Clinical trials: Basic Physiology, open to volunteers
Dementia, Sleepiness
VR-based Multi-dimensional Intervention on Cognitive Function, With AI-agents
Virtual Reality-based multi-dimensional intervention for cognition and well-being will be provided to older adults, with AI-agents. The digital health intervention include physical activity, gamification, cognitive trainings.
- Conditions
- Dementia, Sleepiness, Mental Health, Alzheimer Disease
- Trial name
- NCT07064382
- Testing
- VR-based multi-dimensional intervention
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hong Kong University of Science and Technology
Healthy Volunteers
Acute Effects of High-intensity Interval Training With Mindfulness-based Recovery on Executive Function in Children
The goal of this randomized cross-over trial is to learn about the effect of a single bout of 20-min mindfulness-based high-intensity interval training (MF-HIIT), MF-only, and HIIT-only in relative to sitting rest on executive…
- Trial name
- NCT06270589
- Testing
- MF-HIIT, MF-only, HIIT-only
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Purdue University
Postpartum Physical Fitness and Functional Performance
Strong as a Mother
This study will evaluate Strong as a Mother, an existing community exercise program for women returning to exercise after childbirth.
- Trial name
- NCT07867275
- Testing
- Supervised Postpartum Functional Strength Training and Aerobic Conditioning
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Penn State University
Down Syndrome, Trisomy 21
Executive Function Play Opportunities for Children With Down Syndrome
The Executive Function Play Opportunities (EXPO) study is a sequential, multiple assignment, randomized trial (SMART) evaluating adaptive caregiver-mediated intervention pathways for improving executive function (EF) in children…
- Trial name
- EXPO (NCT07792382)
- Testing
- EXPO, EXPO Extended, EXPO Foundations
- Where
- 2 sites in United States, Italy
- Volunteers
- 150 people
- Sponsor
- Colorado State University
Mild Cognitive Impairment
Effectiveness of an ACT-Based Cognitive Intervention on Quality of Life and Cognitive Function in Elderly Residents With MCI
This study investigates the effects of an Acceptance and Commitment Therapy (ACT)-based cognitive intervention on Quality of Life (QOL) and cognitive function among elderly residents with Mild Cognitive Impairment (MCI) in…
- Trial name
- EACT (NCT06753578)
- Testing
- Acceptance and Commitment Therapy (ACT), standard care
- Where
- Spain
- Volunteers
- 215 people
- Sponsor
- Instituto de Investigación Marqués de Valdecilla
Chronic Neck Pain
Virtual Reality Program for Managing Chronic Neck Pain
The goal of this clinical trial is to find out if a virtual reality-based rehabilitation program developed by our team can help people with chronic neck pain.
- Trial name
- NCT07189052
- Testing
- Virtual Reality Rehabilitation, Conventional Rehabilitation
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Hacettepe University
Stroke
Efficacy of Personalized Repetitive Transcranial Magnetic Stimulation Protocol Based on Functional Reserve to Enhance Upper Limb Function in Subacute Stroke Patients
The objective of this study was to determine the effects of protocols of repetitive transcranial magnetic stimulation (rTMS) therapy based on the functional reserve of each hemiplegic stroke patient in subacute phase, compared to…
- Trial name
- NCT06270238
- Testing
- High-Frequency1, cTBS1, High-Frequency2
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- Samsung Medical Center
Cerebrovascular Circulation, Physiology
Assessment of the Relationship Between Cerebral Blood Flow and Heart Rate
The investigators will seek to determine the relationship between heart rate and middle cerebral artery (MCA) cerebral blood flow (CBF), as well as better understand the hemodynamic determinants of MCA CBF velocity.
- Trial name
- NCT04391465
- Testing
- Electrophysiological Pacing
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Calgary
Adolescent Mental Health, Adolescent - Emotional Problem
A Validation Study of the Neuro-cognitive Emotion Monitoring-Intervention (NEMO-I) Application in Adolescents
This study aims to evaluate the validity and effectiveness of NEMO-I (Neuro-cognitive Emotion Monitoring-Intervention), a mobile application designed to help adolescents monitor and manage their cognitive and emotional…
- Conditions
- Adolescent Mental Health, Adolescent - Emotional Problem, Cognition Improvement
- Trial name
- NCT07700264
- Testing
- NEMO-I (Neuro-cognitive Emotion Monitoring-Intervention)
- Where
- South Korea
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Seoul Women's University
CLL (Chronic Lymphocytic Leukemia)
CLL-IMPACT: A Clinical Nutrition Trial Investigating Immune and Metabolic Changes in Early-Stage CLL
The goal of this clinical trial is to investigate whether a short-term (4-week) whole-food, plant-based (WFPB) diet has an effect on metabolism, immune function, and disease activity in early-stage chronic lymphocytic leukemia…
- Trial name
- CLL-IMPACT (NCT07487428)
- Testing
- Diet
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Technical University of Munich
Multiple Sclerosis
Augmented Reality-Based Dual-Task Training in People With Multiple Sclerosis
Multiple Sclerosis (MS) is the most common NDD affecting young people worldwide. MS can seriously affect quality of life and hinder daily functional activities.
- Trial name
- MS (NCT07434934)
- Testing
- Augmented Reality Exercises
- Where
- United Arab Emirates
- Volunteers
- 40 people
- Sponsor
- University of Sharjah
Sickle Cell Disease
Blood Collection for Research Related to Certain Diseases Involving Blood Vessels
The collection of human specimens from both patients and healthy volunteers is necessary for the development of laboratory assays to further basic and clinical research studies.
- Trial name
- NCT00047996
- Where
- 2 sites in United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Cerebral Palsy (CP)
Neuromuscular Electrical Stimulation and Leap Motion-Based Exercises in Cerebral Palsy
Cerebral palsy (CP) is a group of disorders resulting from a permanent but non-progressive lesion in the developing brain, which affects the development of movement and posture and may lead to activity limitations.
- Trial name
- NCT07311018
- Testing
- Leap Motion-Based Exercise Program, NMES, Conventional Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Medipol University
Stroke, Hemiparesis
Assessment of a Physio-neuro Platform (SynPhNe) for Home-based Retraining of Hand Function in Stroke Survivors
The goal of this study is to: 1. Assess the usability of the SynPhNe device in a home environment. 2. Evaluate the efficacy of the SynPhNe home use device to improve motor hand function in chronic stroke subjects as compared to…
- Trial name
- NCT02896348
- Testing
- SynPhNe platform, Conventional therapy
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Spaulding Rehabilitation Hospital
Hypertension, Elevated Blood Pressure
Feasibility of a Community-Integrated Isometric Handgrip Exercise Program and Its Preliminary Effects on Blood Pressure and Cognitive Function in Older Adults
The goal of this clinical trial is to evaluate whether a short, supervised isometric handgrip exercise program is feasible and acceptable for older adults with elevated blood pressure or hypertension.
- Trial name
- NCT07648498
- Testing
- Zona Plus 4-Week Isometric Handgrip Exercise Intervention, Squegg 4-Week Isometric Handgrip Exercise Intervention
- Where
- 2 sites in Canada
- Volunteers
- 30 people
- Sponsor
- McMaster University
Healthy
Chatbot Intervention Effects on Resting-State Brain Function in Anhedonia
The main aim of the present study is to investigate the effects of a Motivational Interviewing-based artificial intelligence chatbot on resting-state brain function in college students with elevated anhedonia and depressive…
- Trial name
- NCT07665216
- Testing
- MI Chatbot Interaction, Active Control Chatbot Interaction
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Locally Advanced or Metastatic Urothelial Carcinoma
Neurological Function in Patients With Locally Advanced or Metastatic Urothelial Carcinoma Treated With Enfortumab Vedotin-Based Therapy
This prospective observational study aims to evaluate the correlation between neurological function and patient-reported symptoms of peripheral neuropathy (PN) in patients with locally advanced or metastatic urothelial carcinoma…
- Trial name
- NCT07072637
- Testing
- Neurological function assessment
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Asthma
Nutrition for Asthmatics
Determine to what extent three distinct dietary approaches improve asthma control and lung function.
- Trial name
- INHALE (NCT06151405)
- Testing
- DGA Diet, MCT Diet, KETO Diet
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Pennington Biomedical Research Center
Myocardial Infarction (MI), Cardiac Rehabilitation
Eccentric Exercise Rehabilitation After Myocardial Infarction
This clinical trial will evaluate a two-week eccentric exercise program conducted as part of comprehensive cardiac rehabilitation in patients after a heart attack (myocardial infarction).
- Trial name
- ECCENTRIC-MI (NCT07729410)
- Testing
- Standard Inpatient Cardiac Rehabilitation, Eccentric Cycling Exercise
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- Medical University of Gdansk
Perioperative Bleeding, Coagulopathy During Cardiac Surgery
Flow-Based Platelet Function Assessment Using Total Thrombus-Formation Analysis System (T-TAS) and Early Bleeding After Cardiac Surgery With Cardiopulmonary Bypass (CPB)
The goal of this observational study is to learn how flow-based platelet function measured with the Total Thrombus-formation Analysis System (T-TAS) relates to early postoperative bleeding in adults undergoing cardiac surgery…
- Conditions
- Perioperative Bleeding, Coagulopathy During Cardiac Surgery, Platelet Dysfunction, Cardiac Surgery
- Trial name
- TTAS-CPB (NCT07619261)
- Testing
- Total Thrombus-formation Analysis System (T-TAS)
- Volunteers
- 30 people
- Sponsor
- Hospital de la Santa creu i Sant Pau - Barcelona