
- 2 sites in Norway
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ostfold University College
Blood Pressure
The Influence of Angiotensin Converting Enzyme Inhibitors and Angiotensin Receptor Blockers on Renal Function in Patients Undergoing Non-emergent Coronary Angiography
The aim of the current study is to evaluate prospectively whether concomitant administration of RAAS blockers (namely ACE-I and ARBs') influence the change in estimated GFR (eGFR) after administration of contrast media in…
- Trial name
- NCT01071642
- Testing
- stop ace-i/arb 24 h before procedure and restarted 24 hours after the procedure, ACE/ARB stopped 24 hours before procedure and start immediately after
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Soroka University Medical Center
Spondylitis, Ankylosing
Growth Factor Concentration to Predict an Ankylosing Spondylitis Patient's Response to Infliximab (Study P04041)(COMPLETED)
This is a Phase 4, multi-center, open-label, one-arm, pilot study in patients with active ankylosing spondylitis refractory to conventional treatment.
- Trial name
- NCT00779935
- Testing
- Remicade
- Volunteers
- 44 people
- Sponsor
- Merck Sharp & Dohme LLC
HIV Infection
Safety of Lopinavir/Ritonavir (Kaletra) in HIV/HCV Co-infected Subjects vs Baseline Liver Biopsy Metavir Score
The purpose of this study is to evaluate clinical response and safety of a Kaletra containing antiretroviral treatment regimen in HIV positive subjects with HCV coinfection.
- Trial name
- NCT00234975
- Testing
- Lopinavir/Ritonavir
- Where
- 11 sites in Puerto Rico
- Volunteers
- 86 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Depression
The Effect of Fluvoxamine on Polysonogram in Depressed Patients With Insomnia
Major depressive disorder is associated with several sleep Polysomnograph (PSG) findings: (1) impaired sleep continuity; (2) non-REM (NREM) changes; and (3) enhanced rapid eye movement (REM) sleep.
- Trial name
- NCT02442713
- Testing
- fluvoxamine
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Guang Dong Provincial Mental Health Institute
HIV-1-infection
Study to Compare Bictegravir/Lenacapavir Versus Current Therapy in People With HIV-1 Who Are Successfully Treated With a Complicated Regimen (ARTISTRY-1)
The goal of this clinical study is to learn more about the effects of switching to the study drugs, bictegravir (BIC) plus lenacapavir (LEN), versus current therapy (Phase 2) and BIC/LEN fixed-dose combination (FDC) versus…
- Trial name
- ARTISTRY-1 (NCT05502341)
- Testing
- Bictegravir, Lenacapavir, BIC/LEN FDC
- Where
- 94 sites in United States, Argentina and 13 more
- Volunteers
- 689 people
- Sponsor
- Gilead Sciences
Alzheimer Disease
Evaluation of Flortaucipir PET Signal and Cognitive Change in Early Alzheimer's Disease
This study will evaluate whether visual interpretation of flortaucipir-PET (positron emission tomography) scans, examining patterns of tracer uptake at baseline, can predict the rate of clinically-meaningful cognitive decline due…
- Trial name
- NCT03901105
- Testing
- flortaucipir F18, Brain PET Scan
- Where
- United States
- Volunteers
- 205 people
- Sponsor
- Avid Radiopharmaceuticals
Influenza
Annual Study to Investigate Inactivated Subunit Influenza Vaccine Due to New Virus Strains for the 09/10 Season
Influenza (flu) viruses change continuously, therefore also the parts of viruses used in influenza vaccines can vary from year to year.
- Trial name
- NCT00881842
- Testing
- Trivalent influenza subunit vaccine Influvac
- Where
- 2 sites in Belgium, Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Abbott Biologicals
Type 2 Diabetes Mellitus
Glycemic Holter Study (Continuous Glucose Monitoring) -
The study will assess glycemic variability and optimized glycemic control in T2DM patients treated with a DPP-4 inhibitor as add-on therapy to metformin.
- Trial name
- OPTIMA (NCT01193296)
- Testing
- Vildagliptin, Sitagliptin
- Where
- 7 sites in France
- Volunteers
- 36 people
- Sponsor
- Novartis
Rheumatoid Arthritis
EMDR for Persistent Pain in RA
Rationale: Around 20% of rheumatoid arthritis (RA) patients have persistent pain, despite having well-controlled disease activity.
- Trial name
- NCT05941559
- Testing
- EMDR
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Medisch Spectrum Twente