Clinical trials: Behavior And Behavior Mechanism
Emotional Well-being, Psychological Stress
Feasibility of a Mind-Body Intervention for Optimism
This pilot study tests whether three brief mind-body activities can be delivered remotely to midlife adults, and whether they show early signs of improving cardiovascular health, emotional well-being, and stress.
- Conditions
- Emotional Well-being, Psychological Stress, Cardiovascular Risk
- Trial name
- NCT07862478
- Testing
- Emotional Well-Being Writing, Chair-Assisted Squats, Slow-Paced Breathing
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Penn State University
Adjustment Disorder, Anxiety
Online MBCT for Adjustment Disorder During COVID-19: Efficacy, Mechanisms, and RCT
This study tested a 4-week, internet-based Mindfulness-Based Cognitive Therapy (MBCT) program designed to help people experiencing adjustment disorder during the COVID-19 pandemic.
- Conditions
- Adjustment Disorder, Anxiety, Depressive
- Trial name
- NCT07128017
- Testing
- Mindfulness-Based Cognitive Therapy (Internet-delivered), Progressive Muscle Relaxation (Internet-delivered), No Intervention - Waitlist Control
- Where
- Poland
- Volunteers
- 301 people
- Sponsor
- University of Warsaw
Sarcopenia
Exercise and Nutrition for Healthy AgeiNg
The aim of this randomized placebo-controlled 5-arm clinical trial is to evaluate the effect of combined anabolic interventions compared to single or placebo interventions on physical performance in community-dwelling…
- Trial name
- ENHANce (NCT03649698)
- Testing
- Home-based training program, High-quality protein supplement, Omega-3 fatty acid
- Where
- Belgium
- Volunteers
- 180 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Depression, Unipolar, Depression, Bipolar
BioClock: Bright Light Therapy for Depressive Disorders
Bright Light Therapy (BLT) is a proven treatment for depression in seasonal and non-seasonal depressive disorders, as well as bipolar disorder.
- Trial name
- NCT05958940
- Testing
- Bright Light Therapy, Blue Light Blocking Glasses
- Where
- 2 sites in Netherlands
- Volunteers
- 231 people
- Sponsor
- Universiteit Leiden
Hypertension, Diabetes Mellitus
Goal Commitment and Proactive Health Behavior in Chronic Disease Patients
Chronic diseases such as hypertension, diabetes, and dyslipidemia are major contributors to mortality and healthcare burden worldwide.
- Conditions
- Hypertension, Diabetes Mellitus, Dyslipidemia
- Trial name
- NCT07552571
- Testing
- Goal Commitment-Based Behavioral Intervention, Usual Care
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Xiong Juyang
Major Depression
Psilocybin for Depression in Veterans
More efficacious treatments for Major Depressive Disorder (MDD) in Veterans are urgently needed. Psilocybin is a promising novel treatment that is likely to be the first FDA-approved psychedelic, but its safety and efficacy…
- Trial name
- PACT (NCT07895134)
- Testing
- Psilocybin, modafinil, zolpidem
- Where
- 4 sites in United States
- Volunteers
- 150 people
- Sponsor
- VA Office of Research and Development
Attention Deficit Hyperactivity Disorder
Towards an Understanding of the Mechanism of Action of Methylphenidate in ADHD
Approximately 1-in-20 children worldwide have Attention Deficit Hyperactivity Disorder (ADHD), a condition associated with disabling inattention, hyperactivity and impulsivity.
- Trial name
- NCT05600881
- Testing
- Methylphenidate
- Volunteers
- 35 people
- Sponsor
- University of Dublin, Trinity College
Alcohol Use Disorder
Effect of CBT Microinterventions on Mechanisms of Behavior Change Among Adults With AUD
This proposed R21, Effect of CBT Microinterventions on Mechanisms of Behavior Change among Adults with AUD: Using Eye Tracking to Measure Pre-Post Cognitive Control, uses a translational team science approach to isolate and…
- Trial name
- NCT03661853
- Testing
- Control, Functional Analysis, Cognitive Restructuring
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- University of Massachusetts, Worcester
Cardiovascular-kidney-metabolic Syndrome
Mechanisms and Interventions for Physical Activity in Frail Cardiovascular-kidney-metabolic Syndrome Patients: A Temporal Self-Regulation Approach
Longitudinal physical activity data and associated factors were collected at baseline (diagnosis), 3-month, 6-month, and 9-month follow-ups in cardiovascular-kidney-metabolic syndrome patients.
- Trial name
- CKM (NCT07131488)
- Volunteers
- 614 people
- Sponsor
- Nanjing Medical University
Binge Eating Behaviour, Eating Disorders
Biobehavioral Mechanisms of Activity and Loss of Control Eating in Children
Loss of control eating in children and adolescents is associated with a host of negative physical and psychological health outcomes and a prognostic marker for development of eating disorders.
- Conditions
- Binge Eating Behaviour, Eating Disorders, Physical Activity, Functional Magnetic Resonance Imaging (fMRI)
- Trial name
- NCT07823153
- Testing
- Go/No-go task, Visual food task, Emotion regulation task
- Where
- 3 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Dallas
Eating Behavior
Mother-Baby Study - Relative Reinforcing Value (RRV)
The study will test a model of biobehavioral mechanisms involved in the development of a system of emotion, attachment, and nutritive intake in the mother-infant dyad and the association of this system with maternal feeding…
- Trial name
- NCT06072651
- Testing
- Relative Reinforcing Value of Food
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Depression, Unipolar, Anxiety Disorder Social
Trans-diagnostic Group CBT vs. Standard Group CBT for Depression, Social Anxiety and Agoraphobia/Panic Disorder
Transdiagnostic Cognitive Behavior Therapy (CBT) delivered in the individual format, have been proven just as effective as traditional diagnosis specific CBT manuals.
- Conditions
- Depression, Unipolar, Anxiety Disorder Social, Panic Disorder
- Trial name
- TRACT-RCT (NCT02954731)
- Testing
- UP-CBT, Standard-CBT
- Where
- 4 sites in Denmark
- Volunteers
- 292 people
- Sponsor
- Psychiatric Research Unit, Region Zealand, Denmark
Obesity, Aging
Obesity, Inflammation and Aging: Effects of Physical Exercise and Omega-3 Fatty Acids.
Dysfunction of adipose tissue in obesity, inflammation and aging: mechanisms and effects of physical exercise and omega-3 fatty acids.
- Conditions
- Obesity, Aging, Inflammation
- Trial name
- OBELEX (NCT03300388)
- Testing
- Omega-3 (DHA-rich dietary supplement), Resistance training
- Where
- Spain
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Elderly, Sedentary
Mechanisms and Functional Outcomes of Exercise Progression Models in the Elderly
The aim of this study is to devise a sufficiently high intensity training program that provided an optimal stimulus to remove the peripheral factors known to reduce functional capacity, and can be cardiovascular and…
- Trial name
- FIT (NCT01899586)
- Testing
- Regional Specific Training Stimulus (RSTS), Aerobic Exercise Regimen (AE)
- Where
- 2 sites in United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Duke University
Postural Orthostatic Tachycardia Syndrome (POTS), Dysautonomia
Guanfacine and Cromolyn Sodium for POTS: The DBPOTS Trial
The goal of this clinical trial is to learn whether guanfacine or cromolyn sodium can improve symptoms and physical functioning in adults with Postural Orthostatic Tachycardia Syndrome (POTS).
- Conditions
- Postural Orthostatic Tachycardia Syndrome (POTS), Dysautonomia, Orthostatic Intolerance, Autonomic Nervous System Diseases
- Trial name
- DBPOTS (NCT07757555)
- Testing
- Guanfacine (GFC), Cromolyn Sodium
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Johns Hopkins University
Binge Drinking, Alcohol Drinking in College
Balanced Lifestyle for Undergraduate Excellence - Mobile (Project BLUEM)
The purpose of this study is to evaluate a text-message delivered approach for improving college adjustment and experience and reducing risky alcohol use in young adult college students.
- Conditions
- Binge Drinking, Alcohol Drinking in College, Behavior, Drinking, Behavior and Behavior Mechanisms
- Trial name
- BLUEM (NCT04105725)
- Testing
- Brief Motivational Intervention+Substance-Free Activity Session, Alcohol + Nutrition Education Session
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- University of Memphis
Refractory Angina Pectoris
Effect of Daily Remote Ischemic Conditioning on the Life Quality of Refractory Angina Pectoris Patients
The purpose is to test whether daily ischemic conditioning of the arms over 30 days could reduce the frequency and severity of angina pectoris and improve the life quality of refractory angina pectoris patients.
- Trial name
- D-RIC-RAP (NCT02499250)
- Testing
- remote ischemic conditioning (TDFT-12-A2), Optimal medical treatment
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Navy General Hospital, Beijing
Depression Mild, Depression Moderate
Neural Mechanisms of Meditation Training in Healthy and Depressed Adolescents: An MRI Connectome Study PART 2
The primary objective will be to study changes in putamen connectivity and depression severity in depressed teens with meditation training.
- Conditions
- Depression Mild, Depression Moderate, Depression, Teen
- Trial name
- NCT05267340
- Testing
- TARA, Psycho-Education
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of California, San Francisco
Exercise Therapy, Behavior and Behavior Mechanisms
Health-Enhancing Adapted Physical Activity Program at "Mon Stade"
Introduction: Regular practice of exercise or physical activity (PA) is a recognized intervention as a determinant of good health acquisition, maintenance, or recovery for a large number of chronic pathologies.
- Conditions
- Exercise Therapy, Behavior and Behavior Mechanisms, Adherence, Patient, Lifestyle, Sedentary
- Trial name
- SESAME (NCT04716322)
- Testing
- Adapted Physical Activity
- Where
- France
- Volunteers
- 2,024 people, healthy volunteers welcome
- Sponsor
- Mon Stade Sports Medicine Centre
Physical Activity, Behavior Change
Individual and Environmental Mechanisms of PA Change
The focus of this study is to determine the mechanisms that underlie Physical Activity behavior change. We have 2 primary objectives.
- Trial name
- NCT00432133
- Testing
- Protection Motivation Theory-Based Intervention, Environmenta
- Where
- United States
- Volunteers
- 452 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente