Clinical trials: Benign Disease
Metabolically Healthy Obesity, Intermittent Fasting
Healthy vs Unhealthy Obesity: Mehanistic Insights and Effects of Time-Restricted Eating
Obesity-related cardiometabolic diseases are now a leading cause of death worldwide. These diseases result from a dysfunctional adipose tissue (AT) that induces inflammation, insulin resistance and altered endocrine function.
- Trial name
- NCT05136313
- Testing
- Time-restricted eating
- Where
- Chile
- Volunteers
- 53 people
- Sponsor
- Instituto de Nutrición y Tecnología de los Alimentos
Benign Prostatic Hyperplasia, Micturition Disorder
The Effect of Urinating Through the Zipper or by Pulling Down the Trousers on Uroflowmetry Parameters in LUTS
There are many factors that affect uroflowmetry parameters. One of these is the urination position. Research has mostly focused on standing and sitting urination positions.
- Conditions
- Benign Prostatic Hyperplasia, Micturition Disorder, Urinary Obstruction, Urinary Tract Disease
- Trial name
- NCT06260917
- Testing
- position of urination
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Ankara City Hospital Bilkent
Overactive Bladder
Extension Study of Vibegron in Men With Overactive Bladder (OAB) Symptoms on Pharmacological Therapy for Benign Prostatic Hyperplasia
This study will assess the long-term safety of vibegron when dosed up to 52 weeks in men with overactive bladder (OAB) symptoms on pharmacological therapy for Benign Prostatic Hyperplasia (BPH) who previously completed treatment…
- Trial name
- NCT04103450
- Testing
- Vibegron
- Where
- 35 sites in United States, Poland
- Volunteers
- 276 people
- Sponsor
- Urovant Sciences GmbH
Benign Prostatic Hyperplasia
Economic Evaluation of Prostatic Urethral Lift
Prostatic urethral lift (Urolift) has been developed as a minimally invasive alternative to transurethral resection of the prostate with no need of general anaesthesia, less need of urinary catheter and less exposure to…
- Trial name
- ECOLIFT (NCT04726748)
- Testing
- Comparisons between the Prostatic urethral lift (PUL) and the TURP/Laser cohorts, Comparison between the Prostatic urethral lift (PUL) and the SNDS cohorts
- Where
- 6 sites in France
- Volunteers
- 1,360 people
- Sponsor
- University Hospital, Bordeaux
Stomach Neoplasms, Benign
Identification of Therapeutic Targets in Metastatic Gastric Cancer
This is a pilot study aiming at identifying novel therapeutic molecular targets in patients with gastric cancer with lymph nodes or distant metastasis.
- Trial name
- NCT07551440
- Where
- Hong Kong
- Volunteers
- 100 people
- Sponsor
- Chinese University of Hong Kong
Uterine Bleeding Disorders, Benign Uterine Conditions
Comparison of BiCision® Versus UltraCision® During Laparoscopic Supracervical Hysterectomy (LASH)
The aim of the study is the evaluation of the efficiency and safety of the new, CE-certified thermofu-sion and dissection instrument BiCision® in comparison with the long established Ultracision® Har-monic Scalpel(Ethicon)during…
- Conditions
- Uterine Bleeding Disorders, Benign Uterine Conditions, Focus: Comparison of Two Instruments
- Trial name
- NCT01752725
- Testing
- BiCision®, Ultracision® Har-monic Scalpel(Ethicon)
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- University Hospital Tuebingen
Kidney Stone, Benign Prostatic Hyperplasia
Utilization of a Web-Based Application to Improve Patient Health Literacy and Reduce Clinic Visit Times in Holmium Laser Enucleation of the Prostate (HoLEP) Procedures and Kidney Stone Surgery
The investigator and research team plan to investigate whether patients who receive access to WellPrept website will report greater confidence and understanding of their medical condition, have shorter clinic visit times, and…
- Trial name
- NCT07580391
- Testing
- WellPrept, Standard Care
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Crohn Disease, Polyposis
Clinical Database of Colorectal Robotic Surgery
Evaluation of robot Da Vinci Xi by determining its learning curve.The operating time will be defined by patient then the operating average will be calculated.
- Conditions
- Crohn Disease, Polyposis, Ulcerative Colitis, Diverticulitis
- Trial name
- ROBOT CR (NCT04013152)
- Testing
- Clinical database
- Where
- 4 sites in France
- Volunteers
- 1,800 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Breast Cancer
VisR Ultrasound for Noninvasively Interrogating Stromal Collagen Organization in Women as a Breast Cancer Biomarker: Evaluation of Anisotropy in Cancer Patients
Purpose: This study will evaluate how measurements of tissue stiffness, viscosity, and anisotropy using non-invasive ultrasound imaging correlate with breast tumor malignancy and response to chemotherapy.
- Trial name
- NCT06878547
- Testing
- Ultrasound
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Goiter
Subtotal Versus Total Thyroidectomy for Benign Goiter
The extent of thyroid resection in benign goiter is controversial. Potential advantages of TT over BST may include: one-stage removal of incidental thyroid cancer reported in up to 10% of operatively treated benign thyroid…
- Trial name
- NCT01273714
- Testing
- thyroid resection
- Where
- Poland
- Volunteers
- 8,006 people
- Sponsor
- Jagiellonian University
Benign Prostatic Hyperplasia
Comparing Rezum and Urolift
This is a randomized controlled trial using a non-inferiority design with the subjects randomized 1:1 to either water vapour thermal treatment (REZUM) arm or prostatic urethral lift (UroLift) arm.
- Trial name
- NCT06820606
- Testing
- Rezum, UroLift
- Where
- Hong Kong
- Volunteers
- 120 people
- Sponsor
- Chinese University of Hong Kong
Thyroid Nodule, Thyroid Diseases
Fusion UltraSound Imaging Of the Thyroid GlaNd With I-124 PET. Evaluation of Nodule Allocation.
Regular thyroid diagnostics versus augmented thyroid work-up with additional I-124 PET/US fusion for metabolic-sonographic nodule allocation in patients with benign thyroid diseases
- Conditions
- Thyroid Nodule, Thyroid Diseases, Thyroid Goitre
- Trial name
- FUSION iENA (NCT03128255)
- Testing
- Assessment of already preacquired I-124 PET/US
- Where
- Germany
- Volunteers
- 70 people
- Sponsor
- Jena University Hospital
Benign Prostatic Hyperplasia, Stress Urinary Incontinence (SUI)
Optimization of Surgical Treatment Pathways for BPH Based on Real-World Data
Benign prostatic hyperplasia is a noncancerous enlargement of the prostate that can cause difficulty urinating. Holmium laser enucleation of the prostate (HoLEP) uses a laser to remove prostate tissue blocking urine flow.
- Trial name
- NCT07872085
- Testing
- Conventional HoLEP Without Apical Pre-disconnection, HoLEP With Fixed 12 O'clock Apical Pre-disconnection, HoLEP With MRI-Guided Individualized Apical Pre-disconnection
- Where
- China
- Volunteers
- 153 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Benign Brain Tumors, Proton Therapy
Changes in the MRI Signal in Patients With Benign Tumors of the Brain and Meninges Treated With Proton Therapy: Impact of TEL and the Biological Dose Received
The main objective is to detect with TESLA multiparametric 3 MRI, the MRI secondary changes to protontherapy irradiation and to correlate them with TEL mapping, physical dose and biological dose.
- Trial name
- BRAIN TEL (NCT04584086)
- Testing
- MRI 3 tesla
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Francois Baclesse
Benign Thyroid Gland Neoplasm, Recurrent Thyroid Gland Carcinoma
Radiofrequency Ablation for the Treatment of Benign or Low Risk Thyroid Nodule
This phase IV trial studies the effect of radiofrequency ablation in treating patients with benign or low risk thyroid nodule. Radiofrequency ablation uses a needle to deliver a high-frequency electric current to kill tumor cells…
- Conditions
- Benign Thyroid Gland Neoplasm, Recurrent Thyroid Gland Carcinoma, Thyroid Gland Follicular Tumor of Uncertain Malignant Potential, Thyroid Gland Nodule
- Trial name
- NCT05003856
- Testing
- Quality-of-Life Assessment, Radiofrequency Ablation
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- M.D. Anderson Cancer Center
Biliary Stricture, Biliary Anastomotic Stenosis
DIGEST I Drug Coated Balloon for Biliary Stricture
DIGEST I Pilot study is a feasibility study for evaluating the safety and efficacy of DCBs.
- Conditions
- Biliary Stricture, Biliary Anastomotic Stenosis, Biliary Obstruction, Biliary Disease
- Trial name
- DIGEST (NCT03997994)
- Testing
- GIE Drug Coated Balloon
- Where
- Paraguay
- Volunteers
- 8 people
- Sponsor
- GIE Medical
Benign Uterine Disease
Disposable Energy Sources and Operating Room Time for Laparoscopic Hysterectomy
Over 600,000 hysterectomies are performed each year nationwide. Over 99% of these are accomplished laparoscopically in the investigators current surgical practice to allow women a quicker recovery than a traditional large…
- Trial name
- NCT02065453
- Testing
- disposable device (Ligasure, Covidien), Reusable device
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- St. Louis University
Fibroadenoma, Breast Fibroadenoma
Management of Breast Fibroadenoma: Comparing Observation, Microwave Ablation, and Surgical Excision
The purpose of this study is to evaluate and compare three different management strategies for benign breast fibroadenoma: conservative management with clinical and radiological follow-up (observation), ultrasound-guided…
- Conditions
- Fibroadenoma, Breast Fibroadenoma, Benign Breast Disease
- Trial name
- NCT07890766
- Testing
- Ultrasound-guided percutaneous microwave ablation, Conventional open surgical excision
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Sohag University
Gastric Cancer, Molecular Imaging
Novel Humanized Ferritin-based NIR Fluorescent Molecular Probe for Identifying Tumor Margins in Gastric Tissue
Radical surgery remains the primary treatment for gastric cancer, but intraoperative tumor margin assessment relies on surgeons' visual inspection, limiting accuracy.
- Trial name
- NCT07276854
- Testing
- Diagnostic Test: ICG-FTn perfusion solution
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Female Genital Diseases, Ovarian Cancer
Prospective Evaluation of Lymphoedema Among Patients With Gynaecological Cancer
This project will conduct a prospective, longitudinal, observational cohort study to assess the onset and incidence of lymphoedema, as well as investigate factors associated with its development among women newly diagnosed with…
- Conditions
- Female Genital Diseases, Ovarian Cancer, Cervical Cancer, Endometrial Cancer
- Trial name
- LEGS (NCT00604994)
- Where
- 6 sites in Australia
- Volunteers
- 761 people
- Sponsor
- Queensland Centre for Gynaecological Cancer
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