Clinical trials: Behavioral Symptoms
Depressive Symptoms, Quality of Life
Testing TRUST Depression Management Intervention
This study evaluates the effectiveness of a novel depression self-management intervention in adolescents with depression.
- Trial name
- TRUST (NCT03599141)
- Testing
- Trust-building Self-management Together, Depression Management
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Agitation, Schizophrenia
Dexmedetomidine in the Treatment of Agitation Associated With Schizophrenia
This is a definitive study to support the safety and efficacy evaluation of BXCL501 for the acute treatment of agitation in schizophrenia.
- Conditions
- Agitation, Schizophrenia, Schizo Affective Disorder, Schizoaffective Disorder
- Trial name
- SERENITY I (NCT04268303)
- Testing
- Sublingual film containing dexmedetomidine (BXCL501)
- Where
- 15 sites in United States
- Volunteers
- 380 people
- Sponsor
- BioXcel Therapeutics Inc
Suicidal Ideation, Suicide, Attempted
The Acceptability and Feasibility of an ED-based, Peer-delivered, Suicide Safety Planning Intervention
Safety planning is a brief, ED-feasible intervention which has been demonstrated to save lives, and has been universally recommended by every recent expert consensus panel on suicide prevention strategies.
- Conditions
- Suicidal Ideation, Suicide, Attempted, Mental Health Issue
- Trial name
- NCT04068142
- Testing
- Peer Supporter Safety Planning
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- University of Arkansas
Depression
Spanish Intervention for Caregivers of Veterans With Stroke
This research study will test a problem-solving intervention for Spanish-speaking stroke caregivers that will be delivered over the telephone and online via the previously developed and nationally available Spanish version of the…
- Trial name
- RESCUE (NCT03142841)
- Testing
- RESCUE Problem Solving Intervention
- Where
- 4 sites in United States, Puerto Rico
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Mobility Limitation, Motor Activity
Cognitive Remediation to Improve Mobility in Sedentary Seniors
The investigators propose to conduct a single-blind randomized clinical trial to test the efficacy of a computerized cognitive remediation intervention program on improving locomotion in sedentary seniors, a group at an…
- Conditions
- Mobility Limitation, Motor Activity, Difficulty Walking, Cognitive Ability General
- Trial name
- CREM (NCT02567227)
- Testing
- Cognitive Remediation, Active Control
- Where
- United States
- Volunteers
- 383 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Post Traumatic Concerns, Post Traumatic Stress Disorder
A Comparative Effectiveness Trial of Optimal Patient-Centered Care
The nation's trauma care system, which includes trauma center hospitals \& emergency departments, is where over 30 million Americans receive care after traumatic injuries each year.
- Conditions
- Post Traumatic Concerns, Post Traumatic Stress Disorder, Depression and Suicide Ideation, Alcohol and Drug Use
- Trial name
- TSOS 5 (NCT02274688)
- Testing
- Stepped Care Management
- Where
- United States
- Volunteers
- 171 people
- Sponsor
- University of Washington
Suicidal Ideation
Home-based tDCS for Prevention of Suicidal Ideation
Risk for suicide is elevated in the period after discharge from hospital among adults with major affective disorder. The primary objective of this study is to investigate the feasibility of delivering tDCS sessions for high-risk…
- Trial name
- NCT05280756
- Testing
- Home-based transcranial direct current stimulation (tDCS)
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Rochester
Suicide, Engagement, Patient
The BH-Works Suicide Prevention Program for Sexual and Gender Minority Youth
Youth suicide is a serious public health concern. Compared to their heterosexual and cisgender peers, sexual and gender minority (SGM) adolescents report higher rates of suicidal ideation and suicide attempts.
- Trial name
- NCT05922670
- Testing
- The Behavioral Health-Works Suicide Prevention Program for Sexual and Gender Minority Youth
- Where
- 4 sites in United States
- Volunteers
- 18 people
- Sponsor
- Virginia Polytechnic Institute and State University
Social Anxiety Disorder, Selective Mutism
Treatment of Social Anxiety Disorder and Selective Mutism
This study is to assess the efficacy of a brief, 11-week, manualized Taming Sneaky Fears for Social Anxiety Disorder (SAD) and/or Selective Mutism (SM) child and parent group Cognitive Behavioural Therapy (CBT) treatment…
- Trial name
- SAD&SMTRMT (NCT02554929)
- Testing
- Taming Sneaky Fears, Parent Psycho-education and Child Socialization
- Where
- Canada
- Volunteers
- 93 people
- Sponsor
- The Hospital for Sick Children
Neurotic Excoriation, Pathologic Skin Picking
Double-Blind Lamictal (Lamotrigine) in Neurotic Excoriation
The goal of the proposed study is to evaluate the comparative efficacy of Lamictal (lamotrigine) to placebo in neurotic excoriation.
- Conditions
- Neurotic Excoriation, Pathologic Skin Picking, Psychogenic Excoriation, Dermatillomania
- Trial name
- NCT00513019
- Testing
- Lamictal (lamotrigine)
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Chicago
Reproductive Behavior, Sexual Behavior
Reducing Teen Pregnancy in the Emergency Department
This study will determine the feasibility, acceptability, and potential efficacy of an emergency department-based pregnancy prevention intervention targeting sexually active adolescent female emergency department patients.
- Conditions
- Reproductive Behavior, Sexual Behavior, Adolescent Behavior, Contraception
- Trial name
- ERICA (NCT03866811)
- Testing
- Dr. Erica
- Where
- United States
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Columbia University
Chronic Kidney Disease, Depression
Chronic Kidney Disease Antidepressant Sertraline Trial
This is a randomized double-blinded placebo-controlled trial to see if treatment with sertraline as compared with placebo tablets will improve depression symptoms in patients with chronic kidney disease who have not yet started…
- Trial name
- CAST (NCT00946998)
- Testing
- Sertraline
- Where
- 2 sites in United States
- Volunteers
- 201 people
- Sponsor
- VA Office of Research and Development
Psychiatric Emergency, Aggression
TREC-Lebanon: A Trial for Rapid Tranquilisation for Agitated Patients in the Emergency Setting
This is a randomised controlled trial comparing haloperidol + promethazine versus haloperidol + promethazine + chlorpromazine for agitated patients in the emergency department.
- Conditions
- Psychiatric Emergency, Aggression, Agitation
- Trial name
- TREC (NCT03639558)
- Testing
- Haloperidol + Promethazine + Chlorpromazine, Haloperidol + Promethazine
- Where
- 2 sites in Lebanon
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Joseph Dib
Depression, Suicidal Ideation
BRITEPath, Component 3 of iCHART (Integrated Care to Help At-Risk Teens)
BRITEPath (BP) aims to support co-located mental health clinicians in the development of a high quality, effective, and personalized safety plan for referred patients who screen positive for depression and/or suicidal ideation.
- Trial name
- NCT04000399
- Testing
- BRITEPath
- Where
- 6 sites in United States
- Volunteers
- 43 people
- Sponsor
- University of Pittsburgh
Suicide, Suicide Prevention
Suicide Prevention Integration Into Task-shifted Mental Health Interventions
Investigators will conduct a pilot clinical trial to assess the feasibility and acceptability of implementing a Suicide Prevention Package (SuPP) within an existing task-shifted depression intervention in rural Pakistan.
- Conditions
- Suicide, Suicide Prevention, Suicidal Ideation
- Trial name
- KPZ (NCT06208293)
- Testing
- KPZ Program (KPZ), Enhanced Usual Care (EUC)
- Where
- Pakistan
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Yale University
Sedentary Behavior, Cardiovascular Risk Factor
Combined Effects of Prolonged Sitting and Mental Stress on the Cardiovascular System
Prolonged sitting may pose a public health risk through its effects on the cardiovascular system, and may lead to impaired whole-body cardiovascular health, which includes both vascular and cerebrovascular function.
- Conditions
- Sedentary Behavior, Cardiovascular Risk Factor, Mental Stress, Cognitive Change
- Trial name
- NCT04207333
- Testing
- Mental Arithmetic Test
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Delirium, Agitation
Randomized Controlled Trial of Dexmedetomidine for the Treatment of Intensive Care Unit (ICU) Delirium
The purpose of the research is to see if dexmedetomidine (a drug that has a calming effect - a sedative) is effective for the treatment of acute delirium
- Trial name
- NCT00351299
- Testing
- Dexmedetomidine, Standard of Care
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Brigham and Women's Hospital
Smoking Cessation, Depression
Safety And Efficacy Of 12 Weeks Of Varenicline For Smoking Cessation In Smokers With Depression
Patients with depression tend to have a higher prevalence of smoking as well as increased severity of nicotine dependence. Phase 2 and Phase 3 varenicline clinical trials that demonstrated its efficacy and tolerability have not…
- Trial name
- NCT01078298
- Testing
- varenicline
- Where
- 41 sites in United States, Bosnia and Herzegovina and 6 more
- Volunteers
- 525 people
- Sponsor
- Pfizer
Depression
Adapting Behavioral Activation to Technology Platform
This project aims to use an asynchronous remote communities (ARC) approach both to discover the design requirements for adapting Behavioral Activation (BA) to ARC as well as design/build an ARC platform for administering BA.
- Trial name
- NCT03783533
- Testing
- Behavioral Activation
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Washington
Tobacco Use Cessation, Alcohol-related Disorders
Concurrent Alcohol and Smoking Treatment: Effects on Alcohol Relapse Risk
The majority of individuals with alcohol problems remain current smokers, and the negative health consequences of smoking among these individuals are substantial.
- Trial name
- NCT00861146
- Testing
- behavioral counseling plus contingency management
- Where
- 2 sites in United States
- Volunteers
- 151 people
- Sponsor
- Yale University
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