Clinical trials: Behaviour
Depressive Disorder, Violence
Text-Message-Based Depression Prevention for High-Risk Youth in the ED
The purpose of this randomized controlled study is to evaluate acceptability and feasibility, and to gather preliminary data about efficacy, of "iDOVE," a brief emergency department introductory session + longitudinal automated…
- Trial name
- iDOVE (NCT02332239)
- Testing
- iDOVE Intervention (ED+text), Control (EUC)
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- Rhode Island Hospital
Prevention and Control
PrOVE QUERI Project #1
The overall goal of this project is to test two strategies for implementing a shared decision making tool to be used by providers while talking to patients about lung cancer screening.
- Trial name
- NCT02765412
- Testing
- Webinar, Promotion, and Tool Access, LEAP, Audit and Feedback
- Where
- 8 sites in United States
- Volunteers
- 17,033 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Attention Deficit Disorder With Hyperactivity
Cognitive Behavioral Therapy for Treatment of Adult Attention Deficit Hyperactivity Disorder
This study will determine the efficacy of cognitive behavioral therapy in treating adults with attention deficit hyperactivity disorder.
- Trial name
- NCT00118911
- Testing
- Cognitive behavioral therapy (CBT), Relaxation techniques and education about ADHD
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- Massachusetts General Hospital
Borderline Personality Disorder
Treating Suicidal Behavior and Self-Mutilation in People With Borderline Personality Disorder
This study will determine whether dialectical behavior therapy and fluoxetine are more effective combined or alone in treating people with borderline personality disorder.
- Trial name
- NCT00533117
- Testing
- Fluoxetine, Dialectical Behavior Therapy, Supportive psychotherapy
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- New York State Psychiatric Institute
Chronic Pelvic Pain, Endometriosis
Novel Web-based, Self-directed Intervention for Chronic Pelvic Pain
The study is being completed to evaluate the effectiveness of a web-based, self-management program for patients with Chronic Pelvic Pain (CPP).
- Trial name
- NCT06352840
- Testing
- My Pelvic Plan Website, Control Group website
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Michigan
Chronic Kidney Disease
Peer-mentoring, Quality of Life and Caregiver Burden in Patients With Chronic Kidney Disease and Their Caregivers
Receiving supportive mentoring from well-adjusted individuals who share similar experiences has had a positive influence on adjustment with some chronic diseases.
- Trial name
- NCT02429115
- Testing
- Mentoring
- Where
- United States
- Volunteers
- 241 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Type 2 Diabetes Mellitus
A Psychological-behavioral Intervention to Increase Activity in Type 2 Diabetes
The focus of this study is to examine the feasibility, acceptability, and impact of a customized, combined positive psychology and motivational interviewing (PP-MI) health behavior intervention in a group of patients with type 2…
- Trial name
- BEHOLD-16 (NCT03164538)
- Testing
- Positive Psychology + Motivational Interviewing, Diabetes Education
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Massachusetts General Hospital
Adolescent Behavior, Tobacco Use
Pittsburgh and Rural Area High School Tobacco Prevention
This research project will explore the feasibility and acceptability of a web-based media literacy tobacco prevention program. The project will be conducted with 9th graders in two schools in the Pittsburgh area.
- Conditions
- Adolescent Behavior, Tobacco Use, E-Cig Use
- Trial name
- NCT05081843
- Testing
- AD IT UP media literacy intervention, Usual health education curriculum
- Where
- United States
- Volunteers
- 318 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Smoking Cessation
Take a Break (TAB): mHealth-assisted Skills Building Challenge for Unmotivated Smokers
Take a Break (TAB) is a randomized trial designed to evaluate Nicotine Replacement Therapy (NRT)-sampling and a mHealth suite of apps.
- Trial name
- NCT02973425
- Testing
- Take a Break as an augmentation to NRT-sampling in Motivation Phase, NRT and mHealth assessment tool without feedback
- Where
- 4 sites in United States
- Volunteers
- 433 people
- Sponsor
- University of Massachusetts, Worcester
Stress, Anxiety
Effects of Open-label Placebos on COVID-related Psychological Health
This project aimed to test the efficacy of a telehealth-administered placebo without deception intervention on stress, anxiety, and depression related to the COVID-19 pandemic.
- Conditions
- Stress, Anxiety, Depression
- Trial name
- NCT05035550
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Michigan State University
Dementia, Alzheimer Disease
Assessing a Novel Virtual Environment That Assists With Activities of Daily Living
This Phase 1 study looks at how a new videogame-based program can help residents and care partners prepare for ADLs in a fun way with minimal risk, potentially reducing escalating problems associated with ADL completions.
- Conditions
- Dementia, Alzheimer Disease, Neurodegenerative Diseases
- Trial name
- NCT05418296
- Testing
- A novel digital health device
- Where
- 2 sites in United States
- Volunteers
- 38 people
- Sponsor
- mandy
Alcohol Use Disorder, Cigarette Smoking
Semaglutide for Alcohol Use Disorder
This is an early-Phase II human laboratory trial using a randomized, placebo-controlled, dose-ranging design to investigate the effects of semaglutide, a GLP-1 receptor agonist, on alcohol-related outcomes in adults with alcohol…
- Trial name
- NCT05520775
- Testing
- Semaglutide
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Major Depressive Disorder
The Effects of Videogames on Depression Symptoms and Brain Dynamics
The purpose of the study is to evaluate the effects of a game-based digital-therapeutics (DTx) medical software device on the symptoms of depression in adults with confirmed major depressive disorder.
- Trial name
- NCT05426265
- Testing
- MEL-T01, MEL-S01
- Where
- 6 sites in Finland
- Volunteers
- 1,001 people, healthy volunteers welcome
- Sponsor
- Aalto University
Depression
Depression Screening in Black Churches
The overall aim of this study is to employ Community Health Workers (CHWs) to screen for depression in 30 Black churches and compare the effectiveness of Screening, Brief Intervention, and Referral to Treatment (SBIRT)…
- Trial name
- NCT04524767
- Testing
- SBIRT, Referral as Usual
- Where
- 2 sites in United States
- Volunteers
- 505 people, healthy volunteers welcome
- Sponsor
- Columbia University
Major Depressive Disorder
Augmentation of Treatment-Resistant Depression With An Analog of the Neuroactive Steroid Allopregnanolone
Major depressive disorder (MDD) is highly prevalent and nearly 70% of individuals with MDD do not respond to standard antidepressant therapies despite adequate dosing.
- Trial name
- NCT02900092
- Testing
- Ganaxolone
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Massachusetts General Hospital
Cigarette Smoking
Effects of Smoking Environments on Craving and Smoking (CameraCue2.0)
The goal of this study is to evaluate the effects of varenicline versus nicotine replacement versus placebo on personal smoking environment cue (PSE) reactivity.
- Trial name
- NCT02551692
- Testing
- Nicotine Patch, Varenicline
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Duke University
Periodontal Diseases, Chronic Periodontitis
Effect of Switching From Cigarette Smoking to the Use of IQOS on Periodontitis Treatment Outcome
The purpose of this study was to demonstrate in patients with generalized chronic periodontitis that switching from cigarette smoking to using IQOS improves the response to periodontal therapy and the overall oral health status…
- Conditions
- Periodontal Diseases, Chronic Periodontitis, Periodontal Pocket, Tooth Mobility
- Trial name
- NCT03364751
- Testing
- IQOS, Cigarette
- Where
- 26 sites in Japan
- Volunteers
- 179 people
- Sponsor
- Philip Morris Products S.A.
Mental Health
Computerized Assessment and Referral System Screener for Mental Health Evaluations in the Emergency Setting
This is a hybrid effectiveness-implementation randomized controlled trial which will be conducted at the emergency department (ED) at the University of Arkansas for Medical Sciences (UAMS) in Little Rock, Arkansas.
- Trial name
- CARS-SA (NCT03323853)
- Testing
- Computerized Assessment and Referral System (CARS) Self-Assessment Screener, CARS-SA Summary Results
- Where
- United States
- Volunteers
- 451 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Obesity
Semaglutide Treatment, Appetite, and Eating Behavior: Long-term Effects
This study will evaluate the effect of semaglutide on eating behavior, appetite (hunger/fullness), and food liking in the long-term, as compared to placebo.
- Trial name
- STABLE Wt Loss (NCT05548647)
- Testing
- Behavioral Treatment, Semaglutide 2.4 MG/0.75 ML Subcutaneous Solution [WEGOVY]
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Pennsylvania
Major Depressive Disorder
Randomised Placebo-controlled Duloxetine-referenced Study of Efficacy and Safety of 5 mg of Vortioxetine (Lu AA21004) in Acute Treatment of Major Depressive Disorder in Elderly Patients
To assess the efficacy of Vortioxetine (5 mg daily) versus placebo in the acute treatment of depression by means of the change from baseline in the 24-item Hamilton Depression Scale (HAM-D24) total score after 8 weeks of…
- Trial name
- NCT00811252
- Testing
- Vortioxetine (Lu AA21004), Duloxetine
- Volunteers
- 453 people
- Sponsor
- H. Lundbeck A/S
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