Clinical trials: Basic Science
Heart Failure Acute, Point-of-care Ultrasound
Simulation-Based Cardiac Point-of-Care Ultrasound Program to Improve Clinical Outcomes in Acute Heart Failure Patients
The aim of this study is to co-design a cardiac POCUS simulation training intervention and implementation strategy for EM clinicians and evaluate the effectiveness of the cardiac point-of-care ultrasound (POCUS) simulation-based…
- Conditions
- Heart Failure Acute, Point-of-care Ultrasound, Simulation Training, Implementation Science
- Trial name
- NCT07592598
- Testing
- Simulation POCUS training, Clinical Practice Guidelines
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- Duke University
Cognitive Function, Functional Status
Implementing a Skills-Based Caregiver Training Program (Caregivers FIRST): Function QUERI 2.0
Implementing a Skills-Based Caregiver Training (Caregivers FIRST): Function QUERI 2.0 aims to compare implementation strategies for large-scale spread of Caregivers FIRST, a group training for friend or family caregivers of…
- Trial name
- NCT05319535
- Testing
- Implementation Strategy: Foundational REP, Implementation Strategy: Enhanced REP
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- VA Office of Research and Development
Firefighters
PeerOnCall: Implementing and Evaluating App-Based Peer Support in Canadian Fire Services
The goal of this clinical trial is to test how best to implement a mobile peer support app called PeerOnCall in Canadian fire services. The main questions it aims to answer are: 1.
- Trial name
- NCT07199387
- Testing
- App Users (Structured Implementation), App Users (Standard Implementation)
- Where
- Canada
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- McMaster University
Parenting, Gender-based Violence
Implementation Science and Impact Evaluation of PfR Programme: A Hybrid cRCT Design
The Implementation science and impact evaluation of PfR programme: A hybrid cRCT design study will use an effectiveness-implementation hybrid type 2 design to a) determine the effectiveness and cost-effectiveness of PfR, and b)…
- Conditions
- Parenting, Gender-based Violence, Child Maltreatment, IPV
- Trial name
- UPRISE (NCT05105373)
- Testing
- Parenting for Respectability
- Where
- Uganda
- Volunteers
- 3,162 people, healthy volunteers welcome
- Sponsor
- Makerere University
Child Behavior Disorders, Implementation Science
Pre-Implementation Enhancement Strategy To Improve Teachers' Intention to Implement Evidence-Based Practices
Background: As the most common setting where youth access behavioral health services, the education sector frequently employs training and follow-up consultation as cornerstone implementation strategies to promote the uptake and…
- Conditions
- Child Behavior Disorders, Implementation Science, Adolescent Problem Behavior at School, Healthcare Providers
- Trial name
- SC-PIES (NCT05240222)
- Testing
- Pre-implementation enhancement strategies (SC-PIES)
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Iowa
HIV, STI
HIV/STI Prevention Among Black Adolescents With Mental Illnesses (Project GOLD)
Despite advances in HIV/sexually transmitted infection (STI) prevention, Black youth account for the largest number of new HIV infections among heterosexual youth.
- Conditions
- HIV, STI, Emotional Disturbances, Mental Disorder
- Trial name
- NCT03348813
- Testing
- HIV/STI Prevention Intervention, General Health Control Intervention
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Mammography, Medical Overuse
A Multi-Level Strategy for De-implementing Mammography Overuse Among Older Women
This project aims to advance methodological and theoretical approaches for developing, selecting, refining, and piloting a multilevel de-implementation strategy to reduce the overuse of screening mammography in women aged ≥75…
- Conditions
- Mammography, Medical Overuse, Evidence-based Practice, Older Adults
- Trial name
- NCT07511621
- Testing
- Enhanced Usual Care (EUC), Multilevel De-Implementation Strategy
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Columbia University
Team-effectiveness Research, School-based Interventions
Enhancing Team Effectiveness for a Collaborative School-based Intervention for ADHD
The proposed project aims to integrate team-based implementation strategies with an established school-based intervention for children with ADHD, the Collaborative Life Skills Program (CLS), to enhance its implementation and…
- Conditions
- Team-effectiveness Research, School-based Interventions, Attention Deficit/ Hyperactivity Disorder, Implementation Science
- Trial name
- NCT06180681
- Testing
- Team-Enhanced Collaborative Life Skills Program, Standard Collaborative Life Skills Program
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- University of California, San Diego
Pleural Effusion
Clinical Implementation of the Use of Positive Pressure in Chest Drainage
Background: Scientific evidence appoints that the use of non-invasive positive airway pressure in pleural effusion drainage patients is associated with a reduction in these complications, as well as with other benefits.
- Trial name
- NCT03896672
- Testing
- Continuous Positive Airway Pressure
- Where
- Brazil
- Volunteers
- 64 people
- Sponsor
- Universidade Cidade de Sao Paulo
Obesity, Child
Scaling up Building Healthy Families
Evidence-based interventions for childhood obesity (EBI-CO) can improve children's weight status, but families in rural areas and small cities have limited access to the interdisciplinary healthcare teams recommended to deliver…
- Trial name
- NCT07404839
- Testing
- Building Healthy Families Program
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Utah
Insomnia, Behavioral Intervention
The Effectiveness of an Educational Intervention Based on Self-help for Sleep Hygiene Promotion on Patients With Insomnia
This plan will be implemented on the staff of the Qazvin University of Medical Sciences. The Insomnia Severity Index questionnaire will be used to screen for insomnia and low sleep health.
- Trial name
- NCT03605732
- Testing
- self help sleep hygiene intervention application, patients education
- Where
- Iran
- Volunteers
- 312 people
- Sponsor
- Qazvin University Of Medical Sciences
Healthy
Developing and Validating Food-based Dietary Guidelines and a Healthy Eating Index
Among several factors contributing to the occurrence of undernutrition, micronutrient deficiencies, overnutrition, and chronic disease, unhealthy diet is one of the most important factors that need to be addressed to tackle the…
- Trial name
- NCT03394963
- Testing
- Food-based dietary guidelines for healthier diet
- Where
- Ethiopia
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Ethiopian Public Health Institute
Software Evaluation for Visualizing Anatomical Structures That Are Not Typically Identified on Clinical MR Images
Accuracy Evaluation for SIS Software-based Visualization of Anatomical Brain Structures
SIS has developed a software technology, based on machine learning and image processing, designed to enhance standard clinical images for the visualization of anatomical structures.
- Trial name
- NCT02902328
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Surgical Information Sciences Inc.
Opioid-Dependence Among Adolescents
Science-Based Treatment for Opioid-Dependent Adolescents
The purpose of this study is to evaluate ways to optimize outcomes from combined behavioral-pharmacological treatment for opioid-dependent youth.
- Trial name
- NCT00182572
- Testing
- buprenorphine, naltrexone, behavior therapy
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- National Development and Research Institutes, Inc.
Implementation Science
An Exposure-Based Implementation Strategy to Decrease Clinician Anxiety Around Suicide Prevention
Study objectives are to design and pilot test a novel, exposure-based implementation strategy (EBIS) directly targeting clinician anxiety and low self-efficacy for use of evidence-based suicide screening, assessment, and…
- Trial name
- NCT05172609
- Testing
- Exposure Based Implementation Strategy (EBIS), Implementation as Usual (IAU)
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Cardiovascular Diseases, Physical Inactivity
MoST-Influenced Behavioral Intervention for Walking
This study is a randomized, factorial experiment using the basic Science of Behavior Change (SOBC) approach to efficiently test the effects of four distinct behavior change techniques (BCTs), goal setting, action planning, self…
- Trial name
- NCT05425641
- Testing
- Goal Setting, Action Planning, Self-Monitoring of Behavior
- Where
- United States
- Volunteers
- 606 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Neuropharmacological Investigation of Ayahuasca Constituents DMT and Harmine
Molecular Imaging Study of Harmine/DMT: a Basic Research Approach
The few reports on effects of psychedelic substances on cerebral metabolic rate (CMRglc) indicate increases (psilocybin; human FDG-PET) or decreases (LSD, rat autoradiography; 5-MeO-DMT rat autoradiography).
- Trial name
- HaD-PET (NCT06252506)
- Testing
- N,N-dimethyltryptamine (DMT) + harmine
- Where
- 2 sites in Switzerland
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
PTSD, Depression
Local Participatory Systems Dynamics to Increase Reach of Evidence Based Addiction and Mental Health Care
The most common reasons Veterans seek VA addiction and mental health care is for help with opioid and alcohol misuse, depression and PTSD.
- Conditions
- PTSD, Depression, Alcohol Use Disorder, Opioid Use Disorder
- Trial name
- NCT04356274
- Testing
- Participatory System Dynamics (PSD), Audit and Feedback (AF)
- Where
- United States
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- Palo Alto Veterans Institute for Research
Child Behavior Disorders
Teachers Leading the Frontlines (Tealeaf) - a Hybrid Effectiveness, Implement, and Context Trial
Purpose: The overall aim of this study is to evaluate the effectiveness, implementation, and contextual influences of a teacher-delivered transdiagnostic model of child mental health care (Tealeaf) for school-aged children in…
- Trial name
- Tealeaf (NCT05179759)
- Testing
- Tealeaf, Enhanced Usual Care
- Where
- India
- Volunteers
- 20,160 people
- Sponsor
- University of North Carolina, Chapel Hill
Substance Abuse
Efficacy of Centervention-ATOD: An Implementation Tool for Dissemination of Evidence-based Programs for Substance Abuse
The pilot test of Centervention-ATOD, a customizable suite of online tools specifically designed to support quality implementation and sustainability of any ATOD-EBP within real-world service settings, will evaluate whether the…
- Trial name
- CV-ATOD (NCT03084406)
- Testing
- Centervention-ATOD (CV-ATOD)
- Where
- United States
- Volunteers
- 327 people, healthy volunteers welcome
- Sponsor
- 3-C Institute for Social Development