Clinical trials: Bedrest
Muscle Atrophy, Insulin Sensitivity
Metabolic and Muscular Adaptations During Inactivity in 3 Days of Bed-rest
Space flight is associated with detrimental changes to the human body, including bone and muscle loss, fluid changes and deconditioning of muscles in the heart and blood vessels.
- Trial name
- NCT03495128
- Testing
- Bed Rest, Reconditioning
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Endothelial Dysfunction, Aging
Passive Mobilization and Vascular Function
With aging, vascular function (VF) declines. Inactivity and sedentary life style have been shown to contribute to the worsening of VF.
- Conditions
- Endothelial Dysfunction, Aging, Bed Rest
- Trial name
- NCT03087643
- Testing
- Passive mobilization - PM
- Where
- 3 sites in Italy
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Universita di Verona
Preterm Birth, Cervical Insufficiency
Bed Rest With a Short Cervix on Preterm Birth
Maternal AR has long been used to prevent PTB. However, definitions of AR vary widely, ranging from complete bed rest to partial limitation of physical activity for one or more hours daily.
- Conditions
- Preterm Birth, Cervical Insufficiency, Bed Rest, Pregnancy Complications
- Trial name
- BEWISE (NCT07577388)
- Testing
- Activity Restriction, No Activity Restriction
- Volunteers
- 6,000 people
- Sponsor
- Julie Glavind
Preterm Premature Rupture of the Membranes, Physical Activity
A Comparison of Bed Rest Versus Moderate Activity in Preterm Premature Rupture of Membranes (PPROM)
Bed rest has been a commonly prescribed intervention for high risk pregnancies, despite the lack of data to support its benefits, and increasing evidence pointing to potential harms.
- Trial name
- PACT (NCT02327637)
- Testing
- Moderate Activity
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of California, San Diego
Bed Rest, Pregnancy
Physical Activity in Bed Rest Hospitalized High-Risk Pregnant Women.
This study aims to evaluate the impact of a specifically designed exercise program for hospitalized high-risk pregnant individuals on bed rest.
- Conditions
- Bed Rest, Pregnancy, Pregnancy Complications
- Trial name
- BedRest-1 (NCT07657000)
- Testing
- Exercise
- Where
- Spain
- Volunteers
- 140 people
- Sponsor
- Hospital Clinic of Barcelona
Simulation of Weightlessness by Anti-Orthostatic Long Term Bed Rest
Toulouse Male Long Term Bed Rest 2001-2002
Microgravity during space flight induces physiological changes that affect astronauts' health and performance. Space flight simulations such as prolonged bed rest can mimic some of these changes and provide study conditions that…
- Trial name
- NCT00311571
- Testing
- Ethidronate, Physical training
- Where
- France
- Volunteers
- 28 people
- Sponsor
- Centre National d'Etudes Spatiales
Atrial Fibrillation, Atrial Flutter
The Z Stitch Early Bed Rest Assessment Study
The goal of this study is to understand the effects of early mobilization after a Z stitch procedure in patients undergoing certain heart-related treatments.
- Conditions
- Atrial Fibrillation, Atrial Flutter, Supraventricular Tachycardia, Syncope
- Trial name
- ZEBRA (NCT06087497)
- Testing
- Early mobilization
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- Oregon Health and Science University
Bone Metabolism, Electrolyte Metabolism
Salty Life 7 Study: Effect of High Salt Intake on Several Physiological Systems in Immobilisation
The Salty Life 7 study aimed to examine the effect of a high salt (sodium chloride, NaCl) intake on different forms of sodium retention, acid-base balance and bone metabolism and other influenced physiological systems.
- Conditions
- Bone Metabolism, Electrolyte Metabolism, Acid-Base Metabolism, Energy Metabolism
- Trial name
- SL7 (NCT01183299)
- Testing
- Dietary salt intake
- Where
- Germany
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- DLR German Aerospace Center
Physical Deconditioning, Weakness
Effect of Therapeutic Modalities on the Physical Fitness and Functional Capacity in Critical Patient
CONTEXT: The physical deconditioning in the critically ill patient is favored by prolonged immobilization, which compromises the ability to function. This perpetuates the stays in hospital and intensive care units (ICU).
- Trial name
- ICUPT (NCT01881477)
- Testing
- kinetics modalities
- Where
- Colombia
- Volunteers
- 24 people
- Sponsor
- CES University
Bed Rest, Space Analogue
Impact of Energy Density on Energy Intake During Bed Rest
Brief summary: This study is conducted in the context of a 60 days strict bed-rest study with 6° head-down-tilt (HDT) body position.
- Trial name
- ED-REST (NCT06571877)
- Testing
- Dietary intervention with manipulation of the energy density
- Where
- Germany
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Sudden Loss of Hearing
Bed Rest for Idiopathic Sudden Sensorineural Hearing Loss
sudden sensorineural hearing loss: idiopathic in most cases 5-20/100,000 new cases annually in the U.S no establishes pathogenesis treated with oral steroids in most cases ~50% improvement in hearing levels bed rest - acceptable…
- Trial name
- NCT00416143
- Testing
- bed rest, prednisone - oral corticosteroid 1mg/kg/D for 1 week
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Sheba Medical Center
Muscular Atrophy
Effect of 14 Day Bed Rest on Health Outcomes in Young and Older Participants
This investigation aimed to compare the response of older adult and young men to 14 day bed-rest and subsequent 28 day rehabilitation.
- Trial name
- BEDREST (NCT02694471)
- Testing
- physical inactivity or bed rest with supervised recovery
- Where
- Slovenia
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Primorska
Cartilage Degeneration, Weightlessness
Effects of 60-day-6° Head-down Bed Rest on Cartilage and Function of the Knee Joint
Objective: To investigate the effects of long-term simulated unloading in bed on articular cartilage quality based on functional magnetic resonance imaging (FMRI) and Knee joint function.
- Trial name
- NCT06612372
- Testing
- 60-day-6° head-down bed rest
- Where
- China
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Bedrest
Effect of Bedrest With and Without Exercise on the Heart
The purpose of this research sub-study is to determine the changes in heart function during the bedrest period using ultrasound and MRI. This topic is important for medical care of astronauts in space.
- Trial name
- NCT00598494
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Adenoma Pituitary, CSF Leakage
Bed Rest on the Effect of CSF Leakage Repair After Transsphenoidal Pituitary Surgery
Postoperative cerebrospinal fluid (CSF) leakage is a well-known complication that might occur after transnasal transsphenoidal adenomectomy at an incidence of 0.5-15% according to different literature reports.
- Trial name
- NCT05682391
- Testing
- Bed rest
- Where
- Taiwan
- Volunteers
- 180 people
- Sponsor
- National Taiwan University Hospital
Simulated Microgravity by Head Down Tilt Bedrest, Weightlessness
A 60 Days Head Down Tilt Bedrest With Artificial Gravity and Cycling Exercise on 24 Healthy Male (BRACE)
The objective of this study is to investigate whether a cycling exercise coupled with artificial gravity via a short-arm human centrifuge helps to prevent and / or reduce the deleterious effects induced by 60 days of…
- Trial name
- BRACE (NCT06544213)
- Testing
- Control Group, Countermeasure Supine Bike, Countermeasure AG-Bike
- Where
- France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Centre National d'Etudes Spatiales
Chronic Subdural Hematoma
GET-UP Trial: Impact of an Early Out-of-bed Paradigm in Postoperative Outcomes of Chronic Subdural Hematomas
Compare rates of medical complications, recurrence and outcome in 2 randomized groups of patients with surgical chronic subdural hematomas.
- Trial name
- GET-UP (NCT03788005)
- Testing
- Early mobilization
- Where
- Portugal
- Volunteers
- 208 people
- Sponsor
- Centro Hospitalar do Porto
Pregnancy, Pre-term Premature Rupture of Membranes
Preterm Premature Rupture of Membranes (PPROM): Bed Rest Versus Activity Trial
The objective of this study is to determine, through a randomized clinical trial, whether bed rest is helpful for the management of pregnancies complicated by preterm premature rupture of membranes (PPROM).
- Trial name
- BRAT (NCT01544387)
- Testing
- Bed Rest, Activity
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Weightlessness Simulation
A Comparison Study Between 10 Days of Dry Immersion Versus 10 Days of Head-down Bedrest on 20 Healthy Male Volunteers
The space agencies are actively engaged in studying the physiological adaptation to space environment through studies on board the International Space Station (ISS) but also on the ground.
- Trial name
- VIVALDI 3 (NCT06777329)
- Testing
- 10 days of dry immersion, 10 days of Head Down Bed Rest
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centre National d'Etudes Spatiales
Healthy Aging, Physical Inactivity
Bed Rest Study SBI 2023
The study will consist of three groups of subjects. Ten young male subjects (18-30 years) will lie supine for 21 days, 10 older male subjects (65+ years) will lie supine for 10 days, and a third group of 10 older male subjects…
- Trial name
- NCT06141291
- Testing
- High protein diet, OGTT
- Where
- Slovenia
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Science and Research Centre Koper