Clinical trials: Basic Science
AI (Artificial Intelligence)
Scientific Validity Assessment and Optimization of AI-Generated A3/A4 Type Questions for the Chinese Medical Licensing Examination
This is a cross-sectional study that primarily employs quantitative analysis, supplemented by qualitative assessment. The research is conducted in two stages: Phase I consists of a model performance comparison experiment, and…
- Trial name
- NCT07505862
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Guangdong Provincial People's Hospital
Substance Use Disorders, Substance-Related Disorders
Socializing a Science-Based Digital Therapeutic for Substance Use Disorders
The purpose of this study is to evaluate the effectiveness of an intervention delivered on a smartphone. This study examines whether this intervention might improve treatment outcomes for people with substance use disorders.
- Trial name
- NCT05648786
- Testing
- Laddr® plus Behavioral- Group and individual counseling, Behavioral- Group and individual counseling
- Where
- United States
- Volunteers
- 189 people
- Sponsor
- Square2 Systems, Inc.
Back Pain Lower Back Chronic
The Impact of an Instructional Web-based Healthcare App for Relieving Back Pain From Spinal Compression Fractures
With the expected rise of patients with osteoporosis-induced fractures, it has become increasingly urgent to design and use specialized health education materials aimed at easing pain and improving bodily functions
- Trial name
- NCT05386212
- Testing
- web app healthcare instructions for relieving back pain
- Where
- 3 sites in Taiwan
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- National Taipei University of Nursing and Health Sciences
Physiotherapy
Scientific Content Disseminated Via Social Media for Physiotherapists
This study is designed to assess how effective social media is in disseminating scientific knowledge to physiotherapists in Brazil.
- Trial name
- ASTEROID (NCT06605040)
- Testing
- Dissemination via Social Media, Dissemination via Email
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- Universidade Federal de Santa Maria
Inappropriate Prescribing, Implementation Science
Reduction of Low-value Prescribing Through Audit and Feedback
The objective is to estimate the effect attributable to a primary care pharmacist-led audit and feedback (AF) strategy compared to the currently used AF strategy as a management tool to evaluate healthcare performance focusing on…
- Conditions
- Inappropriate Prescribing, Implementation Science, Behavioral Sciences
- Trial name
- AFFAP (NCT07336550)
- Testing
- Usual AF, Facilitated AF
- Where
- Spain
- Volunteers
- 540 people, healthy volunteers welcome
- Sponsor
- Basque Health Service
Burnout, Professional, Resilience, Psychological
Web-based Implementation for the Science of Enhancing Resilience Study
Resilience means a healthcare provider's ability to cope, recover, and learn from stressful events, as well as their access to resources that promote health and well-being.
- Trial name
- WISER (NCT02603133)
- Testing
- Three Good Things, Gratitude, Random Acts of Kindess
- Where
- 9 sites in United States
- Volunteers
- 2,650 people, healthy volunteers welcome
- Sponsor
- Stanford University
Cystinosis, Primary Hyperoxaluria
Genetic Newborn Screening for Cystinosis and Primary Hyperoxaluria
In Germany parents of newborns are offered newborn screening (NBS) for 17 congenital diseases as a standard benefit of statutory health insurance. NBS in Germany is voluntary. Cystinosis and hyperoxaluria are very rare diseases.
- Trial name
- GENESIS (NCT05843851)
- Testing
- Diagnostic test
- Where
- Germany
- Volunteers
- 200,000 people
- Sponsor
- Cystinose Stiftung
Sports Performance, Sports Nutritional Sciences
Effect of Infusion of Yerba Mate on Oxidative Stress, Physiology, and Performance of Trained Cyclists
This project comes forward with investigations regarding the use of yerba mate infusion in sports performance, providing new knowledge about the effects of its consumption on the performance of trained individuals, thus…
- Conditions
- Sports Performance, Sports Nutritional Sciences, Endurance Performance
- Trial name
- NCT04642144
- Testing
- Yerba mate infusion, Carbohydrate meal
- Where
- Brazil
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Santa Catarina
Chronic Low-back Pain (cLBP)
Pain Phenotypes in Individuals With Chronic Low Back Pain
This observational cross-sectional study aims to determine pain phenotypes in individuals with chronic low back pain (CLBP). Participants will be classified according to a mechanism-based clinical pain phenotyping algorithm as…
- Trial name
- NCT07766200
- Testing
- Pain classification method
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Kutahya Health Sciences University
Health Knowledge, Attitudes, Practices
The Science Tooth Fairy: A Randomized Trial of a Storytelling-Based Educational Intervention to Promote Primary Tooth Donation in a Pediatric Setting
Study Overview Primary ("baby") teeth are unique biological samples because they can permanently store information about a child's early life health and development.
- Trial name
- STF RCT (NCT07711301)
- Testing
- Science Tooth Fairy Narrative, Cavities vs. Toothpaste, book by Didi Dragon
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Physical Inactivity, Dyslipidemia
Implementation Facilitation of Exercise is Medicine Greenville
A public health priority exists for the U.S. healthcare sector to integrate physical activity (PA) as a part of the patient care model.
- Conditions
- Physical Inactivity, Dyslipidemia, Obesity and Overweight, Hypertension
- Trial name
- NCT07340580
- Testing
- Clinic Implementation Facilitation
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Adolescent HIV Infection, Transition to Adult Care
Scale-up of an Evidence-based Adolescent Transition Package to Support Transitional Care Among Youth Living With HIV
Ending the HIV epidemic for youth living with HIV will require implementation and optimization of evidence-based interventions that address barriers to treatment.
- Conditions
- Adolescent HIV Infection, Transition to Adult Care, Implementation Science, Implementation Strategies
- Trial name
- ATTACH-Scale (NCT06924073)
- Testing
- ATP-Youth Enhanced Strategy (ATP-YES)
- Where
- 25 sites in Kenya
- Volunteers
- 1,920 people, healthy volunteers welcome
- Sponsor
- University of Washington
Chemotherapy-induced Peripheral Neuropathy (CIPN)
Topical Herbal Medicine for Chemotherapy-Induced Peripheral Neuropathy
The goal of this clinical trial is to learn if menthol works to relieve chronic neuropathic pain and chemotherapy-induced peripheral neuropathy (CIPN).
- Trial name
- NCT07693387
- Testing
- menthol-based hand and foot gloves
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Taiwan Municipal An-Nan Hospital-China Medical University
Health Education
The Effect of Education Based on Roy Adaptation Model for Infertile Individuals on Adaptation and Coping With Stress
Psychosocial counseling applied together with infertility treatment programs makes infertile women more resistant to stress, increases the effectiveness of infertility treatments and encourages infertile patients to continue…
- Trial name
- NCT04741867
- Testing
- Education
- Where
- Turkey (Türkiye)
- Volunteers
- 61 people
- Sponsor
- Gaziantep Islam Science and Technology University
Implementation Science, Delirium
Behavioral Economic & Staffing Strategies in the ICU
The overarching goal of this study is to support the "real world" assessment of strategies used to foster adoption of several highly efficacious evidence-based practices in healthcare systems that provide care to critically ill…
- Conditions
- Implementation Science, Delirium, Critical Illness, Mechanical Ventilation Complication
- Trial name
- BEST-ICU (NCT06184945)
- Testing
- Realtime audit and feedback, RN Implementation Facilitator
- Where
- 3 sites in United States
- Volunteers
- 16,500 people
- Sponsor
- University of Nebraska
Hematologic Cancer, Acute Myeloid Leukaemia (AML)
Home-based Intravenous Cytarabine Treatment for Acute Myeloid Leukemia: a National Danish Study of Feasibility, Costs, and Implementation
The goal of this observational multicenter feasibility and implementation study is to evaluate home-based treatment with intravenous Cytarabine for patients with acute myeloid leukemia in Denmark.
- Conditions
- Hematologic Cancer, Acute Myeloid Leukaemia (AML), Hospital At Home, Home-based Chemotherapy
- Trial name
- HOME-CALM (NCT07802015)
- Volunteers
- 80 people
- Sponsor
- Zealand University Hospital
Anxiety Symptoms, Post-traumatic Stress Symptoms
Improving Student Mental Health Through a Universal Trauma-Informed Intervention
The goal of this trial is to identify the most effective ways for schools to deliver RAP Club, a universal school-based mental health intervention.
- Conditions
- Anxiety Symptoms, Post-traumatic Stress Symptoms, Depressive Symptoms, Behavioral Problems
- Trial name
- PPP (NCT07842432)
- Testing
- RAP Club Delivered by a School Clinician, RAP Club Delivered by a Teacher, Standard Supervision
- Where
- 3 sites in United States
- Volunteers
- 960 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Basic Science
A Mass Balance Study Of 14C-RAY1225 Injection In Healthy Chinese Participants
This is an open-label, single-center, single-dose study.
- Trial name
- NCT07460284
- Testing
- 14C-RAY1225
- Where
- China
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Guangdong Raynovent Biotech Co., Ltd
Sleep Disturbances, Insomnia
Home-Based Auricular Transcutaneous Vagus Nerve Stimulation (tVNS) for Sleep Quality and Psycho-Academic Outcomes in Health Sciences Students
This study aims to evaluate the efficacy, safety, and feasibility of a home-based auricular transcutaneous vagus nerve stimulation (tVNS) program in Health Sciences university students with poor sleep quality.
- Conditions
- Sleep Disturbances, Insomnia, Stress
- Trial name
- NEUROSLEEP (NCT07371715)
- Testing
- Auricular Transcutaneous Vagus Nerve Stimulation (tVNS)
- Volunteers
- 60 people
- Sponsor
- University of Malaga
Depression, Problematic Alcohol Use
Scaling Up Science-based Mental Health Interventions in Latin America
Conduct systematic, multi-site mental health implementation research in both rural and urban primary care settings with a broad group of stakeholders in the US and Latin America.
- Trial name
- DIADA (NCT03392883)
- Testing
- Laddr
- Where
- 6 sites in Colombia
- Volunteers
- 1,348 people
- Sponsor
- Dartmouth-Hitchcock Medical Center