Clinical trials: Basic Science
Basic Science
Acute Effects of Maximal Exercise on Balance and Cognitive Domains in Young Men
The project involves conducting a series of motor, physiological, biochemical, and psychological tests. The series of tests within the experiment will assess the effect of a single aerobic exercise (graded test) on changes in…
- Trial name
- NCT07453043
- Testing
- maximal exercise
- Where
- Poland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University School of Physical Education, Krakow, Poland
Sepsis
Implementation and Effectiveness of Engagement and Collaborative Management to Proactively Advance Sepsis Survivorship
The purpose of this study is to evaluate if implementation of the Sepsis Transition and Recovery (STAR) program within a large healthcare system will improve outcomes for high-risk patients with suspected sepsis, while…
- Trial name
- ENCOMPASS (NCT04495946)
- Testing
- Sepsis Transition and Recovery (STAR) program, Usual care
- Where
- United States
- Volunteers
- 3,894 people
- Sponsor
- Wake Forest University Health Sciences
Psychological Trauma, Mental Health
Collaborative Organizational Approach to Selecting and Tailoring Implementation Strategies
The purpose of this study is to partner with the North Carolina Child Treatment Program (NC CTP) and the SAMHSA-funded National Child Traumatic Stress Network (NCTSN) to develop and pilot the Collaborative Organizational Approach…
- Trial name
- COAST-IS (NCT03799432)
- Testing
- COAST-IS, TF-CBT Learning Collaborative
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Chronic Kidney Disease, Type 2 Diabetes
RAndomized EHR-based Prescribing to Improve Disease-modifying Therapies for Cardio-Kidney-Metabolic Care (RAPID-CKM)
The goal of this pragmatic randomized clinical trial is to determine whether an Epic-based clinician notification increases initiation of guideline-directed cardio-kidney-metabolic (CKM) therapies in adults with type 2 diabetes…
- Trial name
- NCT07605390
- Testing
- Epic-Based Clinician Notification, Usual Care
- Where
- 2 sites in United States
- Volunteers
- 600 people
- Sponsor
- Baylor Research Institute
Control Condition, Intervention Condition
Extending the Reach of Evidence-based Practices to Support Student's Attention and Behavior Through Technology
The purpose of this study is to integrate digital health (dHealth) technology into the Collaborative Life Skills Program (CLS), an established, school-based behavioral intervention for students with ADHD, to make the program…
- Trial name
- CLS-D (NCT06886217)
- Testing
- Collaborative Life Skills dHealth tool (CLS-D)
- Where
- United States
- Volunteers
- 216 people
- Sponsor
- San Diego State University
Chronic Pain, Depression, Anxiety
Cognitive Behavioral Therapy and Real-Time Pain Management Intervention for Sickle Cell Via Mobile Applications
The investigators are conducting a comparative effectiveness trial among adult patients with sickle cell disease (SCD) who report chronic pain (N = 350), randomized to receive either mobile phone-delivered computerized cognitive…
- Conditions
- Chronic Pain, Depression, Anxiety, Opioid Use
- Trial name
- CaRISMA (NCT04419168)
- Testing
- cCBT, m-Education
- Where
- 7 sites in United States
- Volunteers
- 359 people
- Sponsor
- University of Pittsburgh
Neonatal Death, Perinatal Death
CHV-NEO: Community-based Digital Communication to Support Neonatal Health
Neonatal mortality (defined as death in the first 28 days of life) remains unacceptably high in sub-Sarahan Africa. The concentrated risk of neonatal illness in the first weeks of life and its potential to rapidly deteriorate…
- Trial name
- NCT05187897
- Testing
- CHV-NEO
- Where
- Kenya
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- University of Washington
Implementation Science, Transportation of Patients
Implementation Study of Intra-hospital Transfer of Pediatric Inpatients
This study implemented the "Clinical Practice Guidelines for In-hospital Transfer of Pediatric Inpatients (2023 edition)" released by the research team in June 2023 in real clinical settings.
- Trial name
- NCT06512805
- Testing
- Routine transport, Post-guideline transfer
- Where
- China
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Fudan University
Dietary Intakes, Physical Activity
Implementing Modified Practices to Leverage Evidence for Movement, Engagement, and Nutrition Topics in Early Childcare and Education
The goal of this cluster-randomized, controlled trial is to learn if a professional development program for childcare educators, called the Boston Healthy Child Care Initiative, can help improve the nutritional quality of…
- Conditions
- Dietary Intakes, Physical Activity, Child Care, Early Education
- Trial name
- IMPLEMENT (NCT07874295)
- Testing
- Boston Healthy Child Care Initiative
- Where
- United States
- Volunteers
- 456 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Child Abuse, Decision Making
K-ORCA: Testing a Decision Support Tool and Group Process for Selecting Interventions
This proposal responds to NIMH Objective 4.2.c to develop "decision-support tools and technologies that increase the effectiveness and continuous improvement of mental health interventions" by leveraging the Family First…
- Conditions
- Child Abuse, Decision Making, Child Welfare, Decision Making, Shared
- Trial name
- K-ORCA (NCT06375551)
- Testing
- Optimizing Responses with Collaborative Assessments-Automated (ORCA-A), Optimizing Responses with Collaborative Assessments-Live (ORCA-L)
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Chestnut Health Systems
Cancer, Thoracic Cancer
Fatigue and Molecular Mechanisms in Cancer Patients Receiving CCRT
Cancer-related fatigue (CRF) is a significant problem for cancer patients. This prospective, basic science, observational study will evaluate for changes in CRF associated with molecular characteristics prior to, during, and at…
- Conditions
- Cancer, Thoracic Cancer, Gynecologic Cancer, Head and Neck Cancer
- Trial name
- NCT06633224
- Testing
- Blood Specimen Collection, Stool Specimen Collection, Quality of Life (QOL) Questionnaires
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- University of California, San Francisco
Basic Science
Factors Affecting Sensory and Motor Learning
How participants perceive the position of their own hand in various contexts will be examined. This will include changing the visual display to suggest the hand is in a slightly different position, and asking participants to…
- Trial name
- NCT05374460
- Testing
- Explanatory diagram, Direct vision, Movement feedback, target hand
- Where
- United States
- Volunteers
- 389 people, healthy volunteers welcome
- Sponsor
- Indiana University
Postoperative Delirium
The Role of Remazolam in Reducing the Incidence of Postoperative Delirium in Elderly Patients
This study is a prospective, randomized, controlled trial.The selected patients were randomly divided into remazolam general anesthesia group and propofol + midazolam general anesthesia control group according to computer…
- Trial name
- NCT05466279
- Testing
- remazolam, Propofol, Midazolam
- Where
- China
- Volunteers
- 131 people
- Sponsor
- Fang Jun
Community Dwelling
Effectiveness of Basic Life Support Training for Rural Community Dwelling Elderly
The goal of this pre-post study is to test the effectiveness of basic life support (BLS) training for rural community-dwelling Elderly.
- Trial name
- NCT05814120
- Testing
- BLS training program
- Where
- Taiwan
- Volunteers
- 218 people, healthy volunteers welcome
- Sponsor
- Chang Gung University of Science and Technology
Basic Science, Intervention Studies
Comprehensive Multi-omics Characterization and Implications of Non-Pharmaceutical Dental Hygiene Product in a Randomized Controlled Large Population Study.
The goals of this clinical study are: 1. Survey approximately 600 persons between the ages of 18-80 regarding their medical history \& oral hygiene habits, diet \& exercise habits, and emotional \& physical stressors to…
- Conditions
- Basic Science, Intervention Studies, Biomarker Discovery
- Trial name
- NCT07451782
- Testing
- Oral Lozenges (Tradename pHossident), Water additive (Tradename Protektin)
- Where
- United States
- Volunteers
- 595 people, healthy volunteers welcome
- Sponsor
- Delta Dental of Minnesota Foundation
Disaster Readiness Among Health Science Students
The Effect of Virtual Reality-Based Disaster Training on Disaster Readiness of Health Science Students
This study evaluated the effect of three-dimensional (simulations) virtual reality-based disaster training with simulation on disaster readiness among health science students. The study used a randomized controlled design.
- Trial name
- VR-DT-DRHSS (NCT07886866)
- Testing
- simulations Virtual Reality-Based Disaster Training With Simulation
- Where
- Saudi Arabia
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Vision College - Riyad
Traumatic Brain Injury
A TMU/NIH Integrated Research Project Translation of Basic Research to Clinical Diagnosis and Treatment of Mild Traumatic Brain Injury (mTBI)
This integrated research project is cooperated by an fully-experienced team of Taipei Medical University and National Institutes of Health.
- Trial name
- NCT01266356
- Where
- Taiwan
- Volunteers
- 500 people
- Sponsor
- Taipei Medical University WanFang Hospital
Inflammatory Bowel Diseases, Crohn Disease
Quantify the Value of Transmural Inflammation in the Treatment of Crohn's Disease With Ustekinumab:an Analysis Based on Imaging Science
Crohn's disease(CD),a type of inflammatory bowel disease(IBD), is a chronic intestinal recurrent inflammatory disease involving the entire digestive tract.
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Biologics
- Trial name
- NCT05642247
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Endometriosis
" Development of Primary Cultures of Diaphragmatic Myoblasts for Basic Research Purposes "
Neuromuscular diseases (NMDs) affecting motor neurons (MN) induce progressive muscle denervation, and become fatal when respiratory muscles e.g. the diaphragm are affected and can no longer contract.
- Trial name
- MYODiaph (NCT07380308)
- Testing
- During the surgery planned as part of the routine care of the patient, a part of the tissue sample will be saved in order to carry out the analysis planned for the research.
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Vaccine Refusal
Clinic-based HPV and COVID-19 Vaccine Promoting Intervention for AfAm Adolescents in Alabama
In this 30-month study, the investigators propose to develop a culturally appropriate vaccine confidence intervention, targeting positive change related to HPV vaccine uptake behavior and reducing sentiments of hesitancy towards…
- Trial name
- NCT04604743
- Testing
- Intervention, TBN
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham