Clinical trials: Basic Science
Opioid Use Disorder
MBC2OTP Project (Measurement-Based Care Implementation in Community Opioid Treatment Programs)
The goal of this clinical trial is to evaluate the effectiveness and implementation of measurement-based care, which involves the systematic use of client self-report data to inform and enhance treatment, in opioid treatment…
- Trial name
- MBC2OTP (NCT06345274)
- Testing
- Measurement Based Care Training and Monthly Consultation
- Where
- 5 sites in United States
- Volunteers
- 35 people
- Sponsor
- Northwestern University
Cerebral Palsy
Web-based Daily Care Training of Children With Cerebral Palsy
Purpose:Effect of web-based daily care training on the quality of life of caregivers of children with cerebral palsy. study design: Single-blind clinical trial. study population: Caregivers of children with cerebral palsy.
- Trial name
- NCT02545179
- Testing
- web-based daily care training
- Volunteers
- 100 people
- Sponsor
- University of Social Welfare and Rehabilitation Science
Malignant Tumor of Small Intestine Metastatic to Liver
Study of TCM Syndrome of Hepatocellular Carcinoma and Colorectal Cancer Based on System Science
Traditional Chinese medicine (TCM) syndrome is a core foundation of disease knowledge, clinical diagnosis and treatment and curative effect evaluation in TCM.
- Trial name
- NCT03189992
- Testing
- Bushen-Jianpi Dedoction, cinobufotalin injection
- Where
- China
- Volunteers
- 320 people
- Sponsor
- Shanghai University of Traditional Chinese Medicine
Preventive Health Care
Effects of Streak-Based Versus Tally-Based Feedback on Daily Lesson Completion During a 30-Day Digital Health Challenge
The study will test two interventions for increasing engagement with a target behavior, delivered via a digital web application that participants can access using their phones or computers.
- Trial name
- Streaks (NCT07220044)
- Testing
- Interventions for increasing engagement with a target behavior
- Where
- United States
- Volunteers
- 7,004 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Behavior, Health Risk, Implementation Science
Incentive-based and Media Literacy Informed Approaches to Improve Vaping Cessation
This study aims to evaluate the feasibility and compare the preliminary effect of vaping cessation program consisting of media literacy education and real-time text messaging support and leverage insights from behavioral…
- Conditions
- Behavior, Health Risk, Implementation Science, E Cigarette Use, Cessation, Smoking
- Trial name
- NCT05586308
- Testing
- Text-massaging suport, Financial incentive, Media literacy
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Nebraska
HIV (Human Immunodeficiency Virus)
Evaluating an Algorithm-Based Implementation Strategy to Improve HIV Care Outcomes
This study tests a strategy for helping Care Management Agencies prioritize patients with HIV (PWH) for outreach and support. Under the new strategy, care managers are given a list of highest-priority patients who have been…
- Trial name
- NCT07279376
- Testing
- predictive emergency room alerts (pERA), Standard of care
- Where
- United States
- Volunteers
- 2,600 people
- Sponsor
- Hunter College of City University of New York
Epilepsy Idiopathic, Clinical Disease and/or Syndrome
Omics-based Precision Medicine of Epilepsy
Epilepsy is a major disease of the nervous system (WHO, 2015), as well as the second most common neural disease. It has been recorded that there have been 65 million epilepsy patients all over the world, more than 10 million in…
- Conditions
- Epilepsy Idiopathic, Clinical Disease and/or Syndrome, Gene Mutation
- Trial name
- NCT03358459
- Testing
- non
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Fudan University
Basic Science
Evaluation of the Bioequivalence of RAY1225 Injection in Healthy Participants
This is a single-center, randomized, open, parallel-designed bioequivalence study aimed at evaluating the pharmacokinetic differences of RAY1225 injection after site and batch changes compared to before the changes.
- Trial name
- NCT07827027
- Testing
- RAY1225
- Volunteers
- 68 people
- Sponsor
- Guangdong Raynovent Biotech Co., Ltd
Continuity of Patient Care, Workflow
Development of a Sign-Out Tool to Improve Handoffs in Care
The purpose of this grant is to fund the research necessary to fully understand the impact of this sign-out tool on clinician workflow, quality of sign-out, and continuity of care.
- Conditions
- Continuity of Patient Care, Workflow, Quality of Signout
- Trial name
- NCT01398761
- Testing
- Signout tool
- Where
- United States
- Volunteers
- 295 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Cancer
Mindfulness-Based Art Therapy for Cancer Patients
The purpose of this study is to determine whether cancer patients who receive the mindfulness-based art therapy (MBAT) program demonstrate improvement in health-related quality of life, a reduction in stress-related symptoms, and…
- Trial name
- NCT00034970
- Testing
- Mindfulness-based at therapy
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Spinal Cord Injuries, Rehabilitation
Feasibility of Home-Based Rehabilitation on Body Composition, Some Anthropometric Measures and Muscular Strength After Interruption 4-5 Years of Spinal Cord Injury: Serial Cases Study on ISIS War Survivors in Iraq
Feasibility of Home-Based Rehabilitation on Body Composition, some Anthropometric Measures and Muscular Strength after interruption 4-5 years of Spinal Cord Injury: Serial Cases Study on ISIS War Survivors in Iraq Summary…
- Conditions
- Spinal Cord Injuries, Rehabilitation, Exercises
- Trial name
- HBRP-SCI (NCT06230627)
- Testing
- Home-Based Rehabilitation rogram
- Where
- Tunisia
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Mosul
Healthy Adult Male
Acute Effects of Caffeine on Repeated Sprint Performance and Energy Distribution
The goal of this study is to learn if low-dose caffeinated coffee improves repeated sprint performance and affects energy system contributions in combat sports athletes.
- Trial name
- NCT07596511
- Testing
- Cycling Repeated Sprint Test (6 × 10 s), Breath-by-Breath VO₂ Monitoring - COSMED K5, Capillary Blood Lactate Sampling (non-invasive)
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Trabzon University
Episiotomy, Episiotomy Extended by Laceration
Evaluation of Interventions Based on Behavioral Sciences to Reduce Episiotomy Use
This pilot study seeks to analyze the impact of interventions based on behavioral economics theory (e.g., feedback and information) on episiotomy use.
- Conditions
- Episiotomy, Episiotomy Extended by Laceration, Episiotomy Infection, Episiotomy Wound
- Trial name
- NCT06625866
- Testing
- Feedback and information
- Volunteers
- 2 people
- Sponsor
- Universidad Panamericana
Health Knowledge, Attitudes, Practice
Evaluation of Educational Intervention to Teach Principles of Evidence-based Medicine (EbM) in Biology Classes
The purpose of this study is to identify the effect of a short term educational intervention for upcoming biology teachers to teach principles of Evidence-based Medicine (EbM) and Good Scientific Practice (GSP) to high-school…
- Trial name
- NCT01567267
- Testing
- Experimental educational intervention, Standard educational intervention
- Where
- Germany
- Volunteers
- 87 people
- Sponsor
- Goethe University
Sleep, Circadian Rhythm
Examining the Biological Factors That Affect Sleep Duration
Sleep is necessary for healthy functioning, and people who sleep too little or too much may have an increased risk of developing health problems.
- Conditions
- Sleep, Circadian Rhythm, Cognitive Performance
- Trial name
- NCT00607204
- Where
- United States
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Independent Living
Implementation of CAPABLE in the Michigan Medicaid Waiver
Main study: Nearly half of older adults report problems with function, which can lead to difficulty with activities of daily living and nursing home placement.
- Trial name
- NCT03634033
- Testing
- MiCAP with IF (Main Study), MiCAP with IF and EF (Main Study), MiCAP with IF and Caregiver Engagement (Administrative Supplement)
- Where
- 18 sites in United States
- Volunteers
- 7,777 people, healthy volunteers welcome
- Sponsor
- Grand Valley State University
Substance Abuse, Substance Use Disorders
Testing Strategies to Improve Substance Misuse Prevention Research Use in State Policy Contexts
If science is to inform effective substance misuse prevention policy and ultimately improve public health, the field needs an effective strategy for directly supporting policymakers' use of research evidence, yet our field lacks…
- Conditions
- Substance Abuse, Substance Use Disorders, Prevention, Legislation
- Trial name
- NCT06856148
- Testing
- Intervention: RPC Group, Active Comparator: Control Group
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Penn State University
Basic Science
The Effects of Buprenorphine on Responses to Verbal Tasks
In this study, the investigators will examine the effects of buprenorphine, as compared to placebo, upon physiological, subjective, and hormonal responses to a stressful speech task and a non-stressful control task in healthy…
- Trial name
- NCT01860287
- Testing
- Buprenorphine 0.2 MG Sublingual Tablet, Buprenorphine 0.4 MG Sublingual Tablet
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Basic Science: Visual Attention in Healthy Participants, Attention
Probing the Role of Feature Dimension Maps in Visual Cognition: Impact of Salience Level (Eye-tracking Follow-up Study)
How does one know what to look at in a scene? Imagine a "Where's Waldo" game - it's challenging to find Waldo because there are many 'salient' locations in the picture, each vying for one's attention.
- Trial name
- NCT06852534
- Testing
- Stimulus properties: salience-defining feature, Stimulus properties: magnitude of salience
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, Santa Barbara
Aquired Brain Injury, Traumatic Brain Injuries
Effectiveness of a Customized Digital Platform to Increase Coordination of Care and Uptake of Evidence-based Practices
Background: Cardiovascular and neurological conditions are major causes of disability worldwide. Early, intensive rehabilitation is essential but often challenging to access in current healthcare systems.
- Conditions
- Aquired Brain Injury, Traumatic Brain Injuries, Stroke, Cardiovascular Diseases
- Trial name
- NCT06867081
- Testing
- The intervention will be the BRILLIANT Platform, an online platform which provides five Modules aimed at increasing coordination of care and direct rehabilitation time
- Where
- 2 sites in Canada
- Volunteers
- 962 people, healthy volunteers welcome
- Sponsor
- Centre for Interdisciplinary Research in Rehabilitation of Greater Montreal