Clinical trials: Behavioral Inhibition
Tobacco Smoking, Nicotine Dependence
Effects of Intensive Behavioral Training Program on Impulsivity and Inhibitory Control in Smokers
Dependence on tobacco derived nicotine is a major public health problem. Substance users who complete training in mindfulness subjectively report increased patience and improved motor control over their impulses.
- Conditions
- Tobacco Smoking, Nicotine Dependence, Impulsivity, Addiction
- Trial name
- IBTP (NCT01314378)
- Testing
- Mindfulness Training, Cognitive-Behavioral Therapy
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Addiction
Effects of Repetitive tDCS on ad Libitum Smoking Behavior: EMA and EEG Study
Bilateral (left cathodal/ right anodal) transcranial Direct Current Stimulation (tDCS) over the dorsolateral prefrontal cortex (DLPFC) seems to reduce craving and to increase the time till smoking the first cigarette after the…
- Trial name
- NCT03027687
- Testing
- tDCS
- Where
- Netherlands
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Erasmus Medical Center
ADHD
Accelerated iTBS Targeting of Working Memory Versus Inhibitory Control in Adolescent ADHD
The objective of this project is to examine the differential therapeutic effect of intermittent theta burst stimulation (iTBS; a type of repetitive transcranial magnetic stimulation) to the left DLPFC versus right PreSMA in…
- Trial name
- WINK (NCT07219810)
- Testing
- intermittent theta burst stimulation (iTBS)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Bradley Hospital
Obesity, Overweight
Changing Eating Behavior Using Cognitive Training
Obesity is a global health problem. New and more efficient interventions are needed to overcome this disease. This randomized clinical trial aims to evaluate the effectiveness of changing eating behavior using cognitive training.
- Conditions
- Obesity, Overweight, Weight Loss
- Trial name
- NCT04450524
- Testing
- Hypnosis, Food inhibition training, Control
- Where
- 2 sites in Romania
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Babes-Bolyai University
Attention Deficit Hyperactivity Disorder
The Effects of Methylphenidate and Non-invasive Brain Stimulation on Inhibitory Control in Children With ADHD
The aim of this study is comparing the effects of non-pharmacological intervention (transcranial Direct Current Stimulation, tDCS) with those of drug (methylphenidate, MPH) administration in children and adolescents with ADHD.
- Trial name
- NCT04964427
- Testing
- Methylphenidate, anodal tDCS
- Where
- Italy
- Volunteers
- 26 people
- Sponsor
- Bambino Gesù Hospital and Research Institute
Rheumatoid Arthritis (RA)
Evaluation Effects of Treatment With IL-6R Inhibitor on Clinical Response and Biomarkers in Patients With Rheumatoid Arthritis (RA) Not Responding to DMARDs and/or a First Biological Agent.
The purpose of this study is to assess the clinical response to IL-6 inhibition defined as Low Disease Activity (DAS44) <2.4) at the follow-up visit at 12 months and the correlation between the biomarkers and treatment response.
- Trial name
- NCT01835613
- Testing
- Biomarkers Measures
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Osservatorio Epidemiologico GISEA
KINESIOTAPING
Effect of Kinesiotaping in Different Directions on Muscle
The study was conducted to investigate the effects of different Kinesio taping directions on dynamic muscle endurance. This randomized, double-blind, crossover study was implemented on 27 healthy male subjects.
- Trial name
- NCT04379674
- Testing
- FACILITATION TAPING, INHIBITION TAPING
- Where
- Turkey (Türkiye)
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Muğla Sıtkı Koçman University
Obsessive Compulsive Disorder, Trichotillomania
Developing Effective Response Inhibition Training for Symptom Relief in OCD and Trichotillomania
Obsessive-compulsive disorder (OCD) and its related disorders (e.g., trichotillomania) are characterized by the marked difficulty in inhibiting unwanted or inappropriate responses.
- Trial name
- NCT02059980
- Testing
- Response inhibition training
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Wisconsin, Milwaukee
Attention Deficit Hyperactivity Disorder
Methylphenidate on Intracortical Inhibition in Methamphetamine Abusers Attention Deficit Hyperactivity Disorder (ADHD)
Previous studies using transcranial magnetic stimulation (TMS) with paired pulse protocols have shown that a conditioning TMS pulse applied to the human motor cortex changes the excitability of motor pathways from the motor…
- Trial name
- ADHD (NCT01651169)
- Testing
- methylphenidate tablets and Inter-stimulus Intervals (ISI)
- Where
- Iran
- Volunteers
- 30 people
- Sponsor
- Tehran University of Medical Sciences
Focal Dystonia
EEG and EMG Studies of Hand Dystonia
This study will examine how the brain operates during execution and control of voluntary movement and what goes wrong with these processes in disease.
- Trial name
- NCT00025701
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Pathological Gambling
Effects of Transcranial Direct Current Stimulation (tDCS) in Gambling Disorder
Gambling disorder is associated to high impulsivity and excessive risk-taking behaviour. These behavioural characteristics related to addiction are linked to cognitive processes in specific brain areas located in the prefrontal…
- Trial name
- NCT03464838
- Testing
- Transcranial direct current stimulation (tDCS), Cognitive Behavioural Therapy (CBT)
- Where
- United Kingdom
- Volunteers
- 32 people
- Sponsor
- University of East London
Adjustment Disorder With Work Inhibition
Neurobiological Effects of Work-related Adjustment Disorder
INTRODUCTION: Stress is one of the greatest burdens of our society and often imply impairments in cognitive and emotional functions.
- Trial name
- NeuroWAD (NCT03334045)
- Testing
- PET/MR scans
- Where
- Denmark
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Impulsive Behavior, Inhibition
Inhibition Transcranial Random Noise Stimulation
Inhibition control deficits is a major risk factor in the transition to the act in suicidal patients. Neuroimaging studies have shown that this failure was associated with hypoactivity in the prefrontal cortex (PFC), a brain area…
- Trial name
- inhibistim (NCT02717260)
- Testing
- transcranial random noise stimulation (tRNS) (Starstim)
- Where
- France
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Hôpital le Vinatier
Dyslexia, Executive Dysfunction
The Effects of Play and Competition-Based Cognitive Therapy
Purpose: The aim of this study was to investigate the effects of play and competition-based cognitive therapy (PCB-CT) on executive function and occupational routines in children with dyslexia.
- Trial name
- NCT03906097
- Testing
- Play and Competition-Based Cognitive Therapy
- Volunteers
- 64 people
- Sponsor
- Hacettepe University
Sleep Deprivation
fMRI-behavioral Study of Cholinergic Augmentation With Donepezil in Healthy Sleep Deprived Adults
The purpose of this study was to characterize how the anti-cholinesterase inhibitor (AChE-I) donepezil modulates brain regions involved in visual short-term memory, episodic memory and inhibitory efficiency following 24 hours of…
- Trial name
- NCT00800553
- Testing
- donepezil
- Where
- Singapore
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Duke-NUS Graduate Medical School
Drug-drug Interaction
Inhibition Metamizole 2020
This clinical phase I trial had 3 arms: inhibition by fluconazole, inhibition by ciprofloxacin and placebo. Subjects were treated for 3 days prior to the study day. The intervention was a single dose of 1 gram metamizole.
- Trial name
- NCT04621253
- Testing
- Novalgin
- Where
- Switzerland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Drinking, Alcohol, Drinking Behavior
Inhibitory Control Smartphone App
The proposed study will address a critical knowledge gap: there are no evidence-based smartphone apps for reducing young adult drinking.
- Trial name
- NCT04243759
- Testing
- Control App Version, Standard App Version, Experimental, Feedback App Version
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of Florida
Major Depressive Disorder, Major Depressive Disorder, Recurrent
Glutamate Probes in Adolescent Depression
The purpose of this study is to learn if measures of brain chemicals from a brain scan called Magnetic Resonance Imaging and Spectroscopy (MRI/MRS) and brain activity (known as cortical excitability and inhibition) collected by…
- Conditions
- Major Depressive Disorder, Major Depressive Disorder, Recurrent, Major Depressive Disorder, Remitted
- Trial name
- GPII (NCT02307617)
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Endotoxemia, Inflammation
Short-Chain Fatty Acids in Lypopolysaccharide-Induced Inflammation and Executive Function
Short-chain fatty acids (SCFAs) are substances produced by gut bacteria when they ferment dietary fiber. They can act as signals between the gut and the brain and may help regulate the body's immune and stress responses.
- Conditions
- Endotoxemia, Inflammation, Executive Function (Cognition)
- Trial name
- NCT07713641
- Testing
- Short-Chain Fatty Acid Colon-Delivery Capsules, Lipopolysaccharide (LPS)
- Where
- Belgium
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Opioid Withdrawal
Dexmedetomidine in the Treatment of Symptoms Of Acute Opioid Withdrawal
This Phase 1b/2 inpatient study assessed the safety, pharmacokinetics, and early signs of efficacy of escalating doses of BXCL501 versus placebo following discontinuation of morphine maintenance.
- Trial name
- NCT04470050
- Testing
- Dexmedetomidine
- Where
- 3 sites in United States
- Volunteers
- 225 people
- Sponsor
- BioXcel Therapeutics Inc