Clinical trials: Behavioral and Psychological Symptoms of Dementia
Depression
Effectiveness of Escitalopram in Preventing or Reducing Depressive Symptoms in People Receiving Interleukin-2 Treatment
This study will determine the effectiveness of an antidepressant in preventing or reducing depressive symptoms in people with melanoma who are receiving Interleukin-2 (IL-2) treatment.
- Trial name
- NCT00352885
- Testing
- Escitalopram, IL-2
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Emory University
Mild Cognitive Impairment (MCI)
Instant Message-delivered Personalised Acceptance and Commitment Therapy (ACT) for Neuropsychiatric Symptoms in Persons With Mild Cognitive Impairment
This pilot study aims to develop an automated instant message-delivered intervention (i.e., EMI) for people with mild cognitive impairment, and to investigate the feasibility and effectiveness of the intervention.
- Trial name
- iact (NCT07332624)
- Testing
- Automated instant message-guided neuropsychiatric symptoms management
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- The University of Hong Kong
Mild Cognitive Impairment (MCI)
Instant Message-delivered Personalised Acceptance and Commitment Therapy (IMPACT) for Neuropsychiatric Symptoms in Persons With Mild Cognitive Impairment
This study aims to develop an automated instant message-delivered intervention (i.e., EMI) for people with mild cognitive impairment to reduce their NPS, and to investigate the feasibility and effectiveness of the intervention.
- Trial name
- IMPACT (NCT07420426)
- Testing
- automated instant message-guided neuropsychiatric symptoms management, general mental health management
- Where
- Hong Kong
- Volunteers
- 160 people
- Sponsor
- The University of Hong Kong
Transcranial Random Noise Stimulation (tRNS), Electroencephalography
Transcranial Random Noise (tRNS) for BPSD in Alzheimer's Disease: A Double-blind Randomized Controlled Trial
To investigate the treatment effect of Transcranial random noise (tRNS) on Alzheimer patients, and the underlying neural mechanism by EEG.
- Conditions
- Transcranial Random Noise Stimulation (tRNS), Electroencephalography, Alzheimer Disease, BPSD (Behavioral and Psychological Symptoms of Dementia)
- Trial name
- NCT07827196
- Testing
- High frequency transcranial random noise
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Anhui Medical University
Stress, Psychological, Anxiety
App-Based Mindfulness Meditation for People of Color Who Experience Race-Related Stress
In the United States, people of color (POC) are disproportionally affected by stressors related to race/ethnicity compared with their non-Latinx White (NLW).
- Conditions
- Stress, Psychological, Anxiety, Depression, Rumination
- Trial name
- NCT05027113
- Testing
- Mindfulness meditation
- Where
- United States
- Volunteers
- 155 people
- Sponsor
- University of California, Los Angeles
Alzheimer's Disease and Related Dementias, Quality of Life
Supporting Our Caregivers In ADRD Learning (SOCIAL)
Building on limitations of prior research, the investigators developed the Mindful and Self-Compassionate Care Program (MASC) to help caregivers of persons with Alzheimer Disease and Related Dementias (ADRD) manage stress…
- Conditions
- Alzheimer's Disease and Related Dementias, Quality of Life, Caregiver Stress
- Trial name
- SOCIAL (NCT06276023)
- Testing
- Mindful and Self-Compassionate Care Program (MASC), Health Education Program (HEP)
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Alzheimer's Disease, Agitation
Citalopram for Agitation in Alzheimer's Disease
The purpose of this study is to evaluate the safety and efficacy of citalopram for agitation in Alzheimer's dementia.
- Trial name
- CitAD (NCT00898807)
- Testing
- citalopram
- Where
- 8 sites in United States, Canada
- Volunteers
- 186 people
- Sponsor
- JHSPH Center for Clinical Trials
Caregivers, Burnout
Eudaimonia and Sleep: Effects of a Mindfulness Intervention in Caregivers of People With Dementia
This research study seeks to understand how stress reduction training influences caregiver well-being, sleep, and physiological responses to stress. All participants are caregivers of persons with dementia.
- Conditions
- Caregivers, Burnout, Sleep
- Trial name
- CARING (NCT03857308)
- Testing
- Mindfulness Training, Reappraisal Training
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Caregiver Burden, Alzheimer Disease
I-CARE 2: Mobile Telehealth to Reduce Alzheimer'S-related Symptoms
This study is a randomized, controlled trial (RCT) to evaluate the effect of Brain CareNotes (a mobile health application) on the burden experienced by unpaid caregivers of patients with dementia and on the behavioral and…
- Trial name
- I-CARE 2 (NCT05733520)
- Testing
- Brain CareNotes, Dementia Guide Expert
- Where
- 2 sites in United States
- Volunteers
- 184 people
- Sponsor
- Indiana University
Psychological Distress
Guided Eight-week Online Acceptance and Commitment Therapy for Distressed Family Caregivers of People With Dementia
The pilot randomized controlled trial aims to assess effects of a guided online acceptance and commitment therapy (ACT) intervention on distressed family caregivers of people with dementia (PwD) compared to the control group.
- Trial name
- NCT04847986
- Testing
- acceptance and commitment therapy (ACT), Control group
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Alabama at Birmingham
Alzheimer's Disease
Trial of Dronabinol Adjunctive Treatment of Agitation in Alzheimer's Disease
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease of aging. Neuropsychiatric symptoms (NPS) in AD are a major cause of burden to patients, caregivers, and society and are near-universal at some point in the…
- Trial name
- THC-AD (NCT02792257)
- Testing
- Dronabinol (Marinol®)
- Where
- 5 sites in United States
- Volunteers
- 84 people
- Sponsor
- Johns Hopkins University
Dementia or a Related Disorder, Mental Health Diagnoses
Effectiveness and Implementation of Montessori Approaches in Person-Centered Care Within VA
Background: Addressing behavioral and neuropsychiatric symptoms of Veterans with dementia and serious mental illness (SMI) such as schizophrenia can be challenging for staff in VA long-term care settings, called Community Living…
- Conditions
- Dementia or a Related Disorder, Mental Health Diagnoses, Symptoms of Agitation or Aggression
- Trial name
- MAP-VA (NCT04829500)
- Testing
- Montessori Approaches to Person-Centered Care (MAP-VA)
- Where
- United States
- Volunteers
- 356 people
- Sponsor
- VA Office of Research and Development
Stress Disorders, Traumatic, Stress Disorders, Traumatic, Acute
Researching Resiliency in Stressful Experiences (RISE) Program for Men Leaving Incarceration
The investigators are conducting a randomized controlled trial to assess the impact of Resiliency in Stressful Experiences (RISE) - a comprehensive trauma-based program for young men releasing from a southeastern state's prisons.
- Conditions
- Stress Disorders, Traumatic, Stress Disorders, Traumatic, Acute, Depressive Symptoms, Anxiety
- Trial name
- NCT04785677
- Testing
- Resiliency in Stressful Experiences (RISE) Program
- Where
- United States
- Volunteers
- 403 people
- Sponsor
- Florida State University
Alzheimer Disease
A Study of Zunveyl on Safety, Tolerability, Neuropsychiatric Symptoms, and Caregiver Distress in Alzheimer's Disease (RESOLVE)
The primary purpose of this study is to evaluate the safety and tolerability of Zunveyl® over 12 weeks of routine clinical use in adults with mild to moderate Alzheimer's disease.
- Trial name
- RESOLVE (NCT07633470)
- Testing
- Zunveyl®
- Where
- 22 sites in United States
- Volunteers
- 150 people
- Sponsor
- Alpha Cognition, Inc
Chronic Pain
EEG-characteristics of Neuropsychiatric Symptoms in Chronic Pain
Chronic pain is a challenge for patients, physicians and society due to its high prevalence and its substantial individual and socio-economic burden.
- Trial name
- NCT05261243
- Testing
- EEG / questionnaires / working memory task
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- Technical University of Munich
Caregiving Stress
Mindfulness-Based Intervention Using Consumer-Grade Wearable Devices with Biofeedback for Family Caregivers of People with Dementia
The aim of this study is to investigate the effectiveness of a brief mindfulness training intervention using a consumer-grade wearable device with biofeedback for reducing stress and promoting psychological health in family…
- Trial name
- NCT06619938
- Testing
- Mindfulness With Biofeedback, Mindfulness Without Biofeedback
- Volunteers
- 260 people
- Sponsor
- The Hong Kong Polytechnic University
Alzheimer Disease
Memantine Treatment in Alzheimer's Disease Patients
The aim of this study is to investigate whether there will be any efficacy difference of Memantine treatment in different cognitive severity AD patients stratified with BPSD
- Trial name
- NCT03168997
- Testing
- Memantine Hydrochloride
- Volunteers
- 222 people
- Sponsor
- Wei Cuibai
Alzheimer Disease, End of Life
Palliative Care Education in Assisted Living for Dementia Care Providers (PCEAL-DCP)
The palliative care education in assisted living for dementia care providers (PCEAL-DCP) is a 4-week intervention (once a week for 1.5 hours, a total of 6 hours) for licensed nurses, administrators and dementia care coordinators…
- Conditions
- Alzheimer Disease, End of Life, Caregiver Burden, Caregiver Burnout
- Trial name
- PCEAL-DCP (NCT06722352)
- Testing
- Palliative Care Training
- Where
- 2 sites in United States
- Volunteers
- 792 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Mental Health (Depression), Mental Health and General Well-being
Thrive at Home: A Virtual Reality Social Intervention for Older Adults
The goal of this clinical trial is to evaluate whether a virtual reality (VR) based social platform can improve mental health and social connection for older adults who receive in-home care.
- Conditions
- Mental Health (Depression), Mental Health and General Well-being, Loneliness, Well Being
- Trial name
- Thrive at Home (NCT07835568)
- Testing
- Full Virtual Reality Social Intervention, Abbreviated Virtual Reality Social Intervention
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of California, Santa Barbara
Guilt, Depressive Symptoms
Guilt Focused Psychological Intervention
Participants in the intervention study will be 120 caregivers with guilt feelings linked with care and high levels of emotional distress (anxiety and/or depression), randomly allocated to the intervention conditions: intervention…
- Conditions
- Guilt, Depressive Symptoms, Anxious Symptoms, Stress, Physiological
- Trial name
- LONG-CARE (NCT04656808)
- Testing
- Guilt Focused Intervention, Cognitive behavioral therapy
- Where
- Spain
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Universidad Rey Juan Carlos