Clinical trials: Behavior, Addictive
Cocaine Dependence
Understanding Dopamine Mechanisms in Cocaine Addiction Using AMPT and Methylphenidate With [11C]RAC/[11C]PHNO PET
Studies using positron emission tomography (PET) have been used with great success in demonstrating specific abnormalities in several facets of dopaminergic system function in human populations (Narendran and Martinez 2009).
- Trial name
- NCT02152670
- Testing
- Methylphenidate, Alpha Methyl Para Tyrosine (AMPT), [11C]PHNO
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Yale University
Obesity
W8Loss2Go: mHealth Weight Management Strategy
The investigators will test a recent mobile technology based (mHealth) behavioral weight loss intervention (W8Loss2Go), which is designed for children and adolescents, and uses an addiction model to promote withdrawal from…
- Trial name
- NCT02689154
- Testing
- W8Loss2Go
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Children's Hospital Los Angeles
Addiction, Opioid Use
Phase Ib/2a Drug-drug Interaction Study of a Combination of 45mg Dextromethorphan With 105 mg Bupropion
The overall goal of this project is to collect initial human data on the effects of novel compounds on safety (interactions with an opioid drug, e.g., buprenorphine) and early efficacy signals (subjective effects on negative…
- Conditions
- Addiction, Opioid Use, Substance Use Disorders, Opioid Use Disorder
- Trial name
- NCT05976646
- Testing
- Auvelity
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Virginia Commonwealth University
Cannabis Dependence, Cannabis Withdrawal
Clinical and Neurobiological Effects of Cannabis Dependence in Young Adults
The purpose of this study is to find out more about cognitive functioning in people who are cannabis dependent, relative to people who do not use cannabis, and how their brains process information after one month of not using…
- Trial name
- SCCAN (NCT00656487)
- Testing
- rimonabant
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- The Scripps Research Institute
Cocaine Abuse, Cocaine-Related Disorders
Medications for Stopping Cocaine Dependence and Preventing Relapse
Cocaine dependence is a major public health problem; an effective primary treatment for cocaine dependent individuals has yet to be found.
- Trial name
- NCT00218023
- Testing
- Modafinil, Levodopa/Carbidopa, Naltrexone HCl
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Drug Addiction, Smoking Cessation
Examining the Effect of the Nicotine Patch in Male and Female Smokers - 3
Treatment studies have demonstrated that current smoking cessation techniques are less effective for women. The purpose of this study is to determine the role that gender plays in the effectiveness of nicotine replacement…
- Trial name
- NCT00390559
- Testing
- nicotine transdermal system, Nicotine containing cigarette
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Methamphetamine Addiction, Crystal Meth Addiction
An Assessment of the Safety of Varenicline in Methamphetamine-dependent Volunteers
More people worldwide use amphetamine-type stimulants than any illicit drug besides cannabis, and methamphetamine (MA) abuse and dependence is the fastest growing drug problem in the United States.
- Conditions
- Methamphetamine Addiction, Crystal Meth Addiction, Amphetamine Addiction
- Trial name
- NCT00713479
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of California, Los Angeles
Nicotine Addiction, Serious Mental Illness
Feasibility Trial of a Tailored Smoking Cessation App for People With Serious Mental Illness
Quitting smoking has important health benefits for people with serious mental illness, more than half of whom are smokers. Smoking reductions in this population, in turn, could contribute to saving billions of dollars in…
- Trial name
- NCT03069482
- Testing
- Learn to Quit App, Nicotine patch, Nicotine lozenge
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Duke University
Alcohol Use Disorder, Post Traumatic Stress Disorder
Piloting "Signs of Safety": A Deaf-Accessible Therapy Toolkit for Alcohol Use Disorder and Trauma
The U.S. Deaf community - more than 500,000 Americans who communicate using American Sign Language (ASL) - experiences nearly triple the rate of lifetime problem drinking and twice the rate of trauma exposure as compared to the…
- Trial name
- NCT03845985
- Testing
- Seeking Safety + Signs of Safety toolkit
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Massachusetts, Worcester
Drug Addiction, Executive Dysfunction
Bilateral Prefrontal Modulation in Crack-cocaine Addiction
In this study, eligible crack-cocaine addicted inpatients recruited from specialized clinics for substance abuse disorder treatment, filling inclusion criteria and not showing any exclusion criteria, were randomized to receive…
- Trial name
- tDCS_CRACK (NCT02091167)
- Testing
- transcranial Direct Current Stimulation
- Where
- Brazil
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Federal University of Espirito Santo
Cocaine Dependence
Cocaine Use Reduction With Buprenorphine
The aim of this study is to investigate the safety and effectiveness of buprenorphine in the presence of naltrexone for the treatment of cocaine dependence.
- Trial name
- CURB (NCT01402492)
- Testing
- Buprenorphine + Naltrexone
- Where
- 11 sites in United States
- Volunteers
- 302 people
- Sponsor
- University of California, Los Angeles
Cocaine Related Disorders
Stress and Medication Effects on Cocaine Cue Reactivity
Stressful situations and cues associated with cocaine can lead to craving in cocaine dependent individuals. The purpose of this study is to determine whether guanfacine or modafinil are effective in reducing stress and cue…
- Trial name
- NCT00613015
- Testing
- Guanfacine, Modafinil
- Where
- United States
- Volunteers
- 109 people
- Sponsor
- Medical University of South Carolina
Nicotine Use Disorder
Behavioral Memory Modulation in Nicotine Addiction
The purpose of the study is to see if a behavioral intervention known as retrieval-extinction training (RET) might affect craving in response to nicotine cues (e.g., pictures, videos and objects) and smoking behavior in men and…
- Trial name
- NCT03744559
- Testing
- Retrieval Extinction Training (RET), Control Retrieval Extinction Training (RET)
- Where
- United States
- Volunteers
- 191 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Nicotine Addiction
Acute and Chronic Nicotine Modulation of Reinforcement Learning
The purpose of this study is to use functional magnetic resonance imaging (fMRI) to investigate the acute and chronic effects of nicotine on motivational behavior and prediction error-related neural activation.
- Trial name
- NicLearning (NCT01830842)
- Testing
- Nicotine polacrilex, satiety, abstinence
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Duke University
Opioid-Use Disorder (OUD)
SafetyNet Program for Opioid Use Disorder (OUD)
The principal aim of this study is to determine whether a novel biopsychosocial intervention following opioid overdose (OD) affects 1) the frequency of secondary opioid OD events and 2) the proportion of individuals who remain…
- Trial name
- NCT04253782
- Testing
- Team Intervention
- Where
- 2 sites in United States
- Volunteers
- 81 people
- Sponsor
- Yale University
Cocaine Addiction, Cocaine-related Disorder
Prefrontal Cortex Stimulation as Treatment for Crack-cocaine Addiction
The use of crack-cocaine is growing at alarming rate in our country and it is absolutely worrisome the fast establishment of addiction to it.
- Conditions
- Cocaine Addiction, Cocaine-related Disorder, Executive Dysfunction
- Trial name
- NCT01337297
- Testing
- transcranial Direct Current Stimulation
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Federal University of Espirito Santo
Opioid Dependence, Addiction
Addiction, HIV and Tuberculosis in Malaysian Criminal Justice Settings
The purpose of this study is to conduct empiric studies of tuberculosis (TB) among people in prison with and without a history of opioid dependence.
- Conditions
- Opioid Dependence, Addiction, HIV/AIDS, Tuberculosis
- Trial name
- HARAPAN II (NCT03089983)
- Testing
- Isoniazid, Rifapentine
- Where
- Malaysia
- Volunteers
- 316 people
- Sponsor
- Yale University
Nicotine Addiction
Neural Mechanisms Associated With Risk of Smoking Relapse
This study will examine how abstinence-induced brain changes contribute to smoking cessation outcomes in treatment-seeking smokers.
- Trial name
- NCT02837510
- Testing
- Standard smoking cessation counseling
- Where
- United States
- Volunteers
- 119 people
- Sponsor
- University of Pennsylvania
Nicotine Dependence, Cigarettes
Translational Neuropsychopharmacology Research of Nicotine Addiction
This study will examine the effects of combining Varenicline (VRN) and N-acetylcysteine (NAC) on neural circuitry function and treating nicotine addiction.
- Trial name
- NCT02723162
- Testing
- Varenicline (VRN), N-Acetylcysteine (NAC)
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Addiction
Just-In-Time Adaptive Interventions for Addictive Behaviors
Background: Many smartphone apps intend to help people with addictions. But not enough is known about how they should work. Researchers want to study an app that gives people the advice they need, just when they need it.
- Trial name
- NCT03538652
- Testing
- Formative Interviews (not an intervention), Cognitive-behavioral therapy (CBT), Acceptance and commitment therapy (ACT)
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- National Institute on Drug Abuse (NIDA)