Clinical trials: Basic Science
Headache
Carbachol´s Headache Inducing Characteristics and Effects on the Cerebral Blood Flow
To investigate headache score and accompanying symptoms during and after infusion of carbachol.
- Trial name
- NCT00357864
- Testing
- carbachol
- Where
- Denmark
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Substance Use, Substance-Related Disorders
Clinician Practice Companion to Address Youth Substance Use
Substance use, including the use of opioids, cannabis, and other drugs, is common among adolescents and young adults, and overdose has become a leading cause of death among youth in Canada and the United States.
- Conditions
- Substance Use, Substance-Related Disorders, Adolescent Substance Use, Cannabis Use
- Trial name
- NCT07725289
- Testing
- Practice Companion
- Where
- 5 sites in United States, Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Prostate Cancer, Risk Assessment
PROstate Cancer Risk Calculator for ACTionable Clinical Decision-making in Nigeria
This study is a pilot trial that builds on findings from the validation of prostate cancer risk calculators in Nigerian men. The goal of the overall study is to improve the early detection of prostate cancer in a high-risk…
- Conditions
- Prostate Cancer, Risk Assessment, Clinical Decision Support Systems, Predictive Value of Tests
- Trial name
- PROACT (NCT07733440)
- Testing
- (a) Training and (b) Supported risk assessment
- Where
- Nigeria
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Ahmadu Bello University
Diabetes, Pharmacist-Patient Relations
Refinement and Testing of Recruitment Methodology for Behavioral Medication Adherence Interventions Using Behavioral Science-based Approaches
The overarching goal of the proposed research is to prepare the clinical pharmacist intervention for sustainable implementation and dissemination.
- Conditions
- Diabetes, Pharmacist-Patient Relations, Medication Adherence
- Trial name
- STIC2IT-2 (NCT06569290)
- Testing
- Primer postcard, Control recruitment letter, Behavioral theory-informed recruitment letter (prospect theory)
- Where
- United States
- Volunteers
- 590 people
- Sponsor
- Brigham and Women's Hospital
Basic Science
A Study to Assess the Effect of Olpasiran on QT/QTc Intervals in Healthy Participants
The primary objective of the study is: To assess the effects of a single therapeutic and supratherapeutic dose of olpasiran on the placebo-corrected change from baseline in QT corrected for heart rate (ΔΔQT)/QTc interval in…
- Trial name
- NCT06411860
- Testing
- Olpasiran, Moxifloxacin
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Amgen
Hemiparesis, Stroke
Transforming Robot-mediated Telerehabilitation: Citizen Science for Rehabilitation
The purpose of this study is to advance upper limb robot-mediated tele-rehabilitation for patients recovering from stroke by empowering them through active science participation.
- Trial name
- NCT03096262
- Testing
- Citizen Science intervention using kinect
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Papillomavirus Vaccines, HPV Vaccines
HPV Vaccine Integrated Service Implementation Research in Ethiopia
The goal of this implementation research study is to understand whether a package of community-based interventions can increase access to and uptake of the human papillomavirus (HPV) vaccine among very young adolescent girls in…
- Conditions
- Papillomavirus Vaccines, HPV Vaccines, HPV Vaccine Acceptability, HPV Vaccine Attitudes
- Trial name
- HPV-VISION (NCT06667323)
- Testing
- Integrated health service delivery for very young adolescent girls
- Volunteers
- 1,140 people, healthy volunteers welcome
- Sponsor
- Population Services International
Pregnancy Complications, Preterm Labor
Strengthening Facility-based Intrapartum/Immediate Newborn Care to Reduce Mortality of Preterm Infants in Migori County, Kenya and Busoga Region, Uganda
The purpose of this study is to determine whether a combination of evidence-based strategies can improve intrapartum and newborn care in facilities to reduce mortality among preterm infants.
- Conditions
- Pregnancy Complications, Preterm Labor, PreTerm Birth, Stillbirth
- Trial name
- PTBi-KE-UG (NCT03112018)
- Testing
- data strengthening, modified Safe childbirth checklist - control, modified Safe childbirth checklist - enhanced
- Where
- 2 sites in Kenya, Uganda
- Volunteers
- 102,988 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Hypertension, Prehypertension
UH3 Phase - Mindfulness-Based Blood Pressure Reduction (MB-BP) : Stage 2a RCT
The primary aim is to identify the impacts of a behavioral intervention called "Mindfulness-Based Blood Pressure Reduction" (MB-BP) vs.
- Trial name
- MB-BP (NCT03859076)
- Testing
- MB-BP, Enhanced Usual Care Control
- Where
- United States
- Volunteers
- 119 people
- Sponsor
- Brown University
Depression, Tuberculosis
Effectiveness and Cost-Effectiveness of Depression Treatment for Individuals With TB in South Africa
This hybrid type I effectiveness-implementation trial will increase understanding of the effectiveness and cost-effectiveness of integrating a brief evidence-based treatment for major depressive disorder (MDD) within the…
- Trial name
- NCT05091580
- Testing
- Interpersonal Counseling, Enhanced treatment as usual
- Where
- South Africa
- Volunteers
- 500 people
- Sponsor
- New York State Psychiatric Institute
Migraine Disorders, Headache Disorders
Predicting Migraine Attacks Based on Environmental and Behavioral Changes as Detected From the Smartphone
This study is conducted at the Henry Ford Health System with Lifegraph's behavioral monitoring technology, to examine the relation between migraine attacks and behavioral and environmental changes as detected from the smartphone…
- Conditions
- Migraine Disorders, Headache Disorders, Headache Disorders, Primary, Brain Diseases
- Trial name
- Migraine (NCT03762902)
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Lifegraph Ltd.
Healthy Volunteers, no Condition, Basic Science
Transcranial Ultrasonic Neuromodulation of Primary Visual Cortex and Primary Auditory Cortex in Humans
There are a number of disorders of the brain that have limited treatment options, such as chronic pain, addiction, and major depression.
- Trial name
- NCT07508722
- Testing
- Transcranial Focused Ultrasound Stimulation, Electroencephalography, Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Massachusetts Institute of Technology
CRBSI - Catheter Related Bloodstream Infection, Evidence-based Nursing Practice
Multicenter Clinical Translational Study of "ICU-NO CRBSI" Based on Improvement Science
The goal of this type of study is to construct the continuous quality promotion project "ICU-NO CRBSI(Catheter-Related Bloodstream Infection , CRBSI)" based on improvement science, and to verify its effect in the prevention of…
- Conditions
- CRBSI - Catheter Related Bloodstream Infection, Evidence-based Nursing Practice, Central Venous Catheter Related Bloodstream Infection, Central Venous Catheter Associated Bloodstream Infection
- Trial name
- NCT06085690
- Testing
- evidence-based intervention Plan for the Prevention of CRBSI in ICU patients
- Where
- China
- Volunteers
- 8,050 people, healthy volunteers welcome
- Sponsor
- Fudan University
HIV Infections
Scientific Evaluation of Peer Education and STD Treatment to Reduce the Spread of HIV in Zimbabwe
The purpose of this study is to determine whether community-based peer education and condom distribution combined with improved treatment of sexually transmitted infections are effective in reducing the spread of HIV infection in…
- Trial name
- NCT00390949
- Testing
- Peer education among commercial sex workers and clients, Condom distribution and promotion, Syndromic treatment of sexually transmitted infections
- Where
- Zimbabwe
- Volunteers
- 9,454 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Early Ambulation
Implementing a Hospital-Based Walking Program (STRIDE): Function QUERI 2.0
Implementing a Hospital-Based Walking Program (STRIDE): Function QUERI 2.0 aims to compare implementation strategies for large-scale spread of STRIDE, a supervised walking program for hospitalized older Veterans.
- Trial name
- STRIDE (NCT04868656)
- Testing
- Implementation Strategy: Foundational Support, Implementation Strategy: Enhanced Support
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- VA Office of Research and Development
Polycystic Ovary Syndrome
Clinical and Basic Research on the Treatment of Polycystic Ovary Syndrome
Polycystic ovary syndrome is the most common endocrine and metabolic disorder in gynecology. Traditional Chinese medicine has a good clinical effect in the treatment of PCOS.
- Trial name
- NCT04120597
- Testing
- Zishen Qingre Lishi Huayu Granules
- Where
- China
- Volunteers
- 126 people
- Sponsor
- Jiangxi University of Traditional Chinese Medicine
Mindfulness, Psychological Distress
Brief Mindfulness-Based Intervention to Reduce Psychological Distress in Health Sciences Students
This project aims to evaluate the effectiveness of a brief mindfulness-based intervention in reducing psychological distress among first-year health sciences students at the Universidad Nacional Mayor de San Marcos.
- Trial name
- NCT06777407
- Testing
- Brief Mindfulness-Based Intervention to Reduce Psychological Distress, Psychoeducational brochure
- Where
- Peru
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National University of San Marcos, Peru
Child Maltreatment
Effectiveness and Cost-effectiveness of Coaching Models to Promote Implementation of an Evidence-based Parenting Program
The proposed study will compare purveyor coaching (conducted by National SafeCare Training and Research Center (NSTRC)) to local coaching that is supported by the purveyor (NSTRC).
- Trial name
- NCT01791777
- Testing
- SafeCare Coaching
- Where
- 10 sites in United States
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- Georgia State University
Basic Science: Visual Attention in Healthy Participants, Basic Science: Neural Representations of Location
Probing the Role of Feature Dimension Maps in Visual Cognition: Impact of Task Demands (Expt 2.1)
How does one know what to look at in a scene? Imagine a "Where's Waldo" game - it's challenging to find Waldo because there are many 'salient' locations in the picture, each vying for one's attention.
- Trial name
- NCT06281457
- Testing
- Stimulus properties: task-defining feature
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of California, Santa Barbara
Cell Physiology Education
RGE-Based Cell Physiology Education for International Medical Students
This study evaluated an integrated active-learning approach for teaching cell physiology to international medical students at Tehran University of Medical Sciences.
- Trial name
- NCT07885553
- Testing
- RGE-Based Cell Physiology Education
- Where
- Iran
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Tehran University of Medical Sciences