Clinical trials: Behavioral and Psychological Symptoms of Dementia
Alzheimer Disease, Mild Cognitive Impairment
Sleep Disturbance and Emotion Regulation Brain Dysfunction as Mechanisms of Neuropsychiatric Symptoms in Alzheimer's Dementia
Recent findings suggest that sleep disruption may contribute to the generation and maintenance of neuropsychiatric symptoms including anxiety, depression, agitation, irritation, and apathy while treating sleep disruption reduces…
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Neuropsychiatric Symptoms, Sleep Disturbance
- Trial name
- NCT04100057
- Testing
- Cognitive Behavioral Therapy for Insomnia (CBT-I), Desensitization Therapy for insomnia (DT-I)
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Stanford University
Caregiver Burden, Alzheimer Disease
I-CARE 2: Mobile Telehealth to Reduce Alzheimer'S-related Symptoms
This study is a randomized, controlled trial (RCT) to evaluate the effect of Brain CareNotes (a mobile health application) on the burden experienced by unpaid caregivers of patients with dementia and on the behavioral and…
- Trial name
- I-CARE 2 (NCT05733520)
- Testing
- Brain CareNotes, Dementia Guide Expert
- Where
- 2 sites in United States
- Volunteers
- 184 people
- Sponsor
- Indiana University
Alzheimer Disease, Depression
Transcranial Direct Current Stimulation for Depression in Alzheimer's Disease Patient - Preliminary Research
This project will investigate the safety and efficacy of transcranial direct current stimulation (tDCS) in the treatment of depression among patients with Alzheimer's disease.
- Trial name
- ADAPT (NCT02351388)
- Testing
- Transcranial Direct Current Stimulation
- Where
- Japan
- Volunteers
- 4 people
- Sponsor
- National Center of Neurology and Psychiatry, Japan
Behavioral and Psychological Symptoms in Alzheimer's Disease, Behavioral and Psychological Symptoms in Vascular Dementia
DAOIB for the Treatment of Cognitive Function and Behavioral and Psychological Symptoms of Dementia
The population of dementia is increasing rapidly. Cognitive impairment as well as Behavioral and psychological symptoms of dementia (BPSD) add heavy burdens to caregiver. NMDA activation is critical for learning and memory.
- Trial name
- NCT02103673
- Testing
- DAOIB
- Where
- 2 sites in Taiwan
- Volunteers
- 90 people
- Sponsor
- Chang Gung Memorial Hospital
Depressive Symptoms
A Ten-Week Online Acceptance and Commitment Therapy Intervention for Family Caregivers of People With Dementia
This randomized controlled trial aims to assess the effects of a coach-guided ten-week videoconferencing acceptance and commitment therapy (ACT) program on mental health outcomes in depressed family caregivers of people with…
- Trial name
- NCT05043441
- Testing
- Acceptance and commitment therapy (ACT), Psychoeducation
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Alabama at Birmingham
Alzheimer s Disease, Dementia
CommunityRx-Dementia + Peer Navigation (CRxDpeer)
The CRxDpeer intervention, delivered by a trained peer navigator, in practice called a "peer mentor", includes three evidence-based components: (a) focused education about common social (e.g., food and housing insecurity) and…
- Conditions
- Alzheimer s Disease, Dementia, Caregiver, Loneliness
- Trial name
- CRxDpeer (NCT07346183)
- Testing
- CommunityRx-Dpeer
- Where
- United States
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Dementia Alzheimers
ImGTS for Patients With Behavioral and Psychological Symptoms of Dementia (Phase 2)
The proposed research project aims to answer the question "Are immersive technology systems effective in the management and treatment of patients with BPSD?".
- Trial name
- NCT06072014
- Testing
- Virtual reality
- Where
- Philippines
- Volunteers
- 30 people
- Sponsor
- Augmented eXperience E-health Laboratory
Subjective Cognitive Complaint, Mild Cognitive Impairment
Validation of the MBI-C Scale in French
This study aims to validate the French version of the Mild Behavioral Impairment-Checklist (MBI-C) scale, hypothetically effective for measuring behavioral symptoms in patients presenting with a subjective cognitive complaint or…
- Conditions
- Subjective Cognitive Complaint, Mild Cognitive Impairment, Neuropsychiatric Symptoms
- Trial name
- MBI-C (NCT06516159)
- Testing
- MBI-C Scale in French
- Where
- 5 sites in France
- Volunteers
- 170 people
- Sponsor
- University Hospital, Toulouse
Neuropsychiatric Disorders, Neuroinflammatory Disorders
A Longitudinal Natural History Study of Immune Biomarkers in Neuropsychiatric Illness
Background: Some brain or mental health conditions may be caused when a person s immune system attacks their own body. These are called immunologic neuropsychiatric disorders.
- Conditions
- Neuropsychiatric Disorders, Neuroinflammatory Disorders, Post-Infectious Neuropsychiatric Disorders
- Trial name
- NCT07877246
- Where
- 3 sites in United States
- Volunteers
- 5,000 people
- Sponsor
- National Institute of Mental Health (NIMH)
Dementia
Multisensory Stimulation in Dementia.
Dementia is one of the main causes of disability in the elderly. It is characterized by cognitive, functional and social impairment, as well as behavioral changes.
- Trial name
- NCT04008342
- Testing
- Multisensory intervention
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Federal University of Minas Gerais
Anxiety, Anxiety Generalized
Telephone Acceptance and Commitment Therapy Intervention for Caregivers of Adults With Dementia
Caregivers of adults with dementia report higher distress, including anxiety and depressive symptoms, burden, and existential suffering, than caregivers of people with other chronic diseases.
- Conditions
- Anxiety, Anxiety Generalized, Anxiety Disorders and Symptoms, Caregiver Burnout
- Trial name
- TACTICs (NCT04338750)
- Testing
- Telephone Acceptance and Commitment Therapy Intervention for Caregivers, minimally-Enhanced Usual Care
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Indiana University
Dementia, Alzheimer's Disease
Virtual Reality Intervention for the Reduction of Behavioral and Psychological Symptoms of Dementia
Alzheimer's disease and related disorders (AD2) are characterised by cognitive changes and Behavioural and Psychological Symptoms of Dementia (BPSD).
- Conditions
- Dementia, Alzheimer's Disease, Neurocognitive Disorders
- Trial name
- LUMEENCOMPAD (NCT04769024)
- Testing
- LUMEEN Virtual Reality sessions, Control/non-digital stimulation sessions
- Where
- 6 sites in France
- Volunteers
- 56 people
- Sponsor
- Hospices Civils de Lyon
Caregivers, Burnout
Eudaimonia and Sleep: Effects of a Mindfulness Intervention in Caregivers of People With Dementia
This research study seeks to understand how stress reduction training influences caregiver well-being, sleep, and physiological responses to stress. All participants are caregivers of persons with dementia.
- Conditions
- Caregivers, Burnout, Sleep
- Trial name
- CARING (NCT03857308)
- Testing
- Mindfulness Training, Reappraisal Training
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Exercise, Gait
Rhythmically Entrained Exercise in Community-Dwelling Older Adults
Researchers at the University of North Carolina at Greensboro conduct a single-arm intervention trial to investigate the efficacy of a music-based group exercise program for community-dwelling older adults.
- Conditions
- Exercise, Gait, Cognitive Decline, Caregiver Burden
- Trial name
- REECO (NCT05462977)
- Testing
- Group exercise program
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Greensboro
Alzheimer's Disease
Trial of Dronabinol Adjunctive Treatment of Agitation in Alzheimer's Disease
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease of aging. Neuropsychiatric symptoms (NPS) in AD are a major cause of burden to patients, caregivers, and society and are near-universal at some point in the…
- Trial name
- THC-AD (NCT02792257)
- Testing
- Dronabinol (Marinol®)
- Where
- 5 sites in United States
- Volunteers
- 84 people
- Sponsor
- Johns Hopkins University
Dementia, Burden, Caregiver
An Internet-Based Education Program for Care Partners of People Living With Dementia
With the aging population, the prevalence of dementia is increasing dramatically. People living with dementia are highly dependent on family care partners, who may have little knowledge of the disorder.
- Conditions
- Dementia, Burden, Caregiver, Self Efficacy, Knowledge
- Trial name
- NCT05114187
- Testing
- Education Intervention, Education Control
- Where
- Canada
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- McMaster University
Dementia, Family Relations
Management of Psychological and Behavioral Symptoms in Patients With Dementias
Background: The psychological and behavioral symptoms (SPCD) of dementias are the manifestations that cause the most suffering in the patient and caregiver, worsening the other two symptomatic areas (cognitive and functional) and…
- Conditions
- Dementia, Family Relations, Psychological and Behavioral Symptoms
- Trial name
- PRESTA (NCT03732521)
- Testing
- Educational therapy
- Where
- Spain
- Volunteers
- 36 people
- Sponsor
- Institut Investigacio Sanitaria Pere Virgili
Alzheimer Disease, Dementia
HEARS-NPS: Addressing Hearing Loss as a Common Unmet Contributor of Neuropsychiatric Symptoms
This randomized controlled trial study aims to evaluate a revised hearing care intervention for older adults with Alzheimer's Disease and Related Dementias (ADRD).
- Conditions
- Alzheimer Disease, Dementia, Hearing Loss, Cognitive Impairment
- Trial name
- HEARS-NPS (NCT06930560)
- Testing
- HEARS-NPS device, HEARS-NPS program
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Dementia, Caregiver Burden
Efficacy of VR Educational Program on Empathy and Attitudes Toward Dementia in Caregivers
This randomized controlled trial evaluated a single-session virtual reality (VR) dementia simulation with guided small-group reflection compared with a time-matched, instructor-led lecture.
- Trial name
- NCT06072274
- Testing
- Virtual reality dementia simulation with guided reflection, Traditional dementia education (lecture)
- Where
- Taiwan
- Volunteers
- 227 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Alzheimer's Disease, Dementia
A Study of Acupuncture for Patients With Behavioural and Psychological Symptoms of Dementia
The purpose of the study is to evaluate the safety and tolerability of acupuncture for patients with BPSD \& healthy volunteers.
- Trial name
- NCT01055561
- Testing
- Acupuncture
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Chengdu University of Traditional Chinese Medicine