Clinical trials: Benign Neoplasm
Bronchial Neoplasm Benign
Survivin and Fibulin-3 in Benign and Malignant Respiratory Diseases
Purpose: Survivin is a common member of the inhibitors of the apoptosis protein (IAP) family with a dual role in promoting cell proliferation and preventing apoptosis.
- Trial name
- NCT04413292
- Testing
- ELISA assays and Westren blot analysis of survivin and fibulin-3 expression
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- South Valley University
Ovarian Cancer, Borderline Ovarian Tumors
Treg, Th17 Cells, NKT in Epithelial Ovarian Tumor
The aim of the study was to estimate the percentage and of Treg, Th17 and NKT in peripheral blood and the tissue of the epithelial ovarian tumor and relationship with blood serum level of HE4, CA125, as well as algorithm ROMA.
- Conditions
- Ovarian Cancer, Borderline Ovarian Tumors, Benign Ovarian Tumor, Unexplained Infertility
- Trial name
- NCT03779399
- Testing
- Assessment of percentage of Treg, Th17, NKT and serum level of HE4, CA125 and ROMA.
- Where
- Poland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medical University of Lublin
Malignant Tumor of Breast, Benign Breast Lumps
Implantation of CEST and CESL MRI Methods for Detection of Breast Tumors
MRI is a well-established method in breast imaging. It gives excellent morphological information but does not reflect the metabolic activity leading to high proportion of false positive results.
- Conditions
- Malignant Tumor of Breast, Benign Breast Lumps, High-Risk Breast Cancer
- Trial name
- NCT05305937
- Testing
- MRI scan
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Bladder Cancer
Urinary Microbiome Differences in Bladder Cancer, Benign Urinary Diseases and Healthy Counterparts in Adult Male Population
The study aims to investigate alterations in the bladder microbiome in adult men with bladder cancer, healthy men, and men with benign urinary disease
- Trial name
- NCT06992986
- Testing
- Investigating differences in the bladder microbiome
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Regina Elena Cancer Institute
Seborrheic Keratosis (SK), Oxidative Stress
Relationship Between Serum Xanthine Oxidase Levels and Seborrheic Keratosis
This observational study aims to examine the relationship between serum xanthine oxidase (XO) levels and seborrheic keratosis (SK), a common benign skin tumor, especially in middle-aged and older adults.
- Conditions
- Seborrheic Keratosis (SK), Oxidative Stress, Skin Aging
- Trial name
- SK-XO (NCT07095348)
- Testing
- Serum Xanthine Oxidase Level Assessment
- Where
- Indonesia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sri Nauli Dewi Lubis
Breast Cancer, Mass Cystic
Combined Digital X-ray and Ultrasound Technique for Improved Detection and Characterization of Breast Lesions
The study will evaluate and refine a breast screening and diagnosis device.
- Conditions
- Breast Cancer, Mass Cystic, Benign Mass
- Trial name
- NCT00721435
- Testing
- 3D Tomosynthesis and ultrasound imaging
- Where
- 2 sites in United States
- Volunteers
- 183 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Skin Cancer, Skin Cancer Prevention
Developing and Testing the Effectiveness of a Skin Cancer Self-Detection Educational Program
Skin cancer is a significant public health concern, even in an Asian society like Singapore where it ranks among the top 10 cancers.
- Conditions
- Skin Cancer, Skin Cancer Prevention, Benign Skin Growth
- Trial name
- NCT07247123
- Testing
- Skin Cancer Self-Detection Educational Program with gain-framing, Skin Cancer Self-Detection Educational Program with loss-framing, Wait-list Control
- Where
- Singapore
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Skin Cancers - Basal Cell Carcinoma, Skin Cancers - Squamous Cell Carcinoma
An Observational Study Using The LumAssure Device In Participants Undergoing Assessment Of Skin Conditions.
This is an observational study in adult males and females utilising skin condition measurements using the LumAssure Raman device.
- Conditions
- Skin Cancers - Basal Cell Carcinoma, Skin Cancers - Squamous Cell Carcinoma, Melanoma of Skin, Inflammatory Dermatoses
- Trial name
- NCT06661577
- Where
- 2 sites in New Zealand
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- University of Auckland, New Zealand
Breast Cancer, Benign Breast Disease
Johns Hopkins Breast Cancer Program Longitudinal Repository
The Breast Cancer Program Longitudinal Repository (BCPLR) is being established to fulfill the research mission of the Breast Cancer Program at Johns Hopkins and to serve investigators affiliated with it - to develop a repository…
- Trial name
- NCT01937039
- Testing
- Sample collection
- Where
- United States
- Volunteers
- 810 people, healthy volunteers welcome
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Breast Cancer Female
Identification of Benign and Malignant Breast Nodules Using Ultrasound-modulated Optical Tomography: A Multicenter Study
Ultrasonic light scattering imaging is a new functional imaging technology that combines traditional B-mode ultrasound imaging and light scattering tomography (DOT).
- Trial name
- NCT06468566
- Testing
- Ultrasound light scattering imaging equipment
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Xin-Wu Cui
Benign Skin Tumor, Basal Cell Carcinoma
Study to Examine Lesions of the Skin Using Confocal Laser Microscopy
Using ex-vivo confocal laser scanning microscopy, a reliable statement can be made about the extent, histological structure and possible significance of a skin change without having to send tissue samples for demanding and…
- Conditions
- Benign Skin Tumor, Basal Cell Carcinoma, Melanoma, Squamous Cell Cancer
- Trial name
- NCT06598137
- Testing
- Ex vivo confocal laser microscopy
- Where
- Germany
- Volunteers
- 645 people, healthy volunteers welcome
- Sponsor
- LMU Klinikum
Leiomyoma
Trial of Mifepristone for Fibroids
The purpose of this trial is to determine if low-dose mifepristone benefits women with symptomatic fibroids.
- Trial name
- NCT00133705
- Testing
- Mifepristone, Inert Capsule
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Neurofibromatosis 2, Vestibular Schwannoma
Lapatinib Study for Children and Adults With Neurofibromatosis Type 2 (NF2) and NF2-Related Tumors
The purpose of this study is to determine if Lapatinib has any effect on tumors found in patients with Neurofibromatosis Type 2 (NF2). NF2 is a condition that mainly affects the skin and nervous system.
- Trial name
- NCT00973739
- Testing
- Lapatinib
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Tumor Gastric
Telomeric Abnormalities in Colorectal Diseases by Fluorescent in Situ Hybridization Technique
Colorectal carcinoma is a heterogeneous disease that is caused by the interaction of genetic and environmental factors. colorectal carcinoma encompasses a complex disease with different molecular pathways and biological…
- Trial name
- NCT03208777
- Testing
- taking blood samples
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Benign Breast Neoplasm, Breast Carcinoma
MR Correlated Spectroscopic Imaging for Diagnosing Breast Cancer
This trial studies how well an imaging technique called magnetic resonance (MR) spectroscopic imaging works in identifying breast cancer in women with benign or suspicious areas in the breast.
- Conditions
- Benign Breast Neoplasm, Breast Carcinoma, Malignant Breast Neoplasm
- Trial name
- NCT06090630
- Testing
- Diffusion Weighted Imaging, Magnetic Resonance Spectroscopic Imaging
- Where
- United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Jonsson Comprehensive Cancer Center
Hepatocellular Carcinoma, Cholangiocarcinoma
Hepatobiliary Tumors Tissue Samples Acquisition
Hepatobiliary tumors have a poor prognosis and high individual heterogeneity, so it is of great significance to find important prognostic markers and then screen out specific subgroups of people; meanwhile, chronic hepatitis…
- Conditions
- Hepatocellular Carcinoma, Cholangiocarcinoma, Gallbladder Cancer, Biliary Tract Cancer
- Trial name
- NCT04445532
- Testing
- Gene expression analysis, Genomic analysis, Protein expression analysis
- Where
- China
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Breast Cancer
Role of Cytochrome P450 2D6 (CYP2D6) *4 Polymorphism,in Malignant Breast Diseases
The aim of our study is to investigate the potential role of the CYP2D6*4 polymorphism in breast cancer and furthermore to assess the role of oxidative stress, antioxidant capacity and ferretin in pathogenesis of breast cancer in…
- Trial name
- NCT00539422
- Testing
- pcr and serum markers for breast cancer
- Where
- Egypt
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mansoura University
Pulmonary Nodules, Multiple, Pulmonary Nodules, Solitary
Differentiation of Benign and Malignant Pulmonary Nodules by Volatile Organic Compounds in Human Exhaled Breath
The goal of this observational study is to develop an advanced expiratory algorithm model utilizing exhaled breath volatile organic compound (VOC) markers.
- Conditions
- Pulmonary Nodules, Multiple, Pulmonary Nodules, Solitary, Lung Cancer
- Trial name
- NCT06518655
- Testing
- Gas chromatography-mass spectrometry(GC-MS) and micro Gas Chromatography-photoionisation detector (μGC-PID) system
- Where
- 15 sites in China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- ChromX Health
Metrorrhagia, Menorrhagia
Surgical Success After Laparoscopic vs Abdominal Hysterectomy
The purpose of the proposed pilot study is to investigate the effectiveness, cost, safety, and long-term impact on quality of life of laparoscopic hysterectomy (LH) in relation to abdominal hysterectomy (AH) for the treatment of…
- Conditions
- Metrorrhagia, Menorrhagia, Leiomyoma, Adenomyosis
- Trial name
- NCT01793584
- Testing
- Laparoscopic hysterectomy, Abdominal hysterectomy
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Robotic Hysterectomy (Benign Indications/Early-stage Cancer)
Effect of Preoperative Simulator Warmup on Intraoperative Robotic Surgical Skills
Surgical residents and fellows acquire operative knowledge and skills by assisting attending surgeons in the operating room. Previous research has shown that practising technical skills prior to operating on patients can improve…
- Trial name
- NCT01969487
- Testing
- Preoperative warm-up on simulator
- Where
- 2 sites in United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University