Clinical trials: Behavioral Symptoms
Bipolar Depression
Riluzole in the Treatment of Bipolar Depression
Bipolar disorder is a common and often chronic and debilitating mental illness. The depressive phase of bipolar disorder contributes the largest portion of the disorder, and treatment resistant bipolar depression represents a…
- Trial name
- NCT00544544
- Testing
- Riluzole
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Mclean Hospital
Depression
Does Adding a Tailored Cognitive Behavioral Therapy (CBT) Mobile Skills App Mediate Rates of Depression
Depression is a common psychological disorder seen in 18.5% of Operation Enduring Freedom (OEF), Operation Iraqi Freedom (OIF), and Operation New Dawn (OND) Veterans.
- Trial name
- CBTMobileV (NCT04002063)
- Testing
- CBT MobileWork-V plus CBT, CBT alone
- Where
- 9 sites in United States
- Volunteers
- 15 people
- Sponsor
- VA Office of Research and Development
Suicide, Suicide, Attempted
Technology-Assisted Systems Change for Suicide Prevention
Effective prevention of suicide among adult emergency department (ED) patients hinges on an indispensable component: the ability to translate evidence-based interventions into routine clinical practice on a broad scale and with…
- Trial name
- TASCS (NCT04720911)
- Testing
- In-person TASCS, Telehealth TASCS, Self-administered TASCS
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- University of Massachusetts, Worcester
Attention Deficit Hyperactivity Disorder, Reading Disabilities
Interventions for Children With Attention and Reading Disorders
The objective of this randomized clinical trial is to address unanswered questions about the relative effectiveness of treatments for children with both Attention Deficit Hyperactivity Disorder (ADHD) and significant reading…
- Trial name
- ICARD (NCT01133847)
- Testing
- Methylphenidate, Intensive reading instruction, Parent Training
- Where
- 2 sites in United States
- Volunteers
- 222 people
- Sponsor
- The University of Texas Health Science Center, Houston
Suicidal Ideation
Evaluation of a Computerized Intervention for Learning to Re-Evaluate Suicidal Thoughts
As rates of suicide have increased over the last several decades, research has identified that roughly two-thirds of individuals who attempt suicide do so within one year from the time that they begin to think about suicide.
- Trial name
- REST (NCT04254809)
- Testing
- Re-Evaluating Suicidal Thoughts, Healthy Social Living
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- Florida State University
Bipolar Disorder, Depression
Acute Psychotherapy for Bipolar II Depression
This proposed study is designed to compare the efficacy of interpersonal and social rhythm therapy (IPSRT) alone to IPSRT plus medication as an acute treatment for bipolar II depression.
- Trial name
- NCT01133821
- Testing
- IPSRT plus quetiapine
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Holly Swartz
Major Depressive Disorder
Depression, Epinephrine, and Platelet Function
Men and women who have suffered sexual and/or physical abuse before the age of 12 are at increased risk for anxiety and mood disorders, other serious psychiatric disorders, and likely medical illnesses.
- Trial name
- NCT00166114
- Testing
- Escitalopram, Desipramine
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Emory University
Phantom Limb
Cognitive Behavior Therapy (CBT) and Mirror Training for Phantom Limb Pain
The goal of this study is to test whether a combination of cognitive-behavior therapy and mirror training reduces phantom limb pain for veterans with amputations.
- Trial name
- NCT00731614
- Testing
- Cognitive Behavioral Therapy and Mirror Retraining, Supportive therapy, Mirror retraining
- Where
- 3 sites in United States
- Volunteers
- 59 people
- Sponsor
- VA Office of Research and Development
Smoking, Nicotine Dependence
Naltrexone and Varenicline: Weight Gain and Tolerability in Cigarette Smokers
The purpose of this study is to determine whether the combination of naltrexone (Depade) and varenicline (Chantix) minimizes post-smoking cessation weight gain and how well the combination is tolerated.
- Trial name
- NCT00502216
- Testing
- Naltrexone, Varenicline
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Yale University
Suicide
SAFER: A Brief Intervention Involving Family Members in Suicide Safety Planning
The management of suicide risk is a pressing national public health issue especially among Veterans, and there exist no guidelines of how best to involve family members in this effort.
- Trial name
- SAFER (NCT03034863)
- Testing
- Safe Actions for Families to Encourage Recovery, Individual Safety Planning Intervention
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- VA Office of Research and Development
Iron-deficiency, Pregnancy, High Risk
A Randomized Placebo Controlled Pilot Study of Probiotic Supplementation in At-risk Pregnant Women
The goal of this randomized supplementation feasibility trial is to learn about the feasibility and preliminary efficacy of the probiotic, lactobacillus plantarum 299v (Lp299v), in pregnant individuals at-risk for iron deficiency…
- Conditions
- Iron-deficiency, Pregnancy, High Risk, Stress, Psychological
- Trial name
- NCT03646487
- Testing
- Probiotic LP299v 10x10 colony forming units in capsule form
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Chronic Obstructive Pulmonary Disease (COPD), Heart Failure
An Intervention to Improve Function in Severe Cardiopulmonary Illness
The study is a randomized trial of a cardiopulmonary self-management intervention to improve functional capacity, health-related quality of life, and to reduce health care utilization.
- Trial name
- NCT00467298
- Testing
- Exercise adherence, Self-management- prevention of illness, Self-management of illness
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- VA Office of Research and Development
Study Focus: 30-day Rehospitalizations Among At-risk Older Adults Randomized to a Social Work-driven Care Transitions Intervention, Heart Disease
Social Work Intervention Focused on Transitions
In response to Program Announcement (PA)-09-164, "NIH Exploratory/Developmental Research Grant Program (R21) a randomized pilot study testing the efficacy of SWIFT: Social Work Intervention Focused on Transitions among at-risk…
- Conditions
- Study Focus: 30-day Rehospitalizations Among At-risk Older Adults Randomized to a Social Work-driven Care Transitions Intervention, Heart Disease, Diabetes, Hypertension
- Trial name
- SWIFT (NCT02232126)
- Testing
- SWIFT home intervention
- Where
- 2 sites in United States
- Volunteers
- 181 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Brain Fog
Transcranial Direct Current Stimulation (tDCS)
Cognitive impairment refers to when an individual struggles to learn, concentrate, remember, or make decisions. This can be due to underlying neurological diseases (i.e.
- Trial name
- tDCS (NCT05524233)
- Testing
- Active Transcranial Direct Stimulation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Baylor College of Medicine
Delirium on Emergence
Post Anesthesia Emergence and Behavioral Changes in Children Undergoing MRI
Children who receive general anesthesia may become agitated (emergence delirium) in the recovery period. This occurs more often after inhalational anesthetics, particularly sevoflurane and desflurane than after propofol.
- Trial name
- NCT02111447
- Testing
- Propofol, Sevoflurane, Isoflurane
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- State University of New York at Buffalo
Inflammation, Oxidative Stress
Reduction of Exposure, Inflammation, and Oxidative Stress Following at Least 2 Years of Switching to THS Use Compared to Cigarette Smoking
This is a cross-sectional 3-group study with subjects enrolled and matched by region (Asia, Europe), age, sex, and average daily product consumption over the last 2 years as self-reported.
- Conditions
- Inflammation, Oxidative Stress, Smoking, Smoking Abstinence
- Trial name
- NCT05385055
- Testing
- THS use, Cigarette smoking, Smoking abstinence
- Where
- 37 sites in Bulgaria, Czechia and 4 more
- Volunteers
- 974 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
HIV, Sexually Transmitted Diseases
Reducing HIV Risk Among Adolescents: Evaluating Project HEART
This study evaluates an educational web-based intervention designed to increase adolescent girls' motivation and skills to engage in safer sexual behavior (Project HEART: Health Education and Relationship Training).
- Trial name
- NCT02579135
- Testing
- Safer Sex, Growth Mindsets
- Where
- United States
- Volunteers
- 222 people, healthy volunteers welcome
- Sponsor
- North Carolina State University
Major Depressive Disorder (MDD)
Study to Evaluate the Efficacy, Safety and Tolerability of an Oral Aripiprazole/Escitalopram Combination Therapy in Participants With Major Depressive Disorder (MDD)
This will be a multicenter, randomized, double-blind study designed to assess the efficacy, safety and tolerability of an oral Aripiprazole/Escitalopram combination therapy in participants with MDD who have demonstrated an…
- Trial name
- NCT01111552
- Testing
- Escitalopram, Aripiprazole
- Where
- 60 sites in United States, Australia and 5 more
- Volunteers
- 237 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Depression, Depressive Symptoms
VITAL-DEP: Depression Endpoint Prevention in the VITamin D and OmegA-3 TriaL
The VITamin D and OmegA-3 TriaL (VITAL; NCT 01169259) is an ongoing randomized clinical trial in 25,871 U.S. men and women investigating whether taking daily dietary supplements of vitamin D3 (2000 IU) or omega-3 fatty acids…
- Conditions
- Depression, Depressive Symptoms, Mood
- Trial name
- VITAL-DEP (NCT01696435)
- Testing
- vitamin D3, omega-3 fatty acids (fish oil)
- Where
- United States
- Volunteers
- 18,353 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Depression
Inflammation-Induced CNS Glutamate Changes in Depression
Increased inflammation has been implicated in the pathophysiology of a number of neuropsychiatric illnesses including mood disorders, which affect almost 30 million adults in the United States alone.
- Trial name
- NCT03004443
- Testing
- Infliximab
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Emory University
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